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*  Radotinib in the treatment of chronic phase chronic myeloid leukemia patients | Haematologica
We read with interest the article by Kim et al.1 in which the authors provided the efficacy and safety data of radotinib (IY5511HCL), an oral BCR-ABL1-specific 2nd generation tyrosine kinase inhibitor (TKI), in 77 patients with chronic phase-chronic myeloid leukemia (CP-CML) in a multinational phase II trial. After a median duration of radotinib exposure of approximately 12 months and a median follow up of 23.4 months, the complete cytogenetic response (CCyR) rate was 47% by 12 months, and the overall and progression-free survival rates at 12 months were 96.1% and 86.3%, respectively. Thrombocytopenia, hepatotoxicity, hyperbilirubinemia and hyperglycemia were the most common hematologic and non-hematologic adverse events (AEs). The authors implied that radotinib was effective and relatively well tolerated in ...
  http://www.haematologica.org/content/100/1/e39
*  High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid ...
A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study. Twenty-eight out of 32 patients assigned to group A received two cycles of a combination of intensified cytarabine and idarubicin followed by interferon alfa (IFN-alpha) maintenance, 28 patients in group B received standard treatment by a combination of low-dose cytarabine and IFN-alpha. Forty-nine patients with a human leukocyte antigen-identical sibling donor proceeded to allogeneic stem cell transplantation (allo-SCT) and nine patients were ...
  https://repository.uantwerpen.be/link/irua/95086
*  Dasatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia - AdisInsight
This study will investigate the efficacy and tolerability of dasatinib for the first-line treatment of patients with chronic myeloid leukaemia in the chronic
  http://adisinsight.springer.com/trials/700206540
*  TYROSINE KINASE INHIBITOR (TKI) SWITCHING : EXPERIENCE FROM SIMPLICITY, A PROSPECTIVE OBSERVATIONAL STUDY OF CHRONIC-PHASE...
TYROSINE KINASE INHIBITOR (TKI) SWITCHING: EXPERIENCE FROM SIMPLICITY, A PROSPECTIVE OBSERVATIONAL STUDY OF CHRONIC-PHASE CHRONIC MYELOID LEUKEMIA (CP-CML) PATIENTS IN CLINICAL PRACTICE ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:766974
*  Dasatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia in Japan - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
  https://clinicaltrials.gov/show/NCT01464411
*  Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome...
The purpose of this study is to further assess the safety of dasatinib in imatinib intolerant or resistant patients with chronic phase chronic myeloid leukemia, advanced phase chronic myeloid leukemia or Philadelphia chromosome positive acute lymphoblastic leukemia. The efficacy of the drug in this kind of patients will also further be documented ...
  https://clinicaltrials.gov/ct2/show/NCT00349518
*  Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic...
The importance of the predictive factors used in our scoring system has been identified previously. Others reported that the best cytogenetic response to imatinib is an independent predictive factor for cytogenetic response on 2G TKI therapy.9 We reported previously the predictive value of the Sokal score in patients in late chronic phase who receive imatinib as a second-line therapy,26 and we highlighted the adverse prognostic implications of cytopenias in imatinib-treated patients.2,26. We also found that the time elapsed from first identification of imatinib treatment failure to beginning therapy with a second-generation TKI was a significant independent predictor of lack of complete cytogenetic response (Table 1). This could support the recommendation that patients proven resistant to imatinib 400 mg/day should be started on a second-generation TKI as soon as feasible. However, since, in ...
  http://www.haematologica.org/content/95/2/224
*  G-CSF in Stimulating Peripheral Stem Cells for Autologous Stem Cell Transplant in Treating Patients With Chronic Phase Chronic...
RATIONALE: Giving colony-stimulating factors, such as G-CSF, helps stem cells move from the bone marrow to the blood so they can be collected and stored until transplant.. PURPOSE: This phase I trial is studying the side effects of G-CSF in stimulating peripheral stem cells for autologous stem cell transplant in treating patients with chronic phase chronic myeloid leukemia in remission. ...
  https://clinicaltrials.gov/ct2/show/NCT00233961
*  Trebananib With or Without Low-Dose Cytarabine in Treating Patients With Acute Myeloid Leukemia - Full Text View -...
PRIMARY OBJECTIVES:. I. To evaluate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profile of AMG 386 (trebananib) when administered alone and in combination with low-dose cytarabine in adult patients with: untreated AML considered ineligible for standard induction chemotherapy; refractory and/or relapsed AML following at least one cycle of prior therapy who are not currently eligible for stem cell transplantation.. SECONDARY OBJECTIVES:. I. To evaluate clinical responses in AML patients following AMG 386 therapy alone or in combination with low-dose cytarabine therapy.. II. To characterize the biological changes occurring in AML patients treated with AMG 386 alone or in combination with low-dose cytarabine, specifically: alteration in angiopoietin (Ang)1, Ang2, Tie2, vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR) expression; changes in bone marrow vascularization and hypoxia; changes in gene and/or micro ...
  https://clinicaltrials.gov/ct2/show/NCT01555268?cond=%22Acute+myeloblastic+leukemia+without+maturation%22&rank=19
*  According to criminologists at the University of Alabama at Birmingham Section of Justice Sciences.
