Loading...
*  Nav1.5 - Wikipedia
... neuronal channels (NaV1.7, NaV1.8 and NaV1.9), skeletal muscle channels (NaV1.4) and the cardiac sodium channel NaV1.5. SCN5A ... NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found ... Voltage sensing is mediated by the remaining segments, of which the positively charged S4 segments plays a fundamental role. ... The conformational state of the channel, which is both voltage and time-dependent, determines whether the channel is opened or ...
  https://en.wikipedia.org/wiki/Nav1.5
*  Plus it
Nav1.8 is a voltage-gated sodium channel expressed in most DRG neurons with C fibers. The Nav1.8-Cre-expressing neurons include ... DRGs from all segments of the vertebral column were dissected from 4-week-old control (Nav1.8-Cre−/− OgtloxP/Y) and Nav1.8-Ogt ... Nav1.8-Ogt knock-out mice are overtly healthy but exhibit altered weight and glucose tolerance. Pan-neuronal loss of OGT has ... were crossed to male Nav1.8-Cre mice (Nav1.8-Cre−/+) or brn3a-CreERT2 mice (brn3a-CreERT2−/+). Nav1.8-Cre is expressed in most ...
  http://www.jneurosci.org/content/37/8/2125
*  Frontiers | The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional...
... molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels. ... on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal ... on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal ... We will also discuss the relevance of proper ion channel targeting for neuronal physiology and how alterations in polarized ...
  https://www.frontiersin.org/articles/10.3389/fncel.2017.00115/full
*  Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds | Journal of Neuroscience
2F), and this may be related to the lower levels of expression of the voltage-gated sodium channel Nav1.8, which is known to be ... In other neuronal conditional Dicer knock-outs, substantial neuronal cell loss has been observed (Schaefer et al., 2007). With ... sodium azide in 0.1 m PB at 4°C. The lumbar segments were then cut serially (40 μm thickness) on a freezing microtome. Every ... 2004) Voltage-gated sodium channels and pain pathways. J Neurobiol 61:55-71. ...
  http://www.jneurosci.org/content/30/32/10860.full
*  GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells |...
2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel ... 2005) Kv2.1: a voltage-gated K+ channel critical to dynamic control of neuronal excitability. Neurotoxicology 26:743-752, doi: ... 2004) Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ. Res. 95:284-291, doi: ... The IK is one of the most ubiquitously expressed voltage-gated K+ channels and plays many diverse physiological roles. Kv2.1 is ...
  http://www.biochemj.org/content/460/1/35
*  Frontiers | MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats | Frontiers in...
Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic ... Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic ... Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central ... An intrathecal catheter was implanted in the lumbar enlargement (close to the L4-5 segments) according to the method of Wu et ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2017.00126/full
*  JCI - Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders
Sodium channels. Voltage-gated sodium channels play a critical role in the generation and conduction of action potentials and ... Channel, neuronal and clinical function in sodium channelopathies: from genotype to phenotype. Nat. Neurosci. 10:405-409. View ... B) A schematic of the Nav1.7 sodium-channel subunit showing the 4 domains (D1-D4), each with 6 transmembrane segments. ... The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive ...
  https://www.jci.org/articles/view/33297
*  Gain-of-function Nav1.8 mutations in painful neuropathy | PNAS
2008) Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: Evidence for a role in pain. Pain 139(1 ... 2004) Mutations of neuronal voltage-gated Na+ channel alpha 1 subunit gene SCN1A in core severe myoclonic epilepsy in infancy ( ... Although S5 segments have not been directly implicated in activation, mutations in DIII/S5 of Nav1.5 (20), Nav1.1 (21, 22), and ... 1996) A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379(6562):257-262. ...
  http://www.pnas.org/content/109/47/19444
*  Channelpedia
Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of ... Nav1.7/Nav1.8 double KO [1427]. - Nav1.7/Nav1.8 double KO (infammatory pain) [1428] - Nav1.7 null [1428]. This mutation in ... with each domain consisting of six transmembrane segments (S1-S6), with S4 acting as a voltage-sensor and S5 and S6 lining the ... voltage-gated sodium channel complex. A sodium channel in a cell membrane whose opening is governed by the membrane potential. ...
  http://channelpedia.epfl.ch/ionchannels/126
*  Plus it
... channels are classically organized into voltage-gated, two-pore, inwardly rectifying, and Ca2+-activated channels. Slack ... Slack (Slo2.2) is a sodium-activated potassium channel that regulates neuronal firing activities and patterns. Previous studies ... 2007) Differential slow inactivation and use-dependent inhibition of Nav1.8 channels contribute to distinct firing properties ... 1995) A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells ...
