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*  Study of the Safety of BEMA™ Fentanyl Use for Breakthrough Pain in Cancer Subjects on Chronic Opioid Therapy - Full Text View -...
The purpose of this study is to evaluate the safety of BEMA fentanyl at any dose in the management of breakthrough pain in cancer subjects on background opioid therapy. The standard of care for these breakthrough pain episodes is a rapid onset, short acting analgesic with minimal associated sleepiness. Oral morphine, oxycodone and hydromorphone are routinely used, but because of slow and variable oral absorption, the pain control is not the best with these products. Oral transmucosal fentanyl citrate (OTFC) has been used successfully in treating breakthrough pain episodes associated with cancer. OTFC is a lozenge of fentanyl on a stick and is administered by continuously swabbing the interior of the subject's mouth until the ...
  https://clinicaltrials.gov/ct2/show/NCT00293020
*  The Diagnosis and Treatment of Breakthrough Pain - Perry Fine - Oxford University Press
Breakthrough pain (BTP) is episodic pain that emerges through the treatment of otherwise well-managed chronic background pain. Often called pain flare or transient pain, BTP negatively affects the function and quality of life of the patient and often results in a number of other physical, psychological and social problems. Breakthrough pain is a common occurrence affecting approximately two-thirds of the estimated 50 to 100 million chronic pain sufferers in the US.
  https://global.oup.com/academic/product/the-diagnosis-and-treatment-of-breakthrough-pain-9780195369045?cc=us&lang=en&%250D%250Afacet_narrowbyproducttype_facet=Digital&facet_narrowbyproducttype_facet=Digital
*  Breakthrough Pain In Non-Cancer Patients
A limited number of studies have begun to examine breakthrough pain (BTP) in the non-cancerous population. The objective of this study was to describe characteristics of BTP in a non-cancerous group of patients with low back pain refractory to one or more surgical interventions.
  https://www.practicalpainmanagement.com/pain/spine/breakthrough-pain-non-cancer-patients
*  Sebastiano Mercadante, MD - ppt video online download
6 Episodic (Breakthrough) Pain Consensus Conference of an Expert Working Group of the EAPC, Cancer 2002 Sebastiano Mercadante, M.D.1 Lukas Radbruch, M.D.2 Augusto Caraceni, M.D.3 Nathan Cherny, M.D.4 Stein Kaasa, M.D., Ph.D.5 Friedemann Nauck, M.D.6 Carla Ripamonti, M.D.3 Franco De Conno, M.D.3 the Steering Committee of the European Association for Palliative Care (EAPC) Research Network BACKGROUND: Breakthrough pain is transitory exacerbation of pain that occurs in addition to otherwise stable persistent pain. The wide differences in estimation of incidence reported in literature are probably because of different settings and meanings attributed to the definition to breakthrough pain. ...
  http://slideplayer.com/slide/549731/
*  How Can Mesothelioma Pain Be Treated With the Use of Medication? | Mesothelioma Information
How Can Mesothelioma Pain Be Treated With the Use of Medication?. One of the main ways by which mesothelioma pain can be treated is with the use of proper medication.. However,the type of medicine and the way the medicine is given depend on the type and cause of pain. For example, chronic pain is best relieved by methods that deliver a steady dose of pain medicine over a long period of time, such as a patch that releases medicine through the skin or slow-release oral tablets. On the other hand, breakthrough pain {Breakthrough pain is flare of pain that happens even though ...
  http://mesotheilioma.com/how-can-mesothelioma-pain-be-treated-with-the-use-of-medication/
*  Breakthrough Cancer Pain BTcP: a Synthesis of Taxonomy, Pathogenesis, Therapy, and Good Clinical Practice in Adult Patients in...
Breakthrough Cancer Pain BTcP: a Synthesis of Taxonomy, Pathogenesis, Therapy, and Good Clinical Practice in Adult Patients in Italy. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jul4/149912447840-Breakthrough-Cancer-Pain-BTcP-a-Synthesis-of-Taxonomy-Pathogenesis-Therapy-and-Good-Clinical-Practice-in-Adult-Patients-in-Italy.php
*  AcelRx European Patent Covering its NanoTab® Sublingual Delivery Technology for Acute and Breakthrough Pain Pipeline Products...
