*  Plus it
... is generated largely by type 1 phosphatidylinositol phosphate (PIP) kinases but can also be produced from PI-5-P at ... Phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2), the principal substrate for phosphoinositide 3-kinase (PI3K), ... intracellular membranes by the type 2 family of PIP kinases known as phosphatidylinositol-5-phosphate 4-kinases (PI5P4K). The ... Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell 2013;155:844 ...
  http://cancerdiscovery.aacrjournals.org/content/4/1/OF14
*  Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α | JEM
... phosphatidylinositol 3, 4, 5-trisphosphate; PIPKI, type I phosphatidylinositol phosphate kinase; PIPKIα, α isozyme of PIPKI; ... Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J. Biol. Chem. 271: ... The phosphatidylinositol phosphate kinases (PIPKs) are enzymes important for PI(4,5)P2 synthesis. There are two types of PIPKs ... Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α. Junko Sasaki, Takehiko Sasaki, Masakazu ...
  http://jem.rupress.org/content/201/6/859
*  Phosphatidylinositol phosphate - Wikipedia
Phosphatidylinositol phosphate may refer to: Phosphatidylinositol 3-phosphate, also known as PI(3)P Phosphatidylinositol 4- ... phosphate, also known as PI(4)P Phosphatidylinositol 5-phosphate, also known as PI(5)P. ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol_phosphate
*  An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis | JCB
phosphatidylinositol. PI4,5P2. PI 4,5-bisphosphate. PI4P. PI 4-phosphate. PIP4K. PI 5-phosphate 4-kinase. PIP5K. PI4P 5-kinase ... Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol ... Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J. Cell Biol. 169:139-149. doi: ... Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 420:89-93. doi:10.1038/ ...
  http://jcb.rupress.org/content/187/5/701
*  Phosphatidylinositol phosphate kinases - Wikipedia
Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that ... The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 2000 5:1-11. ... Phosphatidylinositol phosphate kinases, a multifaceted family of signalling enzymes. J Biol Chem 1999; 274:9907-9910 Kunz J, ... are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol_phosphate_kinases
*  ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ |...
Phosphatidylinositol 4-phosphate 5-kinase type Iγ (PIPKIγ) and synaptojanin 1, the major brain PI(4)phosphate 5-kinase and PI(4 ... phosphatidylinositol (4,5)-bisphosphate; PIPKIγ, phosphatidylinositol 4-phosphate 5-kinase type Iγ; PLD, phospholipase D; SV, ... DTSP, l-phosphatidylinositol 4-phosphate, and total brain lipid extracts were purchased from Sigma-Aldrich; γ[32P]ATP was ... Phosphatidylinositol 4-phosphate 5-kinase α is a downstream effector of the small G protein ARF6 in membrane ruffle formation. ...
  http://jcb.rupress.org/content/162/1/113
*  Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and...
Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and ... Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and ... Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and ...
  http://www.suddenoakdeath.org/?bibliography=novel-phosphatidylinositol-phosphate-kinases-with-a-g-protein-coupled-receptor-signature-are-shared-by-dictyostelium-and-phytophthora
*  Phosphatidylinositol-4-phosphate 5-kinase (IPR023610) | InterPro | EMBL-EBI
Phosphatidylinositol-4-phosphate 5-kinase (IPR023610) *Phosphatidylinositol-4-phosphate 5-kinase, plant (IPR017163) ... Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members ... Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members ... Phosphatidylinositol-4-phosphate 5-kinase (IPR023610). Short name: PInositol-4-P-5-kinase ...
  http://www.ebi.ac.uk/interpro/entry/IPR023610?q=kinase%20type:family
*  phosphatidylinositol-5-phosphate 4-kinase type 2 beta | Phosphatidylinositol phosphate kinases | IUPHAR/BPS Guide to...
Phosphatidylinositol phosphate kinases. Detailed annotation on the structure, function, physiology, pharmacology and clinical ... Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Last modified on 19/08/2015. ... 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta , 1-phosphatidylinositol-5-phosphate 4-kinase B , diphosphoinositide kinase ... phosphatidylinositol-5-phosphate 4-kinase, type II, beta , phosphatidylinositol-5-phosphate 4-kinase ...
