*  Dopamine receptor - Wikipedia
... unless blocked by a receptor antagonist or a synthetic partial agonist. D3 is encoded by the Dopamine receptor D3 gene (DRD3). ... D4-adrenoceptor α1B D4-adrenoceptor β1 Dopamine receptor D1 and Dopamine receptor D5 are Gs coupled receptors that stimulate ... D4 is encoded by the Dopamine receptor D4 gene (DRD4). The D4 receptor gene displays polymorphisms that differ in a variable ... D1-adenosine A1 D1-D2 dopamine receptor heteromer D1-D3 dopamine receptor heteromer D2-D4 dopamine receptor heteromer D2- ...
  https://en.wikipedia.org/wiki/Dopamine_receptor
*  Dopamine receptor D3 - Wikipedia
"Entrez Gene: DRD3 dopamine receptor D3". Joyce JN, Millan MJ (February 2007). "Dopamine D3 receptor agonists for protection and ... 200-fold binding selectivity over D4, D2, 5-HT1A, and α1-receptors (-)-7-{[2-(4-Phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8 ... "The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 ... a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats". European ...
  https://en.wikipedia.org/wiki/Dopamine_receptor_D3
*  Dopamine receptor D4 - Wikipedia
... partial agonist Roxindole - D4 selective but also D2 and D3 autoreceptor agonist, 5HT1A receptor agonist, serotonin reuptake ... Current Research on the DRD4 Gene Receptors, Dopamine D4 at the US National Library of Medicine Medical Subject Headings (MeSH ... partial agonist, > 8600-fold selective over other dopamine receptor subtypes FAUC 299: partial agonist (E)-1-aryl-3-(4- ... partial agonist Flibanserin - partial agonist PD-168,077 - D4 selective but also binds to α1A, α2C and 5HT1A CP-226,269 - D4 ...
  https://en.wikipedia.org/wiki/Dopamine_receptor_D4
*  Dopamine receptor D4 - Wikipedia
Ro10-5824 - partial agonist. *Roxindole - D4 selective but also D2 and D3 autoreceptor agonist, 5HT1A receptor agonist, ... Current Research on the DRD4 Gene. *Receptors, Dopamine D4 at the US National Library of Medicine Medical Subject Headings ( ... The dopamine receptor D4 is a G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5.[5] ... LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL (May 1996). "Dopamine D4 receptor gene polymorphism is ...
  https://en.wikipedia.org/wiki/Dopamine_D4_receptor
*  PAR-11-207: National Cooperative Drug Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders, Drug or...
G-protein coupled receptors, such as the dopamine receptor, an indirect site of action for cocaine and amphetamine, or ligand ... Given the clinical availability of mu-opiate agonists, partial agonists and antagonists and the large number of NIDA-supported ... dopamine: D1, D3, D4, D5; estrogen; GABA A subunits; GABA ion channel; GABA B; glutamatergic, glycine site; metabotropic ... Intracellular targets: gene expression/transcription markers; markers of neurogenesis or neuronal cell death; markers of ...
  https://grants.nih.gov/grants/guide/pa-files/PAR-11-207.html
*  F-15063 - Wikipedia
... partial agonist at the D4 receptor, and agonist at the 5-HT1A receptors. It has greater efficacy at the 5-HT1A receptors than ... receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal ... Assié, MB (June 2007). "F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial ... 5-HT1A agonist and D4 partial agonist properties: (I) in vitro receptor affinity and efficacy profile". British Journal of ...
  https://en.wikipedia.org/wiki/F-15063
*  Comparative pharmacology of antipsychotics possessing combined dopamine D2and serotonin 5-HT1Areceptor properties | SpringerLink
There is increasing interest in antipsychotics intended to manage positive symptoms via D2 receptor blockade and improve ... a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial ... Role of 5-HT1A receptors in the ability of mixed 5-HT1A receptor agonist/dopamine D2 receptor antagonists to inhibit ... The role of 5-HT2A receptor and 5-HT2A/5-HT1A receptor interaction in the suppression of catalepsy. Genes Brain Behav 9:519-524 ...
  https://link.springer.com/article/10.1007%2Fs00213-011-2247-y
*  Dopamine receptor D2 - Wikipedia
... is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in ... D4 receptor agonist Quinelorane - affinity for D2 > D3 Quinpirole - also D3 receptor agonist Ropinirole - full agonist ... The dopamine D2 receptor is the main receptor for most antipsychotic drugs. This gene encodes the D2 subtype of the dopamine ... LSD is also a 5-HT2A agonist. OSU-6162 - also 5-HT2A partial agonist, acts as "dopamine stabilizer" Roxindole (only at the D2 ...
  https://en.wikipedia.org/wiki/Dopamine_receptor_D2
*  Textbook of Psychiatry/Psychopharmacology - Wikibooks, open books for an open world
... binds weakly at the D2 receptor (although with relatively greater net antagonism at D3 and D4 dopamine receptors) and has ... Buprenorphine is an opioid mu-receptor partial agonist (with very high affinity for this receptor) that is used as an ... 50 mg/day). Individuals with a specific polymorphism of the mu-opioid receptor gene (OPRM1), i.e., individuals with an Asp40 ... Varenicline is an alpha4beta2 nicotinic acetylcholine receptor partial agonist, with high affinity for this receptor. It is the ...
