*  Diverse Functions of Secretory Phospholipases A2
... phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung- ... M. Triggiani, F. Granata, A. Petraroli et al., "Inhibition of secretory phospholipase A2-induced cytokine production in human ... phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-α," ... "Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages ...
  https://www.hindawi.com/journals/avm/2014/689815/ref/
*  PLA2R1 - Wikipedia
Secretory phospholipase A2 receptor is an enzyme that in humans is encoded by the PLA2R1 gene. M-type phospholipase A2 receptor ... "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, ... "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal ... "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand ...
  https://en.wikipedia.org/wiki/PLA2R1
*  PLA2G1B - Wikipedia
Ancian P, Lambeau G, Mattéi MG, Lazdunski M (1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular ... Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene. Phospholipase A2 (EC 3.1.1.4) catalyzes ... 1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J. Biol. Chem. 272 (25): ... "Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung". DNA. 5 (6): 519-27. ...
  https://en.wikipedia.org/wiki/PLA2G1B
*  PLA2G2A - Wikipedia
Ancian P, Lambeau G, Mattéi MG, Lazdunski M (1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular ... Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene. Phospholipase A2 GRCh38: ... 1995). "Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2 ... 1991). "Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate". Science. 254 (5034): 1007 ...
  https://en.wikipedia.org/wiki/PLA2G2A
*  Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J. Biol. Chem. 274:24973-24979. doi: ... Recent progress in phospholipase A₂ research: from cells to animals to humans. Prog. Lipid Res. 50:152-192. doi:10.1016/j. ... Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial ... Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. J. Biol. Chem. 275: ...
  http://jem.rupress.org/content/early/2013/05/14/jem.20121887
*  PLA2G10 - Wikipedia
Group 10 secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G10 gene. ENSG00000069764 GRCh38: Ensembl ... 2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial ... and expression of a novel human secretory phospholipase A2". J Biol Chem. 272 (25): 15745-52. doi:10.1074/jbc.272.25.15745. ... 2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ...
  https://en.wikipedia.org/wiki/PLA2G10
*  Reversible activation of secretory phospholipase A2 by sulfhydryl reagents.
Secretory phospholipase A(2)s (sPLA(2)s) have been implicated in physiological and pathological events, but the regulatory ... Group II Phospholipases A2. Humans. PC12 Cells. Phospholipases A / drug effects, metabolism*. Phospholipases A2. Rats. ... Both sulfhydryl reagents stimulated AA release from the HEK293T cells expressing human sPLA(2)X, and stimulated the sPLA(2) ... Phospholipases A; EC 3.1.1.4/Group II Phospholipases A2; EC 3.1.1.4/Phospholipases A2 ...
  http://www.biomedsearch.com/nih/Reversible-activation-secretory-phospholipase-A2/15752719.html
*  Phospholipase A2 Activity in Normal and Staphylococcus aureus-Infected Rabbit Eyes | IOVS | ARVO Journals
1998) Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears ... phospholipases A2 in human tissues Inflammation 17,453-464 [CrossRef] [PubMed] ... 1979) Complement in tears from normal humans Am J Ophthalmol 88,758-763 [CrossRef] [PubMed] ... Phospholipase A2 Activity in Normal and Staphylococcus aureus-Infected Rabbit Eyes You will receive an email whenever this ...
  https://iovs.arvojournals.org/article.aspx?articleid=2163213
*  PLA2G5 - Wikipedia
2003). "Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human ... 2000). "Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells". ... Calcium-dependent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G5 gene. This gene is a member of the ... "Entrez Gene: PLA2G5 phospholipase A2, group V". Otha, Shin (15 June 2013). "Group V secretory phospholipase A2 is involved in ...
  https://en.wikipedia.org/wiki/PLA2G5
*  Why Pleiotropic Interventions are Needed for Alzheimer's Disease
Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat ... Passive or active Aβ vaccines, which can clear amyloid from the brain in animals and humans, appear to be most beneficial for ... 4-Hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease. J Neuropathol Exp Neurol. 1997;56:866-871. [PubMed] ... after it is freed from membrane phospholipids by phospholipases. For example, while COX-2 is inducible and elevated in neurons ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2876259/
*  IJMS | Free Full-Text | Lipid Based Therapy for Ulcerative Colitis-Modulation of Intestinal Mucus Membrane Phospholipids as a...