  http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2162&familyId=782&familyType=ENZYME
*  Frontiers | Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation | Immunology
... and phosphatidylinositol 3,4,5-triphosphate (PIP3), which are essential for the activation of signalling pathways regulating ... and phosphatidylinositol 3,4,5-triphosphate (PIP3), which are essential for the activation of signalling pathways regulating ... are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5- ... are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5- ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00186/full
*  PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)
... phosphatidylinositol-5-phosphate 4-kinase, type II, alpha), Authors: Keli Lima, João Agostinho Machado-Neto. Published in: ... 4-phosphate 5-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase ... 4-phosphate 5-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase ... PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha). Written. 2015-09. Keli Lima, João Agostinho Machado-Neto. ...
  http://atlasgeneticsoncology.org/Genes/GC_PIP4K2A.html
*  Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production | Science Signaling
Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production ... Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production ... Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production ... Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production ...
  http://stke.sciencemag.org/content/11/547/eaan1210.full
*  Phosphatidylinositol 4-phosphate - Wikipedia
Phosphatidylinositol 3-phosphate Phosphatidylinositol 5-phosphate Phosphatidylinositol (3,4,5)-trisphosphate Godi A et al., ... Phosphatidylinositol 4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. ... "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8: 3090-3093. doi:10.1039/ ... "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol_4-phosphate
*  Phosphatidylinositol 5-phosphate - Wikipedia
Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and ... Phosphatidylinositol 4-phosphate and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate). Notably, steady-state PtdIns5P ... Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is ... Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol_5-phosphate
*  PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta)
... phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta), Authors: Dessen P. Published in: Atlas Genet ... 1-phosphatidylinositol-4-phosphate 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol ... 1-phosphatidylinositol-4-phosphate 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol ... phosphate biosynthetic process protein kinase B signaling phosphatidylinositol phosphorylation phosphatidylinositol-mediated ...
  http://atlasgeneticsoncology.org/Genes/GC_PIK3C2B.html
*  Pip4k2c MGI Mouse Gene Detail - MGI:2152214 - phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal. IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N- ... J:75718 Akiba Y, et al., Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development ... PIP4K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. Orthology source: HGNC, HomoloGene ... J:234283 Shim H, et al., Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the ...
  http://www.informatics.jax.org/marker/MGI:2152214
*  Pip4k2b MGI Mouse Gene Detail - MGI:1934234 - phosphatidylinositol-5-phosphate 4-kinase, type II, beta
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal. IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N- ... PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Orthology source: HomoloGene, HGNC ... J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53- ... interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5- ...
  http://www.informatics.jax.org/marker/MGI:1934234
*  PIP5K8 - Phosphatidylinositol 4-phosphate 5-kinase 8 - Arabidopsis thaliana (Mouse-ear cress) - PIP5K8 gene & protein
Phosphatidylinositol 4-phosphate 5-kinase 8Add BLAST. 769. Proteomic databases. PaxDb, a database of protein abundance averages ... sp,Q8RY89,PI5K8_ARATH Phosphatidylinositol 4-phosphate 5-kinase 8 OS=Arabidopsis thaliana GN=PIP5K8 PE=1 SV=1 ... ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. ...
  http://www.uniprot.org/uniprot/Q8RY89
*  Phosphatidylinositol 3-phosphate - Wikipedia
Phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of ... D J Gillooly; A Simonsen; H Stenmark (April 15, 2001). "Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain ... It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol. ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol_3-phosphate
*  Phosphatidylinositol-4-phosphate 3-kinase - Wikipedia
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ... the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol-4-phosphate_3-kinase
*  1-phosphatidylinositol-4-phosphate 5-kinase - Wikipedia
... phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme ... In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in ... participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol-4-phosphate_5-kinase
*  1-phosphatidylinositol-5-phosphate 4-kinase - Wikipedia
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase
*  1-phosphatidylinositol-3-phosphate 5-kinase - Wikipedia
... and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates in phosphatidylinositol signaling system and regulation ... In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". Curr ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase. Other names in ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol-3-phosphate_5-kinase
*  Phosphatidylinositol-4-phosphate 5- kinases (PIP5K) in neuronal development - Wikipedia
"Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain". The Journal of ... November 1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in ... Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K) or PIP5K or PI5K family regulates diverse cellular processes such as G ... Both Type I and Type II phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol-4-phosphate_5-_kinases_(PIP5K)_in_neuronal_development
*  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Phosphatidylinositol kinases | IUPHAR/BPS Guide to...
Phosphatidylinositol kinases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance ... phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Rat. -. 1687. 1 q34-q35. Pik3c2a phosphatidylinositol- ... phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha , phosphatidylinositol-4-phosphate 3-kinase ... Phosphatidylinositol kinases: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha. Last modified on 29/01/ ...
  http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2150&familyId=781&familyType=ENZYME