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*  Synapse-Associated Protein 102/dlgh3 Couples the NMDA Receptor to Specific Plasticity Pathways and Learning Strategies |...
... through synaptic Ras-GTPase-activating protein, to facilitate withdrawal of AMPA receptors from the postsynaptic membrane, ... a, No change in total hippocampal levels of postsynaptic proteins in mutant mice. i, MAGUKs; ii, postsynaptic receptors; iii, ... does not use a single pathway or set of postsynaptic proteins. For example, inhibition of extracellular signal-regulated kinase ... proteins, including synapse-associated protein 102 (SAP102), postsynaptic density-95 (PSD-95), and PSD-93, are proximal ...
  http://www.jneurosci.org/content/27/10/2673
*  SYNGAP1 Gene - GeneCards | SYGP1 Protein | SYGP1 Antibody
Protein Coding), Synaptic Ras GTPase Activating Protein 1, including: function, proteins, disorders, pathways, orthologs, and ... Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and ... Synaptic Ras GTPase activating protein 1 homolog (Rat) (B1AZX6_HUMAN). *Synaptic Ras GTPase-activating protein 1 (SYGP1_HUMAN) ... Protein Symbol:. Q96PV0-SYGP1_HUMAN. Recommended name:. Ras/Rap GTPase-activating protein SynGAP Protein Accession:. Q96PV0. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SYNGAP1&rf=/home/genecards/current/website/carddisp.pl&origene_ab_prot=3
*  Syngap1 - Ras/Rap GTPase-activating protein SynGAP - Mus musculus (Mouse) - Syngap1 gene & protein
AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. ... Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role ... Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long- ... Major constituent of the PSD essential for postsynaptic signaling. ...
  http://www.uniprot.org/uniprot/F6SEU4
*  SYNGAP1 - Wikipedia
Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded ... One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, ... Jaffe H, Vinade L, Dosemeci A (Aug 2004). "Identification of novel phosphorylation sites on postsynaptic density proteins". ... Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (May 1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ...
  https://en.wikipedia.org/wiki/SYNGAP1
*  The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors |...
2003) The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci 23:1119-1124. ... protein kinase B (AKT) and the mitogen-activated protein kinase (MAPK) pathways (Moodie et al., 1993; Orban et al., 1999; ... play a role in cellular mechanisms underlying synaptic plasticity and memory formation via both presynaptic and postsynaptic ... GTPase-activating proteins such as neurofibromin protein type 1 (NF1) stimulate the intrinsic GTPase activity of H-Ras leading ...
  http://www.jneurosci.org/content/32/45/15849.full
*  Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression | Journal of Neuroscience
Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ... Craven SE, Bredt DS (1998) PDZ proteins organize synaptic signaling pathways. Cell 93: 495-498. ... The network of scaffolding proteins at postsynaptic densities is crucial for synaptic plasticity in a wide variety of species. ... NMDA receptors (NMDARs) colocalize with postsynaptic density protein-95 (PSD-95), a multivalent synaptic scaffolding protein ...
  http://www.jneurosci.org/content/24/45/10138
*  Fragile x syndrome and autism: from disease model to therapeutic targets | Journal of Neurodevelopmental Disorders | Full Text
TSC 1/2 inhibits this same mTOR pathway, by acting as a GTPase-activating protein for the Ras-related small G protein Rheb [135 ... In summary, we have discovered that FMRP is a protein that acts to regulate protein synthesis and synaptic plasticity triggered ... Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23(3):583-92. ... Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci. 2001;24:299-325.PubMedGoogle Scholar. ...
  https://jneurodevdisorders.biomedcentral.com/articles/10.1007/s11689-009-9015-x
*  Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry | Journal of Neuroscience
1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20:895-904. ... receptors with associated signaling and scaffolding proteins that organize signal transduction pathways near the postsynaptic ... a ras GTPase-activating protein phosphorylated by CaMKII (Chen et al., 1998). Other prominent PSD proteins are scaffold ... a synapse-specific Ras GTPase-activating protein (Chen et al., 1998; Kim et al., 1998); citron, a target for Rac GTPases (Zhang ...
  http://www.jneurosci.org/content/20/11/4069
*  Plus it
1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20:895-904. ... 6 A). SynGAP, a Ras GTPase-activating protein, is also highly concentrated at the same postsynaptic sites that contain CaM ... 1998) The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. Proc Natl Acad Sci USA 95:3245- ... In contrast to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three PDZ domains ...