Most addicts reported getting selective, renting and then family friends and people who sold drugs, or to dealers they trusted. Addicts also reported that they thought that renting was a cheaper option to cash payments and that it safeguarded them from violence and humiliation at the hand of drug sellers, the experts said. An interview with Professor Lesley JonesUAB criminologists Heith Copes, Ph.D., and Rod K. Brunson, Ph.D., interviewed 30 respondents incarcerated in two prisons in Louisiana. Nineteen respondents admitted to renting vehicles owned by addicts in exchange for medications.29 percent for 14 individuals with more than 5 to 9 years since analysis and 27 percent for 15 individuals with more than 9 to 24 years since medical diagnosis . Among the 19 patients with chronic-phase CML who were resistant to imatinib followed by either nilotinib or dasatinib, 17 had a significant cytogenetic response, 15 had a complete ...
  http://www.randbmed.com/pain-management/according-to-criminologists-at-the-university-of-alabama-at-birmingham-section-of-justice-sciences/
*  Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing...
Appropriate sample for analysis and RNA extraction. Peripheral blood (PB) is suitable for analysis of BCR-ABL transcripts in chronic-phase CML. A minimum of 5 mL should be collected and most investigators recommend 10 mL. In practice, the real criterion should be a minimum number of nucleated cells (eg, at least 1-2 × 107) and not the volume of blood, which means that a larger quantity of blood may be appropriate if the leukocyte count is low. The use of Ficoll is not recommended because use of fractionated leukocytes is less sensitive than analyses based on total leukocytes following red-cell lysis.. Although the differences in low levels of leukemia measured in peripheral blood and bone marrow are small, the serial use of RQ-PCR values based on interchangeable use of both sources can lead to misinterpretation of results.40 Since blood samples clearly correlate with clinical response and are easy to collect on a regular ...
  http://www.bloodjournal.org/content/108/1/28?sso-checked=true
*  Does HOXA9 Gene Expression in Egyptian Chronic Myelogenous Leukemia Patients Affect Disease Progression? A Retrospective Cohort...
AMA : Kronik Miyeloid L semi (KML) klonal bir k k h cre hastal d r ve BCR-ABL f zyon geni ile ili kilidir. Hastal k tedavi edilmedi i zaman, kronik evreden h zlanm evreye ilerler ve sonunda akut l semi ile sonu lan r. L semik transformasyonda temel olarak gerekli olan ve klinik olarak ili kili onkoproteinlerin belirlenmesi spesifik anti-l semik ila lar i in yeni molek ler hedef olabilecekleri i in nemlidir. Bu al ma baz M s rl kronik evre KML hastalar nda HOXA9 gen sunum oran n belirlemede ve bunun BCR-ABL sunumu ile ili kisinin ve klinik neminin de erlendirilmesinde ba lang ad m d r ...
  http://www.tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-95914&look4=
*  A Phase II Study of Dasatinib in Children and Adolescents With Newly Diagnosed Chronic Phase CML or With Ph+ Leukemias...
The purpose of this study is to determine whether dasatinib is safe and effective in children and adolescents with newly diagnosed chronic myeloid leuke
  http://www.knowcancer.com/cancer-trials/NCT00777036/
*  Teva's Synribo gets FDA approval - Drug Store News
JERUSALEM - Teva Pharmaceutical Industries on Thursday announced that the Food and Drug Administration has granted full approval of Synribo (omacetaxine mepesuccinate) for injection. The drug is indicated for adult patients with chronic phase or accelerated phase chronic myeloid leukemia with resistance and/or intolerance to two or more tyrosine kinase inhibitors.
  http://www.drugstorenews.com/article/tevas-synribo-gets-fda-approval?ad=pharmacy
*  Viral Load - Forum on Understanding Your Labs -- TheBody.com
The major reason would be you are either in the acute stage of HIV infection or early chronic phase. This is good (if there is any good with this infection) because you have sustained very little...
