*  Patent US6346376 - Optical sensor unit and procedure for the ultrasensitive detection of ... - Google Patents
Method for Screening Chemical or Pharmaceutical Libraries for the Identification of Small Compound Molecules Useful for Therapy ... In view of the exceedingly small quantities of analytes in test samples (105 to 108 molecules), biosensor technologies must ... Method for Employing a Biosensor to Detect Small Molecules ('Fragments') that Bind Directly to Immobilized Protein Targets. ... there is still a need for a detection system which impairs as little as possible the conformation of the molecules or ...
  http://www.google.com/patents/US6346376?dq=6181294
*  Imaging in Cancer Drug Development : Pharmaceuticals : All
11:40 Imaging modalities in drug discovery: high-content screening of a kinase inhibitor small molecule library to identify ... Teva Pharmaceuticals Ltd; TNO Pharma; U T M D Anderson Cancer Center; UCL; UCL Cancer Institute; UCL Centre for Advanced ...
  http://www.smi-online.co.uk/pharmaceuticals/archive/2-2004/conference/
*  Samaritan Discovers Long-Sought-After Small Molecule Drug That Induces Human Neuron Differentiation. - Free Online Library
Samaritan Discovers Long-Sought-After Small Molecule Drug That Induces Human Neuron Differentiation. by 'Business Wire'; ... Moreover, such a molecule may offer an adjuvant treatment in neuronal stem cell therapy. About Samaritan Pharmaceuticals ... Chicago style: The Free Library. S.v. Samaritan Discovers Long-Sought-After Small Molecule Drug That Induces Human Neuron ... Samaritan Discovers Long-Sought-After Small Molecule Drug That Induces Human Neuron Differentiation.. (n.d.) >The Free Library. ...
  https://www.thefreelibrary.com/Samaritan+Discovers+Long-Sought-After+Small+Molecule+Drug+That+...-a085161815
*  Schaus, Scott
... of small-molecule libraries is widespread in the pharmaceutical industry, the goal of the Molecular Libraries (ML) Roadmap ... the problem of how to develop small molecule libraries and techniques for making them that meet all the needs of pharmaceutical ... Target pilot libraries include complex dihydropyrimidones, azaphilone-derived libraries, tetracyclic alkaloid-type libraries, ... The overarching objective of our research is synthesis of small molecules that are used as tools to study human diseases. To ...
  http://www.bu.edu/chemistry/category/faculty/schaus-scott/
*  RFA-RM-09-005: New Methodologies for Natural Products Chemistry (R01)
... of small-molecule libraries is a standard approach in the pharmaceutical industry, the goal of the Molecular Libraries Program ... small-molecules is readily rationalized, as these molecules have evolved in order to enhance the survival of the organisms that ... The long-term goal is to reinvigorate the investigation of nature as a prolific source of bioactive small molecules with the ... Accordingly, a secondary purpose of this FOA is to expand the NIH small molecule collection by the addition of these compounds ...
  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-005.html
*  Vertex Pharmaceuticals Archives - CenterWatch News Online
X-Chem will apply its proprietary DEXTM libraries, which contain more than 120 billion small molecules, toward the discovery of ... Enanta Pharmaceuticals, a R&D-focused biotechnology company dedicated to creating small molecule drugs for viral infections and ... Home » Vertex Pharmaceuticals Vertex Pharmaceuticals. Gilead's $12 billion acquisition of Kite ignites speculation about an M&A ... Concert Pharmaceuticals has announced that the FDA has granted Orphan Drug designation for CTP-656, Concert's next generation ...
  http://www.centerwatch.com/news-online/tag/vertex-pharmaceuticals/
*  Spatial Sequencing Platform Developer Wins Chan Zuckerberg Grant | GEN
Gilead Steps Into Kinase Biology with Acquisition of CGI Pharmaceuticals for up to $120M. Firm has generated a library of small ... FISSEQ is a spatial sequencing platform designed to read and visualize the 3D coordinates of molecules of intact tissue, a ... Current State of Protocol Design Impacting Small to Mid-Sized Biotech Companies ... molecule kinase inhibitors. * ACT Raises $10M to Progress Preclinical Cancer Therapeutics. Lead candidates are licensed through ...
  https://www.genengnews.com/gen-news-highlights/spatial-sequencing-platform-developer-wins-chan-zuckerberg-grant/81255332
*  Drug Discovery Technologies Market by Technology and End User - Global Industry Analysis and Forecast to 2025
Many biotech and pharmaceutical companies have small molecule compound libraries which can be used for screening of potential ... Advancements in Bioinformatics are expected to shape the pharmaceutical industry and will enhance drug development technologies ... reliable and sensitive biocompatible analysis for easy identification of pharmaceutical ingredients for drug development and ...
