Beta-site amyloid precursor protein cleaving enzyme 1 inhibition impairs synaptic plasticity via seizure protein 6. K Zhu, X ... In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model. P Marinković, S Blumenstock, PM ... In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. E ... An assay to image neuronal microtubule dynamics in mice. T Kleele, P Marinković, PR Williams, S Stern, EE Weigand, P Engerer ...

Where does amyloid-beta come from? It is derived from the amyloid precursor protein (APP), of which amyloid-beta is but a small ... neuronal plasticity.. The realization that multiple factors induce brain growth as well as brain destruction will explain why ... Provision of synaptic structural components: Provide synaptic structural components using citicoline and docosahexaenoic acid ( ... Increasing beta-amyloid degradation. *Decreasing beta-amyloid oligomerization, i.e., the creation of longer molecules of beta- ...

"Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". The ... It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates ... "Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice". Neuroscience Letters. 316 (3): ... The protein is thought to act on migrating neuronal precursors and thus controls correct cell positioning in the cortex and ...

... is proteolytically derived from beta-amyloid precursor protein (APP). Here we describe cellular assays to detect the activity ... Recent work has implicated APP in the regulation of synaptic plasticity. Substantial evidence exists for a role of APP and its ... Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems. ... The physiological role of the amyloid-precursor protein (APP) is insufficiently understood. ...

... which cleaves the amyloid precursor protein (APP) to release the amyloid beta peptide (Abeta), is also involved in regulating ... This has functional consequences as CP-AMPARs can be expressed at synapses by various neuronal activities both in vitro and in ... synaptic plasticity. Using mice lacking the BACE1 gene, I found that BACE1 is involved in specific forms of synaptic plasticity ... These results suggest that the functional change in synaptic transmission and the structural synaptic plasticity may utilize ...

Magnesium modulates amyloid-beta protein precursor trafficking and processing.. Yu J1, Sun M, Chen Z, Lu J, Liu Y, Zhou L, Xu X ... Magnesium affects many biochemical mechanisms vital for neuronal properties and synaptic plasticity, and magnesium levels were ... which is derived from the amyloid-beta protein precursor (AbetaPP) following processing by beta- and gamma-secretase. Metal ... Yu, J., Sun, M., Chen, Z., Lu, J., Liu, Y., Zhou, L., … & Chui, D. (2010). Magnesium modulates amyloid-β protein precursor ...

Serum Amyloid A Protein 100% * Amyloid beta-Protein Precursor 87% * Neuronal Plasticity 72% ... Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of ... Knock down of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinsons disease.. Horvath, L., van Marion ... Neuronal Differentiation and Extensive Migration of Human Neural Precursor Cells following Co-Culture with Rat Auditory ...

Amyloid precursor protein; BACE1; Cognitive impairment; Endothelium; Exercise; Hippocampus; Microglia; Mitochondria; Neuronal ... Together with findings from prior studies demonstrating the ability of endothelial NO to affect synaptic plasticity, ... APLP1 protein, human * Amyloid beta-Protein Precursor * Nitric Oxide * Nitric Oxide Synthase Type III ... We will discuss the recognized ability of endothelial NO to modulate processing of amyloid precursor protein (APP), influence ...

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. ... Some proteins, e.g., HSPs, which ameliorate oxidative stress, calpains, which help in regulating synaptic plasticity, and ... heat shock proteins (HSPs), and prion protein are some of the chief elements in the foremost hypotheses of AD like amyloid-beta ... Proteins such as amyloid precursor protein (APP), apolipoprotein E (ApoE), presenilin, mortalin, calbindin-D28K, creactive ...

Intraneuronal amyloid precursor protein (APP) and appearance of extracellular beta-amyloid peptide (A beta) in the brain of ... Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. Journal ... Behavioral Phenotyping of a Transgenic Caenorhabditis elegans Expressing Neuronal Amyloid-beta Journal Article ... Distribution of beta-amyloid and amyloid precursor protein in the brain of spawning (senescent) salmon: a natural, brain-aging ...

Accordingly, our laboratory has developed small molecule p75NTR ligands that increase survival signaling and inhibit amyloid-β- ... 1999) Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. ... The beta-amyloid precursor protein of Alzheimers disease enhances neuron viability and modulates neuronal polarity. J Neurosci ... 2008) Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci 28: 3941-3946. * View Article ...

There is a notion that Aβ might serve as an essential synaptic protein in synaptic structural-functional plasticity underlying ... generated from the intracellular cleavage of the amyloid precursor protein (APP) by the sequential action of two proteolytic ... APP is a single-pass transmembrane protein that is highly expressed in the brain and is concentrated at neuronal synapses [11, ... Generally, amyloid refers to misfolded peptides or proteins that demonstrate a stable, cross-beta super-secondary structure ...

Amyloid beta-Protein Precursor 100% * Amyloid 81% * Alzheimer Disease 66% * Seizures 66% ... A promising dreadded strategy: exploring the rol of astrocyte signalling on synaptic plasticity and refractory epilepsy. Van ... Whats so exciting about Alzheimers disease? The effect of amyloid ß and tau on seizure susceptibility. Vande Vyver, M., 12 ...

They used it to investigate neurons surrounding amyloid beta plaques in mice lacking functional amyloid precursor protein (APP ... Topics included neuronal plasticity, inflammation, glial cell function, autophagy, and mitochondrial function, as well as ... In 1983, Collingridges lab identified the role of the NMDA receptor in synaptic plasticity, finding that its activation could ... What is the best way of clinically testing the amyloid beta hypothesis?. Can the signaling mechanism linking neuronal activity ...

