*  Molecular Pathways: Response and Resistance to BRAF and MEK Inhibitors in BRAFV600E Tumors | Clinical Cancer Research
RAF kinases activate the dual specificity kinases MEK1 and MEK2 through phosphorylation at serine 218 and serine 222, ... Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation ... The RAS-RAF-MEK (MAP-ERK kinase)-ERK (extracellular signal-regulated kinase) pathway plays a central role in driving ... The RAS-RAF-MEK (MAP-ERK kinase)-ERK (extracellular signal-regulated kinase) pathway controls cell growth, differentiation, ...
  http://clincancerres.aacrjournals.org/content/20/5/1074?rss=1
*  STK38 - Wikipedia
"Entrez Gene: STK38 serine/threonine kinase 38". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2- ... 2004). "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the ... 2003). "Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an ... Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene. GRCh38: Ensembl release 89: ...
  https://en.wikipedia.org/wiki/STK38
*  CST - Phospho-Erk1/2 Pathway Sampler Kit
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Each antibody in the Phospho-Erk1/2 Pathway Sampler Kit recognizes only the phosphorylated form of ...
  https://www.cellsignal.com/products/primary-antibodies/phospho-erk1-2-pathway-sampler-kit/9911?Ntt=erk&fromPage=plp
*  Recombinant Human RUNX2 protein (ab112259) | Abcam
A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and ... contains the phosphorylation sites.. * Post-translational. modifications. Phosphorylated; probably by MAP kinases (MAPK) (By ... Tissue specificity. Specifically expressed in osteoblasts.. * Involvement in disease. Defects in RUNX2 are the cause of ... alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. ...
  http://www.abcam.com/recombinant-human-runx2-protein-ab112259.html
*  Anti-RUNX2 antibody (ab23981) | Abcam
A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and ... contains the phosphorylation sites.. * Post-translational. modifications. Phosphorylated; probably by MAP kinases (MAPK) (By ... Tissue specificity. Specifically expressed in osteoblasts.. * Involvement in disease. Defects in RUNX2 are the cause of ... Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice.. Biol Open 7:N/A (2018). Read ...
  https://www.abcam.com/runx2-antibody-ab23981.html
*  Protein Phosphatases - QIAGEN
DUSPs can dephosphorylate serine and threonine as well as tyrosine residues, primarily targeting MAP kinases. PP1 family ... By reversing the phosphorylation of key regulatory proteins mediated by protein kinases, phosphatases serve as an important ... dual specificity phosphatases (DUSPs), cell cycle regulatory phosphatases, the 4 major serine/threonine protein phosphatase ... and signal transduction pathway activation. Solutions optimized for protein phosphatase studies include PCR array, miRNA, siRNA ...
  https://www.qiagen.com/lu/shop/genes-and-pathways/complete-biology-list/protein-phosphatases/
*  MAPK1 - Wikipedia
The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to ... "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909-20. doi:10.1093/ ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal- ...
  https://en.wikipedia.org/wiki/MAPK1
*  Mitogen-activated protein kinase 9 - Wikipedia
"A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126/science ... "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes & ... Hu MC, Qiu WR, Wang YP (Nov 1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277-87. doi: ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_9
*  CST - PhosphoPlus® p44/42 MAPK (Erk1/2)(Thr202/Tyr204) In-Cell Duet (ICW Compatible)
Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) detects endogenous levels of p44 and p42 MAP kinase ( ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ...
  https://www.cellsignal.com/products/primary-antibodies/7263?Ntt=P44%2F42+MAPK+
*  MAP4K2 - Mitogen-activated protein kinase kinase kinase kinase 2 - Homo sapiens (Human) - MAP4K2 gene & protein
The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation ... Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 ... Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N- ... Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns ( ...
  http://www.uniprot.org/uniprot/Q12851
*  Mitogen-activated protein kinase - Wikipedia
Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... MAP2 kinases in turn, are also activated by phosphorylation, by a number of different upstream serine-threonine kinases (MAP3 ... This is conducted by specialized enzymes of the STE protein kinase group. In the case of classical MAP kinases, the activation ... Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase
*  CST - Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Biotinylated)
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Biotinylated) detects ...
  https://www.cellsignal.com/products/antibody-conjugates/4094?productId=5682&N=4294960384&fromPage=plp
*  ERK1 / ERK2 pThr202/pTyr204 - NBP1-19924 | acris-antibodies.com
... hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular- ... The activation of signal transduction pathways by growth factors, ... In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase ... Specificity. Specificity:. p-ERK1/2 (T202/Y204) detects endogenous levels of p-ERK1/2 protein.. Species:. Human, Mouse, Rat. ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/erk1-erk2-nbp1-19924.htm
*  4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors - Patent # 6821963 -...