  https://www.crystalmarketresearch.com/report/drug-discovery-technologies-market
*  Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening - Current Protocols
... quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs ... The NCGC pharmaceutical collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical ... Quantifying structure and performance diversity for sets of small molecules comprising smallmolecule screening collections. ... Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening. Sivaraman Dandapani1, Gerard Rosse2, ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ch110252.html?quicktabs_cp=abstract
*  Management of Chemical and Biological Samples for Screening Applications. (eBook, 2012) [WorldCat.org]
... practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical ... Get this from a library! Management of Chemical and Biological Samples for Screening Applications.. [Mark Wigglesworth; Terry ... With its treatment of libraries of small molecules as wel. Read more... ... With its treatment of libraries of small molecules as wel."@en ;. schema:exampleOfWork   http://www.worldcat.org/title/management-of-chemical-and-biological-samples-for-screening-applications/oclc/773567113
*  Small Molecule Inhibitors of C. perfringens Epsilon-Toxin | SBIR.gov
2) Utilize initial testing data in concert with pharmaceutical chemistry to design and synthesize a biased library of beta- ... 3) Screen the library using the cell-based assay to select the most potent inhibitors and test their ability to block the pore ... It is based on the blocking of the target pore with molecules having the same symmetry as the pore itself. Results from our ... Based on the successful completion of this feasibility study, we propose to de sign, synthesize and screen a library of beta- ...
  https://www.sbir.gov/sbirsearch/detail/73308
*  Hollis-Eden to Present Interim Data From Its Phase I/II Clinical Studies of Apoptone(R) (HE3235) at Molecular Targets and...
Hollis-Eden Pharmaceuticals is pursuing clinical development of a second oral small-molecule candidate, Triolex®, from its ... synthetic steroid library. Triolex decreases macrophage infiltration into fatty tissues and pro-inflammatory processes. The ... About Hollis-Eden Pharmaceuticals. Hollis-Eden Pharmaceuticals is a development-stage company with two product candidates in ... Apoptone and Triolex represent the lead candidates from Hollis-Eden's small molecule platform based on metabolites or synthetic ...
  http://www.bio-medicine.org/biology-technology-1/Hollis-Eden-to-Present-Interim-Data-From-Its-Phase-I-II-Clinical-Studies-of-Apoptone-28R-29--28HE3235-29-at-Molecular-Targets-and-Cancer-Therapeutics--14819-1/
*  https://www.thefreelibrary.com/Pfizer+Announces+USD3.6+Billion+Acquisition+of+King+Pharmaceuticals.-a0239185584
by 'Feedinfo News Service'; Agricultural industry Food and beverage industries Pharmaceutical industry Mergers, acquisitions ... Pfizer Announces USD3.6 Billion Acquisition of King Pharmaceuticals. ... Our diversified global health care portfolio includes human and animal biologic and small molecule medicines and vaccines, as ... Chicago style: The Free Library. S.v. Pfizer Announces USD3.6 Billion Acquisition of King Pharmaceuticals.." Retrieved Mar 21 ...
  https://www.thefreelibrary.com/Pfizer+Announces+USD3.6+Billion+Acquisition+of+King+Pharmaceuticals.-a0239185584
*  Parkinson's Disease Grants funded by the Michael J. Fox Foundation | Parkinson's Disease
Addex Pharmaceuticals has developed drug discovery tools that can be used to screen its small molecule compound library for ... Mitochon Pharmaceuticals has demonstrated that a once-a-day oral treatment with MP101, a brain-penetrant mitochondrial ...
  https://www.michaeljfox.org/foundation/funded-grants.php?srch=Trophic
*  Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries | Molecular...
As such, GPCRs have become the target for over one third of current pharmaceuticals, the vast majority of which bind to the ... DNA-Encoded Small-Molecule Library.. The DNA-encoded small-molecule libraries used for screening were created using a tagged- ... with DNA-encoded small-molecule libraries, we have discovered and characterized the first β2AR small-molecule positive ... β2AR in HDL particles has yielded the first small-molecule PAMs for the β2AR. We had isolated a small-molecule β2AR NAM, Cmpd- ...
  http://molpharm.aspetjournals.org/content/94/2/850
*  Warner Chilcott and Paratek Pharmaceuticals Sign Collaboration Agreement for Novel, Narrow-Spectrum Agents for Acne and Rosacea...
Warner Chilcott and Paratek Pharmaceuticals Sign Collaboration Agreement for Novel, Narrow-Spectrum Agents for Acne and Rosacea ... international Transportation industry Antiacne agents Chelating agents Pharmaceutical industry ... Paratek has an active chemical synthesis effort to produce novel and diverse small molecules, with the goal of developing non- ... Chicago style: The Free Library. S.v. Warner Chilcott and Paratek Pharmaceuticals Sign Collaboration Agreement for Novel, ...
  https://www.thefreelibrary.com/Warner+Chilcott+and+Paratek+Pharmaceuticals+Sign+Collaboration+...-a0166181630
*  Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope...
