*  Research programme: thiopurine prodrugs - Angiogene - AdisInsight
Angiogene Pharmaceuticals was developing bioreductive prodrugs of 6-mercaptopurine (6-MP) or 6-thioguanine (6-TG) for the ... Research programme: thiopurine prodrugs - Angiogene Alternative Names: ANG 706; ANG 719; ANG700 series; Hypoxia activated ...
  http://adisinsight.springer.com/drugs/800023606?error=cookies_not_supported&code=24064d70-2f02-4796-94d0-e8a5ae4df68d
*  A new prodrug form of Affibody molecules (pro-Affibody) is selectively activated by cancer-associated proteases
In addition, a prodrug concept for small affinity proteins is developed.. Two of the developed methods are for engineering and/ ... The prodrug Affibody (pro-Affibody) against the HER2 receptor was constructed by fusing a HER2-specific Affibody (ZHER2) to an ... A new prodrug form of Affibody molecules (pro-Affibody) is selectively activated by cancer-associated proteases. Sandersjöö, ... We believe this prodrug approach with proteolytic activation is promising for improving tissue specificity in future in vivo ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:788314
*  Patent US6352996 - Liposomal prodrugs comprising derivatives of camptothecin and methods of ... - Google Patents
Liposomal prodrugs including these specific derivatives of camptothecin restrained by a liposomal delivery system are also ... Processes for making these prodrugs and for using them in cancer treatment are also disclosed. ... Typically, the prodrugs bind to the lipid bilayer membrane of the liposome with high affinity. The liposome bound prodrug can ... Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs. US 6352996 B1 ...
  http://www.google.com/patents/US6352996?dq=6,373,753
*  Badass Quote of the Day
... pro-drugs being legal, pro-practice religion if you want to), how he or she is treated because of his or her body (pro-equality ... pro-drugs being legal, pro-practice religion if you want to), how he or she is treated because of his or her body (pro-equality ...
  http://www.patheos.com/blogs/dispatches/2012/12/29/badass-quote-of-the-day-18/?ak_action=force_mobile&wpmp_switcher=mobile
*  Replies
Pro-choice, pro-drugs, etc.. 16 posted on 10/09/2012 8:25:28 AM PDT by xzins (Retired Army Chaplain and Proud of It! True ...
  http://www.freerepublic.com/focus/f-news/2942219/replies?c=13
*  PLOS ONE: Substrate Mediated Enzyme Prodrug Therapy
... dose response was achieved using SMEPT and administration of judiciously chosen concentration of SN-38 glucuronide prodrug thus ... β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples ... drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug ... we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in ...
  http://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0049619&imageURI=info:doi/10.1371/journal.pone.0049619.g003
*  Indian Patents. 209030:THE COMPOUND 4-(2-BUTYLAMINO)2,7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-YL)(1,5-A)-PYRAZOLO-1,3,5...
A thorough discussion of prodrugs is provided in the following: Design of Prodrugs, H. Bundgaard, ed., Elsevier, 1985; Methods ... vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of Formula (I) are, within the scope ... in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of Formula (I) are prepared by ... 1984; Pro-drugs as Novel Delivery Systems, T. Higuchi and V. Stella, Vol. 14 of the A.C.S. Symposium Series, and Bioreversible ...
  http://www.allindianpatents.com/patents/209030-the-compound-4-2-butylamino-2-7-dimethyl-8-2-methyl-6-methoxypyrid-3-yl-1-5-a-pyrazolo-1-3-5-triazine-of-formula-i
*  Wiley: Prodrugs and Targeted Delivery: Towards Better ADME Properties - Jarkko Rautio, Raimund Mannhold, Hugo Kubinyi, et al
5.5 Additional Applications of Prodrugs for Modulating Solubility.. 5.6 Parallel Exploration of Analogues and Prodrugs in Drug ... 16 The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs (Jane P.F. Bai, Mike Pacanowski, Atiqur Rahman, and ... 12 Directed Enzyme Prodrug Therapies (Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley, and ... 6 Prodrugs Designed to Target Transporters for Oral Drug Delivery (Mark S. Warren and Jarkko Rautio). ...
  http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527326030,subjectCd-CH62.html
*  Pharmaceuticals | Free Full-Text | A New Classification of Prodrugs: Regulatory Perspectives
A prodrug may belong to multiple categories and be recognized as a Mixed-Type prodrug. For example a prodrug may be converted ... whereas Type IB prodrugs' conversion occurs in the primary metabolic tissues such as liver, gut, or lung. For Type II prodrugs ... a new classification system for prodrugs is proposed to provide useful information about where in the body a prodrug is ... In this system, prodrugs are classified into Type I or Type II and the respective Subtypes IA, IB, IIA, IIB or IIC based on ...
  http://www.mdpi.com/1424-8247/2/3/77
*  Molecules | Free Full-Text | Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs
Prodrugs 3-5 rapidly underwent enzymatic hydrolysis to release the parent compound LZDO in 1-3 h in rat liver microsomes and ... Prodrugs 3-5 were found to display a potent positive inotropic effect on the myocardium, without the risk of arrhythmia. ... The half-life of the parent compound was prolonged after intragastric administration of prodrug 3, which was found to be a ... ester prodrugs 3-5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of ...
  http://mdpi.com/1420-3049/18/4/4561
*  Nucleotides as Antiviral Compounds. On the Feasibility of an Esterase-dependent Prodrug Strategy for 2-5A
Inside the cell, upon unmasking by cellular enzymes, such as esterases, the prodrug is transformed into active drug. In the ... A common prodrug strategy includes masking of the negatively charged phosphate groups with biodegradable lipophilic protecting ... On the Feasibility of an Esterase-dependent Prodrug Strategy for 2-5A. Kiuru, Emilia (2015-06-05). .fb_iframe_widget span { ... The efficiency of nucleotide and oligonucleotide based drugs is largely dependent on the prodrug strategy used to enhance their ...
  http://www.utupub.fi/handle/10024/104610
*  Molecules | Free Full-Text | Soft Alkyl Ether Prodrugs of a Model Phenolic Drug: The Effect of Incorporation of Ethyleneoxy...
