*  Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors | Science
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors ... Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors ... Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors ... Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors ...
  http://science.sciencemag.org/content/302/5653/2126?ijkey=8f31bdb658a51997a57118b1ba1ef9fe38daa6e7&keytype2=tf_ipsecsha
*  A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway ...
... which are activated by secreted pattern-recognition receptors. Here, we demonstrate the essential role of ModSP, a modular ... molecules GNBP3 and PGRP-SA and connects them to the Grass-SPE-Spätzle extracellular pathway upstream of the Toll receptor. It ... Our analysis shows that ModSP integrates signals originating from the circulating recognition ... The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form ...
  https://infoscience.epfl.ch/record/151706
*  CLEC7A Gene - GeneCards | CLC7A Protein | CLC7A Antibody
... pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... pattern recognition receptor signaling pathway. IEA. --. GO:0002223. stimulatory C-type lectin receptor signaling pathway. TAS ... Toll-Like receptor Signaling Pathways. Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ... It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC7A&keywords=GH12G010033&prefilter=genomic_location
*  Gene Expression sub-cluster 46
Mannose-binding lectin (MBL), a pattern recognition receptor of the lectin pathway of complement, has been implicated in ... ... TSLP Expression Induced via Toll-Like Receptor Pathways in Human Keratinocytes. Takai Toshiro T Atopy (Allergy) Research Center ... We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This ... Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 ... ...
  http://www.biomedsearch.com/cluster/10/Gene-Expression/sub-46-p10.html
*  Cell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral...
Thus, RIG-I as well as additional as yet unidentified pattern recognition receptor-driven pathways contribute to the host ... IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6 ... Successful defense against virus infection relies on early detection by germ line-encoded pattern recognition receptors and ... Several classes of germ line-encoded pattern recognition receptors have been identified that recognize different components of ...
  http://www.jimmunol.org/content/184/3/1168.long
*  The essential, non-redundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection (P1385) | The...
Our results highlight the necessity of multiple pattern recognition receptors in the same pathway acting in concert to affect a ... Exome sequencing identifies novel mutations in the Toll-like receptor 3 pathway contributing to herpes simplex encephalitis ... disease of West Nile virus has previously been shown to be dependent on viral recognition by the host RIG-I-like receptor (RLR ... Virus recognition by the innate immune system represents a critical component of host defense against infection. Proper ...
  http://www.jimmunol.org/content/190/1_Supplement/57.4
*  Pro-autophagic signal induction by bacterial pore-forming toxins
... activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways ... The first pathway is triggered via AMP-activated protein kinase (AMPK). AMPK is a major energy sensor which induces autophagy ... The second pathway is activated by the conserved eIF2α-kinase GCN2, which causes global translational arrest and promotes ... The TOR pathway comes of age. Biochim Biophys Acta. 2009;1790:1067-1074. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2955911/
*  Collection of Inhibitors from InvivoGen
InvivoGen provides a collection of inhibitors for different pathways: Signal Transduction Inhibitors, Protein Kinase inhibitors ... such as immunomodulators of the signaling transduction pathways initiated by pattern recognition receptors (PRRs).. Moreover, ... InvivoGen offers a collection of inhibitors for different pathways, ...
  http://www.invivogen.com/inhibitors
*  ASMscience | Fungi that Infect Humans
Bacterial and fungal pattern recognition receptors in homologous innate signaling pathways of insects and mammals. Front ... Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal ... Global patterns in threats to vertebrates by biological invasions. Proc Biol Sci 283:20152454. doi:10.1098/rspb.2015.2454. [ ... Mitochondrial activity and Cyr1 are key regulators of Ras1 activation of C. albicans virulence pathways. PLoS Pathog 11: ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.FUNK-0014-2016
*  Host Defence against Bacterial Biofilms: "Mission Impossible"?
... activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways ... S. Akira and H. Hemmi, "Recognition of pathogen-associated molecular patterns by TLR family," Immunology Letters, vol. 85, no. ... A. Ozinsky, D. M. Underhill, J. D. Fontenot et al., "The repertoire for pattern recognition of pathogens by the innate immune ... D. El Kebir, L. József, and J. G. Filep, "Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and - ...
  https://www.hindawi.com/journals/isrn/2012/853123/ref/
*  NLRP3 siRNA interferes with secretion of IL-1β and IL- | Open-i
Introduction: Pattern recognition receptor-mediated signaling pathways have recently been elucidated to bridge the innate ... Introduction: Pattern recognition receptor-mediated signaling pathways have recently been elucidated to bridge the innate ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC5016581_AMS-12-28012-g005&req=4
*  Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG...