... and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg equivalents. AMS provides an ... The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup ... this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and ... excretion of pharmaceutical compounds as a fundamental step in drug development. ...
  https://digital.library.unt.edu/ark:/67531/metadc1012307/
*  Bio-economy news | BioTalent Canada
The collaboration will exploit Cyclenium's proprietary QUEST Library™ of next generation synthetic small-molecule m ... Aurinia Pharmaceuticals Added to the NASDAQ Biotech Index Mon, 11/12/2017 - 17:00 ... She has deep expertise in the development of small-molecule drug candidates and has directed pr ... Mark Lievonen has over 30 years of experience in the pharmaceutical industry, more recently as the President of Sanofi Pasteur ...
  https://biotalent.ca/bio-economy-news
*  Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. - Free Online Library
Free Online Library: Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. by 'Alcohol ... small molecule-containing vesicles, and thus many neurons have the capacity to release both small molecule and opioid peptide ... Current Pharmaceutical Design 13(25): 2621-2637,2007. PMID: 17897004 KOOB, G.F. A role for GABA mechanisms in the motivational ... THE NEUROTRANSMITTER MOLECULES Many small organic molecules serve as neurotransmitters in the brain. For example, amino acids ...
  https://www.thefreelibrary.com/Communication+networks+in+the+brain%3A+neurons%2C+receptors%2C+...-a0193246752
*  Discovery of Novel Biomarkers by Text Mining: A New Avenue for Drug Research? | OMICS International
... of discovering drugs by happenstance in natural products or synthetizing and screening large libraries of small molecule ... Pharmaceutical research is undergoing a profound change. The deluge of molecular data and the advent of computational ... Note that the overlap between ClinicalTrials.gov and Merck internal research documents "P3" is too small (i.e., count of 5) to ... developed into a new avenue for pharmaceutical research, especially to shorten time-to-market of novel drugs, or. speed up ...
  https://www.omicsonline.org/discovery-of-novel-biomarkers-by-text-mining-a-new-avenue-for-drug-research-2155-9929.S3-004.php?aid=14884
*  Maxia Pharma - Bay City Capital
The company focused on small molecule drugs that target major diseases such as cancer and metabolic disorders. In Feb 2003, ... Formed to exploit the non-dermatological applications of a patented library of compounds licensed from Galderma. ... Incyte Pharmaceuticals (NASDAQ:INCY) completed its acquisition of Maxia.. « Previous. Next ». , Back to Portfolios Initial ...
  http://baycitycapital.com/portfolios/maxia-pharma/
*  Pharmaceutical drug - Wikipedia
Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole ... One of the key classifications is between traditional small molecule drugs, usually derived from chemical synthesis, and ... Another key distinction is between traditional small-molecule drugs, usually derived from chemical synthesis, and ... and the representatives of the Pharmaceutical industry brands, the Association of the British Pharmaceutical Industry (ABPI). ...
  https://en.wikipedia.org/wiki/Pharmaceutical_drug
*  'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries. - PubMed - NCBI
Pharmaceutical Preparations. *Small Molecule Libraries. Grant support. *BB/D007747/1/Biotechnology and Biological Sciences ... Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries.. Dobson PD1, Patel Y, Kell DB ... National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA ... Present drug screening libraries are constrained by biophysical properties that predict desirable pharmacokinetics and ...
  https://www.ncbi.nlm.nih.gov/pubmed/19049901
*  ACD/Labs MS Databases :: Chinese Translation :: ACD/Labs
Pharmaceutical compounds. *Pesticides. *Other small bioorganic molecules. Each compound has been carefully measured by the ... EI-MS Spectral Library: over 240,000 spectra covering over 212,000 compounds. *Ion Trap Spectral Library: over 9,900 spectra ... It is a reliable tool for the identification of small molecules. Specificity is usually above 95%; sensitivity exceeds 92%. The ... Wiley Registry 10th Edition/NIST 2012 Mass Spectral Library*. The Wiley Registry 10th Edition/NIST 2012 is the largest mass ...
  https://www.acdlabs.com/zh-cn/products/spectrus/dbs/ms_db/
*  US Patent # 9,656,984. PI3K/AKT/mTOR inhibitors and pharmaceutical uses thereof - Patents.com
Mao, et al.: "A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via ... phosphoinositide 3-kinase pathway", Blood Journal, Hemotology Library, vol. 117, No. 6, dol:10.1182/blood-2010-05-284810, Feb. ... it is preferred to present them as pharmaceutical compositions. The pharmaceutical compositions, both for veterinary and for ... These molecules inhibit the PI3K/AKT/mTOR pathway and are more potent than the above mentioned compound A and the well-known ...
  http://patents.com/us-9656984.html