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*  Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited...
... anti-tumoral effects of IC261 were tested in vivo in a subcutaneous mouse xenotransplantation model for pancreatic cancer. ... Background: Pancreatic ductal adenocarcinomas (PDACs) are highly resistant to treatment due to changes in various signalling ... Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited ... Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited ...
  http://gut.bmj.com/content/57/6/799
*  Soriatane - FDA prescribing information, side effects and uses
Two of the deaths were not drug-related (pancreatic adenocarcinoma and lung cancer); the other subject died of an acute ... including abnormal liver function tests and inflammation of your liver (hepatitis). Your prescriber should do blood tests to ... Liver Function Tests: Elevations of AST (SGOT), ALT (SGPT), or LDH were experienced by approximately 1 in 3 patients treated ... Liver function test results in these subjects returned to normal after Soriatane was discontinued. Two of the 1,289 subjects ...
  https://www.drugs.com/pro/soriatane.html
*  Beta-Blocker Drug Use and Survival among Patients with Pancreatic Adenocarcinoma | Cancer Research
In a large, general population-based cohort of patients with pancreatic adenocarcinoma, we test the hypothesis that β-blockers ... orchestrate various cell and tissue functions essential for the occurrence and progression of most common cancers (12, 13). In ... Age-adjusted pancreatic cancer survival curves by β-blocker use among patients with pancreatic adenocarcinoma diagnosis (2006- ... Adenocarcinoma, the most lethal form of pancreatic cancer, accounts for more than 85% of pancreatic tumors. Unsurprisingly, ...
  http://cancerres.aacrjournals.org/content/77/13/3700
*  TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
Physiological Functions and Roles in Cancer. With identification of the role of TRPM7 in pancreatic development and cancer, we ... This hypothesis was tested by repressing TRPM8 with siRNA and then assaying for activity of SA -gal as a marker of cellular ... in pancreatic cancer and discuss their potential as clinical biomarkers and therapeutic targets. Pancreatic adenocarcinoma is a ... and in the most recent finding pancreatic adenocarcinoma [6, 8]. In a panel of seven human pancreatic adenocarcinoma cell lines ...
  https://www.hindawi.com/journals/scientifica/2012/415158/
*  Expression of miRNA-143 in Pancreatic Cancer and Its Clinical Significance.
... in the patients with pancreatic cancer and to explore the influence of overexpression of miRNA-143 on pan... ... MicroRNA-876-3p functions as a tumor suppressor gene and correlates with cell metastasis in pancreatic adenocarcinoma via ... Genomic testing for pancreatic cancer in clinical practice as real-world evidence. ... in the patients with pancreatic cancer and to explore the influence of overexpression of miRNA-143 on pancreatic cancer cells. ...
  https://www.bioportfolio.com/resources/pmarticle/2097347/Expression-of-miRNA-143-in-Pancreatic-Cancer-and-Its-Clinical-Significance.html
*  Abstract 2723: The chorio-allantoicmembrane (CAM) model for testing HOX gene antagonism in pancreatic cancer. | Cancer Research
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid cancers with a 5-year survival rate approaching a ... HOX gene function can be antagonised by HXR9, a peptide that competitively inhibits binding of HOX proteins to their co-factor ... model for testing HOX gene antagonism in pancreatic cancer. Message Subject (Your Name) has forwarded a page to you from Cancer ... Abstract 2723: The chorio-allantoicmembrane (CAM) model for testing HOX gene antagonism in pancreatic cancer.. Sophie Gray, ...
  http://cancerres.aacrjournals.org/content/73/8_Supplement/2723
*  miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer | Cancer Research
The pancreatic cancer cell lines MIA PaCa-2, PANC-1, and BxPC-3 and the cervical adenocarcinoma cell line HeLa were obtained ... To test the hypothesis that KRAS might be a target of miR-96, a reporter plasmid harboring the wild-type 3′-UTR region of KRAS ... Aberrant miR-96 expression in pancreatic cancer. To assess the expression of miR-96 in pancreatic cancer, Northern blotting ... breast cancer (25), colon cancer (26), and pancreatic cancer (27). Previous studies have shown the importance of the KRAS/Akt ...
  http://cancerres.aacrjournals.org/content/70/14/6015
*  scusorryshaoqrifoce's Blog - MiGente.com
Pancreatic Cancer In Women All sorts of cancer has its different risk factors, causes, symptoms, diagnostic tests, treatments, ... Symptoms In Women The most popular kind of pancreatic cancer starts in the exocrine glands that are called as adenocarcinoma of ... Predicated on its effects on exocrine or endocrine functions from the pancreas, this cancer is categorized from the medical ... pancreatic-cancer originates from pancreatic cells. Nevertheless , cancers from other organs might metastasize to pancreases. ...