...REDWOOD CITY Calif. May 10 2011 /- AcelRx Pharmaceutic...AcelRx developed the NanoTab technology as a basis for delivering sufe... This patent is the first to issue from our broad portfolio of pending...,AcelRx,European,Patent,Covering,its,NanoTab®,Sublingual,Delivery,Technology,for,Acute,and,Breakthrough,Pain,Pipeline,Products,Emerges,From,Opposition,Period,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
  http://www.bio-medicine.org/medicine-technology-1/AcelRx-European-Patent-Covering-its-NanoTab-AE-Sublingual-Delivery-Technology-for-Acute-and-Breakthrough-Pain-Pipeline-Products-Emerges-From-Oppositio-17109-1/
*  Radiation Oncology Associates
Onsolis (fentanyl buccal soluble film) has been approved by the U.S. Food and Drug Administration for the treatment of breakthrough cancer pain.[1]. Pain may be a side effect of cancer treatment or may be caused by the cancer itself. If not adequately managed, pain may have a tremendous effect on quality of life. Many cancer patients with chronic pain receive treatment with an opioid; however, they continue to experience flares of pain referred to as breakthrough pain. Breakthrough pain can become intensely ...
  http://radiationoncologyassociates.co/2009/07/28/onsolis-approved-for-breakthrough-pain/
*  Study to Evaluate the Efficacy and Safety of ORAVESCENT Fentanyl Citrate for Management of Breakthrough Pain - Full Text View -...
Women must be surgically sterile, 2 years postmenopausal, or, if of childbearing potential, using a medically accepted method of birth control (ie, barrier method with spermicide, steroidal contraceptive [oral, transdermal, implanted, or injected contraceptives must be used in conjunction with a barrier method], or intrauterine device [IUD]) and agree to continued use of this method for the duration of this study ...
  https://clinicaltrials.gov/show/NCT00214942
*  Other caring roles | Topics, Caring for someone with a terminal illness, Dying & bereavement, People's Experiences | healthtalk...
And the irony of it was there were all these sort of little note papers stuck on the end of each bed about pain, you know, if you were in pain, tell us immediately. And yet she was doing nothing about it. And then she sort of said to me, "I'm not allowed to give her anything for the next four hours because I can't give her anything in between." And I said, "Yeah, but she's having breakthrough pain, you can see, even I, not a doctor, knowing that she is having breakthrough pain at this stage. So whatever you're giving her is obviously not working." You know, "It knocks her out for a few hours and then she's breaking through it." I then had to just march down to the doctor's office on, in the hospital ward and I sort of said to them, "Look, if you cannot manage ...
  http://healthtalk.org/peoples-experiences/dying-bereavement/caring-someone-terminal-illness/other-caring-roles
*  Circadian variation of breakthrough pain in cancer patients - Saini - 2012 - European Journal of Pain ...
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  http://onlinelibrary.wiley.com/doi/10.1002/j.1532-2149.2012.00184.x/abstract
*  HealthBoards - View Single Post - breakthrough pain meds????? warning, long!!
Post 1426599 - Health related message boards offering discussions of numerous health topics including allergies, cancer, diabetes, heart disease, exercise, attention deficit disorder, diet, and nutrition.
  https://www.healthboards.com/boards/1426599-post1.html
*  HealthBoards - View Single Post - breakthrough pain meds????? warning, long!!
Post 1427690 - Health related message boards offering discussions of numerous health topics including allergies, cancer, diabetes, heart disease, exercise, attention deficit disorder, diet, and nutrition.
  http://www.healthboards.com/boards/1427690-post5.html
*  Instanyl® Non-Interventional Study - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
  https://clinicaltrials.gov/ct2/show/NCT01045603
*  Insys Executives Arrests Related to Sale of Fentanyl Spray « Section News
Subsys, is an opioid for cancer patients experiencing severe breakthrough pain. The DOJ has charged that executives at Insys, which produces Subsys, bribed physicians to prescribe Insys inappropriately for patients, executives gave kickbacks based on sales. Most prescriptions written were for patients who were not diagnosed with cancer and did not qualify for treatment under the FDA guidelines for Subsys use. Further, DOJ charged that Insys officials and employees engaged in a conspiracy to defraud insurance providers to assure payment for non-cancer treatment.. ...
  https://www.americanbar.org/groups/health_law/news/2017/11/insys_executivesarr.html
*  A Two-Part Study of Sativex® Oromucosal Spray for Relieving Uncontrolled Persistent Pain in Patients With Advanced Cancer -...