  http://www.jneurosci.org/content/35/3/1125
*  Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy | Molecular Pain | Full Text
Several studies have suggested the involvement of various sodium channels, including tetrodotoxin-resistant NaV1.8, in affected ... Nav1.8 mRNA observed in the sciatic nerve was likely of axonal origin since it was not detected in non-neuronal cells cultured ... Further analysis of NaV1.8 distribution revealed that immunoreactivity and mRNA levels were decreased and unaffected, ... The concomitant axonal accumulation of NaV1.8 mRNA may play a role in the pathogenesis of this model of neuropathic pain. ...
  https://molecularpain.biomedcentral.com/articles/10.1186/1744-8069-5-14
*  Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion
... voltage-gated Na+ and K+ channels), hyperpolarizing activated cation channels, and TRP channels. TRPV4 is a highly Ca2+- ... M. Belkouch, M.-A. Dansereau, P. Tétreault et al., "Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers ... A. J. Todd, "Neuronal circuitry for pain processing in the dorsal horn," Nature Reviews Neuroscience, vol. 11, no. 12, pp. 823- ... and the communicating branches of L4 and L5 were cut to block signals from other segments. A bath around the incision was built ...
  https://www.hindawi.com/journals/bmri/2016/6978923/
*  Frontiers | A computational paradigm for dynamic logic-gates in neuronal activity | Frontiers in Computational Neuroscience
Here we propose a new experimentally corroborated paradigm in which the truth tables of the brain's logic-gates are time ... Here we propose a new experimentally corroborated paradigm in which the truth tables of the brain's logic-gates are time ... We demonstrate that the underlying biological mechanism is the unavoidable increase of neuronal response latencies to ongoing ... We demonstrate that the underlying biological mechanism is the unavoidable increase of neuronal response latencies to ongoing ...
  https://www.frontiersin.org/articles/10.3389/fncom.2014.00052/full
*  Channelpedia
CAP-1A binds to a conserved motif present in NaV1.8 linking voltage-gated sodium channels to clathrin, which is involved in ... pGSN protects HIV-1 gp120-Induced neuronal injury via voltage-gated K+ channel Kv2.1. Treatment with pGSN (a secreted form of ... which enhance activation of sodium channels. Photoaffinity labeling and mutagenesis studies implicate transmembrane segments ... KCNE channel alters KCNQ5 channel gating. The proteins KCNE1 and KCNE3 alter the gating of the Kv7.5 channel in Xenopus oocytes ...
  http://channelpedia.epfl.ch/reports/interaction
*  Channelpedia
voltage-gated sodium channel complex. A sodium channel in a cell membrane whose opening is governed by the membrane potential. ... State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol. ... Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage- ... Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer. Oncol. Rep., 2010 May , 23 (1293-9).. ...
  http://channelpedia.epfl.ch/ionchannels/123
*  Subtype Identification in Acutely Dissociated Rat Nodose Ganglion Neurons Based on Morphologic Parameters
Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory ... The attached segments with significant nodes are easily distinguished from neuronal satellite cells because of their numbers, ... Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats. J ... Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents. Auton Neurosci. 2012 ...
  http://www.ijbs.com/v09p0716.htm
*  Gene Report for G00000157 - Genes2Cognition Neuroscience Research Programme
Epithelial Na(+) channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut, and lungs and are ... G protein-coupled receptors (GPCRs) respond to agonists to activate downstream enzymatic pathways or to gate ion channel ... Neutrophil depletion reduced brain damage, but neuronal loss was still more pronounced in GRK2(+/-) animals. Onset of neuronal ... In myocytes voltage-clamped with microelectrodes (18-26 MOmega; 2.7 M KCl) to minimize intracellular dialysis, contractions ...
  http://www.genes2cognition.org/db/gene/G00000157
*  Channelpedia
voltage-gated potassium channel complex. A protein complex that forms a transmembrane channel through which potassium ions may ... These channels activity underlie neuroadaptation to alcohol and neuronal plasticity [1471].BK channels also contribute to the ... BK-beta2/3 channels give rise to a pronounced afterhyperpolarization that relieves voltage-dependent sodium channels from ... a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N ...
  http://channelpedia.epfl.ch/ionchannels/209
*  2017-2021 NIDCD Strategic Plan | NIDCD
Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents. J Neurophysiol. 2016; ... Hearing loss affects people of all ages, in all segments of the population, and across all socioeconomic levels. It can ... Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste ... The scientists are the first to use piezoelectric materials, which turn mechanical pressure into electrical signals (voltage) ...
  https://www.nidcd.nih.gov/about/strategic-plan/2017-2021-nidcd-strategic-plan