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*  Frontiers | Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds | Immunology
... antibody dependent cell-mediated phagocytosis [ADCP] and extended serum half-life via interaction with neonatal Fc rec... ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... Promisingly, Fc antigen binding fragment [Fcab] and monomeric antibody or half antibody may be particularly advantageous to ... antibody dependent cell-mediated phagocytosis [ADCP] and extended serum half-life via interaction with neonatal Fc receptor [ ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00038/full
*  Durable antitumor responses to CD47 blockade require adaptive immune stimulation | PNAS
Here, we use a novel anti-CD47 single domain antibody, derived from an alpaca, in an immunocompetent mouse model of melanoma ... mice bearing human tumors enhances therapeutic antitumor antibody responses by promoting phagocytosis of antibody-bound tumor ... Anti-CD47 Nanobodies Bind with High Affinity and Specificity to Mouse CD47.. To further evaluate the binding properties of the ... and can be readily reformatted as a genetic fusion to alternative protein domains, making them ideal therapeutic and research ...
  http://www.pnas.org/content/113/19/E2646
*  Antibody - Wikipedia
Magnetic immunoassay Microantibody Monoclonal antibody Neutralizing antibody Secondary antibodies Single-domain antibody Slope ... One of these domains is called the variable domain, which is present in each heavy and light chain of every antibody, but can ... Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are usually artificial ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ...
  https://en.wikipedia.org/wiki/Antibody
*  Trends in recombinant protein use in animal production | Microbial Cell Factories | Full Text
Engineered antibody fragments and the rise of single domains. Nat Biotechnol. 2005;23:1126-36.View ArticleGoogle Scholar. ... produced recombinant llama single-domain antibody fragments (VHHs) using recombinant strains of S. cerevisiae to confer rapid ... Wang M, Zhang Y, Li B, Zhu J. Construction of scFv that bind both fibronectin-binding protein A and clumping factor A of ... Kaur P, Satyanarayana T. Production of cell-bound phytase by Pichia anomala in an economical cane molasses medium: optimization ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0654-4
*  Frontiers | Characterization of Ixodes ricinus Fibrinogen-Related Proteins (Ixoderins) Discloses Their Function in the Tick...
Further, we found that ixoderins were important for phagocytosis of Gram-negative bacteria and yeasts by tick hemocytes and ... Further, we found that ixoderins were important for phagocytosis of Gram-negative bacteria and yeasts by tick hemocytes and ... Here, we show that the tick genome contains at least 27 genes encoding single-domain FRePs (ixoderins, IXO), which can be ... leading to the phagocytosis of pathogens. Different pools of CL5a and CL5b isoforms bind to bacteria and fungi, suggesting ...
  https://www.frontiersin.org/articles/10.3389/fcimb.2017.00509/full
*  Protein A - Wikipedia
It is composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins ... Through these interactions in serum, where IgG molecules are bound in the wrong orientation (in relation to normal antibody ... Engineered versions are multimers (typically tetramers, pentamers or hexamers) of a single domain which has been modified to ... thus impairing phagocytosis of the bacteria via immune cell attack. Protein A facilitates the adherence of S. aureus to human ...
  https://en.wikipedia.org/wiki/Protein_A
*  Frontiers | Therapeutic Antibodies against Intracellular Tumor Antigens | Immunology
Advances in the production of TCRm antibodies have enabled the generation of multiple TCRm antibodies, which have been tested ... Advances in the production of TCRm antibodies have enabled the generation of multiple TCRm antibodies, which have been tested ... Antibodies have been developed to target externalized antigens, have also been engineered to enter into cells or may be ... Antibodies have been developed to target externalized antigens, have also been engineered to enter into cells or may be ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
*  Antibody - Wikipedia
One of these domains is called the variable domain, which is present in each heavy and light chain of every antibody, but can ... Antibody mimeticEdit. Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are ... To obtain antibody that is specific for a single epitope of an antigen, antibody-secreting lymphocytes are isolated from the ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ...
  https://en.m.wikipedia.org/wiki/Antibody
*  Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins | Malaria...