The primary objective of this study is to determine the efficacy of Sativex, compared with placebo, an adjunctive medication in relieving persistent chronic pain (not breakthrough pain) in patients with advanced cancer, who have this pain even when they are on optimized/maximized chronic opioid therapy.. This multi-center study will be conducted in two parts. All participants enrolled into the trial will receive Sativex during one of two parts of the study, but they will not know which part.. Eligible patients will not be required to stop any of their current treatments or medications. ...
  https://clinicaltrials.gov/ct2/show/NCT01424566?term=cannabis&lup_s=03/17/2014&lup_d=30
*  Are there Drs. in Ft.Myers/Naples prescribing actiq for pain mgmt.?
1 Answer - Posted in: actiq, pain, breakthrough pain - Answer: Hello lebutcher. You might contact The Florida Medical Association at ...
  https://www.drugs.com/answers/are-there-drs-in-ft-myers-naples-prescribing-63541.html
*  Ask an expert - neuro and psycho logical - parkinson's
Q: My wife has had Parkinsons for 5 and a half years. For the last couple of years or so she has been experiencing severe pain in both legs for which the GP was unable to prescribe satisfactory analgesia. The local pain clinic recommended Oxycodone (up to 40 mg) both as controlled release and instant acting for breakthrough pain. Despite all of this her pain is still more than is bearable and we are at our wit's end to find something to help. Would acupuncture be of value in such a case? I realise I have not given any other clinical info, but would welcome any comments you can make. The treatment of Parkinson's disease when it starts to manifest in the kind of muscle tightening and freezing is not that well researched. We tend to be a little tentative when we have discussed this in the past. ...
  https://www.acupuncture.org.uk/category/public-content/public-ask-an-expert/ask-an-expert-neuro-and-psycho-logical/ask-an-expert-neuro-and-psycho-logical-parkinsons.html
*  Plus it
In this study, we identified three pairs of cysteine residues, Cys 79 and Cys 308 of NR1, Cys 744 and Cys 798 of NR1, and Cys 87 and Cys 320 of NR2A, as the molecular determinants of redox modulation of NR1-1a/NR2A receptors. Additionally, these three pairs of cysteines influence high-affinity, voltage-independent Zn2+ inhibition of NR1-1a/NR2A receptor responses.. Based on the observations concerning Zn2+chelation by the sulfhydryl reducing agent, DTT, made by Paoletti et al. (1997), and our result showing that the rapid-onset potentiation by DTT is largely eliminated in tricine-buffered 0 Zn2+ solution, it is likely that the predominant effect of rapid-onset potentiation by DTT of NR1/NR2A receptors is caused by the chelation of Zn2+. However, one can alternatively interpret the result as evidence that rapid-onset potentiation by DTT is a result of relief of high-affinity voltage-independent Zn2+ inhibition after changing the properties of the Zn2+-binding site by redox agents, as discussed ...
  http://www.jneurosci.org/content/21/2/392
*  Electronic nasal-spray package limits dosing for opioid medication | Packaging Digest
Patient compliance is important with any prescription drug, but particularly if the drug could be habit-forming. To help ensure compliance with Instanyl, a nasal opioid, Takeda Pharmaceuticals International AG has chosen pharmaceutical packaging that doesn't just count the doses-it electronically limits the number of doses that can be delivered in a 24-hour period.
  http://www.packagingdigest.com/pharmaceutical-packaging/electronic-nasal-spray-package-limits-dosing-for-opioid-medication-2017-06-08
*  A Successful 2007 Paves the Way for Future of Nycomed - Drugs.com MedNews
Total net turnover increases by 3.0 to 3,497.4 million 31.0 increase in adjusted EBITDA Instanyl filed for European approval Own Pantoprazole generic as respons
  https://www.drugs.com/news/successful-2007-paves-way-future-nycomed-7894.html
*  Transmukosale Applikation von Fentanyl: sublingual, buccal, nasal - egal? | springermedizin.de
Aufgrund der besonderen zeitlichen Charakteristik sollten BTCP als eigenständiges Krankheitsbild angesehen und gezielt behandelt werden [ 1 , 2 , 5
  https://www.springermedizin.de/transmukosale-applikation-von-fentanyl-sublingual-buccal-nasal-e/15111578
*  Learn more about breakthrough method | (e) Science News
San Diego have developed a breakthrough method for sequencing-based methylation ... and his group describe the breakthrough in a recent paper ... the utility of this method. The method we developed would be ...
  http://esciencenews.com/dictionary/breakthrough.method
*  Breakthrough in Control of Cancer, Infections
... Canadian researchers claimed that their breakthrough would have a far–reaching impact on the treatment of cancers and infectious diseases.
  http://www.aarogya.com/news-and-updates/year-2009/breakthrough-in-control-of-cancer-infections.html/