*  Dogger Bank itch - Wikipedia
This salt is also found in some sea sponges and has potent cytotoxic activity against P388 leukemia cells. A study of two cases ... The rash is caused by a type of cell-mediated hypersensitivity reaction; this type of hypersensitivity normally occurs in ... it reappeared with greater severity when he returned to the area and performed the same activities; this time the rash spread ... dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis". Comparative ...
  https://en.wikipedia.org/wiki/Dogger_Bank_itch
*  Halogenated Indole Alkaloids from Marine Invertebrates
This type of compounds exhibit a potent cytotoxic activity against P388 murine leukemia cell line, also being effective against ... Finally, aplysinopsins show specific toxicity for cancer cells; however, the most potent pharmacological activity of ... The antimitotic activity of these variants has also been assessed. Cytotoxic activity in the submicromolar range as well as ... Aplycianins are cytotoxic to the human tumor cell lines MDA-MB-231 (breast adenocarcinoma), A549 (lung carcinoma), and HT-29 ( ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2885079/
*  Recent Progress in Drug Discovery Based on Plant-Derived Natural Products Research - CHEMICAL BIOLOGY
It also has in vivo activity against P388 leukemia. H1 likely is a general cytotoxic rather than a cell-specific agent (83). ... K1 and K2 demonstrated potent antileukemic activity against P-388 leukemia in mice (105). A related ingenol-type diterpene ( ... Cytotoxic activity of maytanprine isolated from M. diversifolia in human leukemia K562 cells. Biol. Pharm. Bull. 2004; 27:1236- ... has been investigated for growth-inhibiting and apoptosis-inducing activities in K562 leukemia cells (86). Cytotoxic ...
  http://schoolbag.info/chemistry/chemical_biology/105.html
*  Cerevisterol - Wikipedia
The sterol is cytotoxic to mouse P388 leukemia cells and A549 human alveolar epithelial cells grown in culture. Bills CE, ... "A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells". Chemistry and Biodiversity. 5 (1 ... Cerevisterol inhibits the eukaryotic enzyme DNA polymerase alpha, and it is also a potent inhibitor of NF-kappa B activation. ... 6β-Oxygenated sterols from the South China Sea gorgonian Muriceopsis flavida and their tumor cell growth inhibitory activity ...
  https://en.wikipedia.org/wiki/Cerevisterol
*  Plus it
... of MX affects the cytotoxic activity and the ability to stimulate topoisomerase II-mediated DNA damage in intact cells and with ... In addition, 9-aza-APs were highly effective in vivo against both systemic P388 murine leukemia and MX-1 human mammary ... The 2-aza derivatives are substantially more potent than the 1-aza or the 2,3 di-aza congeners against L1210 cells in vitro. ... Synthesis and structure-activity relationship against murine leukemias. J Med Chem 30:121-131. ...
  http://molpharm.aspetjournals.org/content/59/1/96
*  The Raw Food World
showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.. https://www.ncbi.nlm.nih.gov/pubmed/ ... I am positive that it takes only 1 - 1.5 drops of our extremely potent Reishi Spore Oil to get the same amount/strength of ... Cervical, Liver, Leukemia, Lymphoma, Tumor. https://www.ncbi.nlm.nih.gov/pubmed/20615519. All of the compounds were assayed for ... Lzps processed antitumor activity against sarcoma 180 and Lewis lung cancer in mice and enhanced the NK cell activity. Lzps-1 ...
  https://www.therawfoodworld.com/vid/pre-order-reishi-spore-powder-o-pi1008792
*  Marine Drugs | Free Full-Text | Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the ...
Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with ... Investigating human tumor xenografts in an ex-vivo clonogenic assay revealed selective antitumor activity, whereas sensitive ... ascites hepatoma AH13 and mouse P388 leukemia [8]. The first isolated four dragmacidins 4, containing the six membered ... e were screened for in vitro antitumor activity in a panel of 12 human tumor cell lines. All compounds showed cytotoxic ...
  http://www.mdpi.com/1660-3397/11/3/643/htm
*  The anti-neoplastic activity of ethylamine-carboxyborane and triphenylphosphine-carboxyborane in L-1210 lymphoid leukemia...
... murine L-1210 lymphoid leukemia, P-388 lymphocytic leukemia, human Tmolt, acute lymphoblastic T cell leukemia, colorectal ... St Louis, MO, USA). Pharmacological methods Cytotoxic activity Compounds 1 and 2 were tested for cytotoxic activity by ... Previously two carboxyborane derivatives demonstrated potent antineoplastic activity in murine screens and cytotoxicity in ... The anti-neoplastic activity of ethylamine-carboxyborane and triphenylphosphine-carboxyborane in L-1210 lymphoid leukemia cells ...
  https://www.docme.ru/doc/1941487/the-anti-neoplastic-activity-of-ethylamine-carboxyborane-..