  http://www.jneurosci.org/content/19/1/96
*  DAP1 | definition of DAP1 by Medical dictionary
... male germ cell Rac GTPase-activating protein; MKLP1, mitotic kinesin-like protein I; Rho, Ras homolog family member; RhoA, Ras ... which is concentrated in synaptosomal regions of the brain and forms part of the post-synaptic scaffold of neurons.. ... The potential of brittle star extracted polysaccharide in promoting apoptosis via intrinsic signaling pathway ... GTPase-activating protein; INCENP, inner centromere protein; MgcRacGAP, ...
  https://medical-dictionary.thefreedictionary.com/DAP1
*  Anti-SynGAP antibody (ab3344) | Abcam
Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. ... Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the ... a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown ... Synaptic Ras GTPase activating protein 1 homolog antibody. *Synaptic Ras GTPase activating protein 135kDa antibody ...
  https://www.abcam.com/syngap-antibody-ab3344.html
*  Frontiers | Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders...
This perspective highlights temporal patterns of synaptic and neuronal impairment, with a restricted focus on autism and ... and timing of NDD impairments are not fully investigated.This perspective highlights temporal patterns of synaptic and neuronal ... dependent and BDNF-induced synaptic plasticity mechanisms depend on protein synthesis via the Ras-mitogen-activated protein ... mediate spine morphology changes via small GTPase-mediated signaling pathways and F-actin in response to synaptic activation ...
  https://www.frontiersin.org/articles/10.3389/fnsys.2013.00075/full
*  Circuit and Synaptic Mechanisms Underlying Experience-Dependent Cortical Plasticity | HHMI.org
We have used 2pFLIM to dissect the role of the small GTPase Ras in synaptic plasticity at the level of single synapses. ... based on the synaptic vesicle proteins synaptophysin and VAMP (vesicle-associated membrane protein). These systems have been ... and detected highly specific developmental defects in particular synaptic pathways.. Experience-Dependent Structural Synaptic ... To decipher complex computations and behaviors at the level of cortical circuits we will need to be able to activate and ...
  https://www.hhmi.org/research/circuit-and-synaptic-mechanisms-underlying-experience-dependent-cortical-plasticity
*  Frontiers | Epilepsy Mechanisms in Neurocutaneous Disorders: Tuberous Sclerosis Complex, Neurofibromatosis Type 1, and Sturge...
Potential routes for target-specific treatments are emerging as the genetic and molecular pathways involved in neurocutaneous ... Potential routes for target-specific treatments are emerging as the genetic and molecular pathways involved in neurocutaneous ... yet some molecular pathways overlap. For instance, the mechanistic target of rapamycin (mTOR) signaling cascade plays a central ... yet some molecular pathways overlap. For instance, the mechanistic target of rapamycin (mTOR) signaling cascade plays a central ...
  https://www.frontiersin.org/articles/10.3389/fneur.2017.00087/full
*  Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease | Springer for Research & Development
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... Fu AK, Ip NY (2017) Regulation of postsynaptic signaling in structural synaptic plasticity. Curr Opin Neurobiol 45:148-155. ... The pathway analysis offered a high-level view of the pathways connecting Rac1 to AD relevant proteins and highlighted the ... Ras-related C3 botulinum toxin substrate 1 (Rac1), cell division protein 42 (Cdc42), and Ras homologous member A (RhoA). By ...
  https://rd.springer.com/article/10.1186%2Fs40478-018-0567-4
*  Rho family of GTPases - Wikipedia
GTPase-activating proteins (GAPs) and guanine nucleotide dissociation inhibitors (GDIs). GEFs activate Rho proteins by ... Mental retardation in some cases involves malformation of the dendritic spines, which form the post-synaptic connections ... After finding that Ras proteins are mutated in 30% of human cancers, it was suspected that mutated Rho proteins might also be ... To explain the role of Rho pathways without mutation, researchers have now turned to the regulators of rho activity and the ...
