*  Recombinant Human RUNX2 protein (ab112259) | Abcam
A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and ... contains the phosphorylation sites.. * Post-translational. modifications. Phosphorylated; probably by MAP kinases (MAPK) (By ... Tissue specificity. Specifically expressed in osteoblasts.. * Involvement in disease. Defects in RUNX2 are the cause of ... alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. ...
  http://www.abcam.com/recombinant-human-runx2-protein-ab112259.html
*  Anti-RUNX2 antibody (ab76956) | Abcam
A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and ... contains the phosphorylation sites.. * Post-translational. modifications. Phosphorylated; probably by MAP kinases (MAPK) (By ... Tissue specificity. Specifically expressed in osteoblasts.. * Involvement in disease. Defects in RUNX2 are the cause of ... Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in ...
  https://www.abcam.com/runx2-antibody-ab76956.html
*  Anti-RUNX2 antibody (ab23981) | Abcam
A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and ... contains the phosphorylation sites.. * Post-translational. modifications. Phosphorylated; probably by MAP kinases (MAPK) (By ... Tissue specificity. Specifically expressed in osteoblasts.. * Involvement in disease. Defects in RUNX2 are the cause of ... Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice.. Biol Open 7:N/A (2018). Read ...
  https://www.abcam.com/runx2-antibody-ab23981.html
*  Molecular Pathways: Response and Resistance to BRAF and MEK Inhibitors in BRAFV600E Tumors | Clinical Cancer Research
RAF kinases activate the dual specificity kinases MEK1 and MEK2 through phosphorylation at serine 218 and serine 222, ... Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation ... The RAS-RAF-MEK (MAP-ERK kinase)-ERK (extracellular signal-regulated kinase) pathway plays a central role in driving ... The RAS-RAF-MEK (MAP-ERK kinase)-ERK (extracellular signal-regulated kinase) pathway controls cell growth, differentiation, ...
  http://clincancerres.aacrjournals.org/content/20/5/1074?rss=1
*  CST - Phospho-Erk1/2 Pathway Sampler Kit
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Each antibody in the Phospho-Erk1/2 Pathway Sampler Kit recognizes only the phosphorylated form of ...
  https://www.cellsignal.com/products/primary-antibodies/phospho-erk1-2-pathway-sampler-kit/9911?Ntt=erk&fromPage=plp
*  Protein Phosphatases - QIAGEN
DUSPs can dephosphorylate serine and threonine as well as tyrosine residues, primarily targeting MAP kinases. PP1 family ... By reversing the phosphorylation of key regulatory proteins mediated by protein kinases, phosphatases serve as an important ... dual specificity phosphatases (DUSPs), cell cycle regulatory phosphatases, the 4 major serine/threonine protein phosphatase ... and signal transduction pathway activation. Solutions optimized for protein phosphatase studies include PCR array, miRNA, siRNA ...
  https://www.qiagen.com/lu/shop/genes-and-pathways/complete-biology-list/protein-phosphatases/
*  CST - PhosphoPlus® p44/42 MAPK (Erk1/2)(Thr202/Tyr204) In-Cell Duet (ICW Compatible)
Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) detects endogenous levels of p44 and p42 MAP kinase ( ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ...
  https://www.cellsignal.com/products/primary-antibodies/7263?Ntt=P44%2F42+MAPK+
*  MAP2K1 - Dual specificity mitogen-activated protein kinase kinase 1 - Cricetulus griseus (Chinese hamster) - MAP2K1 gene &...
Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of ... leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular ... RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. ... cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. ...
  http://www.uniprot.org/uniprot/Q63980
*  STK38 - Wikipedia
"Entrez Gene: STK38 serine/threonine kinase 38". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2- ... 2004). "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the ... 2003). "Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an ... Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene. GRCh38: Ensembl release 89: ...
  https://en.wikipedia.org/wiki/STK38
*  MAP4K2 - Mitogen-activated protein kinase kinase kinase kinase 2 - Homo sapiens (Human) - MAP4K2 gene & protein
The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation ... Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 ... Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N- ... Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns ( ...
  http://www.uniprot.org/uniprot/Q12851
*  WikiGenes - IFNA1 - interferon, alpha 1
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. Goh, K.C., ... ISGF3 gamma p48, a specificity switch for interferon activated transcription factors. Bluyssen, A.R., Durbin, J.E., Levy, D.E. ... Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. Barbieri, G., Velazquez, L., Scrobogna, M., Fellous, M ... To determine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we examined NF-kappaB ...
  http://www.wikigenes.org/e/gene/e/3439.html
*  ERK1 / ERK2 pThr202/pTyr204 - NBP1-19924 | acris-antibodies.com
... hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular- ... The activation of signal transduction pathways by growth factors, ... In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase ... Specificity. Specificity:. p-ERK1/2 (T202/Y204) detects endogenous levels of p-ERK1/2 protein.. Species:. Human, Mouse, Rat. ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/erk1-erk2-nbp1-19924.htm
*  4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors - Patent # 6821963 -...
