*  Explaining the Phenomenon of Nitrate Tolerance | Circulation Research
... and cyclic nucleotide-degrading phosphodiesterases. These shape the biological response, ie, inhibition of smooth muscle ... Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast. Eur J Pharmacol. 1993; 243: 141 ... This Review is part of a thematic series on Cyclic GMP-Generating Enzymes and Cyclic GMP-Dependent Signaling, which includes ... Activation of endothelial PKC induces phosphorylation of NOSIII, leading to an inhibition of NO production by the enzyme,77,78 ...
  http://circres.ahajournals.org/content/97/7/618
*  Frontiers | PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis | Pharmacology
Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and ... Our data highlight the potential use of PDE5 inhibitors in CF. Therapeutic approaches using clinically approved PDE5 inhibitors ... Studies using PDE5 inhibitors in mice homozygous for the clinically relevant F508del mutation have been conducted with the aim ... Studies using PDE5 inhibitors in mice homozygous for the clinically relevant F508del mutation have been conducted with the aim ...
  https://www.frontiersin.org/articles/10.3389/fphar.2012.00167/full
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Two phosphodiesterase genes, PDEL and PDEH, regulate development and pathogenicity by modulating intracellular cyclic AMP ... In this mini-review, we describe the current view on the role of a plant protease, vacuolar processing enzyme (VPE), and the ... Inhibition of the plant NADPH oxidase by diphenyleneiodonium prevented host-derived H(2)O(2) accumulation and restored ... a potent inhibitor of SPT, had no effect on Bax-induced programmed cell death, suggested that suppression of cell death was not ...
  https://www.jove.com/visualize?author=Xiaobo%20Zheng%20
*  Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5...
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev. Physiol. Biochem. Pharmacol. 135:67- ... and presence of both PDE inhibitors (100 μM each; solid line) are shown in Fig. 5 A. Clearly, the inhibition of PDEs in NO- ... NO-induced cGMP formation was determined in the presence of PDE inhibitors. As PDE5 and PDE2 are the major enzymes responsible ... Cyclic nucleotide phosphodiesterases: relating structure and function. Prog. Nucleic Acid. Res. Mol. Biol. 65:1-52. ...
  http://jcb.rupress.org/content/155/2/271
*  US-6440981-B1: Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
... response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and ... Ahn, H.S. et al., Effects of Selective Inhibitors on Cyclic Nucleotide Phosphodiesterases of Rabbit Aorta, Biochemical ... The sulfoxide is reportedly converted by liver enzymes to the corresponding sulfide, which is acknowledged to be the active ... Souness, John E. et al., Role of Selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,943, MY ...
  http://vb.reconstructed.us/patent/US-6440981-B1
*  The Best Viagra Substitute
The inhibitor will be more inhibitors and calories to check this site. miles and the best insurance page prescription are ... In the phosphodiesterase do many to use or bleed out the ingredients initially. This the of weight payment may or may not try ... A: While every the best on the mg is an genetic enzyme Track, never in this pressure, request, it belongs versa not green as ... Across all zoals, VIAGRA removed the results of 43 consultation of cyclic week prices found to 15 base on prevention. Any ...
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*  Plus it
However, when the inhibitors were included during conditioned medium production, stronger inhibition (52-73%) was observed ( ... Synthesis of photoreactive phosphatidic acid analogues displaying activatory properties on cyclic AMP-phosphodiesterases. ... suggesting that both enzymes are involved in LPA production ( Fig. 3A ). At the concentrations of the PLA2 inhibitors used here ... Photoaffinity labeling of an isoform of phosphodiesterase. J Med Chem 2002; 45: 1678-85. ...
  http://cancerres.aacrjournals.org/content/66/6/3006
*  PDE4B - Wikipedia
"A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology". ... cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. This gene is a member ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important ...
  https://en.wikipedia.org/wiki/PDE4B
*  PDE4A - Wikipedia
cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene. The protein encoded ... Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A (Feb 2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced ... Zhou L, Thompson WJ, Potter DE (Jul 1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells" ( ... cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]" (pdf). ...
  https://en.wikipedia.org/wiki/PDE4A
*  PDE4D - Wikipedia
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is ... Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A (Feb 2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced ... Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (Aug 2000). "Phosphodiesterases 4D and 7A splice ... Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ...
  https://en.wikipedia.org/wiki/PDE4D
*  PDE1 - Wikipedia
PDE1 (phosphodiesterase type 1) is a phosphodiesterase enzyme also known as calcium- and calmodulin-dependent phosphodiesterase ... Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. ... Initially PDE1 inhibitors were claimed to be effective vascular relaxants. With availability of purified cloned enzymes, ... It can therefore be speculated that inhibition of PDE1C could produce beneficial effects due to its putative inhibition of SMC ...
  https://en.wikipedia.org/wiki/PDE1
*  Phosphodiesterase - Wikipedia
... is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, ... Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second ...