  https://en.wikipedia.org/wiki/Rho_family_of_GTPases
*  Ultrasensitivity - Wikipedia
... and GTPase activating proteins (GAPs). Computational studies on the switching behavior of GTPases have revealed that the GTPase ... Extended weak signaling can result in long-term depression (LTD), in which activation of the post-synaptic neuron requires a ... The distribution of receptors into the two pathways was shown to be EGF concentration-dependent. In the presence of low ... such as Ran and Ras, can exist in either a GTP-bound form (active) or a GDP-bound form (inactive), and the conversion between ...
  https://en.wikipedia.org/wiki/Ultrasensitivity
*  Plus it
... postsynaptic scaffolding proteins (Shank 3, Homer 1, and PSD95), and several synaptic signaling proteins (neuroligin 3, synGap ... and GTPase/Ras signaling" (Pinto et al., 2010). MET signaling is complex, capable of activating PI3 kinase, MAP kinase, and ... number of synaptic proteins that are known to mediate excitatory synapse maturation or are downstream to MET signaling pathway ... E, Illustration of isolation of whole CA1 tissue lysate (1), total synaptosome protein (2), and synaptic surface protein (3), ...
  http://www.jneurosci.org/content/34/49/16166
*  Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2 | Molecular Brain | Full Text
Furthermore, we observed that the loss of RICH2 leads to a disinhibition of synaptic RAC1 in vivo. The results are in line with ... role in regulating this spine plasticity by the interaction with cytoskeletal components and several signaling pathways within ... and memory formation as it is ultimately altering the number and distribution of receptors and proteins at the post-synaptic ... Rho-GAP interacting CIP4 homologue2/RICH2 is a Rho-GAP protein regulating small GTPases and was identified as an interaction ...
  https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-016-0206-6
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Numerous studies using mouse models, in which the Shh pathway is constitutively activated, have linked Shh signaling with ... A number of proteins can bind to the actin cytoskeleton. The binding of a particular protein to F-actin is often desired to ... postsynaptic neurons. Activation of these GABA-gated ion channels leads to influx of chloride resulting in postsynaptic ... Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 ...
  https://www.jove.com/visualize/abstract/21731601/specific-syndecan-1-domains-regulate-mesenchymal-tumor-cell-adhesion
*  Regulator of G-protein signaling elisa and antibody
Recombinant Protein and Regulator of G-protein signaling Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Shop Regulator of G-protein signaling ELISA Kit, ... Regulator of G-protein signaling 2 Antibody. GTPase activating ... May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor ( ... May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excita. >>> ...
  https://www.mybiosource.com/protein_family.php?root=regulator-of-g-protein-signaling
*  Frontiers | Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease | Endocrinology
Estrogens have multiple actions in the brain including modulating synaptic plasticity, connectivity and cognitive behaviours. ... Estrogens have multiple actions in the brain including modulating synaptic plasticity, connectivity and cognitive behaviours. ... Aromatase co-localizes with the post-synaptic marker, PDS-95 (post-synaptic density protein 95), and the pre-synaptic marker ... Singer, C. A., Figueroa-Masot, X. A., Batchelor, R. H., and Dorsa, D. M. (1999). The mitogen-activated protein kinase pathway ...
  https://www.frontiersin.org/articles/10.3389/fendo.2011.00077/full
*  Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in...
... as Rho Ras and Rac activate downstream effectors that in turn stimulate or inhibit the activity of actin-associated proteins ... activity drives the formation of cofilin rod formation in AD pathology and through this pathway disrupts synaptic properties ... Arp2/3 is inhibited by protein interacting with C kinase 1 (PICK1) which is in turn inhibited by the activity of GTPase ADP- ... Gelsolin is an actin-associated protein predominantly activated by Ca2+ [60]. When activated by Ca2+, gelsolin undergoes ...
  https://www.hindawi.com/journals/np/2016/2371970/
*  ARHGEF7 - Wikipedia
The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging ... "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine ... "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing ... via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth". J. Biol. Chem. 277 (46 ...
  https://en.wikipedia.org/wiki/ARHGEF7
*  Agrin Controls Synaptic Differentiation in Hippocampal Neurons | Journal of Neuroscience
1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895-904. ... Lastly, it may be that contact between presynaptic and postsynaptic terminals is necessary for the stabilization of synaptic ... 1998) Laminin and α-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway. J Neurosci 18:1250- ... Third, agrin may activate specific signaling events that lead to clustering and targeting of synaptic molecules. In fact, the ...
  http://www.jneurosci.org/content/20/24/9086