A direct role for secretory phospholipase A2 and lyso-phosphatidylcholine in the mediation of lipopolysaccharide-induced ... Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and ... Although the anti-inflammatory properties of PC have been shown in cell culture as well as in animal models and humans, the ... would be the increased degradation of PC by phospholipases. As has been previously shown, the arachidonic acid content of PC is ...
  http://www.mdpi.com/1422-0067/11/10/4149/htm
*  Phospholipase A2 - Wikipedia
There are also prokaryotic A2 phospholipases. Additional types of phospholipases include phospholipase A1, phospholipase B, ... Human phospholipase A2 isozymes include: Group I: PLA2G1B Group II: PLA2G2A, PLA2G2C, PLA2G2D, PLA2G2E, PLA2G2F Group III: ... De Luca D, Minucci A, Cogo P, Capoluongo ED, Conti G, Pietrini D, Carnielli VP, Piastra M (Jan 2011). "Secretory phospholipase ... Increased sPLA2 activity is observed in the cerebrospinal fluid of humans with Alzheimer's disease and multiple sclerosis, and ...
  https://en.wikipedia.org/wiki/Phospholipase_A2
*  Nutrients | Free Full-Text | Consequences of Essential Fatty Acids | HTML
... allowing EFA-based signaling to influence nearly every aspect of human physiology. In this way, the health consequences of ... consequences that come from eating imbalanced diets which support excessive chronic actions of n-6 mediators that harm human ... Nearly every cell and tissue in the human body expresses at least one of these receptors, ... Three enzymes, cytosolic PLA2 (cPLA2), Ca2+-independent PLA2 (iPLA2) and secretory phospholipase A2 (sPLA2) all hydrolyze both ...
  http://www.mdpi.com/2072-6643/4/9/1338/htm
*  Faculty Directory › UConn Health
Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth. Belinsky, Glenn S; Rajan, ... Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a ... Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. ... Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. Dong, Mei; Johnson, Michael; Rezaie ...
  http://facultydirectory.uchc.edu/profile?profileId=4268
*  Intracellular- and extracellular-derived Ca2+ influence phospholipase A2-mediated fatty acid release from brain phospholipids
cytosolic phospholipase A2. iPLA2. Ca2+-independent phospholipase A2. sPLA2. secretory phospholipase A2. PUFA. polyunsaturated ... Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. J Biol Chem. 1999;274:8823-8831. [PubMed] ... Brain phospholipases A2: a perspective on the history. Prostaglandins Leukot Essent Fatty Acids. 2004;71:161-169. [PubMed] ... Humans can obtain DHA by eating fish or fish products, or can synthesize it in the liver from circulating α-linolenic acid, ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2735787/
*  Anti-Phospholipase A2 Antibody, clone CH-7 | 05-1406
... clone CH-7 detects level of Phospholipase A2 & has been published & validated for use in WB, ELISA, IH(P). Find MSDS or SDS, a ... One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been ... PLA2 isoforms include membrane-associated, Ca2+-independent forms, cytosolic, Ca2+-dependent forms, and secretory forms. PLC ... ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. ...
  http://www.merckmillipore.com/INTL/en/product/Anti-Phospholipase-A2-Antibody-clone-CH-7,MM_NF-05-1406
*  20-HETE and Circulating Insulin in Essential Hypertension With Obesity | Hypertension
Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth ... Our studies on urinary excretion of this eicosanoid in humans have provided indirect evidence for an analogous role in human ... Increased glomerular cytosolic phospholipase A2 activity of OLETF rats with early diabetes. Exp Clin Endocrinol Diabetes. 1999; ... Increased muscular phospholipase A2 activity in diabetic rats. Diabetes Metab. 1992; 18: 213-217. ...
  http://hyper.ahajournals.org/content/43/2/388
*  Clinical Concentrations of Doxorubicin Inhibit Activity of Myocardial Membrane-associated, Calcium-independent Phospholipase A2...
