*  Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1 - Full Text View -...
Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1. This study has been ... Nicotine. Ganglionic Stimulants. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Nicotinic ... This study will assess whether the reduced effectiveness of nicotine replacement therapy in women is caused by gender ... This study will assess whether the reduced effectiveness of nicotine replacement therapy in women is caused by physical and ...
  https://clinicaltrials.gov/ct2/show/NCT00218140?term=
*  KEGG PATHWAY: Nicotine addiction - Homo sapiens (human)
Nicotine addiction - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , ... Nicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common ... Nicotine acts as an agonist to activate and desensitize these nicotinic acetylcholine receptors (nAChRs). After a short ... and so facilitate the reinforcing effects of nicotine. ... exposure to nicotine, alpha6*- and alpha4beta2*- nAChRs on ...
  http://www.genome.jp/kegg-bin/show_pathway?133837803022751/hsa05033.args
*  "Maternal nicotine exposure: Effect on physical development and fine mo" by Estelle Lacoste Robinson
Nicotine exposure during lactation potentiates the damage which occurred during gestation. A behavioral effect from nicotine ... Nicotine was administered via an osmotic minipump. Gravid rats were randomly assigned to one of the four conditions. The pump ... To more precisely measure the dose response curve, three dose levels of nicotine (3.0, 2.25, 1.5mg/kg) were administered along ... The beam walk, roto rod, swimming ontogeny, and open field provided significant evidence that maternal nicotine consumption ...
  https://aquila.usm.edu/theses_dissertations/3742/
*  The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome - Full Text View - ClinicalTrials.gov
Drug: Transdermal nicotine patch Subjects will apply the nicotine patch on the morning of their treatment day and will keep it ... Drug: Transdermal nicotine patch Subjects will apply the nicotine patch on the morning of their treatment day and will keep it ... The nicotine patch will deliver nicotine to the patient over the period of 24 hours. Patients will be advised to discuss ... Nicotine replacement therapy for patients with coronary artery disease. Working Group for the Study of Transdermal Nicotine in ...
  https://clinicaltrials.gov/ct2/show/NCT00990197?term=Smoking%3A+Clinical+Trials&rank=16
*  Nicotinic Receptor Levels After Stopping Smoking - Full Text View - ClinicalTrials.gov
The nicotine metabolite ratio (NMR), a stable marker of nicotine clearance rate, is a robust predictor of smoking relapse. ... Individuals who are fast nicotine metabolizers have higher rates of relapse, compared to slow metabolizers, on nicotine ... Nicotine metabolite ratio (NMR) serves as the between-subject factor.. The minimum amount of time between scans will be ... Nicotine. Ganglionic Stimulants. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Nicotinic ...
  https://clinicaltrials.gov/ct2/show/NCT01704573
*  Rate of Nicotine Metabolism and Smoking Cessation Outcomes in a Community-based Sample of Treatment- - North American Quitline...
slower nicotine metabolizers. These results provide further evidence that transdermal nicotine is less effective for faster ... Rate of Nicotine Metabolism and Smoking Cessation Outcomes in a Community-based Sample of Treatment-. Tuesday, December 1, 2015 ... Rate of Nicotine Metabolism and Smoking Cessation Outcomes in a Community-based Sample of Treatment-Seeking Smokers.. Addictive ... 33%). Faster nicotine metabolizers exhibited significantly higher levels of anxiety symptoms over time during treatment, vs. ...
  http://www.naquitline.org/news/262751/Research-Rate-of-Nicotine-Metabolism-and-Smoking-Cessation-Outcomes-in.htm
*  Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products. - Full Text View - ClinicalTrials.gov
Experimental Nicotine Replacement Therapy (NRT)(L) 2 mg. Drug: Experimental Nicotine Replacement Therapy (NRT) 2 mg 2 mg Single ... Drug: Experimental Nicotine Replacement Therapy (NRT) 2 mg Drug: Experimental Nicotine Replacement Therapy (NRT) Drug: Marketed ... This study compares new oral Nicotine Replacement Therapy (NRT) products containing 2 and 4 mg nicotine with NiQuitin™ lozenge ... The maximum observed nicotine concentration in plasma (Cmax). *Area under the Curve [ Time Frame: after 12 hours ]. The area ...
  https://clinicaltrials.gov/ct2/show/NCT01227720
*  Abstract PL01-06: Nicotine-dependence pharmacogenetics: Implications for personalized therapy | Cancer Prevention Research
We first examined the NMR in an open label trial of transdermal nicotine patch versus nicotine nasal spray. In the patch ... This marker represents the rate of CYP2A6-mediated nicotine clearance, and is measured using the ratio of the nicotine ... slow nicotine metabolizers had high quit rates on placebo, which were not enhanced further by the non-nicotine medication ... and nicotine) based on their CYP2A6-mediated level of nicotine metabolism. Importantly, this relationship of pretreatment NMR ( ...
  http://cancerpreventionresearch.aacrjournals.org/content/3/12_Supplement/PL01-06
*  Down-Regulation of Hepatic Nicotine Metabolism and a CYP2A6-Like Enzyme in African Green Monkeys after Long-Term Nicotine...
