*  Safety Study of Intranasal Oxytocin in Frontotemporal Dementia - Full Text View - ClinicalTrials.gov
Oxytocin is a hormone produced by the brain that appears to have important roles in social cognition and emotion in humans. In a pilot study, the effects of a single dose of oxytocin on measures of emotion recognition and behaviour in patients with Frontotemporal Dementia were investigated. The results from the pilot study suggested that oxytocin may be associated with a modest improvement in neuropsychiatric behaviours seen in patients with Frontotemporal Dementia. To further examine the safety and tolerability of oxytocin in this disorder, the present study will examine the safety and tolerability of three different doses of intranasal oxytocin administered to patients with Frontotemporal Dementia twice daily for 1 week ...
  https://clinicaltrials.gov/ct2/show/NCT01386333?cond=%22Frontotemporal+dementia%22&rank=6
*  Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in...
This study was performed in order to investigate whether activation of sensory fibres within the sciatic and vagal nerves might influence the release of oxytocin. In anaesthetized rats the sciatic and vagal nerves were stimulated electrically in an afferent direction with a variety of stimuli. Rats were also stroked on their backs or nociception was inflicted by pinching a foot. Plasma oxytocin levels were measured with a highly sensitive radioimmunoassay in samples drawn from the carotid artery. Afferent electrical stimulations of both sciatic and vagal nerves at 5 V, 0.2-2 ms and 3-10 Hz caused immediate significant elevations of oxytocin levels. Thus, basal levels increased by 30-184%. Furthermore, in response to touch and nociceptive stimuli, oxytocin levels rose by 181 % and 206%, respectively. These data indicate that oxytocin can be released by stimulation of peripheral nerves originating in the skin and/or muscle and ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.1988.tb08294.x/abstract
*  Oxytocin
The most important stimulus for release of hypothalamic oxytocin is initiated by physical stimulation of the nipples or teats. The act of nursing or suckling is relayed within a few milliseconds to the brain via a spinal reflex arc. These signals impinge on oxytocin-secreting neurons, leading to release of oxytocin. If you want to obtain anything other than trivial amounts of milk from animals like dairy cattle, you have to stimulate oxytocin release because something like 80% of the milk is available only after ejection, and milk ejection requires oxytocin. Watch someone milk a cow, even with a machine, and what you'll see is that prior to milking, the teats and lower udder are washed gently - this tactile stimulation leads to oxytocin release and milk ejection. A number of factors can inhibit oxytocin release, among them acute stress. For example, oxytocin neurons are ...
  http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/oxytocin.html
*  Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis - Full Text View - ClinicalTrials.gov
Fifty patients will be enrolled in a double-blinded, placebo-controlled single-dose crossover trial comparing intranasal oxytocin to intranasal saline. At the time of enrollment, patients will complete a series of standardized questionnaires detailing information about their IC-related symptoms at baseline as well as comorbid conditions, coping mechanisms (specifically catastrophizing), and baseline ratings of overall pain, depression, anxiety, and global functioning. Once this information is obtained, the patient will receive a one-time dose of intranasal oxytocin or an equivalent volume of intranasal saline. The patients will be monitored for one hour by a physician investigator for toxicities and efficacy and then contacted for follow-up information at 2, 4, 6, and 24 hours. At each of these time points, the patient will be asked to report a verbal pain report, a verbal anxiety report, the number of voids since last contact with an investigator, and the use of any ...
  https://clinicaltrials.gov/ct2/show/NCT00919802?recr=Open&cond=%22Urinary+Bladder+Diseases%22&rank=8
*  Plus it
This study evaluated the influences of central neurotransmitter receptor activation on peripheral and central OT release during gestation and ovarian steroid treatment in rats. Basal systemic OT concentrations were elevated in LATEP females. Furthermore, acute intracerebroventricular injections of phenylephrine, but not HA, caused a significantly greater increase in systemic OT release in LATEP compared with MIDP, OVX, and steroid-treated females. However, intracerebroventricular administration of NE or HA receptor antagonists did not lower plasma OT concentrations of LATEP females. Finally, although basal PVN OT concentrations were of similar magnitude in all groups, phenylephrine stimulation caused a significantly greater increase in dialysate OT concentrations in MIDP females. Taken together, these findings suggest that adrenergic sensitivity of both intranuclear and systemic OT release varies during the course of pregnancy in a differential manner.. The significantly greater increase in ...