Toll-like receptor (TLR) 9 and TLR21 are the cellular receptors of CpG-ODN in mammals and chickens, respectively. The avian ... The distinctive ligand recognition profiles of these two TLRs were determined by their ectodomains. Activation of these two ... Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways. * ... Types of Cell Membrane Receptor 1. G-Protein Coupled Receptor (GPCR) 2. Ion Channel Receptor 3. Tyrosine Kinase Receptor 4. ...
  https://www.semanticscholar.org/paper/Toll-like-receptor-9-and-21-have-different-ligand-Yeh-Liu/1557c638b1db26133c9a8ae21ab7cfb233652482
*  What's hot today: Current papers in developmental biology and gene function
... an Extracellular Pattern-Recognition Receptor, enhances peptidoglycan-mediated activation of the Drosophila Imd pathway. ... the innate immune response in metazoans is initiated through the recognition of microbes by host pattern-recognition receptors ... Receptor composition is dependent on dPak, but independent of the Ral pathway. Thus two major aspects of synapse formation, ... Epistasis analyses in the intersegmental nerve b (ISNb) pathway suggest that PlexB serves as a receptor for both Sema-2a and ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-december2016.htm
*  Plus it
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell ... a pattern recognition receptor, also interacts with multiple members of the proinflammatory S100/calgranulin family and with ... Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products. J Biol Chem 2001; ... Pattern and causes of amputation in diabetic patients-a multicentric study from India. J Assoc Physicians India 2011;59:148-151 ...
  http://diabetes.diabetesjournals.org/content/62/3/931
*  RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice | Diabetes
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell ... lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways ... The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with ... Of note and analogous to inflammatory cell infiltration patterns in PGAT of LFD-fed RAGE null mice, on LFD, RAGE null mice ...
  http://diabetes.diabetesjournals.org/content/63/6/1948.full
*  The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation | JEM
pattern recognition receptor. qPCR. quantitative PCR. RBR. RING between RING. UBL. ubiquitin like. ... As a central pathway downstream from many innate and adaptive immune receptors, the NF-κB signaling pathway is highly regulated ... Because many receptor signaling pathways converge on Nemo activation, linear ubiquitination is expected to be required for the ... NF-κB-dependent gene expression of various pattern recognition receptor (PRR) pathways. Indeed, TLRs, such as TLR2, 3, 4, 7/8, ...
  http://jem.rupress.org/content/211/7/1333
*  Zootermopsis nevadensis - Wikipedia
... including pattern recognition receptors, signaling pathways and regulatory genes. 6 Gram-negative binding proteins (GNBPs), ... The gustative receptor (GRs) are similarly expanded in Z. nevadensis (87 genes) and other eusocial insects (10-97 genes). The ... The olfactive receptors (ORs) confers most of the specificity and sensitivity of insect olfaction. These genes are pretty ... 5 signaling pathway genes related to immune system are overexpressed in reproductive females. 3 antimicrobian peptides (AMPs) ( ...
  https://en.wikipedia.org/wiki/Zootermopsis_nevadensis
*  Ywhaq - 14-3-3 protein theta - Mus musculus (Mouse) - Ywhaq gene & protein
Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally ... Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. ... pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (By ... Enzyme and pathway databases. Reactome - a knowledgebase of biological pathways and processes ...
  http://www.uniprot.org/uniprot/P68254
*  Carboxylated Glycans Mediate Colitis through Activation of NF-κB | The Journal of Immunology
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell ... Tissue-specific expression patterns of the RAGE receptor and its soluble forms-a result of regulated alternative splicing?. ... S100A12 and HMGB-1 both bind to receptor for advanced glycation end products (RAGE), a cell surface signaling receptor ... The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J. Clin. Invest. 108:949.- ...
  http://www.jimmunol.org/content/175/8/5412.long
*  Frontiers | Microbial effectors target multiple steps in the salicylic acid production and signaling pathway | Plant Science
Among these, salicylic acid signaling is an important pathway because of its ability to trigger plant cell death. As biotrophic ... Among these, salicylic acid signaling is an important pathway because of its ability to trigger plant cell death. As biotrophic ... The responses also entail complex changes in phytohormone signaling pathways. ... The responses also entail complex changes in phytohormone signaling pathways. ...
  https://www.frontiersin.org/articles/10.3389/fpls.2015.00349/full
*  YWHAQ Gene - GeneCards | 1433T Protein | 1433T Antibody
... pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion ( ... An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. (PMID: 28436939) ... Pathways by source for YWHAQ Gene. 5 Sino Biological pathways for YWHAQ Gene. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=YWHAQ&ortholog_desc=all
*  Hand-Foot-and-Mouth Disease Publications and Abstracts | PubFacts.com
Association of gene polymorphisms of pattern-recognition receptor signaling pathway with the risk and severity of hand, foot, ... We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk ... Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD ... The heterocyclic compound GS-9620, a potent and selective agonist of Toll-like receptor 7 (TLR7), has been reported to activate ...
  https://www.pubfacts.com/search/Hand-Foot-and-Mouth+Disease
*  Selective Detection of NADPH Oxidase in Polymorphonuclear Cells by Means of NAD(P)H-Based Fluorescence Lifetime Imaging
PMNs initiate the assembly of NADPH oxidase in the cells on different pathways depending on the pattern recognition receptor ... these cells are able to recognise the invading pathogens through specific pattern recognition receptors on their surface [2]. ... The binding of the pathogens to these receptors initiates signalling pathways, which enable the cell to internalise the ...
  https://www.hindawi.com/journals/jbp/2008/602639/
*  Frontiers | Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate | Immunology
... pattern recognition receptors) to trigger immune signaling pathways. In most invertebrates, their roles have been inferred by ... pattern recognition receptors) to trigger immune signaling pathways. In most invertebrates, their roles have been inferred by ... Aerolysin-like proteins (named biomphalysins) were the only ones involved in the recognition of all the five pathogens tested, ... This implies a mediation by different soluble and/or membrane-anchored proteins related to innate immune receptors called PRRs ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01249/full