*  Antitumor Activity of Monoterpenes Found in Essential Oils
... and V79 hamster lung cells [34]. Thymol showed antioxidant activity and cytotoxic activity against the mouse leukemia P388 cell ... vulgaris essential oils on growth of four human tumor cells. The specie T. serpyllum was the most potent in all tested cell ... Terpinene showed significant evidence for antioxidant activity and cytotoxic activity against mouse leukemia P388 cells [31]. ... for mouse P388 leukemia cell among others.. 1.3. Menthol. Menthol was cytotoxic for murine leukemia WEHI-3 cells in a ...
  https://www.hindawi.com/journals/tswj/2014/953451/
*  Healing Powers of Aloes: Pharmacology and Therapeutic Applications | Aloe | Medicinal Plants
DEHP is a plasticizer and has a potent antileukaemic effect in human cells and anti-mutagenic activity in the Salmonella ... Aloe-emodin is active against P-388 leukemia in mice and selectively inhibits human neuroectodermal tumor cell growth in tissue ... However, others have investigated aloe-emodin as a cytotoxic agent on several tumor cell lines but no significant activity was ... The antipsoriatic activity of anthrones is probably multimodal: inhibition of the oxygen consumption of cells; a reduction in ...
  http://medicinalplants.us/healing-powers-of-aloes-pharmacology-and-therapeutic-applications
*  Frontiers | The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates | Pharmacology
This review features pharmacologically active NRPs from marine sponge and tunicates based on their biological activities. ... This review features pharmacologically active NRPs from marine sponge and tunicates based on their biological activities. ... Compound (11) exhibited weak cytotoxic activity against A2780 ovarian tumor and K562 leukemia cancer cells with ID50 of 19.15 ... Both compounds were found to be cytotoxic against P388 murine leukemia cells with IC50 values of 78, 68 pg/mL, respectively ( ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00333/full
*  Compound having antitumor properties - Patent # 4366318 - PatentGenius
Lymphocytic Leukemia P388 Test. The animals used are DBA2 mice all of one sex and weighing between 18.5 and 21.5 grams. The ... The compound (II) unexpectedly has high experimental antitumour activity and is more dose potent than m-AMSA. Compound (II) has ... inoculation above the right axilla of 0.1 ml of dilute ascitic fluid containing 10.sup.6 cells of lymphocyticleukemia P388. The ... cytotoxic agents, such as bleomycin, cyclophosphamide, bisulfan, procarbazine, hyroxyurea, etc.;hormones such as dromostanolone ...
  http://www.patentgenius.com/patent/4366318.html
*  Frontiers | Nanodrug delivery in reversing multidrug resistance in cancer cells | Pharmacology
... cancer stem cells, tumor initiating cells or cancer microenvironment. Selective nanocarrier targeting to tumor overcomes dose- ... cancer stem cells, tumor initiating cells or cancer microenvironment. Selective nanocarrier targeting to tumor overcomes dose- ... effective and promising platforms for treatment of drug resistant cancer cells. Nanocarriers have potential to improve drug ... effective and promising platforms for treatment of drug resistant cancer cells. Nanocarriers have potential to improve drug ...
  https://www.frontiersin.org/articles/10.3389/fphar.2014.00159/full
*  Marine Drugs | Free Full-Text | Marine Antitumor Drugs: Status, Shortfalls and Strategies | HTML
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not ... which has been shown by Dassonneville and coworkers as a strong inducer of apoptosis in HL-60 and P388 leukemia cells. Through ... Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. Cancer Res 2008, 68, 5216- ... Watanabe, J; Natsume, T; Kobayashi, M. Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with ...
  http://www.mdpi.com/1660-3397/8/10/2702/htm
*  Marine Drugs | Free Full-Text | Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance |...
... as the factor that showed inhibitory activity in vivo against P388 lymphocytic leukemia in mice (T/C, tumor volume treated ... They are localized in the cell membrane of nerve cells and other cell types and mediate the effect of serotonin and the ... The most potent pharmacological activity of aplysinopsins is related to modulation of the central nervous system. This can be ... group/tumor volume control group × 100% equal 135 at 200 mg/kg) [2]. Aplysinopsin also appeared to be cytotoxic against P338, ...
  http://mdpi.com/1660-3397/7/2/166/htm
*  In Vitro Ultramorphological Assessment of Apoptosis on CEMss Induced by Linoleic Acid-Rich Fraction from Typhonium...
