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*  Recombinant Human HMGA1 293 Cell Lysate HMGA1-5480HCL - Creative BioMart
5-deoxyribose-5-phosphate lyase activity; AT DNA binding; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; ... sequence-specific DNA binding transcription factor activity; transcription factor binding;. ... Autointegration results in viral DNA circles, organism-specific biosystem; Disease, organism-specific biosystem; Early Phase of ...
  https://www.creativebiomart.net/description_407146_318.htm
*  RCSB PDB - Protein Feature View - Formamidopyrimidine-DNA glycosylase - P42371 (FPG LACLC)
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. UniProt ... Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox. ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes ...
  http://www.rcsb.org/pdb/protein/P42371
*  DNA-(apurinic or apyrimidinic site) lyase - Wikipedia
... phosphate. In the 1970s, this class of enzyme was found to repair at apurinic or apyrimidinic DNA sites in E. coli and in ... In enzymology, DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5'- ... "Homo sapiens GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity". HumanCyc. SRI International. Retrieved March 9, ... Several names for DNA AP lyase include: AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); ...
  https://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase
*  Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. - PubMed - NCBI
DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics. *DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism* ... terminal abasic sites are excised by the 5'-deoxyribose-5-phosphate (5'-dRP) lyase activity of DNA polymerase beta (pol beta): ... In a similar manner to other lyases, Ku nicks DNA 3' of an abasic site by a mechanism involving a Schiff-base covalent ... forming a stable adduct between an abasic site within a radiolabeled DNA substrate and the 5'dPR/AP lyase. c, Adducts were ...
  https://www.ncbi.nlm.nih.gov/pubmed/?term=20383123
*  OGG1 - N-glycosylase/DNA lyase - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - OGG1 gene & protein
Has a beta-lyase activity that nicks DNA 3' to the lesion. ... DNA repair enzyme that incises DNA at 8-oxoG residues. Excises ... 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. ... apurinic or apyrimidinic site) lyase activity Source: UniProtKB-EC. *class III/IV DNA-(apurinic or apyrimidinic site) lyase ... phosphate. ... DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18). Short ...
  http://www.uniprot.org/uniprot/P53397
*  mutM - Formamidopyrimidine-DNA glycosylase - Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/B2VF70
*  mutM - Formamidopyrimidine-DNA glycosylase - Nitrosomonas eutropha (strain C91) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/Q0AD66
*  mutM - Formamidopyrimidine-DNA glycosylase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/Q6FE90
*  Recombinant Human NEIL1 protein (ab123204) | Abcam
DNA glycosylase/AP lyase Neil1. *DNA-(apurinic or apyrimidinic site) lyase Neil1 ... phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. ... Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... Epigenetics and Nuclear Signaling DNA / RNA DNA Damage & Repair Base Excision Repair ...
  http://www.abcam.com/recombinant-human-neil1-protein-ab123204.html
*  KEGG SSDB Paralog Search Result: ade:Adeh 4160
ade:Adeh_0277 DNA-(apurinic or apyrimidinic site) lyase K10563 280 103 ( -) 29 0.340 150 -, ade:Adeh_0577 periplasmic sensor ... ade:Adeh_4320 thiamine-phosphate kinase K00946 329 127 ( -) 35 0.301 306 -, ade:Adeh_0667 cell division protein FtsX K09811 294 ... ade:Adeh_3929 DNA-(apurinic or apyrimidinic site) lyase K10563 320 101 ( -) 29 0.315 232 -, ade:Adeh_4039 Dihydrodipicolinate ... DNA ligase I, ATP-dependent (dnl1); K10747 DNA ligase 1. Update status:. T00326 (acts,aid,bmur,bsaf,bzg,cbae,cpep,cspu,cthm,dcr ...
  http://www.kegg.jp/ssdb-bin/ssdb_paralog?org_gene=ade:Adeh_4160
*  Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional ... and processed with AP lyase activity that cleaves the 3' side of AP sites [22] or with APE1 that cleaves the phosphate backbone ... side of the intact apurinic/apyrimidinic site, this will be incised by apurinic/apyrimidinic endonuclease (APE1/APEX1). Finally ... Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells. J Mol Biol. 1992;227:981-4 ...
  http://www.jcancer.org/v07p1421.htm
*  UniProt: Q4QLW2
... lyase activity; IEA:UniProtKB-EC. DR GO; GO:0140080; F:class III/IV DNA-(apurinic or apyrimidinic site) lyase activity; IEA: ... to generate a single-strand break at the site of the removed base CC with both 3'- and 5'-phosphates. {ECO:0000255,HAMAP- CC ... DNA-(apurinic or apyrimidinic site) lyase MutM {ECO:0000255,HAMAP-Rule:MF_00103}; DE Short=AP lyase MutM {ECO:0000255,HAMAP- ... DNA_glyclase/AP_lyase_DNA-bd. DR InterPro; IPR015887; DNA_glyclase_Znf_dom_DNA_BS. DR InterPro; IPR020629; Formamido-pyr_DNA_ ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:Q4QLW2
*  Frontiers | Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance | Molecular Biosciences
Similar to Polg, in vitro work has demonstrated both Pol beta and PrimPol incorporate NtRTIs into nascent DNA. Cell culture and ... Similar to Polg, in vitro work has demonstrated both Pol beta and PrimPol incorporate NtRTIs into nascent DNA. Cell culture and ... Further complicating NRTI off-target effects on mtDNA maintenance, two additional DNA polymerases, Pol beta and PrimPol, were ... Further complicating NRTI off-target effects on mtDNA maintenance, two additional DNA polymerases, Pol beta and PrimPol, were ...