Single domain VAR2CSA recombinant proteins produced in P. pastoris had limited efficacy in eliciting adhesion blocking antibody ... Of the five domains, DBL3, and to a lesser extent DBL5, induced antibodies that cross-reacted on five diverse CSA-binding ... understanding as to how effective individual VAR2CSA domains are at generating inhibitory antibodies or the number of domain ... To investigate the immunogenic properties of single domain VAR2CSA recombinant proteins, rats or rabbits were immunized with ...
  https://0-malariajournal-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1475-2875-10-36
*  Fibronectin Type III Domain Based Scaffold Compositions, Methods And Uses - Patent application
... single domain antibodies, and fragments thereof. Functional fragments include antigen-binding fragments that bind to a ... 2A-N. Melting profiles of the purified FN3 domains (except for the 7th domain) from human fibronectin as determined by DSC in ... The protein and/or antibody is immobilized or insolubilized before or after the competition and the sample bound to the target ... antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; down regulation of cell surface receptors (e.g., B cell ...
  http://www.patentsencyclopedia.com/app/20100255056
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... Immunology, Issue 57, Phagocytosis, Antibody, ADCC, Effector Function, Fc receptor, antibody-dependent phagocytosis, monocytes ... The antibody against the Uni-1 epitope of HA was able to bind to 13 subtypes of influenza A HA (H1-H13) while the antibodies ... While the properties of the variable domains of antibodies have long been considered critical to in vivo function, the ability ...
  https://www.jove.com/visualize/abstract/24751715/development-vhh-antibodies-against-dengue-virus-type-2-ns1-comparison
*  Indian Patents. 228778:A VACCINE COMPOSITION COMPRISING POLYPEPTIDE ADJUVANT AND AN ANTIGEN
Preferably said fragments are single chain antibody variable regions (scFV's) or "domain". antibody fragments. If a hybidoma ... In a further preferred embodiment of the invention said antibodies are opsonic antibodies.. Phagocytosis is mediated by ... the invention, individual polyladder (e.g. DiAg) domains can be used. Such domains can be. administered as protein solutions in ... These sequences also bind polypeptides which function, inter alia, to facilitate. transcription initiation selection by RNA ...
  http://www.allindianpatents.com/patents/228778-a-vaccine-composition-comprising-polypeptide-adjuvant-and-an-antigen
*  12:53 pm
Antibodies' redirects here. For the film, see Antibodies (film). For the TV-movie, see Antibody (film). Each antibody binds to ... An antibody (Ab), also known as an immunoglobulin (Ig), is a large Y-shaped protein produced by B-cells that is used by… ... One of these domains is called the variable domain, which is present in each heavy and light chain of every antibody, but can ... Blood isolated from these animals contains polyclonal antibodies-multiple antibodies that bind to the same antigen-in the serum ...
  https://novoantibody.wordpress.com/2012/09/26/antibody/
*  2012 Group 8 Project - CellBiology
Structure of Engineered Single Domain Icam-1 D1 With High-Affinity Al Integrin I Domain of Native C-Terminal Helix Conformation ... α subunits influence cell motility and have been shown to limit certain functions of β domains while the integrin is not bound ... Phagocytosis stimulates an oxidative burst, which produces ROS as well as other substances. The production of the oxidation ... The inflammatory process occurs when the body detects a difference in normal antibody function. This can result from a break in ...
  https://cellbiology.med.unsw.edu.au/cellbiology/index.php/2012_Group_8_Project
*  Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses - Patent application
... single domain antibodies, and fragments thereof. Functional fragments include antigen-binding fragments that bind to a ... Detection of bound Tencon was accomplished using an anti-HIS-HRP antibody (Qiagen). Results of the ELISA are shown in FIG. 7. ... 2004). Such engineered FN3 domains have been found to bind to targets with high affinity, while retaining important biophysical ... antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; down regulation of cell surface receptors (e.g., B cell ...