The only prodrug that was more water soluble and more lipid soluble than APAP did not improve JMMIPM of APAP. This result may ... have been measured for the prodrugs. The JMMIPM values were accurately predicted by the Roberts-Sloan (RS) equation. Only ... Two different types of soft alkyl ether prodrugs incorporating ethyleneoxy groups into the promoiety have been synthesized for ... The only prodrug that was more water soluble and more lipid soluble than APAP did not improve JMMIPM of APAP. This result may ...
  http://www.mdpi.com/1420-3049/14/10/4231
*  AQ4N, a Cytotoxic Prodrug, Inhibits Proliferation and VEGF Secretion in Retinal Cells | IOVS | ARVO Journals
Purpose: : AQ4N is an anticancer prodrug, which is bioreduced to the active DNA intercalating topoisomerase II inhibitor, AQ4, ... S. Raghava, U.B. Kompella; AQ4N, a Cytotoxic Prodrug, Inhibits Proliferation and VEGF Secretion in Retinal Cells . Invest. ... AQ4N, a Cytotoxic Prodrug, Inhibits Proliferation and VEGF Secretion in Retinal Cells ... AQ4N, a Cytotoxic Prodrug, Inhibits Proliferation and VEGF Secretion in Retinal Cells ...
  http://iovs.arvojournals.org/article.aspx?articleid=2392721
*  AID 712141 - Prodrug conversion assessed as recombinant human MMP-12 mediated compound conversion to(S)-5-((S)-1-amino-1...
Prodrug conversion assessed as recombinant human MMP-12 mediated compound conversion to(S)-5-((S)-1-amino-1-oxopropan-2-ylamino ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/712141
*  Genetic manipulation of drug sensitivity in haematopoietic cells. - The Christie Research Publications Repository
By contrast, gene transfer of a prodrug activator, to confer sensitivity to otherwise nontoxic prodrugs, might allow deletion ... By contrast, gene transfer of a prodrug activator, to confer sensitivity to otherwise nontoxic prodrugs, might allow deletion ... In addition, expression of a prodrug activator in tumour-infiltrating haematopoietic cells could provide a means of ... In addition, expression of a prodrug activator in tumour-infiltrating haematopoietic cells could provide a means of ...
  http://christie.openrepository.com/christie/handle/10541/78371
*  Patente CA2023404A1 - Phosphorylated glycosidase inhibitor prodrugs - Google Patentes
A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl ... A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl ...
  http://www.google.es/patents/CA2023404A1?hl=es&dq=flatulence
*  Structural Biochemistry/Prodrugs - Wikibooks, open books for an open world
There is another prodrug called the Type II prodrugs. Unlike that of Type I prodrug, Type II prodrugs are bioactivated ... One type of prodrug is called the Type I prodrugs. This type of prodrug is bioactivated intracellularly. Lipid-lowering statins ... Subtypes of Prodrugs[edit]. It is also seen that Type I and Type II prodrugs can be categorized into Subtypes. For example, ... Classification of Prodrugs[edit]. Looking on how the human body converts the prodrug into the final active drug form, there are ...
  https://en.wikibooks.org/wiki/Structural_Biochemistry/Prodrugs
*  Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
... William A. Denny ... This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to satisfy a number of criteria. They ... Both prodrugs and their activated species should have good distributive properties, so that the resulting bystander effects can ... Prodrugs of DNA alkylating agents, that are less cell cycle-specific than antimetabolites and more effective against noncycling ...
  https://www.hindawi.com/journals/bmri/2003/627861/abs/
*  Brevet US6713454 - Prodrugs of etoposide and etoposide analogs - Google Brevets
... prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable ... 4.1 Prodrugs of the Invention. The present invention provides drug-PEG oligomer/polymer prodrugs. The prodrugs of the present ... Soluble prodrugs of paclitaxel. WO1999030727A1. 14 d c. 1998. 24 juin 1999. Enzon, Inc.. Polymeric prodrugs of amino- and ... The prodrugs of the present invention exhibit the following useful properties:. The inactive prodrug form helps to mitigate ...
  http://www.google.fr/patents/US6713454
*  Countering TB prodrug resistance | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://science.sciencemag.org/content/355/6330/1169.6
*  Sex, prodrugs and rock and roll - Mind Hacks
Sex, prodrugs and rock and roll. BBC News has a report on the increasingly popularity of gamma-Butyrolactone or GBL as a ... GBL is closely related to 1,4-Butanediol, which is also a GHB prodrug. 1,4-B recently caused a scare because a toy called 'Aqua ... Compounds that are weak or inactive until the body transforms them into an active drug are called prodrugs, and this is the ... Probably the most commonly used illicit prodrug is heroin, which is metabolised into morphine in the body, but both are Class A ...
  https://mindhacks.com/2007/12/28/sex-prodrugs-and-rock-and-roll/
*  cannabisnews.com: The Pro-Drug Czar
... function share_this(num) { tit=encodeURIComponent('The Pro-Drug Czar'); url= ... The Pro-Drug Czar Posted by CN Staff on October 15, 2009 at 19:23:47 PT By Daniel Lyons, Newsweek Web Exclusive Source: ...
  http://cannabisnews.com/news/thread25066.shtml