  http://ajpendo.physiology.org/content/287/3/E523
*  Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors - Tabular View - ClinicalTrials.gov
There is a tremendous unmet need for accessible treatments that address core symptoms of ASD and are safe for sustained use. The Study of Oxytocin in ASD to improve Reciprocal Social Behaviors or (SOARS-B) will test a very promising potential treatment−intranasal oxytocin−for ASD's fundamental social communication deficits in a large, group of verbal and nonverbal children. SOARS-B will also provide information about the regulation of DNA methylation and transcription of the oxytocin receptor gene (OXTR), as well as other genes relevant to oxytocin's CNS activity, as a function of time and in response to oxytocin treatment. These data will fill a key gap in our understanding of oxytocin's role in ASD and its ability to alter epigenetic modifications of the OXTR ...
  https://clinicaltrials.gov/ct2/show/record/NCT01944046?view=results
*  oxytocin
Maybe I'm jumping too quickly to put two and two together but juxtaposing the description of the effect of Smith's Nambian root with the actions of oxytocin, I can't but wonder if there is some connection. There are numerous examples of other plants which contain hormones. Could this root contain oxytocin or could something in it stimulate oxytocin release in people? Food for thought, eh?. Here is concise but partial summary of oxytocin's actions in the brain from Wikipedia:. 1. Sexual arousal. Oxytocin injected into the cerebrospinal fluid causes spontaneous erections in rats, reflecting actions in the hypothalamus and spinal cord. 2. Bonding. In the Prairie Vole, oxytocin released into the brain of the female during sexual activity is important for forming a monogamous pair bond with her sexual partner. Vasopressin appears to have a similar effect in males. In people, plasma concentrations of ...
  http://www.denvernaturopathic.com/oxytocin.html
*  Oxytocin Injection (Canada) for Animal Use - Drugs.com
Learn about Oxytocin Injection (Canada) for animal usage including: active ingredients, directions for use, precautions, and storage information.
  https://www.drugs.com/vet/oxytocin-injection-can.html
*  INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders - Full Text View - ClinicalTrials.gov
There is substantial evidence from animal model and healthy control data, that oxytocin is involved in the modulation of social cognition. In addition, recent genetics and plasma level studies suggest a possible role for oxytocin in the pathophysiology of Autism Spectrum Disorders (ASD). As a large number of children with ASD are transitioning into adulthood and will likely require treatment, the lack of data to make meaningful treatment recommendations to facilitate adult living is an urgent issue. This study will examine the effect of intranasal oxytocin (IN-OXT) on social function in adults with ASD. It is hypothesized that IN-OXT will be superior to placebo in improving social function by the end of study treatment ...
  https://clinicaltrials.gov/ct2/show/NCT01788072?term=Autism+Spectrum+Disorder&rank=20
*  Oxytocin and Social Cognition in Frontotemporal Dementia - Full Text View - ClinicalTrials.gov
Investigations into the components of cognition damaged in frontotemporal dementia (FTD) demonstrate that patients with FTD show deficits in facial and verbal expression recognition, lack insight into what others think or might do (theory of mind skills), and in decision making tasks requiring processing of positive versus negative feedback. These cognitive functions are thought to be critical for appropriate social behavioural regulation (Blair, 2003). Recent studies in animal models and humans suggest that the neuropeptide oxytocin is an important mediator of social behavior and that oxytocin may facilitate emotion recognition, theory of mind processing, and prosocial behaviors (Donaldson and Young, 2008). Together, these findings suggest that upregulation of oxytocin dependent mechanisms of social and emotional cognition may be a valuable treatment approach in patients with FTD. The aim of this study is to determine how administration of intranasal ...
  https://clinicaltrials.gov/ct2/show/NCT01002300
*  Oxytocin Improves Sex, Sociability and Mood | Smart Publications
Recent studies in humans building on the animal experiments show that oxytocin is important in stimulating a wide range of social skills and interactions including eye contact, empathy, face and emotion recognition, trust, and generosity.9 10 Much of this work has been performed using intranasal (i.e., nasal spray) delivery of oxytocin, which has been shown to raise oxytocin concentrations in the cerebral-spinal fluid.11 One of the first studies on human social behavior examined the effect of intranasal oxytocin in people performing the "trust game," a tool for the study of trust in a controlled laboratory setting in which an "investor" and "trustee" must make decisions on the size of money transfers between them. Investors receiving oxytocin nasal spray transferred significantly more money than investors given a placebo, indicating that the neuropeptide is essential in establishing trust,12 which is a necessary element of ...
