... both telomere shortening and oxidative stress). The DNA damage response (DDR) arrests cell cycle progression until DNA damage, ... Senolytic drugs which induce apoptosis in senescent cells rely on phagocytic immune system cells to remove the apoptosed cells ... They took embryonic progenitor cells, transduced those cells with oncogenic ras, along with the tetracycline transactivator ( ... Mutations in genes relating to genome maintenance has been linked with premature aging diseases, supporting the role of cell ...

... chromatin remodeling genes ARID1A and ARID2, oxidative stress response genes NFE2L2 and KEAP1, RAS/MAPK signaling (RPS6KA3), ... cell-cycle progression, protein-degradation, apoptosis, and genetic instability[100]. Localization of HBx on the outer ... HBV proteins mediate intracellular oxidative stress. Individuals with CHB exhibit 1.5-4 times higher levels of oxidative stress ... HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells. Viruses. 2015;7:2745-2770. [ ...

Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can ... A major contributor to this process is cell senescence. ... oxidative stress (RAS activity) or epigenetic stress has been ... p19 are activated which leads to cell cycle arrest or apoptosis.. Epigenetics of Aging: Aged cells show various features on ... Senescent cells are mitotically inactive but are viable. With the loss of replicative inability changes in metabolism, gene ...

Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. ... High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different ... But if this is not possible, oxidative stress finally activates signals that will lead to cell death. ... in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. Their participation ...

Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by ... Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes ... are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development ... which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. Combined, the ...

S. C. Manolagas and M. Almeida, "Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age- ... Ectopic β-catenin causes the upregulation of all RAS genes [139]. Notably, RAS activation contributes to renal aging through ... Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis ... "High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease," PLoS ...

In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate ... CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. These effects can be ... Furthermore, PA-induced activation of CB1 receptor decreases cell proliferation and induces apoptosis by inducing the ER stress ... These ER stress proteins have been also linked to DN development in vivo [72]. A parallel signaling pathway via Ras, ERK, and ...

Moreover, DATS and CAP significantly up-regulated PI3K, Akt, and eNOS gene expression but down-regulated FOXO-1 expression ... and gene expression of PI3K, Akt, FOXO-1, and eNOS were assessed. Histopathological examination of heart tissue was performed. ... They suppressed oxidative stress and inflammation and thereby attenuate necrosis, apoptosis, and promote autophagy after acute ... The renin-angiotensin system (RAS) is implicated in blood pressure regulation, inflammation, and oxidative stress. Captopril ( ...

... pim1 and anti-apoptotic genes such as B-cell CLL/Lymphoma-2 (Bcl-2), Bcl-xL, survivin and X-linked inhibitor of apoptosis ... confer stress protection by reducing reactive oxygen species (ROS) accumulation and apoptosis (10,11) and support Ras-induced ... progression, metastasis, chemoresistance and immunoevasion (5). Upon cytokine and growth factor stimulation STAT3, a ... where it may trigger oxidative phosphorylation (9), ... The dowstrean targets include cell cycle regulatory genes such ...

Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete ... Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, ... Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed ... especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of ...

Under hypoxia and oxidative stress, cells begin the process of angiogenesis through factors such as HIF-1α to maintain their ... 2000). Manumycin Inhibits Ras Signal Transduction Pathway and Induces Apoptosis in COLO320-DM Human Colon Tumour Cells. Br. J. ... 2014). Thiocoraline Activates the Notch Pathway in Carcinoids and Reduces Tumor Progression In Vivo. Cancer Gene Ther. 21 (12 ... Stopping the cell cycle at G2/M and induction of apoptosis by this compound in HCT-116 cells were other results of this study ( ...

The metabolic and oxidative stress pathways may participate in PC progression. ... Four metabolic pathways and one oxidative stress pathway were identified in the miPPSPC, whereas linoleic acid metabolism and ... Gene set variation analysis (GSVA) was used to establish and validate a miRNA set-based pathway prognostic signature for PC ( ... These results suggest that these genes may play key roles in tumor cells via unknown mechanisms. In PC, most genes were found ...

Ozben, T. Oxidative stress and apoptosis: Impact on cancer therapy. Journal of Pharmaceutical Sciences. 96(9): 2181-2196, 2007. ... 11). It is effective in promoting cell health by promoting normal levels of nuclear factor-kappa B (NF-κB). NF-κB is a ... 2005 Jan; 165(1):9-28; Proanthocyanidins -- a final frontier in flavonoid research? Dixon RA, Xie DY, Sharma SB. ... Elevated stromal chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer. Clin Cancer Res 3: ...

Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element ( ... The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. In contrast, cyclin A ... C/EBPbeta is a ras/MAPkinase signal-sensitive transcription factor that regulates genes involved in metabolism, proliferation, ... thus ensuring that E2F-1 is locked into its cell-cycle progression mode. The Tudor domain protein p100-TSN reads the symmetric ...

Intriguingly, we furthermore identified NRF2 as key regulator of immune-modulating genes, linking oxidative stress with the ... primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids ... ATRA and 9cis-RA induced morphological changes suggestive of differentiation, while fenretinide induced apoptosis in several ... has been associated with a higher risk of relapse and progression and, consequently, restricted prognosis. Its molecular ...

