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*  Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Th1 and Th2 cells show many of the significant signs of inflammation, such as releasing large amount of cytokines. Th1 cells ... 4. Regulatory T Cells. Treg cells, a small subset of T lymphocytes constituting only 5-20% of the CD4+ compartment, are thought ... R. Zhao, D. Tang, S. Yi et al., "Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type ... they regulate the response of other T cell subtypes but can also influence the activities of innate immune cells [44, 45]. Treg ...
  https://www.hindawi.com/journals/jdr/2017/6494795/
*  Protocols and Video Articles Authored by David H. Adams
Different subsets of effector T cells have been described based on their secretion of cytokines and specific functions. These ... Hepatitis C Virus Association with Peripheral Blood B Lymphocytes Potentiates Viral Infection of Liver-derived Hepatoma Cells ... We show that in vitro removal of NK cells augments circulating CD8(+) T cell responses directed against HBV, but not against ... The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each ...
  https://www.jove.com/author/David+H._Adams
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Effector memory T cells express CD45RO, lack CCR7 and display receptors associated with lymphocyte homing to peripheral or ... and memory T cells remain, sometimes for a lifetime. In humans, two functionally distinct subsets of memory T cells have been ... Effector T cells do not express either CCR7 or CD45RO but upon encounter with antigen produce effector cytokines, such as ... Results show that unrestrained Th17 cells result in inflammation and pathology, and is associated with several measurable read- ...
  https://www.jove.com/visualize/abstract/26083736/a-clinical-study-acquired-immunodeficiency-syndrome-associated
*  Candida albicans Dampens Host Defense by Downregulating IL-17 Production | The Journal of Immunology
Memory Th-17 cells specific for C. albicans are persistent in human peripheral blood. Immunol. Lett. 118: 72-81. ... albicans-specific cells are predominately found in the Th17 subset. Moreover, by comparing healthy volunteers and patients with ... In addition, we show that these latter 5-hydroxytryptophan metabolites inhibit IL-17 production. In conclusion, live C. ... IL-17 is one of the key cytokines that stimulate host defense during a Candida infection. Several studies have demonstrated the ...
  http://www.jimmunol.org/content/185/4/2450
*  Sex Hormones and Immune Dimorphism
Th cells) that provide help to other immune cells by producing cytokines. These Th cells are further divided into subtypes, ... Peripheral blood constitutes about 65% of the leukocytes: 32% granulocytes, 5-10% monocytes, and 30% lymphocytes. In females an ... Blood lymphocyte subsets showed a decreasing trend after agonist administration in prepubertal males, whereas no differences ... Previous studies show the role of sex hormones in immune system functioning [10]. The difference in the concentrations and the ...
  https://www.hindawi.com/journals/tswj/2014/159150/
*  Immunomics - Wikipedia
... whereas chronic lymphocytic leukemia cells resemble resting peripheral blood lymphocytes. Furthermore, heterogeneity in each of ... have identified at least two different subtypes in what was previously thought to be a single disease. One subset of these ... Bound T-cells are activated and secrete cytokines, which are captured by specific detection antibodies. This microarray can map ... Other surveys of B cell malignancies show that follicular lymphomas share expression features with germinal center B cells, ...
  https://en.wikipedia.org/wiki/Immunomics
*  Plus it
... and decreased frequencies of activated T lymphocytes and myeloid dendritic cells in peripheral blood (all P , 0.05). An inverse ... Leukocyte subsets and protein expression. Peripheral blood was collected into heparinized tubes and Ficoll (Amersham, ... reduction on cells treated with all three cytokines (P = 0.004). Treatment with TNF-α induced a 20% decline in mean ... Conclusion: These results extend links between fatigue and inflammatory markers to show a functional alteration in ...
  http://clincancerres.aacrjournals.org/content/12/9/2759
*  Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs
... including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of ... PAP is expressed mainly in subsets of γδ T cells and invariant natural killer T cells in thymus and both in CD4 and CD8 ... Next, we concentrated on lymphocytes isolated from peripheral lymph nodes, which drain the periphery and are the primary sites ... we show the consequences of PAP deficiency alone and combined with the absence of CD73 to the composition of immune cells in ...
  https://www.hindawi.com/journals/mi/2014/485743/
*  Different T cell subsets in the nodule and synovial membraneAbsence of interleukin-17A in rheumatoid nodules.
Among peripheral blood cells, IL-17D is produced by resting CD4⫹ T cells and CD19⫹ B cells. Stimulation of human umbilical vein ... Table 3. Expression of IL-17 subtypes A-F and cytokines regulating IL-17A expression in rheumatoid nodules* Cytokine Nodules (n ... Differential control of CD22 ligand expression on B and T lymphocytes and enhanced expression in murine systemic lupus. pdf151 ... Each circle represents data from an individual nodule; bars show the mean for each group. DISCUSSION The IL-17 family members ...
  https://www.docme.ru/doc/2155676/different-t-cell-subsets-in-the-nodule-and-synovial-membr..
