*  Granisetron - DrugBank
... antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. [PubChem] ... for histamine H 1 receptors; for benzodiazepine receptors; for picrotoxin receptors; or for opioid receptors. In most human ... A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy ... receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5- ...
  https://www.drugbank.ca/drugs/DB00889
*  Alcohol (drug) - Wikipedia
... and NMDA receptors, the glycine receptor, the nicotinic acetylcholine receptors, the serotonin 5-HT3 receptor, voltage-gated ... a close analogue of the benzodiazepine antagonist flumazenil (Ro15-1788), has been found to bind to the same site as ethanol ... Méndez M, Morales-Mulia M (2008). "Role of mu and delta opioid receptors in alcohol drinking behaviour". Curr Drug Abuse Rev. 1 ... to accumulate in tissues and trigger the release of histamine, the evoker of these symptoms; 2) true allergy reactions to ...
  https://en.wikipedia.org/wiki/Alcohol_(drug)
*  Demerol Injection - FDA prescribing information, side effects and uses
... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... Serotonin Syndrome. Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from ... Histamine release leading to hypotension and/or tachycardia, flushing, sweating, and pruritus.. Other. Pain at injection site; ...
  https://www.drugs.com/pro/demerol-injection.html
*  Irritable bowel syndrome - Wikipedia
This is thought to be due to the large number of serotonin receptors in the gut. 5HT3 antagonists such as ondansetron are ... Medications may consist of stool softeners and laxatives in IBS-C and antidiarrheals (e.g., opiate, opioid, or opioid analogs ... and associated receptors) which have been implicated in symptoms of IBS or specific subtypes include: histamine (HRH1, HRH2, ... CS1 maint: Multiple names: authors list (link) Professor C Heather Ashton (1987). "Benzodiazepine Withdrawal: Outcome in 50 ...
  https://en.wikipedia.org/wiki/Irritable_bowel_syndrome
*  Opioid - Wikipedia
In this context the term opioid refers to opioid agonists, opioid antagonists, opioid peptides, and opioid receptors. ARNP, ... "FDA requires strong warnings for opioid analgesics, prescription opioid cough products, and benzodiazepine labeling related to ... due to histamine release, except fentanyl and remifentanil). Both therapeutic and chronic use of opioids can compromise the ... Codd EE, Shank RP, Schupsky JJ, Raffa RB (1995). "Serotonin and norepinephrine uptake inhibiting activity of centrally acting ...
  https://en.wikipedia.org/wiki/Opioid
*  Sufentanil - FDA prescribing information, side effects and uses
... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see ... Manifestations of histamine release and/or peripheral vasodilation may include pruritus, flushing, red eyes and sweating and/or ... If the decision is made to manage postoperative pain with Sufentanil Citrate Injection concomitantly with a benzodiazepine or ...
  https://www.drugs.com/pro/sufentanil.html
*  Morphine Injection - FDA prescribing information, side effects and uses
Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid ... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ...
  https://www.drugs.com/pro/morphine-injection.html?vm=r
*  Methadone - FDA prescribing information, side effects and uses
... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... Serotonin Syndrome. Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from ... Some data also indicate that Methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of ...
  https://www.drugs.com/pro/methadone.html
*  DailyMed - MORPHINE SULFATE- morphine sulfate tablet, film coated, extended release
Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid ... Discontinue morphine sulfate extended-release if serotonin syndrome is suspected. (7) * Mixed Agonist/Antagonist and Partial ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... Manifestations of histamine release and/or peripheral vasodilation may include pruritus, flushing, red eyes, sweating, and/or ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=75fb4282-0bbd-4d63-a7d1-5142780a4fae&audience=consumer
*  Protocols and Video Articles Authored by Solomon H. Snyder
Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding' ... Differential binding interactions of various drugs led to the identification of opioid receptor subtypes. Receptor influences ... Peripheral-type Benzodiazepine Receptor Density and in Vitro Tumorigenicity of Glioma Cell Lines Biochemical Pharmacology. Aug ... From the Cover: Antipsychotic Drug-induced Weight Gain Mediated by Histamine H1 Receptor-linked Activation of Hypothalamic AMP- ...
  https://www.jove.com/author/Solomon+H._Snyder
*  DailyMed - TRAMADOL HYDROCHLORIDE- tramadol hydrochloride tablet, extended release
... is believed to be due to both binding to µ-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin. ... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... similar to that of other opioids. In contrast to morphine, tramadol has not been shown to cause histamine release. At ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a4d238b-ca32-45ff-9e4d-10db4db70f32
*  Chemistry Collection - Complete catalog
Tramadol possesses weak agonist actions at the ?-opioid receptor, releases serotonin, and inhibits the reuptake of ... Flumazenil is a benzodiazepine antagonist drug that can be used to treat an overdose of midazolam as well as to reverse ... It differs from morphine in its effects in that it generates less euphoria, sedation, itching and other histamine effects. The ... While it acts on the same benzodiazepine receptors as the benzodiazepine family of drugs it is not classed as a benzodiazepine ...
  https://www.alsachim.com/collection.php
*  Hydrocodone and Acetaminophen - FDA prescribing information, side effects and uses
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics. The concomitant use of opioids with other opioid analgesics, ... Hydrocodone is full opioid agonist with relative selectivity for the mu-opioid (μ) receptor, although it can interact with ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, or linezolid, may manifest as serotonin syndrome ...