E-cig use can cause oxidative stress and endothelial cell dysfunction (8, 9), and compromised innate immune response in lungs ( ... apoptosis and metabolism, as well as in regulation of gene expression at transcription and translation levels. Additionally, ... Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study. JAMA. 1998;279(2): ... Gardiner C, Ferreira YJ, Dragovic RA, Redman CW, Sargent IL. Extracellular vesicle sizing and enumeration by nanoparticle ...

Oxidative stress has an important role in the generation of CCl4-induced liver fibrosis (39). CCl4 damages the hepatocellular ... HSCs are a major type of fibrogenic liver cell found during liver injury and have are responsible for the progression of ... Mera K, Uto H, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, et al: Serum levels of apoptosis ... Cheng K, Yang N and Mahato RI: TGF-beta1 gene silencing for treating liver fibrosis. Mol Pharm. 6:772-779. 2009. View Article ...

Cell-type enrichment calculation. Cell-type gene expression was found in (Zhang et al, 2014a,2014b). Specific genes were ... RA) twenty-four hours after plating the cells. After 5 days in the presence of RA, cells were subjected to paraquat (PQ) ... Zhou L, Yang L, Li YJ, Mei R, Yu HL, Gong Y, Du MY, Wang F (2018) MicroRNA-128 protects dopamine neurons from apoptosis and ... Alteration of the microRNA network during the progression of Alzheimers disease. EMBO Mol Med 5: 1613-1634Wiley Online Library ...

Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been ... Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been ... GSH is a key antioxidant in oxidative stress response and is synthesized by L-cysteine, glycine, and glutamate, among which the ... and genetically distinct from apoptosis, necrosis, and autophagy, this new cell death pattern was named ferroptosis. In 2021, ...

We report how sex hormones and genes encoded by the sex chromosomes could protect from the disease or alternatively predispose ... role of biological sex in the development of the brain and analyze its impact on the predisposition toward and the progression ... Sex hormones and genes on the sex chromosomes are not only key factors in the regulation of sexual differentiation and ... Intriguingly, knockdown of endogenous SRY expression in BE(2)-M17 cells leads to increased cell damage and oxidative stress, ...

... and arrest cell cycle progression in colorectal cancer cells. Moreover, they have been shown to inhibit the RAS-related ... It also activates the p53-PARP signaling cascade and increases oxidative stress. In addition, fenbendazole triggers autophagy ... Induction of apoptosis. The induction of apoptosis caused by fenbendazole has been shown to halt the growth of cancerous cells ... Moreover, it activates p53 and blocks the entry of the cancerous gene c-Myc into mitosis. ...

Proteomic data showed that apoptosis and junction-related pathways were enriched within 3 days of infection, indicating ... Correspondingly, transcriptomic results showed significant enrichment of cell cycle pathway on day 3 and 7. In addition, the ... Proteomic-based GO analysis demonstrated that biological processes such as cell deformation, proliferation, migration and wound ... Histopathological analysis revealed that liver injury, characterized by collagen deposition and inflammatory cell infiltration ...

Apoptosis (programmed cell death) is the principal mechanism by which dysfunctional cells are normally eliminated. The ... Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies ... Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study ... retinoic acid inducible gene 1-like receptors [RLRs] and nucleotide-binding oligomerization domain-like receptors [NLRs]). [10 ...

As one example, TP53 encodes a transcription factor that regulates gene sets critical for cell cycle progression and apoptosis ... the constitutive DNA damage signalling is fuelled by continued replication stress and by enhanced oxidative stress.32 98 100 ... A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009;137:835-48. ... Simultaneous inactivation of both genes, on the other hand, results in cell death.24 It is thought that the cancer cells have ...

The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related ... and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in ... Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science, 2005, 308(5725), 1181-1184.. [http ... Hymowitz, S.G.; Malek, S. Targeting the MAPK pathway in RAS mutant cancers. Cold Spring Harb. Perspect. Med., 2018, 8(11), ...

Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells. ... promotes malignant progression by controlling cell polarity and adhesion between tumour cells, and between tumour cells and the ... 9100 was used in Immunohistochemistry-immunofluorescence to investigate the cell division cycle 20B gene in multiciliated cells ... Langer M,Duggan ES,Booth JL,Patel VI,Zander RA,Silasi-Mansat R,Ramani V,Veres TZ,Prenzler F,Sewald K,Williams DM,Coggeshall KM, ...

... a neuroprotective function by promoting cell proliferation and suppressing apoptosis and oxidative stress in SH-SY5Y cells. ... A TUNEL assay confirmed that LHX2 inhibited apoptosis. Taken together, LHX2 plays a vital role in breast cancers progression ... NCX4040 treatment induced several genes related to ferroptosis (e.g., CHAC1, GPX4 and NOX4) in both cell lines. Metabolomic ... of cytotoxicity of NCX4040 in HT-29 and K-RAS mutant HCT 116 colon cell lines. Ferroptosis is characterized by the accumulation ...

Cell Biology. PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis ... An antibody to PVRL4 decreased xenograft progression, apparently by preventing cell-cell adhesive contacts. ... may also promote cell-to-cell attachment as a part of their survival strategy. Either expression of mutant RasV12, or ... explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular ...

... and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance ... Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its ... Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great ... Although the conventional activities of p53 such as cell cycle arrest, senescence, ...

Analysis of cell malignant phenotypes. See the Supplemental Methods for details about cell viability and apoptosis and cell ... Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress ... Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3-mediated gene silencing. J Biol Chem. ... Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.. View this article via: CrossRef ...