Title: Contribution of microglia to neuronal synaptic plasticity - modelling effects using Alzheimers disease risk genes. ... effects will be determined alone and in the presence of exogenous Ab and Dkk1 proteins and when the b-amyloid precursor protein ... Title: Investigating the role of alpha-synuclein in the beta-amyloid-driven synaptotoxic pathway. ...

... neuronal death and progressive loss of cognitive functio ... is characterized by synaptic failure, dendritic and axonal ... Goodman Y, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta- ... Amyloid-beta protein dimers isolated directly from Alzheimers brains impair synaptic plasticity and memory. Nat Med 14:837-842 ... Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta ...

Lauren J, Gimbel D, et al. (Februari 2009). "Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta ... "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory". Prog. Neurobiol. 70 ... Chun W, Johnson GV (2007). "The role of tau phosphorylation and cleavage in neuronal cell death". Front Biosci 12: 733-56. doi: ... "Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein". Nature 373 (6514): 523- ...

... and proteins involved in synaptic formation (Arc, beta-catenin). CS softened amyloid pathology in terms of reduced levels of A ... Changes in neuronal and glial cells, alterations in synaptic plasticity as well as modifications in cannabinoid receptor ... there was an increase in the amyloidogenic processing of amyloid precursor protein (APP). These results are integrated in a ... The effect of beta-amyloid (A beta) deposition was also evaluated in A beta peptide i.c.v. injected mice. In the hippocampus, ...

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) ... Sex-regulated gene dosage effect of PPARα on synaptic plasticity.. In: Life science alliance, Vol. 2, no. 2, p. e201800262 [1- ... Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta ... Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) ...

The precursor protein of non-A beta component of Alzheimers disease amyloid is a presynaptic protein of the central nervous ... and that an imbalance of these proteins might not only affect neuron function and plasticity, but also neuronal survival. ... We found a robust synaptic localization for αSyn and βSyn, similar to the integral synaptic vesicle proteins SV2 and ... Recombinant protein expression and purification. All proteins were expressed as GST fusion proteins in bacteria (BL21 strain), ...

... peptides and reduced the protein expression of the amyloid precursor protein, presenilin-1, and β-secretase in the cortical and ... tau phosphorylation and improved synaptic function and plasticity by upregulating the expression of synapse-associated proteins ... and synaptic plasticity in Alzheimers disease models have not been reported, we attempted to investigate the same in the ... C3G increased the protein expression of phosphorylated-AMPK/AMPK and Sirtuin 1 and decreased that of mitogen-activated protein ...

Rohn TT, Ivins KJ, Bahr BA, Cotman CW, Cribbs DH (2000) A monoclonal antibody to amyloid precursor protein induces neuronal ... Generation of aggregated β-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory ... Kowall NW, McKee AC, Yankner BA, Beal MF (1992) In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment ... Molecular mechanisms for neuronal cell death by Alzheimers amyloid precursor protein-relevant insults. Neurosignals 11: 236- ...

... increased staining for amyloid precursor protein levels (Gong et al. 2005) and amyloid beta (Ab) levels (Pratico et al. 2002), ... Chen et al. (2002), Wang et al. (2002a) and Wang et al. (2002b) reported impairment of synaptic plasticity, as measured by ... Multifocal neuronal degeneration, abnormal and damaged neurons, and reduced neuronal density were identified in specific brain ... increased levels of amyloid precursor protein (Becaria et al. 2006) and increased TNF-µ (alpha tumour necrosis factor) mRNA ...

2010) Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci 13:190-196. ... 2005) The endosomal protein NEEP21 regulates AMPA receptor-mediated synaptic transmission and plasticity in the hippocampus. ... 2009) Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic ... 1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259:514-516. ...

This review discusses the function of sEH in mammals and its protein structure and catalytic activities. Particular attention ... This review discusses the function of sEH in mammals, its protein structure and catalytic activities. Particular attention was ... which plays an important role in the metabolism of cholesterol precursors. The role of sEHs phosphatase activity has been so ... which plays an important role in the metabolism of cholesterol precursors. The role of sEHs phosphatase activity has been so ...

Roles of Amyloid beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer Disease (Review). J ... An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity. Neuron. 2008 Mar 27; 57(6): 872-82. ... alpha-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J. 2002 Nov, 16(13): ... Effects of the carboxyl-terminal fragment of Alzheimers amyloid precursor protein and amyloid beta-peptide on the production ...

The Role of Protein Kinase C in Short-Term Synaptic Plasticity. Advisor: Wade Regehr. ... Probing the in vivo economy of amyloid beta-protein during the development of Alzheimers disease-type pathology. Advisor: ... Regulation of Expression and Processing of the b-Amyloid Precursor Protein of Alzheimers Disease. Advisor: Dennis Selkoe. ... Transcriptional Regulation of Neuronal Polarity. Advisor: Azad Bonni. Giessel, Andrew. Local, Non-linear Regulation of Synaptic ...

... are necessary for the formation of new synapses during neuronal development4, 5, and maintain and regulate synaptic plasticity ... Aβ is cleaved from the larger amyloid-β protein precursor (AβPP) [4-6]. However, it remains unclear why Aβ, a protein fragment ... What he found were substantial deposits of the amyloid beta protein, one of the two key proteins that Alzheimer discovered in ... Zlokovics study and others point to a complex interplay between beta-amyloid and ApoE4. On the one hand, beta-amyloid is known ...

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci ... Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. ... An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants ... Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion. Neurobiol Dis. ...

... non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; synuclein alpha- ... regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synapse organization regulation of acyl-CoA ... protein N-terminus binding tau protein binding beta-tubulin binding phosphoprotein binding phospholipase D inhibitor activity ... These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- ...