... where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen or substituent groups such as alkyl, and where R. ... the compounds inhibit the phosphorylation of MAP kinase by MEK, thus preventing the activation of MAPkinase in cells in which ... Activated Ras leads in turn to the activation of a cascade of serine/threonine kinases. One of the groups of kinases known to ... This invention provides certain hydroxamic acid derivatives of anthranilic acids which inhibit certain dual specificity kinase ...
  http://www.patentgenius.com/patent/6821963.html
*  CST - Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate)
... consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). ... MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, ... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many ... Specificity / Sensitivity Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) ...
  https://www.cellsignal.com/products/antibody-conjugates/4284?Ntt=P44%2F42+MAPK+
*  MAP2K1 - Dual specificity mitogen-activated protein kinase kinase 1 - Cricetulus griseus (Chinese hamster) - MAP2K1 gene &...
Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of ... leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular ... RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. ... cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. ...
  http://www.uniprot.org/uniprot/Q63980
*  CHAPTER 4 HORMONAL ACTION | Free Medical Textbook
... activates the MAP kinase pathway. The result of this interaction is the activation of a cascade of threonine or serine kinases. ... Activation of the intrinsic tyrosine kinase activity of the insulin receptor results in the phosphorylation of a substrate, ... Protein-tyrosine kinases. Annu Rev Biochem 1985; 54:897.. 6.. Sahal D, Ramachandvan J, Fujita-Yamaguchi Y. Specificity of ... Investigators have considered that tyrosine kinase activation could also initiate a phosphorylation and dephosphorylation ...
  https://medtextfree.wordpress.com/2011/12/19/chapter-4-hormonal-action/
*  TPL2 Antibody (Oligoclonal, 3HCLC)
protein serine/threonine kinase activity. receptor signaling protein serine/threonine kinase activity. MAP kinase kinase kinase ... phosphorylation signal transduction by protein phosphorylation stress-activated protein kinase signaling cascade activation of ... providing the best of both worlds-the sensitivity of a polyclonal antibody with the specificity of a monoclonal, all delivered ... Mitogen-activated protein kinase kinase kinase 8; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; Serine/ ...
  https://www.thermofisher.com/antibody/product/COT-TPL2-MAP3K8-Antibody-3HCLC-Oligoclonal/710377
*  MAPK14 - Wikipedia
The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the ... "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". The EMBO ... p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs). In addition to MAPK14 for p38α MAPK, ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ...
  https://en.wikipedia.org/wiki/MAPK14
*  Protein kinase - Wikipedia
While MAP kinases are serine/threonine-specific, they are activated by combined phosphorylation on serine/threonine and ... which is involved in the MAP kinase cascade, is a mixed serine/threonine and tyrosine kinase and, hence a dual-specificity ... Autophosphorylation of the activation loop causes the two subdomains of the intrinsic kinase to shift, opening the kinase ... Most kinases act on both serine and threonine (serine/threonine kinases), others act on tyrosine (tyrosine kinases), and a ...
  https://en.wikipedia.org/wiki/Protein_kinase
*  WikiGenes - IFNA1 - interferon, alpha 1
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. Goh, K.C., ... ISGF3 gamma p48, a specificity switch for interferon activated transcription factors. Bluyssen, A.R., Durbin, J.E., Levy, D.E. ... Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. Barbieri, G., Velazquez, L., Scrobogna, M., Fellous, M ... To determine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we examined NF-kappaB ...
  http://www.wikigenes.org/e/gene/e/3439.html
*  Neurotrophin signaling endosomes; biogenesis, regulation, and functions
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to ... Trk-harboring endosomes stimulate trophic signaling pathways that include the PI-3 kinase and MAP kinase cascades [12,31]. ... Trk signaling promotes the phosphorylation of dynein intermediate chains on a conserved serine, which enhances dynein binding ... However, specificity in terms of cargo recognition may arise from the existence of different dynein complexes in cells due to ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4987223/
*  CST - Progesterone Receptor Signaling Antibody Sampler Kit
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb recognizes endogenous p44 and p42 MAP Kinase (Erk1/2) ... The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal ... Specificity / Sensitivity Unless otherwise indicated, each antibody will recognize endogenous total levels of target protein. ... PR-B has been shown to promote the activation of the Src/p21ras/Erk pathway (9). ...
  https://www.cellsignal.com/products/primary-antibodies/12807?N=4294959795&fromPage=plp
*  Phospho anti-c-Kit (Y823) antibody (ab5634) | Abcam
Kinase activity is down-regulated by phosphorylation on serine residues by protein kinase C family members. Phosphorylation at ... Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. ... Tissue specificity. Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round ... Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the ...
  http://www.abcam.com/c-Kit-phospho-Y823-antibody-ab5634.html
*  Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... serine/threonine kinases, STK). A fewprotein kinases have dual specificity and phosphorylate threonine and tyrosine residues. ... Thus, the phosphorylation of a substrate, activation of a protein, a change in the expression of genes that are up- or down- ...
  http://www.patentgenius.com/patent/6410294.html