  http://www.migente.com/your_page/blog/index.html?profile_id=7218546&profile_name=scusorryshaoqrifoce&user_id=7218546&username=scusorryshaoqrifoce&c=19&p=3
*  scusorryshaoqrifoce's Blog - MiGente.com
Pancreatic Cancer In Women All sorts of cancer has its different risk factors, causes, symptoms, diagnostic tests, treatments, ... Symptoms In Women The most popular kind of pancreatic cancer starts in the exocrine glands that are called as adenocarcinoma of ... Predicated on its effects on exocrine or endocrine functions from the pancreas, this cancer is categorized from the medical ... cancer begins in pancreas is known as pancreas cancer. This specific type of cancer is probably the common kinds of cancers, ...
  http://www.migente.com/your_page/blog/index.html?profile_id=7218546&profile_name=scusorryshaoqrifoce&user_id=7218546&username=scusorryshaoqrifoce&m=May&y=2012
*  Pancreatic cancerrelated cachexia: influence on metabolism and correlation to weight loss and pulmonary function | BMC Cancer |...
To test for significant differences between the examined groups we used Student's t-test and the Mann-Whitney U test. ... Of 198 patients with a ductal adenocarcinoma of the pancreas, 70% were suffering from weight loss when they presented for ... Pancreatic cancer patients with cachexia had a higher rate of more progressed tumour stages and a worse nutritional status. ... Patients with pancreatic cancer and cachexia had significantly reduced survival. If weight loss exceeded 5% there was a ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-255
*  Gastrointestinal cancer - Wikipedia
The most common is ductal adenocarcinoma. The most significant risk factors for pancreatic cancer are advanced age (over 60) ... or the cancer might be revealed by abnormal liver function tests. An attending practitioner might order a biopsy, an MRI or a ... Pancreatic cancer has a poor prognosis, with a five-year survival rate of less than 5%. By the time the cancer is diagnosed, it ... Pancreatic cancer is the fifth-most-common cause of cancer deaths in the United States, and the seventh most common in Europe. ...
  https://en.wikipedia.org/wiki/Gastrointestinal_cancer
*  S100PBP (S100P binding protein)
Pancreatic ductal adenocarcinoma (PDAC). Note. Overexpression of S100PBP in FA6 pancreatic cancer cells that show low levels of ... While cell migration was not affected in majority of tested pancreatic cancer cell lines after modulation of S100PBP expression ... Function. The exact functions of S100PBP are currently unknown, however it has been shown that S100PBP can bind to the ... a precursor lesion to pancreatic cancer, black arrows= PanIN-1, red arrows= PanIN-2; PDAC= pancreatic cancer).. ...
  http://atlasgeneticsoncology.org/Genes/S100PBPID44308ch1p35.html
*  Soriatane (Acitretin): Side Effects, Interactions, Warning, Dosage & Uses
Two of the deaths were not drug-related (pancreatic adenocarcinoma and lung cancer); the other subject died of an acute ... Liver function test results in these subjects returned to normal after SORIATANE was discontinued. Two of the 1,289 subjects ... The first test (a screening test) is obtained by the prescriber when the decision is made to pursue therapy with SORIATANE. The ... including abnormal liver function tests and inflammation of your liver (hepatitis). Your prescriber should do blood tests to ...
  https://www.rxlist.com/soriatane-drug.htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... pancreatic adenocarcinoma, pancreatic cancer, pancreas, tumor, T-cell immunity, cancer ... The objective of the current study was to further investigate the function and modulation of PDCD4 in ovarian cancer cells. ... We tested plants expressing a model anti-HIV monoclonal antibody (2G12) and a fluorescent marker protein (DsRed). We discuss ... on Panc-1 human pancreatic adenocarcinoma cells 7. In order to actively target pancreatic cancer cell line, EGFR specific ...
  https://www.jove.com/visualize/abstract/22272332/tumour-suppressive-function-modulation-programmed-cell-death-4-pdcd4
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... pancreatic adenocarcinoma, pancreatic cancer, pancreas, tumor, T-cell immunity, cancer ... For example, we tested the relevance of Ng-CaM binding in synaptic function and how different mutations affect this binding. We ... ERα is frequently upregulated in breast cancer and drives the proliferation of breast cancer cells. The ERs function as ... Breast cancer is one of the most common cancers amongst women in North America. Many current anti-cancer treatments, including ...
  https://www.jove.com/visualize/abstract/19924303/transcriptional-regulation-biological-functions-selenium-binding
*  Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer | Molecular Cancer Therapeutics
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 2004;10:2846-50. ... have been synthesized and tested against pancreatic cancer (27).. An important aspect of multistep tumorigenesis is the ... the function of Ras may be targeted by farnesyl transferase inhibitors (67). However, a phase III study in 688 patients showed ... Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res 2005;11:2531-9. ...