Nicotine is inactivated to cotinine by CYP2A6 in human liver [nicotine C-oxidation (NCO)]. CYP2B6 also metabolizes nicotine to ... In addition to nicotine from cigarette smoke, nicotine is also currently administered to patients in the form of nicotine ... 1997) Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine and ... such as nicotine, down-regulate CYP2A6, resulting in slower nicotine metabolism. Nicotine has been shown to increase hepatic ...
  http://molpharm.aspetjournals.org/content/63/1/96
*  What Is the Nicotine Inhaler Used For?
As this eMedTV page explains, it helps reduce nicotine cravings by releasing a controlled amount of nicotine into the body. ... This article covers the uses of the nicotine inhaler in more detail. ... The nicotine inhaler is approved to help people stop smoking. ... What Is the Nicotine Inhaler Used For?. Nicotine Inhaler Dosage ... The nicotine inhaler can reduce the symptoms of nicotine withdrawal, which can help you stop smoking. It will not help with the ...
  http://mental-health.emedtv.com/nicotine-inhaler/what-is-the-nicotine-inhaler-used-for.html
*  Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop...
Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop ... Salivary nicotine metabolites were measured and NMR (3-hydroxycotinine/cotinine) computed, characterising smokers as slow (NMR, ... Shahab L, Mortimer E, Bauld L, McGowan JA, McNeill A & Tyndale RF (2017) Characterising the nicotine metabolite ratio and its ... Pharmacotherapy provision based on Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking ...
  https://www.stir.ac.uk/research/hub/publication/25220
*  Abstract 1678: Nicotine Upregulates Early Growth Factor-1 Expression in Vascular Smooth Muscle Cell via ERK 1/2-Elk-1 Signaling...
... nicotine induced a modest activation of p38 MAPK. Nicotine had no effect on the activation of other Mitogen Activated Protein K ... To demonstrate that nicotine had mitogenic effects on VSMCs in vivo, control rats (n = 9) and rats chronically exposed to ... Abstract 1678: Nicotine Upregulates Early Growth Factor-1 Expression in Vascular Smooth Muscle Cell via ERK 1/2-Elk-1 Signaling ... Conclusions: Nicotine enhanced proliferation of VSMCs in vivo and exacerbated neointimal formation after vascular injury. The ...
  http://circ.ahajournals.org/content/118/Suppl_18/S_367.4
*  Reducing the nicotine content to make cigarettes less addictive | Tobacco Control
... resulting in lower intake of nicotine and a lower level of nicotine dependence. When nicotine levels get very low, cigarettes ... Research on reduced nicotine content cigarettes suggests that smokers do not take in more smoke when the level of nicotine is ... Nicotine reduction: strategic research plan. Nicotine Tob Res Published Online First 15 Nov 2012. doi:10.1093/ntr/nts214. ... Effects of low nicotine content cigarettes on smoke intake. Nicotine Tob Res 2004;6:309-19. ...
  http://tobaccocontrol.bmj.com/content/22/suppl_1/i14
*  Study of Nicotine Replacement Therapy in Pregnancy - Full Text View - ClinicalTrials.gov
More importantly, nicotine replacement therapy (NRT) during pregnancy exposes the fetus to lower levels of nicotine than ... Study of Nicotine Replacement Therapy in Pregnancy. This study has been withdrawn prior to enrollment. ... Nicotine. Ganglionic Stimulants. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Nicotinic ... The most important factor underlying the inability to quit smoking is strong dependence on a certain level nicotine, which is ...
  https://clinicaltrials.gov/ct2/show/NCT00744913?recr=Open&cond=pregnancy+AND+
*  Chronic Nicotine Treatment Impacts the Regulation of Opioid and Non-opioid Peptides in the Rat Dorsal Striatum
... Petruzziello, ... Specially, nicotine altered levels of nine non-opioid peptides derived from precursors, including somatostatin and cerebellin, ... The treatment with chronic nicotine for 3 months led to moderate changes in the levels of endogenous dorsal striatum peptides. ... The chronic use of nicotine, the main psychoactive ingredient of tobacco smoking, alters diverse physiological processes and ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:636992
*  Pharmacogenetics of Nicotine Addiction and Treatment II (PNAT 2) | Global Research Projects
We have shown that the CYP2A6 enzyme is critical in the metabolic inactivation of nicotine, and inherited variation in nicotine ... Home » Health Economics and Policy » Smoking and Tobacco » Pharmacogenetics of Nicotine Addiction and Treatment II (PNAT 2) ... The goal of the Pharmacogenetics of Nicotine Addiction Treatment (PNAT) research program is to generate the evidence base to ... In addition to these goals, we propose within this UOI to: identify additional sources of genetic variation in nicotine ...
