The advantages of the field of chronotherapy are endless. If we can properly time our use of drugs to follow the circadian ... is significantly more effective at sleep-time than at wake-time in hypertensive models. It is thus intuitive to say that the ... When administered at night, this drug causes a dip in blood pressure that is seen in our normal circadian rhythms and can help ... The three rhythms, classified based on their length of oscillation, are the ultradian (less than 8 hours), the circadian (about ...http://circadianmedicine.my-free.website/chronotherapy/
The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes |...
Circadian variation of blood pressure: the basis for the chronotherapy of hypertension. Adv Drug Deliv Rev. 2007;59:904-922. ... Increasing evidence suggests a role for the circadian clock in the control of blood pressure (BP). A subset of hypertensive ... P,0.05 for Per1 KO vs WT at each time point; n=6. Data were also analyzed by 2-way ANOVA (SigmaPlot). Genotype and time effects ... 10 Given the known circadian oscillations in gene expression in these cell types, we used a model of the CCD to identify novel ...http://hyper.ahajournals.org/content/59/6/1151
Neurotransmitters of the suprachiasmatic nuclei
The role of AVP in circadian time keeping has been well established. Its role in the control of circadian rhythm of food and ... Isolated individual neurons are reported to produce circadian oscillations with periods ranging from 20-28 h [26,27]. Circadian ... Green, CB (2005). Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide. Proc Nat Acad Sci USA 102: 3529- ... NO synthesis is required for phase changes of electrical activity . Intracerebroventricular application of L-NAME (a drug ...https://www.jcircadianrhythms.com/articles/10.1186/1740-3391-4-2/print/