... flagelliforme displayed poor cytotoxic activity against in vitro P388 murine leukemia cells [6]. A low cytotoxic activity has ... Our results show that this plant has potent cytotoxicity and anticancer potential through inducing apoptosis in CEMss cells. ... The treated cells showed obvious changes as compared to untreated cells. Treated CEMss cells showed blebbing of the cell ... flagelliforme showed cytotoxic activity toward NCI-H23 cells, but not to noncancerous BALB/c 3T3 cells [4]. ...
  https://www.hindawi.com/journals/ecam/2011/421894/
*  Discovery and development of tubulin inhibitors - Wikipedia
Hemiasterlin A and hemiasterlin B show potent activity against the P388 cell line and inhibit cell division by binding to the ... The cryptophycins are a family of related depsipeptides showing highly potent cytotoxic activity. Cryptophycin 52 was ... A high number of white cells in the blood indicates leukemia, so a new anti-cancer drug had been discovered. These two ... 2-Methoxyestradiol exhibits potent apoptotic activity against rapidly growing tumor cells. It also has antiangiogenic activity ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_tubulin_inhibitors
*  Frontiers | Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines | Immunology
... and five potent inducers of immunogenic cell death (radiotherapy, shikonin, high-hydrostatic pressure, oncolytic viruses and ( ... and five potent inducers of immunogenic cell death (radiotherapy, shikonin, high-hydrostatic pressure, oncolytic viruses and ( ... with a special emphasis on strategies that are applied to obtain a highly immunogenic tumor cell cargo to load and to activate ... with a special emphasis on strategies that are applied to obtain a highly immunogenic tumor cell cargo to load and to activate ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2015.00663/full
*  N-substituted indenoisoquinolines and syntheses thereof - Patent application
... model system used for screening compounds for anti-cancer activity. However, the P388 murine leukemia system was found to be ... allowing impacted cells to recover. Therefore, the search for potent inhibitors of topoisomerase I continues. SUMMARY OF THE ... selectively more cytotoxic to cells of certain types of cancers, thus increasing the ability to select compounds for further ... weak activity; ++ and +++: modest activity; ++++: similar activity as 1 μM camptothecin; +++++: greater activity than 1 μM ...
  http://www.patentsencyclopedia.com/app/20120101119
*  Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses
... as a potent inhibitor of dengue virus 2 infection in cell culture. The antiviral activity is observed at concentrations that do ... In the first study, LTM given at 0.25 mg/kg for nine days significantly extended survival in a murine model of P388 leukemia ( ... Lactimidomycin inhibits DENV2 production in Huh7 cells at concentrations that are non-cytotoxic ... In order to determine whether the antiviral activity of LTM extends to other viruses, we first infected Vero cells with Kunjin ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4850914/
*  Pharmaceuticals: Natural Products and Natural Product Models - CHEMICAL BIOLOGY
... that retained the HDAC and tumor cell line inhibitory activities with significant reduction of inhibition of normal cells (161 ... Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring ... Discodermolide (88) was isolated from Discodermia dissoluta by using a P388 cell line toxicity bioassay; later it was ... Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase ...
  http://schoolbag.info/chemistry/chemical_biology/130.html
*  Concise Synthesis and Biological Assessment of (+)-Neopeltolide and a 16-Member Stereoisomer Library of 8,9-Dehydroneopeltolide...
... and P388 murine leukemia cell lines has revealed marked differences in potency between the stereoisomers. This study provides ... a marine macrolide natural product that elicits a highly potent antiproliferative activity against several human cancer cell ... I. V. Mineeva, New approach to the synthesis of macrocyclic core of cytotoxic lactone (+)-neopeltolide. Synthesis of C7-C14 ... 9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions, Marine Drugs, 2014, 12, 11, ...
  http://onlinelibrary.wiley.com/doi/10.1002/chem.201300664/abstract
*  Protocols and Video Articles Authored by Dominique Schols (Translated to Russian)
Finally, 3d demonstrated an antitumor activity in a model of murine intraperitoneally transplanted P388 leukemia, achieving the ... ribonucleoside 11b showed significant cytotoxic activity (∼7 μM) almost equally active against a variety of tumor cell lines. ... We demonstrated the potent anti-HIV and -HSV activity of this drug in a diverse set of clinically relevant in vitro, ex vivo, ... both in cells as in a cell-free in vitro translation/translocation system. The activity of CADA maps to the cleavable N- ...
  https://www.jove.com/author/Dominique_Schols?language=Russian
*  Plus it
The cytotoxic target of ARC-111 was investigated using the mouse leukemia P388 cell line and its CPT-resistant TOP1-deficient ... h]naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. Bioorg. Med. Chem., 11 ... B, ARC-111-induced apoptosis is reduced in TOP1-deficient P388/CPT45 cells. P388 and p388/CPT45 cells were treated with drug ... which cross-reacted with mouse TOP1 in P388 cells (Fig. 6A) ⇓ . The effect of ARC-111 on apoptosis in P388 and P388/CPT45 cells ...
  http://cancerres.aacrjournals.org/content/63/23/8400
*  OTA Report:Herbal Treatments
No antitumor activity was found in other tests (leukemia L1210 (475,928), leukemia L5222 (75), leukemia P388 (928), Ehrlich ... For many years it has been known that lapachol is a potent cytotoxic agent and is an active antimalarial agent in animal test ... The mutated cells differ radically in appearance and function from their parent cells. Eventually a viciously competent cell ... The results of NCI's tests with Essiac showed no antitumor activity in the mouse lymphocytic leukemia P388 tumor system. In ...
  https://www.quackwatch.org/01QuackeryRelatedTopics/OTA/ota04.html