  https://en.wikipedia.org/wiki/Phosphodiesterase
*  Cyclic nucleotide phosphodiesterase - Wikipedia
5-monophosphate phosphodiesterase) are a family of phosphodiesterases. Generally, these enzymes hydrolyze some nucleoside 3',5 ... and inhibitor sensitivities. Retinal 3',5'-cGMP phosphodiesterase (PDE) is located in photoreceptor outer segments and is an ... The C-terminal of the PDE γ subunit is likely to be involved in inhibition of PDE α and β subunits, the binding site for Tα and ... cyclic 3',5'-mononucleotide phosphodiesterase, PDE, cyclic 3',5'-nucleotide phosphodiesterase, cyclic 3',5'-phosphodiesterase, ...
  https://en.wikipedia.org/wiki/Cyclic_nucleotide_phosphodiesterase
*  CGMP-specific phosphodiesterase type 5 - Wikipedia
"Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Adv Cyclic Nucleotide Res ... PDE5 is an enzyme that accepts cGMP and breaks it down. Sildenafil, vardenafil and tadalafil are inhibitors of this enzyme, ... Fertel R, Weiss B (1976). "Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" (abstract). ... cGMP-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various ...
  https://en.wikipedia.org/wiki/CGMP-specific_phosphodiesterase_type_5
*  Caffeine - Wikipedia
... also acts as a phosphodiesterase inhibitor. As a competitive nonselective phosphodiesterase inhibitor, caffeine raises ... Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ... the effects of non-specific phosphodiesterase inhibition". Clinics. 63 (3): 321-8. doi:10.1590/S1807-59322008000300006. PMC ... Caffeine is metabolized in the liver by the cytochrome P450 oxidase enzyme system, in particular, by the CYP1A2 isozyme, into ...
  https://en.wikipedia.org/wiki/Caffeine
*  Phosphodiesterase 3 - Wikipedia
Matthew M. (2003). "Isoform-Selective Inhibitors and Activators of PDE3 Cyclic Nucleotide Phosphodiesterases". WO 2003/012030: ... PDE3 enzymes are involved in regulation of cardiac and vascular smooth muscle contractility. Molecules that inhibit PDE3 were ... Cilostazol is approved for treatment of intermittent claudication and is thought to involve inhibition of platelet aggregation ... Aggregation of platelets is highly regulated by cyclic nucleotides. PDE3A is a regulator of this process, and PDE3 inhibitors ...
  https://en.wikipedia.org/wiki/Phosphodiesterase_3
*  PDE5 inhibitor - Wikipedia
"Differential Activation and Inhibition of the Multiple Forms of Cyclic Nucleotide Phosphodiesterase". Advances in Cyclic ... PDE5 inhibitors are primarily metabolized by the cytochrome P450 enzyme CYP3A4. The potential exists for adverse drug ... Fertel, Richard; Weiss, Benjamin (1976). "Properties and Drug Responsiveness of Cyclic Nucleotide Phosphodiesterases of Rat ... Weiss, B; Hait, W N (1977). "Selective Cyclic Nucleotide Phosphodiesterase Inhibitors as Potential Therapeutic Agents". Annual ...
  https://en.wikipedia.org/wiki/PDE5_inhibitor
*  Xanthine - Wikipedia
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... Ukena D, Schudt C, Sybrecht GW (February 1993). "Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase ... have been developed searching for compounds with greater selectivity for phosphodiesterase enzyme or adenosine receptor ... the effects of non-specific phosphodiesterase inhibition". Clinics (São Paulo). 63 (3): 321-8. doi:10.1590/S1807- ...
  https://en.wikipedia.org/wiki/Xanthine
*  Theobromine - Wikipedia
As a phosphodiesterase inhibitor, theobromine prevents the phosphodiesterase enzymes from converting the active cAMP to an ... Theobromine is weaker in both its inhibition of cyclic nucleotide phosphodiesterases and its antagonism of adenosine receptors ... 2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... "Phosphodiesterase". On-Line Medical Dictionary. Retrieved 2007-02-23. "Inhibitor". On-Line Medical Dictionary. Retrieved 2007- ...
  https://en.wikipedia.org/wiki/Theobromine
*  Discovery and development of phosphodiesterase 5 inhibitors - Wikipedia
PDEs are enzymes that hydrolyze cyclic adenosine 3,5-monophosphate (cAMP) and cyclic guanosine 3,5-monophospahate (cGMP), which ... By inhibition of PDE5 enzyme the cGMP concentration will be raised and can therefore increase the relaxation of smooth muscles ... Phosphodiesterases (PDEs) are a superfamily of enzymes. This superfamily is further classified into 11 families, PDE1 - PDE11, ... Other phosphodiesterase-5 inhibitors were developed from the structure in figure 7. Although PDE5 inhibitors main use has been ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_phosphodiesterase_5_inhibitors
*  PDE10A - Wikipedia
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. ... August 2006). "Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis". ... Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic ... August 2009). "Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1- ...
  https://en.wikipedia.org/wiki/PDE10A
*  Cyclic nucleotide - Wikipedia
Degradation is carried out primarily by a class of enzymes known as phosphodiesterases (PDEs). In mammalian cells, there are 11 ... cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... Inhibition of sAC, or knockdown by RNA interference (RNAi) transfection has been shown to prevent the proliferation of the ... Caffeine is a known PDE inhibitor, while drugs used for the treatment of erectile dysfunction like sildenafil and tadalafil ...
  https://en.wikipedia.org/wiki/Cyclic_nucleotide