*  B-Lymphocyte Stimulator (BLyS) To Treat Selective IgA Deficiency
... superfamily of cytokines that is expressed on peripheral blood monocytes and dendritic cells. Cellular receptors for BLyS are ... B-cells collected from patients with Common Variable Immune Deficiency show evidence for BLyS binding to B cells and enhanced ... The primary objective of the study is to retrospectively investigate changes in lymphocyte counts and lymphocyte subtypes, with ... Renal changes with glomerular protein deposits were noted in a subset of mice treated at 0.1 and 1.0 mg/kg in the first study ...
  https://www.bioportfolio.com/resources/trial/123432/B-Lymphocyte-Stimulator-BLyS-To-Treat-Selective-IgA-Deficiency.html
*  Protocols and Video Articles Authored by Ben Doron
Notably, lymphocyte subsets were undetectable in naive liver sections. Freshly isolated HCS show high expression of major ... In vitro activation of human hepatic stellate cells cocultured with hepatitis C virus-derived peripheral blood lymphocytes ... Cytokines were measured within the ipsilateral cortex. Pre-injury protein levels of anti-inflammatory interleukins 10 and 4 (IL ... The purpose of the present study was therefore to compare the neuropsychological performance of different subtypes of OCD and ...
  https://www.jove.com/author/Ben_Doron
*  Protocols and Video Articles Authored by Toshiki Ochi
Apr, 2016 , Pubmed ID: 26748722 Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that recognize lipid ... Regardless of their HLA-A2 positivity, a substantial subset of peripheral T cells transduced with SIG35α gained reactivity for ... Importantly, Aur-A-specific CTLs were able to lyse CD34+ CML progenitor cells but did not show any cytotoxicity against normal ... To clarify the incidence and subtypes of FHL in Japan, we performed genetic and functional analyses of cytotoxic T lymphocytes ...
  https://www.jove.com/author/Toshiki_Ochi
*  T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications
"Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and ... in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells (HRSCs) show peculiar phenotypic and functional features. A ... Among the different cytokines tested, RANTES was expressed almost exclusively by T cells. Among receptors, CCR3 and CCR5 were ... As it is known that HLA class I molecules present viral peptides for recognition by CD8+ T cells and that this T cell subset ...
  https://www.hindawi.com/journals/ah/2011/501659/
*  Frontiers | The Dopaminergic System in Autoimmune Diseases | Immunology
The distorted expression of DARs in peripheral lymphocytes of lupus and MS patients also supports the importance of ... dopamine may differentially favor CD4+ T cell differentiation into Th1 or Th17 inflammatory cells. Regulatory T cells can also ... The distorted expression of DARs in peripheral lymphocytes of lupus and MS patients also supports the importance of ... dopamine may differentially favor CD4+ T cell differentiation into Th1 or Th17 inflammatory cells. Regulatory T cells can also ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00117/full
*  Frontiers | T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock...
... disease suppressive activities in many models of experimental autoimmune diseases through the induction of regulatory T cells ( ... disease suppressive activities in many models of experimental autoimmune diseases through the induction of regulatory T cells ( ... Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol (2008) 180: ... Treg cells are probably the subset best characterized (9). The activation of these cells is antigen specific [major ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01408/full
*  Immune repertoire - Wikipedia
Thus if you look at 100 cells and find 50 subtypes-then look at another 100 cells, and are now up to 60 subtypes-and then ... If one type is entirely missing-say B-lymphocytes-then an entire subset of the immune repertoire may be missing. See Primary ... It is perhaps less able to show, when the number of different things in a class is reduced. look at a lot of individual cells, ... T cells in peripheral blood: The use of rearranged T cell receptor gamma genes as clonal markers". Journal of immunological ...
  https://en.wikipedia.org/wiki/Immune_repertoire
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... but present on all other mononuclear cells present in peripheral blood (e.g., T lymphocytes, monocytes...). The antibodies ... cells are a unique subset of T cells that display markers characteristic of both natural killer (NK) cells and T cells1. Unlike ... Our data show that T lymphocytes exhibit a migratory velocity of ~15 μm/min. T lymphocyte migration can be inhibited by ... and a variety of cytokines8. Importantly, these cells retained their original phenotype, secreted cytokines, and displayed ...