... where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen or substituent groups such as alkyl, and where R. ... the compounds inhibit the phosphorylation of MAP kinase by MEK, thus preventing the activation of MAPkinase in cells in which ... Activated Ras leads in turn to the activation of a cascade of serine/threonine kinases. One of the groups of kinases known to ... This invention provides certain hydroxamic acid derivatives of anthranilic acids which inhibit certain dual specificity kinase ...
  http://www.patentgenius.com/patent/6821963.html
*  Prkcq - Protein kinase C theta type - Mus musculus (Mouse) - Prkcq gene & protein
Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine ... In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP ... dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T ... which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN ( ...
  http://www.uniprot.org/uniprot/Q02111
*  CST - Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Biotinylated)
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Biotinylated) detects ...
  https://www.cellsignal.com/products/antibody-conjugates/4094?productId=5682&N=4294960384&fromPage=plp
*  Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral...
... becomes activated by serine/threonine phosphorylation leading to nuclear translocation (4). IRF7, a close homologue of IRF3, is ... mice revealed a MyD88-independent pathway that contributed to DC maturation and delayed NF-κB and MAP kinase activation (18, 19 ... Here, we have compared the role and specificity of TBK1 in the type I IFN response to lipopolysaccharide (LPS), polyI:C, and ... A new family of IKK-related kinases may function as I kappa B kinase kinases. Biochim. Biophys. Acta. 1471:M57-M62. ...
  http://jem.rupress.org/content/199/12/1651
*  Phospho anti-c-Kit (Y823) antibody (ab5634) | Abcam
Kinase activity is down-regulated by phosphorylation on serine residues by protein kinase C family members. Phosphorylation at ... Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. ... Tissue specificity. Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round ... Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the ...
  http://www.abcam.com/c-Kit-phospho-Y823-antibody-ab5634.html
*  TPL2 Antibody (Oligoclonal, 3HCLC)
protein serine/threonine kinase activity. receptor signaling protein serine/threonine kinase activity. MAP kinase kinase kinase ... phosphorylation signal transduction by protein phosphorylation stress-activated protein kinase signaling cascade activation of ... providing the best of both worlds-the sensitivity of a polyclonal antibody with the specificity of a monoclonal, all delivered ... Mitogen-activated protein kinase kinase kinase 8; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; Serine/ ...
  https://www.thermofisher.com/antibody/product/COT-TPL2-MAP3K8-Antibody-3HCLC-Oligoclonal/710377
*  Mitogen-activated protein kinase 9 - Wikipedia
"A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126/science ... "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes & ... Hu MC, Qiu WR, Wang YP (Nov 1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277-87. doi: ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_9
*  Map3k5 - Mitogen-activated protein kinase kinase kinase 5 - Mus musculus (Mouse) - Map3k5 gene & protein
... cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases ... These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription ... Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ ... Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important ...
  http://www.uniprot.org/uniprot/O35099
*  Mitogen-activated protein kinase - Wikipedia
Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... MAP2 kinases in turn, are also activated by phosphorylation, by a number of different upstream serine-threonine kinases (MAP3 ... This is conducted by specialized enzymes of the STE protein kinase group. In the case of classical MAP kinases, the activation ... Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase
*  Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... serine/threonine kinases, STK). A fewprotein kinases have dual specificity and phosphorylate threonine and tyrosine residues. ... Thus, the phosphorylation of a substrate, activation of a protein, a change in the expression of genes that are up- or down- ...
  http://www.patentgenius.com/patent/6410294.html
*  MAPK1 - Wikipedia
The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to ... "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909-20. doi:10.1093/ ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal- ...
  https://en.wikipedia.org/wiki/MAPK1
*  The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells
NO-aspirin was shown to induce the activation (marked by increased phosphorylation) of all three main MAP kinases in a ... Modulation of MAP-Kinase Activity. Mitogen activated protein (MAP) kinases are serine/threonine-specific proteins which respond ... κB may be due to the specificity by which this transcription factor binds to DNA and activates target genes. Such specificity ... and the p38 MAP kinases [121]. NSAIDs such as aspirin and its metabolite salicylate have long been shown to modulate MAP kinase ...
  https://www.hindawi.com/journals/omcl/2013/504230/
*  CST - Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate)
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) ...
  https://www.cellsignal.com/products/antibody-conjugates/4284?Ntt=P44%2F42+MAPK+