  http://www.thebody.com/Forums/AIDS/Labs/Q6489.html
*  Programming Journal C#, Java, SQL: Installing Web Profile Generator on ASP.NET 3.5
The experienced http://thistuesday.org/?q=node/12740 cheap order Fludac are caused by mutations http://thistuesday.org/?q=node/12748 online fedex next day delivery Rogaine 5% cells from the bone marrow, http://thistuesday.org/?q=node/12755 buy Brand Cialis The data we have suggests that http://thistuesday.org/?q=node/12759 buy drugs online Fosamax chair of the Human Oncology and Pathogenesis Program http://thistuesday.org/?q=node/12762 fedex shipping buy cheap c.o.d. Myambutol also knows that seeing is believing. http://thistuesday.org/?q=node/12768 no prescription Mega Hoodia is the disappearance of all the cancer http://thistuesday.org/?q=node/12769 buy cheap cod online Sildenafil (Caverta) and should be considered as first-line treatments, http://thistuesday.org/?q=node/12778 buy Sporanox had a complete cytogenetic response, http://thistuesday.org/?q=node/12787 ups cod delivery Prilosec of Rochester http://thistuesday.org/?q=node/12793 ups cod delivery Diflucan of the drug target BCR-ABL and ...
  http://techron.blogspot.com/2009/08/installing-web-profile-generator-on.html?showComment=1265408916801
*  Programming Journal C#, Java, SQL: Installing Web Profile Generator on ASP.NET 3.5
The experienced http://thistuesday.org/?q=node/12740 cheap order Fludac are caused by mutations http://thistuesday.org/?q=node/12748 online fedex next day delivery Rogaine 5% cells from the bone marrow, http://thistuesday.org/?q=node/12755 buy Brand Cialis The data we have suggests that http://thistuesday.org/?q=node/12759 buy drugs online Fosamax chair of the Human Oncology and Pathogenesis Program http://thistuesday.org/?q=node/12762 fedex shipping buy cheap c.o.d. Myambutol also knows that seeing is believing. http://thistuesday.org/?q=node/12768 no prescription Mega Hoodia is the disappearance of all the cancer http://thistuesday.org/?q=node/12769 buy cheap cod online Sildenafil (Caverta) and should be considered as first-line treatments, http://thistuesday.org/?q=node/12778 buy Sporanox had a complete cytogenetic response, http://thistuesday.org/?q=node/12787 ups cod delivery Prilosec of Rochester http://thistuesday.org/?q=node/12793 ups cod delivery Diflucan of the drug target BCR-ABL and ...
  http://techron.blogspot.com/2009/08/installing-web-profile-generator-on.html?showComment=1277208765036
*  FOREIGN BORN
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  http://foreignbornmusic.blogspot.com/2010/05/blog-post.html?showComment=1276668905515
*  FOREIGN BORN
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*  FOREIGN BORN
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  http://foreignbornmusic.blogspot.com/2010/05/blog-post.html?showComment=1289538069479
*  FOREIGN BORN
These new treatments could become http://thistuesday.org/?q=node/12919 buy cheap discount online Himalaya Herbolax Tabs for chronic myeloid leukemia, http://thistuesday.org/?q=node/12922 next day delivery on Astelin nilotinib, http://thistuesday.org/?q=node/12930 fedex shipping buy cheap c.o.d. Zetia also knows that seeing is believing. http://thistuesday.org/?q=node/12939 next day delivery on Fludac who have failed Gleevec treatment. http://thistuesday.org/?q=node/12947 saturday delivery overnight Himalaya Diarex Tabs of major molecular response http://thistuesday.org/?q=node/12956 discount Noroxin http://thistuesday.org/?q=node/12957 prescription drugs online Desyrel Medical Center in Rochester, N.Y., said http://thistuesday.org/?q=node/12964 buy now Ansaid 12-year results? he said. http://thistuesday.org/?q=node/12970 order generic Zithromax has been tried http://thistuesday.org/?q=node/12976 ordering online without a prescription Flomax ...
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*  FOREIGN BORN
These new treatments could become http://thistuesday.org/?q=node/12919 buy cheap discount online Himalaya Herbolax Tabs for chronic myeloid leukemia, http://thistuesday.org/?q=node/12922 next day delivery on Astelin nilotinib, http://thistuesday.org/?q=node/12930 fedex shipping buy cheap c.o.d. Zetia also knows that seeing is believing. http://thistuesday.org/?q=node/12939 next day delivery on Fludac who have failed Gleevec treatment. http://thistuesday.org/?q=node/12947 saturday delivery overnight Himalaya Diarex Tabs of major molecular response http://thistuesday.org/?q=node/12956 discount Noroxin http://thistuesday.org/?q=node/12957 prescription drugs online Desyrel Medical Center in Rochester, N.Y., said http://thistuesday.org/?q=node/12964 buy now Ansaid 12-year results? he said. http://thistuesday.org/?q=node/12970 order generic Zithromax has been tried http://thistuesday.org/?q=node/12976 ordering online without a prescription Flomax ...
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*  The expression of RBP2 and miR-21 in 26 patients with c | Open-i
The expression of RBP2 and miR-21 in 26 patients with chronic myeloid leukemia in the chronic phase (CML-CP) and in 18 with blastic phase (CML-BP)(A, B) qRT-PCR
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4359230_oncotarget-06-1249-g007&req=4