  https://www.drugs.com/pro/hydrocodone-and-acetaminophen.html
*  DailyMed - HYDROCODONE BITARTRATE AND ACETAMINOPHEN- hydrocodone bitartrate, acetaminophen solution
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics. The concomitant use of opioids with other opioid analgesics, ... Hydrocodone is a semi-synthetic opioid agonist with relative selectivity for the mu-opioid (µ) receptor, although it can ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ... The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, or linezolid, may manifest as serotonin syndrome ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ce39f88-496d-490a-bab4-07d0b628ce65&audience=consumer
*  Diprivan (propofol) dose, indications, adverse effects, interactions... from PDR.net
Angiotensin II receptor antagonists: (Moderate) General anesthetics can potentiate the hypotensive effects of antihypertensive ... Carbon dioxide retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids. Hydroxyzine ... Clobazam: (Moderate) Clobazam, a benzodiazepine, may cause drowsiness or other CNS effects. Potentiation of CNS effects (i.e., ... Propofol reduces the concentration of serotonin and 5-hydroxyindoleacetic acid in the area postrema. The reduction may be ...
  http://www.pdr.net/drug-summary/diprivan?druglabelid=1719
*  A Comprehensive Generic Drug Naming Resource - DrugPatentWatch
cholecystokinin receptor antagonists, benzodiazepine derivatives. -azocine. narcotic antagonists/agonists related to 6,7- ... norepinephrine, serotonin, dopamine reuptake inhibitors. -fentanil. opioid receptor agonists, analgesics, fentanyl derivatives ... cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) receptors. -tadine. tricyclic histamine-H1 receptor antagonists, tricyclic ... thromboxane A2-receptor antagonists; antithrombotic agents. -trodast (see -ast). thromboxane A2-receptor antagonists, ...
  https://www.drugpatentwatch.com/blog/a-comprehensive-generic-drug-naming-resource/
*  OxyContin - FDA prescribing information, side effects and uses
... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see ... However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the ... If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower ...
  https://www.drugs.com/pro/oxycontin.html
*  Exalgo (Hydromorphone Hydrochloride Extended Release Tablets): Side Effects, Interactions, Warning, Dosage & Uses
... administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant ... MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see ... Hydromorphone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other ... Neonatal Opioid Withdrawal Syndrome [see WARNINGS AND PRECAUTIONS]. *Interactions with Benzodiazepine or Other CNS Depressants ...
  https://www.rxlist.com/exalgo-drug.htm
*  Buy Sinequan Online
Six tricyclic antidepressants were tested for their ability to inhibit the binding of the histamine H1-receptor antagonist [3H] ... Focusing on efficacy, clinicians should favor benzodiazepine receptor agonists and classical benzodiazepines over ... Impact of selectivity of serotonin reuptake and/or affinity to the serotonin reuptake transporter on the bleeding risk have not ... opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively ...
  http://medsbypost365.bid/cheap-sinequan-online.html
*  FENS Forum 2004 - Abstracts
BENZODIAZEPINE- AND SEROTONIN 2A-RECEPTORS MODULATE THE AVERSIVE EFFECTS OF NITRIC OXIDE IN THE DORSOLATERAL PERIAQUEDUCTAL ... PRE-CLINICAL EVALUATION OF NOVEL HISTAMINE H3 RECEPTOR ANTAGONISTS.. A149.20. Poster 101 - Tue 13/07, 12:15 - Hall I. ... PHARMACOLOGICAL PROFILE OF A NEW DELTA OPIOID RECEPTOR FROM ZEBRAFISH.. A129.10. Poster 424 - Mon 12/07, 16:00 - Hall II. ... STRONG EXPRESSION OF SEROTONIN 2A RECEPTORS IN DOPAMINERGIC MESENCEPHALIC NUCLEI OF THE DOMESTIC CHICK.. A121.11. Poster 256 - ...
  http://fens2004.neurosciences.asso.fr/posters/Let/LetM.html
*  ενα πολυ ενδιαφερον αρθρο, αναφορικα με τις ουσιες
... mu-opioid receptor agonists offer both unsurpassed pain-relief and extraordinary emotional well-being; and delta-opioid ... Traditionally, serotonin and noradrenaline have attracted the fiercest rival partisans. "Dopaminergic" (and opioid) agents, by ... Unfortunately, mirtazapine is a potent blocker of the histamine H1 receptors too. So it tends to have a somewhat sedative ... Activation of GABA(A) receptors containing the alpha 1 subunit is responsible for benzodiazepine-induced sedation and memory ...
  http://brexmother1.blogspot.com/2007/12/blog-post_6438.html
*  Indian Patents. 252629:'HETEROARYL-TETRAHYDROPIPERIDYL COMPOUNDS USEFUL FOR TREATING OR PREVENTING PAIN'
Selective antagonists of the mGluR5 receptor have also been shown to exert anti-Parkinson activity in vivo (K. J. Ossowska et ... Opioid Dependence, Opioid Abuse, Opioid Withdrawal, Opioid Intoxication, Opioid Intoxication Delirium, Opioid-Induced Psychotic ... H2 antagonists promote ulcer healing by reducing gastric acid and digestive-enzyme secretion elicited by histamine and other H2 ... 5,039,680 and 5,198,459 to Imperato et al disclose using a serotonin antagonist to treat chemical addiction. U.S. Patent No. ...
  http://www.allindianpatents.com/patents/252629-heteroaryl-tetrahydropiperidyl-compounds-useful-for-treating-or-preventing-pain