  http://www.patentsencyclopedia.com/app/20130274145
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Choosing the right antibody platform can speed the discovery of a new therapeutics against these new targets. Single domain ... Although it had well-characterized protein domains such as coiled-coil domains and leucine-zipper domains, its function was ... The IgG bound to the SLE-peptoid was found to react with several autoantigens, suggesting that the peptoids are capable of ... They do not bind 1-anilnonaphthalene-8-sulphonic acid and lack extensive β-sheet structure. Aromatic interactions modulate, but ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  SYNERGISTIC TREATMENT OF CELLS THAT EXPRESS EPHA2 AND ERBB2 - Patent application
VL domain disclosed herein, or other known VL domains. The present invention also provides antibodies that specifically bind to ... 0089]The antibodies of the invention encompass single domain antibodies, including camelized single domain antibodies (see e.g ... or ErbB2 that are bound by the antibodies of the invention). In particular embodiments, the aptamers of the invention can bind ... phagocytosis, and cytotoxic attack. The ability to mediate cytotoxic and phagocytic effector functions is a potential mechanism ...
  http://www.patentsencyclopedia.com/app/20100254996
*  Indian Patents. 245499:'A PHARMACEUTICAL COMPOSITION FOR TREATING A DISEASE'
... the polypeptide is derived from a single. :. domain antibody that binds to an A(3 peptide. Single domain antibodies can be ... Antibodies that bind to various aggregated form of A p are known in the art, for example, antibodies that bind to amyloid beta- ... domains with the desired binding specificities (antibody-antigen combining sites) are fused to immunoglobiilin constant domain ... Antibody 6G bound to immobilized A,3 peptides were measured using goat anti-human kappa HRP conjugated secondary antibody. ...
  http://www.allindianpatents.com/patents/245499-a-pharmaceutical-composition-for-treating-a-disease
*  ANTI-HtrA1 ANTIBODIES AND METHODS OF USE - Patent application
A single VH or VL domain may be sufficient to confer antigen-binding specificity. Furthermore, antibodies that bind a ... domain of an antibody heavy or light chain that is involved in binding the antibody to antigen. The variable domains of the ... Plate-bound HtrA1 was detected during a 1-hour incubation with a biotinylated anti-muHtrA1 rabbit polyclonal antibody ( ... antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; down regulation of cell surface receptors (e.g. B cell ...
  http://www.patentsencyclopedia.com/app/20130129743
*  Multivalent Immunoglobulin-Based Bioactive Assemblies - Patent application
... and includes antibody fragments such as Fab', Fab, F(ab')2, single domain antibodies (DABs), Fv, scFv (single chain Fv), and ... For example, peptides that bind to DDD domains and that therefore may be substituted for naturally occurring AD sequences may ... antigen bound by p53, PAM-4 antibody, placental growth factor, prostatic acid phosphatase, PSA, PSMA, RS5, S100, T101, TAC, TAG ... Another group of preferred targets includes C3b, C4b and C5b, which enhance phagocytosis of foreign cells. Another preferred ...
  http://www.patentsencyclopedia.com/app/20120276608
*  ANTI-LRP6 ANTIBODIES - Patent application
A single VH or VL domain may be sufficient to confer antigen-binding specificity. Furthermore, antibodies that bind a ... domain of an antibody heavy or light chain that is involved in binding the antibody to antigen. The variable domains of the ... bound by an anti-LRP6 antibody of the invention. Detailed exemplary methods for mapping an epitope to which an antibody binds ... antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; down regulation of cell surface receptors (e.g. B cell ...
  http://www.patentsencyclopedia.com/app/20140363439
*  RegenerativeMedicine.net - Article Archives
... of functional and vascularized human brain organoids A single injection of crystallizable fragment domain modified antibodies ... single-molecule interaction strength is independent of ligand endocytosis Inhibitory receptors bind ANGPTLs and support blood ... Marking DNA bound by protein complexes identifies Notch-dimer responsive enhancers Kruppel-like factor 4 is critical for ... 3-year results of the STEP study Structural basis of actin filament nucleation by tandem W domains Ectopic activation of ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=25275&qCat=RMJ