  https://en.wikibooks.org/wiki/Textbook_of_Psychiatry/Psychopharmacology
*  Frontiers | Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder | Neurology
Lusher, J. M., Chandler, C., and Ball, D. (2001). Dopamine D4 receptor gene (DRD4) is associated with novelty seeking (NS) and ... 2008). Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing ... Treatment usually concerns the management of the concomitant sleep disorders (RLS and OSA). Dopaminergic agonists are ... to partial awareness (Winkelman et al., 2011). Morning amnesia for the event is very frequent as well as the undesirable weight ...
  https://www.frontiersin.org/articles/10.3389/fneur.2012.00168/full
*  Risperidone Induced Amenorrhea Resolved by Paliperidone | OMICS International
Interestingly, aripiprazole is considered to be a prolactin-sparing agent due to its partial D2 receptor agonist activity, and ... Calarge CA, Ellingrod VL, Acion L (2009) Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia ... preferential binding to D3 and D4 receptors, peculiar binding dynamics at the D2 receptors or differences in affinity to D2 ... Shim JC, Shin JC, Kelly Dl (2007) Adjunctive Treatment With a Dopamine Partial Agonist, Aripiprazole, for Antipsychotic-Induced ...
  https://www.omicsonline.org/open-access/risperidone-induced-amenorrhea-resolved-by-paliperidone-Psychiatry-1000224.php?aid=41226
*  Aberrant Dopamine D2-Like Receptor Function in a Rodent Model of Schizophrenia | Journal of Pharmacology and Experimental...
2010) Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist ... and D4 receptors and the dopamine transporter (SLC6A3), tyrosine hydroxylase, and dopamine receptor signaling molecules RGS2, ... 2011) Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia. Am J Med Genet B ... dopamine D3 receptor (Rn00567568_m1), dopamine D4 receptor (Rn00564071_m1), dopamine transporter SLC6A3 (Rn00562224_m1), ...
  http://jpet.aspetjournals.org/content/343/2/288
*  CPDD Community Website: June 2012
... also has very high affinity for dopamine D3 receptors (it also appears to be a high affinity dopamine D4 receptor antagonist). ... which is a high affinity partial agonist at serotonin 5-HT1A receptors, ... citing the recent brain imaging and genetics study of over 400 twin pairs that elucidated the influence of genes on human brain ... Labels: Antiretroviral Therapy, Big dataset science, Cocaine Vaccine, Dopamine D3 receptors, HIV Transmission Prevention, ...
  http://www.cpddblog.com/2012/06/
*  FENS Forum 2004 - Abstracts
PHARMACOLOGICAL CHAPERONES AND THE BIOGENESIS OF THE DOPAMINE D4 RECEPTOR.. A220.7. Poster 142 - Wed 14/07, 11:30 - Hall I. ... MATERNAL DEPRIVATION AND HANDLING ALTER DOPAMINERGIC RECEPTOR LEVELS AND MODIFY THE RESPONSE TO THE D3 PARTIAL AGONIST BP897, ... Virology and Gene Therapy, Kuleuven, Belgium.. - EFFECT OF PARKIN OVEREXPRESSION IN A MOUSE MODEL FOR PARKINSON'S DISEASE.. ... MODULATION OF GLUCOCORTICOID RECEPTORS IN NUCLEUS ACCUMBENS AFFECTS ON MEMORY PROCESSING IN RATS.. A192.35. Poster 252 - Tue 13 ...
  http://fens2004.neurosciences.asso.fr/posters/Let/LetV.html
*  Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons | Journal of...
Rivera A, Cuellar B, Giron FJ, Grandy DK, de la Calle A, Moratalla R (2002a) Dopamine D4 receptors are heterogeneously ... Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 350: 614-619. ... receptor agonist quinpirole in two distinct mutants lacking D2L receptors and expressing variable contents of D2S receptors. ... F indicate a cholinergic partial cell that also expresses D5 receptors. G, J, Striatal neurons expressing DA D5 receptors in WT ...
  http://www.jneurosci.org/content/23/15/6245
*  Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying...
1/dopamine 5 receptor agonist could be abrogated when the dopamine 1 receptor and to a lesser extent the dopamine 5 receptors ... the D1 receptor/D5 receptor group (D1-like) and the D2 receptor/D3 receptor/D4 receptor group (D2-like), based on their ... In contrast, genetic removal of the dopamine 5 receptor (with maintenance of the dopamine 1 receptor) resulted in a partial ... with splice variants of many of the dopamine receptors identified [1, 3]. Gene expression analysis of the dopamine receptors ...