  https://www.frontiersin.org/articles/10.3389/fmolb.2017.00074/full
*  FPG IleRS zinc finger - Wikipedia
... apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination ... to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Fpg is a monomer composed of ... phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity; EC). Fpg has a preference for oxidised ... DNA glycosylase/AP lyase enzymes are involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. These ...
  https://en.wikipedia.org/wiki/FPG_IleRS_zinc_finger
*  H2TH domain - Wikipedia
... apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination ... to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Fpg is a monomer composed of ... phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity;EC 4.2.99.18). Fpg has a preference for ... is a DNA-binding domain found in DNA glycosylase/AP lyase enzymes, which are involved in base excision repair of DNA damaged by ...
  https://en.wikipedia.org/wiki/H2TH_domain
*  HMGA1 - High mobility group protein HMG-I/HMG-Y - Homo sapiens (Human) - HMGA1 gene & protein
T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'- ... DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKBInferred from direct assayi*19465398 ... 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct ... R-HSA-175567 Integration of viral DNA into host genomic DNA. R-HSA-177539 Autointegration results in viral DNA circles. R-HSA- ...
  https://www.uniprot.org/uniprot/P17096
*  mutY protein (Idiomarina loihiensis) - STRING interaction network
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (270 aa) ... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ...
  https://string-db.org/network/283942.IL1983
*  DNAtraffic - a database for systems biology of DNA metabolism and repair
DNA glycosylase/AP lyase Nei*DNA-(apurinic or apyrimidinic site) lyase Nei*Endonuclease VIII ... phosphates.. STRUCTURE SIMILARITY:. Contains 1 FPG-type zinc finger.. Belongs to the FPG family. ... Removes damaged bases from DNA, leaving an abasic site.. The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is ... Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ...
  https://dnatraffic.ibb.waw.pl/protein/protein_detail/244/
*  nth protein (Synechocystis sp. PCC6803) - STRING interaction network
... apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, ... Imidazoleglycerol-phosphate dehydratase. Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP- ... apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, ... apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, ...
  https://string-db.org/network/1148.SYNGTS_1186
*  HMGA2 - Wikipedia
found that HGMA2 protein can efficiently cleave DNA containing apurinic/apyrimidinic (AP) sites (is an AP lyase). In addition, ... this protein also possesses the related 5'-deoxyribosyl phosphate (dRP) lyase activity. They demonstrated an interaction ... showed that overexpression of HMGA2 delayed the release of DNA-PKcs (needed for non-homologous end joining DNA repair) from ... "HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy ...
  https://en.wikipedia.org/wiki/HMGA2
*  DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch...
5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1. J. ... DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J ... abasic sites are subsequently recognized by apurinic/apyrimidic endonucleases (APEs), which nick the DNA backbone to create DNA ... Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. J. Biol. Chem. 273:15263- ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2118644/?lang=en-ca
*  R2601 15835 protein (Pelagibaca bermudensis) - STRING interaction network
DNA-(apurinic or apyrimidinic site) lyase MutM ; Involved in base excision repair of DNA damaged by oxidation or by mutagenic ... phosphates (283 aa) ... DNA-(apurinic or apyrimidinic site) lyase MutM ; Involved in ... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ...
  https://string-db.org/network/314265.R2601_15835
*  C497 08839 protein (Halalkalicoccus jeotgali) - STRING interaction network
DNA-(apurinic or apyrimidinic site) lyase. DNA-(apurinic or apyrimidinic site) lyase; Endonuclease IV plays a role in DNA ... to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate (227 ... DNA-(apurinic or apyrimidinic site) lyase. Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP- ... DNA-(apurinic or apyrimidinic site) lyase; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at ...
  https://string-db.org/network/795797.HacjB3_13630
*  MUTYH - Wikipedia
The excision of the bases causes the formation of an apurinic/ apyrimidinic (AP site) gap. These gap sites are mutagenic in ... namely polymerase and dRP lyase. DNA ligase is used to seal the fragments after dRP excision causes the formation of 5'PO4 that ... cuts out the mismatched base pairs at the AP site and this causes the evolvement of 5'dRP (5' deoxyribose phosphate), a ... The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine ...
  https://en.wikipedia.org/wiki/MUTYH
*  AP endonuclease - Wikipedia
Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main ... Class III and class IV AP endonucleases also cleave DNA at the phosphate groups 3´ and 5´to the baseless site, but they ... Levin, Joshua D; Demple, Bruce (1990). "Analysis of class II (hydrolytic) and class I (beta-lyase) apurinic/apyrimidinic ... The AP site is then further stabilized through hydrogen bonding of the phosphate group 5´ to the AP site with Asn174, Asn212, ...
  https://en.wikipedia.org/wiki/AP_endonuclease