  http://globalprojects.ucsf.edu/project/pharmacogenetics-nicotine-addiction-and-treatment-ii-pnat-2-0
*  nicotine - Wiktionary
nicotine (alkaloid). Further reading[edit]. *"nicotine" in le Trésor de la langue française informatisé (The Digitized Treasury ... nicotine (uncountable). *(organic chemistry) An alkaloid (C10H14N2), commonly occurring in the tobacco plant. In small doses it ... Borrowed from French nicotine, named after Jean Nicot, French ambassador to Portugal, who sent tobacco seeds back to France in ... Retrieved from "https://en.wiktionary.org/w/index.php?title=nicotine&oldid=48361646" ...
  https://en.wiktionary.org/wiki/nicotine
*  Nicotine | SpringerLink
Although there has been considerable interest in the effects of nicotine and tobacco... ... Nicotine, one of the compounds that alter brain function, has been shown to have diverse actions in the CNS. ... It has been shown in many experiments that nicotine can influence behavior. Examples are the facilitatory effect of nicotine on ... Facilitatory Effect Nicotinic Receptor Chronic Nicotine Nicotine Administration Nicotinic Cholinergic Receptor These keywords ...
  https://link.springer.com/chapter/10.1007/978-1-4757-6740-7_10
*  nicotine (CHEBI:18723)
... has part (R)-nicotine (CHEBI:39162) nicotine (CHEBI:18723) has part (S)-nicotine (CHEBI:17688) nicotine ... nicotine (CHEBI:18723) has role mitogen (CHEBI:52290) nicotine (CHEBI:18723) has role neurotoxin (CHEBI:50910) nicotine (CHEBI: ... nicotine N1'-oxide (CHEBI:30734) has parent hydride nicotine (CHEBI:18723). nornicotine (CHEBI:28313) has parent hydride ... nicotine (CHEBI:18723) has role teratogenic agent (CHEBI:50905) nicotine (CHEBI:18723) is a racemate (CHEBI:60911) ...
  http://www.ebi.ac.uk/chebi/searchId.do?chebiId=18723
*  Nicotine - Drugs.com
A list of US medications equivalent to Nicotine is available on the Drugs.com website. ... Nicotine is a medicine available in a number of countries worldwide. ... In the US, Nicotine (nicotine systemic) is a member of the drug class smoking cessation agents and is used to treat Smoking ... Nicotine Perrigo. Wrafton Laboratories, Poland. *Nicotinell. GlaxoSmithKline, Netherlands; Novartis, Argentina; Novartis, ...
  https://www.drugs.com/international/nicotine.html
*  S)-nicotine (CHEBI:17688)
nicotine (CHEBI:18723) has part (S)-nicotine (CHEBI:17688). (S)-nicotinium(1+) (CHEBI:59806) is conjugate acid of (S)-nicotine ... S)-nicotine (CHEBI:17688) is conjugate base of (S)-nicotinium(1+) (CHEBI:59806) (S)-nicotine (CHEBI:17688) is enantiomer of (R ... S)-nicotine 1-N-oxide (CHEBI:132572) has functional parent (S)-nicotine (CHEBI:17688). (S)-nicotinium N-α-D-glucosiduronate ( ... S)-nicotine (CHEBI:17688) has role anxiolytic drug (CHEBI:35474) (S)-nicotine (CHEBI:17688) has role biomarker (CHEBI:59163) (S ...
  http://www.ebi.ac.uk/chebi/searchId.do?chebiId=17688
*  nicotine vaccine - Everything2.com
Instead of searching for disease causing antigens, however, these antibodies would seek out nicotine molecules, effectively ...
  https://everything2.com/title/nicotine+vaccine
*  Nicotine's new appeal | Science News
Nicotine's new appeal. Nicotine's new appeal. Mimicking the addictive compound's action in the brain could lead to new drugs ...
  https://www.sciencenews.org/article/nicotines-new-appeal
*  Nicotine Itself Isn't The Real Villain
People smoke for the nicotine but die from the tar. Because the government should regulate e-cigarettes in proportion to risk, ... A smoker who feels anxious or stressed can be calmed with nicotine, and a smoker who is tired will perk up with nicotine. ... A smoker who feels anxious or stressed can be calmed with nicotine, and a smoker who is tired will perk up with nicotine. ... Nicotine is a chemical that is dangerous not because it causes cancer but because it can addict you to cigarettes. As Michael ...
  https://www.forbes.com/sites/sallysatel/2015/06/19/nicotine-can-save-lives/
*  Nicotine Cotinine | LabCorp
Nicotine and cotinine testing may also be ordered in cases of suspected nicotine poisoning. Acute overdoses of nicotine, such ... Levels also rise with use of nicotine replacement products such as nicotine patches and gums. In large amounts, nicotine can be ... Some pesticides contain high concentrations of nicotine. This can be another source of nicotine poisoning. In fact, nicotine is ... Nicotine; Cotinine Why Get Tested?. To detect the presence of and/or measure the quantity of nicotine or cotinine in blood, ...
  https://www.labcorp.com/help/patient-test-info/nicotine--cotinine