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*  Frontiers | MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats | Frontiers in...
Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic ... Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic ... Nav1.3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are closely associated with neuropathic ... Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2017.00126/full
*  Papers: 21 Sep 2013 - 27 Sep 2013 | Pain Research Forum
Isoform Selective Voltage-Gated Sodium Channel Modulators and the Therapy of Pain. ... inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels. ... Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional ... The neurotrophic factor neurturin contributes towards an aggressive cancer cell phenotype, neuropathic pain and neuronal ...
  https://www.painresearchforum.org/papers/papers-of-the-week-archive/32109-papers-21-sep-2013-27-sep-2013
*  Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons | Journal of Cell Science
... and sensitizes ion channels such as the voltage-gated sodium channel NaV1.8 and the transient receptor potential channel TRPV1 ... 2007). AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron 55, 261 ... 2007). Molecular basis for isoform-specific autoregulation of protein kinase A. Cell. Signal. 19, 2024-2034. doi:10.1016/j. ... 2002). Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the ...
  http://jcs.biologists.org/content/127/1/216
*  Application # 2012/0010207. Chemical Compounds - Patents.com
0003] Voltage-gated sodium channels are found in all excitable cells including myocytes of muscle and neurons of the central ... In neuronal cells, sodium channels are primarily responsible for generating the rapid upstroke of the action potential. In this ... an alternative sodium channel modulator, such as a Nav1.3 modulator (e.g. as disclosed in WO2008/118758); or a Nav1.8 modulator ... an agent that binds to NGF and inhibits NGF biological activity and/or downstream pathway(s) mediated by NGF signaling (e.g. ...
  http://patents.com/us-20120010207.html
*  Channelpedia
CAP-1A binds to a conserved motif present in NaV1.8 linking voltage-gated sodium channels to clathrin, which is involved in ... pGSN protects HIV-1 gp120-Induced neuronal injury via voltage-gated K+ channel Kv2.1. Treatment with pGSN (a secreted form of ... interacts with voltage-gated potassium channel Kv1.3. [1987]. Capsid protein VP1. Parvovirus B19 capsid protein VP1 inhibits ... modulate sodium channels in an isoform-dependent manner. In fact, FHF4 (B isoform) reduces current density by 90% of Nav1.1. [ ...
  http://channelpedia.epfl.ch/reports/interaction
*  Channelpedia
... in the adult rat skeletal muscle isoform of the voltage-gated sodium channel (rNaV1.4) may act as molecular switch allowing for ... State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol. ... Binding of the fast inactivating particle inhibits this process. This result demonstrates that there are interactions (mostly, ... voltage-gated sodium channel complex. A sodium channel in a cell membrane whose opening is governed by the membrane potential. ...
  http://channelpedia.epfl.ch/ionchannels/123
*  Gene Report for G00000157 - Genes2Cognition Neuroscience Research Programme
Epithelial Na(+) channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut, and lungs and are ... G protein-coupled receptors (GPCRs) respond to agonists to activate downstream enzymatic pathways or to gate ion channel ... Neutrophil depletion reduced brain damage, but neuronal loss was still more pronounced in GRK2(+/-) animals. Onset of neuronal ... For each of the three GRKs found, the most closely related isoform is assumed to be the mouse homolog of rat GRK2 and GRK3, and ...
  http://www.genes2cognition.org/db/gene/G00000157
*  carbenoxolone: Topics by WorldWideScience.org
... voltage-gated Na+ current (INa, and/or voltage-gated K+ current (IK, rather than by blocking gap junction communication. To do ... These results demonstrated isoform-specific characteristics among the large pore membrane channels; an open (hemi)channel is ... Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels ... of the activity of channels (TRPV1 or Nav1.8) important for electrical activity in primary nociceptors. Nociceptor activity is ...
  https://worldwidescience.org/topicpages/c/carbenoxolone.html
*  Plus it
Maxi-KCa, a Unique Member of the Voltage-Gated K Channel Superfamily ... mice lacking VGLUT2 in primary afferents expressing either TRPV1 or Nav1.8, the tetrodotoxin-resistant sodium channel subunit, ... pain stimulus, how Ca2+ signaling instructs downstream channels such as TRP channels to compute a specific signal into neuronal ... Likewise, it will be interesting to identify the specific PLC isoform that is downstream of Mrgpr and is required for mediating ...
  http://physiologyonline.physiology.org/content/26/4/286