  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-12-27
*  METHOD FOR DETERMINING THE BINDING OF A GIVEN COMPOUND TO A MEMBRANE RECEPTOR - Patent application
Dopamine receptors dopamine D1 dopamine D2 dopamine D3 dopamine D4 dopamine D5 Endothelin receptors endothelin 1, endothelin 2 ... including a partial agonist or an inverse agonist) or an antagonist of the membrane receptors under investigation. It is also ... Receptor of peptide RF-amide P518 gene QRFP P518 product Platelet-activating platelet-activating factor PAF factor receptor ... agonist of the receptor of AT1), Substance P (agonist of the NK1 receptor), Neurokinin A (agonist of the NK2 receptor). [0137] ...
  http://www.patentsencyclopedia.com/app/20120190048
*  Dopaminergic Signaling in the Cochlea: Receptor Expression Patterns and Deletion Phenotypes | Journal of Neuroscience
1997) Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90:991-1001. ... 1996) A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci U S A ... Outcomes are further complicated by the fact that the differences in receptor specificity of the various agonists and ... A posterior craniotomy and partial cerebellar aspiration were performed to expose the floor of the IVth ventricle. To stimulate ...
  http://www.jneurosci.org/content/32/1/344.long
*  Olanzapine - Wikipedia
... and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist". J. ... the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing ... Yeung, Eugene YH; Chun, Soojin; Douglass, Alan; Lau, Timothy E (2017-05-08). "Effect of atypical antipsychotics on body weight ... It may involve antagonism of dopamine and serotonin receptors. Antagonism of dopamine receptors is associated with ...
  https://en.wikipedia.org/wiki/Olanzapine
*  Apomorphine - Wikipedia
Ptácek R, Kuzelová H, Stefano GB (Sep 2011). "Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders". ... Apomorphine is an agonist, or activator, of both D1 and D2 type dopamine receptors with higher activity at D2. The members of ... Apomorphine behaves as a partial agonist at D2S (IA = 79%), D2L (IA= 53%), D3 (IA = 82%), and D4 (IA = 45%), and as an ... Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor". The Journal ...
  https://en.wikipedia.org/wiki/Apomorphine
*  30+ New Antidepressants (2018): Drugs In Clinical Trials
... and D4 receptor partial agonist; 5-HT1A and 5-HT2A receptor partial agonist; and a 5-HT6 and 5-HT7 receptor antagonist. RP-5063 ... Alpha-2A adrenergic receptors; D2 dopamine receptors; and 5-HT2A serotonin receptors. Given DSP-1200's mechanism of action, it ... A combination of: brain augmentation (e.g. hardware chips); nanotechnology; RNA interference; gene editing; stem-cells (to ... It functions as a D3 receptor and D2 receptor partial agonist - with high selectivity for the D3 receptor. As of current, it is ...
  https://mentalhealthdaily.com/2018/02/13/new-antidepressants-2018-drugs-in-clinical-trials/
*  D. Eugene Redmond Jr., MD > Psychiatry | Yale School of...
Jentsch JD, Taylor JR, Redmond DE Jr, Elsworth JD, Youngren KD, Roth RH: Dopamine D4 receptor antagonist reversal of subchronic ... Elsworth JD, Lawrence MS, Roth RH, Taylor JR, Mailman RB, Nichols DE, Lewis MH, Redmond DE Jr: D1 and D2 dopamine receptors ... Taylor JR, Lawrence MS, Redmond DE Jr, Elsworth JD, Roth RH, Nichols DE, Mailman RB: Dihydrexidine, a full dopamine D1 agonist ... Aged monkeys as a partial model for Parkinson's disease. Hurley, P. J., J. D. Elsworth, et al. (2011). 'Aged monkeys as a ...
  https://medicine.yale.edu/psychiatry/people/eugene_redmond-2.profile
*  Most recent papers with the keyword D2 occupancy | Read by QxMD
Background: Blockade of D3 receptor, a member of the dopamine D2-like receptor family, has been suggested as a possible ... METHODS: Animals (n=48) were exposed to either saline (CTRL; 1mL/kg) or quinpirole (QP; dopamine D2-agonist, 0.5mg/kg) in a ... to occupy the available D2 receptors and antagonize the action of dopamine or drugs on D2 in preclinical studies. The aims of ... METHODS: [18F]FM-T-773-d2 and [18F]FE-T-773-d4 were synthesized from the same precursor used for 11C-labeling of T-773 in a two ...
  https://www.readbyqxmd.com/keyword/86416
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... other receptor types; ion channels; transporters; enzymes, and other protein- and non-protein cellular structures. This review ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  Neurotransmitter And Neuropeptide Systems Serotonergic System - Psychopharmacology
... and postsynaptic receptors. Cisapride is a preferential 5-HT4 receptor agonist that is used to treat irritable bowel syndrome ... Haloperidol is a D2 receptor antagonist, and clozapine is a nonspecific D2/D4 receptor antagonist (both are effective ... Buspirone is a partial 5-HTia agonist that activates both pre- ... Neuroanatomy Of The Dopamine System * HPA Axis in Depression ... Evidence suggests that the COMT gene may be linked to schizophrenia (Akil et al. 2003). ...
  https://www.pharmacologicalsciences.us/psychopharmacology/neurotransmitter-and-neuropeptide-systems-serotonergic-system.html