  http://www.smart-publications.com/articles/oxytocin-improves-sex-sociability-and-mood
*  Oxytocin Production: Increase the 'Love Hormone' by Reducing Stress
Oxytocin production increases the more you get the stress out of your life. A very interesting aspect of this hormone is, the more you increase it, the more you make!
  https://www.peak-health-now.com/oxytocin-production.html
*  Crazy Eddie's Motie News: Are your oxytocin levels high enough?
The first bit of evidence that points to oxytocin as nature's love glue comes from researchers who measured the hormone in couples. Psychology professor Ruth Feldman at Bar-Ilan University in Israel, spent years studying oxytocin's role in the mother-child bond and recently decided to dive into the uncharted waters of romantic bonds by comparing oxytocin levels in new lovers and singles. "The increase in oxytocin during the period of falling in love was the highest that we ever found," she says of a study she and her colleagues published in Psychoneuroendocrinology. New lovers had double the amount Feldman usually sees in pregnant women ...
  http://crazyeddiethemotie.blogspot.com/2013/02/are-your-oxytocin-levels-high-enough.html
*  Synthetic Oxytocin and Its Effect on Postpartum Mood and Anxiety
This study used population-based data to examine the relationship between peripartum synthetic oxytocin administration and the development of depressive and anxiety disorders within the first year postpartum.
  https://womensmentalhealth.org/posts/synthetic-oxytocin-effect-postpartum-mood-anxiety/
*  Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes | ScholarBank@NUS
Background: Research in mammals has demonstrated the involvement of oxytocin (OT) in social bond formation; yet, its role in human bonding remains unclear. Plasma OT has been used as a proxy for central activity and studies indicate its association with human affiliative behaviors. Molecular genetic studies also reveal a role for OT neuropathways in shaping the social brain. However, the links between peripheral OT, genetic markers, and their combined contribution to human parenting are unknown. Methods: Participants included 352 individuals: 272 mothers and fathers and their 4- to 6-month-old-infants and 80 nonparents. Plasma OT was assayed from adults who were genotyped for oxytocin receptor (OXTR) and CD38 risk alleles associated with social dysfunctions. CD38 is an ectoenzyme that mediates the release of brain OT. Parent-infant interactions were microcoded for parental touch and gaze synchrony and participants reported on parental care in childhood. Results: OXTR ...
  http://scholarbank.nus.edu.sg/handle/10635/49865
*  Deric's MindBlog: Oxytocin - more sophisticated views of its functions
Helen Shen offers a review of studies on oxytocin, the "hug hormone," which influences maternal behavior and social attachment in various species. She notes research showing that oxytocin acts on inhibitory interneurons in a way that quiets background chatter within neuronal circuits, and thus may help social interaction and recognition is by enhancing the brain's response to socially relevant sights, sounds or other stimuli. MindBlog has done posts on experiments showing that oxytocin, delivered through an intranasal spray, can promote various aspects of social behavior in healthy adults. People who inhale oxytocin before playing an investment game are more willing to entrust their money to a stranger than are placebo-treated players. A dose of the hormone increases the amount of time people spend gazing at the eye region of faces, and improves their ability to infer the emotional state of others from subtle expressions. Shen's review also ...
  http://mindblog.dericbownds.net/2015/09/oxytocin-more-sophisticated-views-of.html
*  Oxytocin hormone crystals - Stock Image A618/0356 - Science Photo Library
Oxytocin. Polarised light micrograph of crystals of the female hormone oxytocin. In women this hormone is secreted naturally by the pituitary gland. It is also manufactured synthetically in the laboratory for use as a drug. Oxytocin causes contractions of the uterus during labour, and it also stimulates the flow of milk in women who are breast-feeding. As a drug it may be used to induce childbirth, or to help to expel the placenta. Oxytocin may be given in the form of a nasal spray to help increase milk flow while breast-feeding. Magnification: x100 at 6x7cm size. - Stock Image A618/0356
  http://www.sciencephoto.com/media/7686/view
*  Oxytocin: the hormone of love, and understanding? - Health Tips
hormone that reduces smooth muscle influences the uterus.It is due to begin oxytocin birth.In addition, the effect of the hormone on the breast promotes the release of milk.Of course, it ensures the production of another substance, prolactin, oxytocin, but it contributes to the removal of the breast.To stop the bleeding after gynecological operations, also using oxytocin.It counteracts the effects of progesterone.If progesterone is not enough, the contractile effects of oxytocin on the uterus lead to miscarriage.The impact on the psyche is associated with increased benevolence, propensity to trust the other party.In the postpartum period, relations between mother and infant, oxytocin regulates it.Hormone provides attachment to the mother the baby, helping him to understand the mood and reduces the feelings of fear and anxiety.. ...