Hazen S. L., Gross R. W. Identification and characterization of human myocardial phospholipase A2 from transplant recipients ... Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2. J. Biol. Chem., 266: 7227-7232, ... 1 ⇓ 2 ⇓ 3 ⇓ 4 ⇓ 5 ⇓ ). Three main types of PLA2 have been described in mammalian tissues: secretory, cytosolic Ca2+-dependent, ... indicating that observed effects are most likely to occur in the course of anthracycline therapy in humans. ...
  http://cancerres.aacrjournals.org/content/61/10/4024
*  Animal Pharm: Dr.Mao, Brain Foods, Autism, And Alzheimer's Prevention
Pro-inflammatory cytokines (TNF-alpha and IL-1), secretory phospholipase A2 IIA and lipoprotein-PLA2 are implicated in vascular ... This Human Life , my observations about living - human biology, emotions and spirituality (Genomic DNA diagnostics) ... Humans and other predators up on the food pyramid of life do it all the time. Ketosis is necessary for survival.. The situation ... Parkinson's disease is to some degree caused by lipid peroxidation due to phospholipases activation. Niemann-Pick diseases A ...
  http://drbganimalpharm.blogspot.com/2009/03/drmao-brain-foods-autism-and-alzheimers.html
*  Method for Improving Vein Performance in Bypass Surgery - Patent application
Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a phase II double- ... Gronroos J M, Kuttila K, Perttila J, Nevalainen T J. Phospholipases A2 in the serum of patients after coronary artery bypass ... A2, cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies ... and humans [35-37]. It has also been noted that early endothelial damage in vein grafts may initiate the development of ...
  http://www.patentsencyclopedia.com/app/20130190270
*  I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural...
The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate ... 1 B). Human (Fig. 1, B and C) and mouse (Fig. 1 D) sera that were deficient in gammaglobulins (HGS) or secretory IgM (sIgM−/−) ... Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2. J. Biol. Chem. 266:7227-7232. ... vaccination with pneumococcal polysaccharide failed to induce anti-DNA antibodies in humans (47). ...
  http://jem.rupress.org/content/196/5/655
*  Molecular Interactions Leading to Lipoprotein Retention and the Initiation of Atherosclerosis | Arteriosclerosis, Thrombosis,...
LDL treatment with phospholipase A2 increased its binding.52 A neighboring region to site B, site A (residues 3148 to 3158), ... Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease. ... The normal human intima is rich in versican and the content increases with lesion progression.17 In lesions, CS chains are ... In contrast, studies in cholesterol-fed monkeys correlated reduced LDL size with less proteoglycan binding.48 In humans, Anber ...
  http://atvb.ahajournals.org/content/24/12/2211
*  Chapter 317. Allergies, Anaphylaxis, and Systemic Mastocytosis | Harrison's Principles of Internal Medicine, 18e |...
The secretory granule of the human mast cell has a crystalline structure, unlike mast cells of lower species. IgE-dependent ... 317-1) involves translocation of calcium ion-dependent cytosolic phospholipase A2 to the outer nuclear membrane, with ... An immediate and late cellular phase of allergic inflammation can be induced in the skin, nose, or lung of some allergic humans ... The calcium ion-dependent activation of phospholipases cleaves membrane phospholipids to generate lysophospholipids, which, ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727118
*  ASMscience | Defensins and Other Anti
Even though the processing of human neutrophil alpha-defensins occurs during neutrophil maturation prior to cellular release ... matrilysin may participate in the activation of beta-defensins or other antimicrobial peptides in the human airways. Defensins ... While the focus is on defensins and antimicrobial peptides from humans, peptides from other species are also included where ... Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with ...
  http://www.asmscience.org/content/book/10.1128/9781555817619.chap2
*  Brain-Immune Signaling: Pathogen Recognition & PG Synthesis | BrainImmune: Trends in Neuroendocrine Immunology
The delayed PGE2 response requires transcription of the inducible enzymes (secretory phospholipase A2 (sPLA2-IIA), ... phospholipases A2 (PLA2); receptors for PGE2 (EP1-4); preoptic area (POA); rostral ventrolateral medulla (rVLM); subfornical ... Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol; 11: 814-9. ... It is estimated that humans have over 10 different TLRs, while other TLRs are also characterized in other mammals as well as ...
  http://www.brainimmune.com/brain-immune-signaling-focus-on-pathogen-recognition-and-pge2-synthesis/