  https://www.jove.com/visualize/abstract/20352088/paucity-cd4-natural-killer-t-nkt-lymphocytes-sooty-mangabeys-is
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Th17 cells are a distinct subset of T cells that have been found to produce interleukin 17 (IL-17), and differ in function from ... DN T cells are, however, rare in peripheral blood and secondary lymphoid organs (spleen and lymph nodes), but are major ... In this method we purify T lymphocytes from the spleen and lymph nodes of C57BL/6 mice, and stimulate purified CD4+ T cells ... T. castaneum show a robust systemic RNAi response, making it possible to perform RNAi at any life stage by simply injecting ...
  https://www.jove.com/visualize/abstract/25271777/association-between-polymorphisms-ikzf3-gene-systemic-lupus
*  Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
Cytokine signaling disorders: Cytokines control the differentiation and activation of innate immune cells, so perturbations at ... Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome. Blood. 2007;109:2416-18. [PubMed] ... and this has now been further refined to a subset of proinflammatory cytokines, particularly IL-1β and IL-6 (144). IL-1β is a ... Radiographs show multiple, symmetrical radiolucent cystic bone lesions of the mandibula and maxilla. The pathologic process is ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2996236/
*  JCI - Astrocytic tight junctions control inflammatory CNS lesion pathogenesis
These findings show that astrocyte cultures exposed to IL-1β and then cocultured with activated T lymphocytes actively surround ... they may potentially be mediated by different T cell subsets, such as effector and regulatory cells. Critically, these findings ... no differences in lymphocyte numbers were seen in peripheral lymphoid organs of mGfap-Cre Cldn4fl/fl mice versus controls with ... penetration into the CNS of inflammatory cells, and soluble factors such as autoantibodies, cytokines, and plasma proteins, ...
  https://www.jci.org/articles/view/91301
*  CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo | JEM
We next analyzed the cytokines ((12)) released by LN cells from mice primed with either subset in vivo. The data in Fig. 1 ... Th cells. As in vitro data suggested that CD8α+ DCs could kill Fas-expressing cells ((3)), T lymphocytes may undergo Fas- ... We show herein that two subclasses of DCs differentially regulate the development of Th cells secreting discrete sets of ... cells could play a role in peripheral tolerance in vivo, whereas conventional CD8α− DCs would initiate immune responses. This ...
  http://jem.rupress.org/content/189/3/587?ijkey=6acace1285417cacab63f2402774cab9fef14ef9&keytype2=tf_ipsecsha
*  MicroRNAs in Immune Response and Macrophage Polarization | Arteriosclerosis, Thrombosis, and Vascular Biology
... nonself-reactive receptors are positively selected to become the peripheral pool of mature B cells. Major subsets of mature B ... in immune cells initiates a cascade of molecular events that leads to the production of proinflammatory cytokines, chemokines, ... removal of Dicer in the early stages of T-lymphocyte development results in reduced T-cell numbers in the thymus and peripheral ... Different miRNAs seem to show synergies that result in fine-tuning of inflammatory responses. An example is the induction of ...
  http://atvb.ahajournals.org/content/33/2/170.full
*  Lymphocyte - Wikipedia
... called T helper cells, produce cytokines that direct the immune response, while other T cells, called cytotoxic T cells, ... or by signaling to other cells of the immune system (helper T cells). Memory T cells remain in the peripheral tissues and ... A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system. Lymphocytes include natural killer ... Some lymphocytes show a clear perinuclear zone (or halo) around the nucleus or could exhibit a small clear zone to one side of ...
  https://en.wikipedia.org/wiki/Lymphocyte
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... but present on all other mononuclear cells present in peripheral blood (e.g., T lymphocytes, monocytes...). The antibodies ... Our data show that T lymphocytes exhibit a migratory velocity of ~15 μm/min. T lymphocyte migration can be inhibited by ... are less prone to apoptosis than more differentiated cells and have a higher ability to respond to homeostatic cytokines 2-7. ... This method may also allow analysis of how PP pDCs affect the frequency or function of other immune subsets in PPs. A unique ...
  https://www.jove.com/visualize/abstract/23555950/an-efficient-low-cost-method-for-gene-transfer-to-t-lymphocytes
*  MHC class I Dk expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine...
B) Proportions of distinct spleen lymphocyte subsets found in uninfected R7, Tg3LN2, or Tg3MN2 and their nontransgenic ... Donor-cell reconstitution in the chimeras was verified by staining for MHC-I Dk on peripheral blood. Donor NK cells and B cells ... Taken together, these data show that licensed Ly49G+ NK cells efficiently recognize and respond to MCMV infection in mice with ... Consistent with this, dendritic cells were shown to respond to MCMV infection with cytokines that stimulate NK cell ...
  http://www.pnas.org/content/107/19/8754