  http://healthtipsing.com/en/pages/103300
*  Oxytocin, [Tyrosyl-3,5-3H]-, 50µCi (1.85MBq) | PerkinElmer
50 µCi quantities of [Tyrosyl-3,5-3H]-Oxytocin are available for your research. Application of [3H]Oxytocin can be found in: identification and characterization of mesotocin and V1a-like vasotocin receptors in endocrinology, progesterone suppressing an oxytocin-stimulated signal pathway in steroid research, muscle layer- and region-dependent distributions of receptors in porcine myometrium in pharmacology, etc. ...
  http://www.perkinelmer.com/product/oxytocin-tyrosyl-2-6-3h-net858050uc
*  3 Ways to Increase Oxytocin Levels - wikiHow
How to Increase Oxytocin Levels. Oxytocin is a powerful hormone in the human body. It starts contractions for pregnant mothers to get childbirth underway. It's also thought of as the 'love' or 'cuddle' hormone, increasing feelings of...
  http://www.wikihow.com/Increase-Oxytocin-Levels
*  Hormone oxytocin improves social cognition but only in less socially proficient individuals | EurekAlert! Science News
Researchers at Mount Sinai School of Medicine have found that the naturally occurring hormone oxytocin selectively improves social cognitive abilities for less socially proficient individuals, but has little effect on those who are more socially proficient. The study was published today in Psychological Science.
  https://www.eurekalert.org/pub_releases/2010-09/tmsh-hoi092110.php
*  Most recent papers with the keyword Neurotransmission | Read by QxMD
Oxytocin (5-100ng), but not Arg(8)-vasopressin (100ng), injected unilaterally into the bed nucleus of the stria terminalis (BNST) induces penile erection and yawning in a dose-dependent manner in male rats. The minimal effective dose was 20ng for penile erection and 5ng for yawning. Oxytocin responses were abolished not only by the oxytocin receptor antagonist d(CH2)5Tyr(Me)(2)-Orn(8)-vasotocin (1μg), but also by (+) MK-801 (1μg), an excitatory amino acid receptor antagonist of the N-methyl-d-aspartic acid (NMDA) subtype, SCH 23390 (1μg), a D1 receptor antagonist, but not haloperidol (1μg), a D2 receptor antagonist, and SMTC (40μg), an inhibitor of neuronal nitric oxide synthase, injected into the BNST 15min before oxytocin ...
  https://www.readbyqxmd.com/keyword/87833
*  Intranasal Oxytocin Treatment for Social Deficits in Children With Autism - No Study Results Posted - ClinicalTrials.gov
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... ...
  https://clinicaltrials.gov/ct2/show/results/NCT01624194
*  "Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supp" by Ilanit Gordon, Allison Jack et al.
Oxytocin (OT) has become a focus in investigations of autism spectrum disorder (ASD). The social deficits that characterize ASD may relate to reduced connectivity between brain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections and contribute to social motivation, and cortical sites involved in social perception. Using functional magnetic resonance imaging and a randomized, double blind, placebo-controlled crossover design, we show that OT administration in ASD increases activity in brain regions important for perceiving social-emotional information. Further, OT enhances connectivity between nodes of the brain's reward and socioemotional processing systems, and does so preferentially for social (versus nonsocial) stimuli. This effect is observed both while viewing coherent versus scrambled biological motion, and while listening to happy versus angry voices. Our findings suggest a mechanism by which intranasal OT may bolster social motivation-one ...
  https://hsrc.himmelfarb.gwu.edu/smhs_pharm_facpubs/147/