  http://mct.aacrjournals.org/content/5/6/1387
*  Perioperative Therapy for Resectable Pancreatic Cancer - Full Text View - ClinicalTrials.gov
2.5 X ULN or if the subject has a biliary stent and the liver function tests (LFTs) are decreasing the subject is eligible ... Adenocarcinoma of the Pancreas Stage IA Pancreatic Cancer Stage IB Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB ... Histology other than adenocarcinoma. *Patients with permanently unresectable pancreatic adenocarcinoma as determined by the ... Perioperative Therapy for Resectable Pancreatic Cancer. The safety and scientific validity of this study is the responsibility ...
  https://clinicaltrials.gov/show/NCT00609336
*  A Phase II Trial of TPI 287 in Patients Advanced, Unresectable Pancreatic Cancer - Full Text View - ClinicalTrials.gov
Must have a negative serum or urine pregnancy test. * Patients must have adequate organ function:. *Bone marrow reserve as ... Patients must have histological or cytological confirmation of ductal adenocarcinoma or undifferentiated carcinoma of the ... A Phase II Trial of TPI 287 in Patients Advanced, Unresectable Pancreatic Cancer. This study has been terminated. ... This is a multicenter, open-label, single arm Phase 2 study in patients with advanced, unresectable pancreatic cancer who have ...
  https://clinicaltrials.gov/show/NCT00553813
*  A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma
Common treatment-related adverse events included liver function test abnormalities, neuropathy, nausea/vomiting, and diarrhea. ... In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by depleting tumor- ... A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. ... in patients with advanced pancreatic cancer.. Methods. Patients were treated with once-daily IPI-926 plus FOLFIRINOX. A 3 + 3 ...
  https://insights.ovid.com/crossref?an=00006676-201603000-00009
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... pancreatic adenocarcinoma, pancreatic cancer, pancreas, tumor, T-cell immunity, cancer ... Here, fully quantitative and clinically validated protocol for testing of autonomic functions is presented. As a bare minimum ... Additionally, blockade of B7-H1 in a mouse model of pancreatic cancer has been shown to produce an anti-tumor response11. These ... DNA Vector-based RNA Interference to Study Gene Function in Cancer. Authors: Daniel B. Stovall, Meimei Wan, Qiang Zhang, ...
  https://www.jove.com/visualize/abstract/19956735/multiple-functions-of-nm23-h1-are-regulated-by-oxido-reduction-system
*  Pancreatic cancer - Wikipedia
Liver function tests can show a combination of results indicative of bile duct obstruction (raised conjugated bilirubin, γ- ... Stage T4 pancreatic cancer Pancreatic cancer in nearby lymph nodes - Stage N1 Locally advanced adenocarcinomas have spread into ... Pancreatic cancer staging (TNM classification) Stage T1 pancreatic cancer Stage T2 pancreatic cancer Stage T3 pancreatic cancer ... Pancreatic cancer is usually staged following a CT scan. The most widely used cancer staging system for pancreatic cancer is ...
  https://en.wikipedia.org/wiki/Pancreatic_cancer
*  Phase 1 Experience with an Anti-Glycotope Monoclonal Antibody, RAV12, in Recurrent Adenocarcinoma | Clinical Cancer Research
Transient and sporadic, self-limited elevations in liver function tests and pancreatic enzyme blood levels, as well as ... European Organization for Research and Treatment of CancerNational Cancer Institute of the United StatesNational Cancer ... Liver function test abnormalities were most commonly seen with first infusion. Only in two patients, treated at 1.5 mg/kg qw, ... Cancer Therapy: Clinical Phase 1 Experience with an Anti-Glycotope Monoclonal Antibody, RAV12, in Recurrent Adenocarcinoma. ...
  http://clincancerres.aacrjournals.org/content/16/5/1673.full
*  Connexin and pannexin channels in cancer | Springer for Research & Development
The bioactive substance sulforaphane inhibits cancer stem cells in pancreatic ductal adenocarcinoma through the increased Cx43 ... that have also been widely tested for their inhibitory effects on Panx1 channel function. These are tools that could be ... Pannexin 1 upregulation or gain-of-function in cancer. Our current knowledge of Panx1 function in cancer is limited (see Table ... such as breast cancer, prostate cancer, lung cancer, and many other cancer types [7]. For example, Cx43 was found to be reduced ...
  https://rd.springer.com/article/10.1186/s12860-016-0094-8
*  STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis | Cancer Research
To define functions of STAT3 in vivo, we developed mouse models that test the impact of conditional inactivation of STAT3 in ... Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States and carries a dismal 5 ... p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997;57:2140-3. ... Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50. ...
  http://cancerres.aacrjournals.org/content/71/14/5020
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... pancreatic adenocarcinoma, pancreatic cancer, pancreas, tumor, T-cell immunity, cancer ... ERα is frequently upregulated in breast cancer and drives the proliferation of breast cancer cells. The ERs function as ... Among many drugs that have been tested so far, bleomycin and cisplatin found their way from preclinical testing to clinical use ... Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center. ...
  https://www.jove.com/visualize/abstract/24204738/tumor-suppressive-function-mir-139-5p-esophageal-squamous-cell