*  Interim Results Released for AMO Pharma Clinical Trial | Myotonic Dystrophy Foundation
Since there have been no prior clinical trials using novel drugs targeted to the brain in congenital myotonic dystrophy (CDM), ... MDF is pleased to see candidate therapeutics moving forward for myotonic dystrophy and appreciates AMO Pharma's efforts. To ... Toll Free (US only): 86-MYOTONIC (866-968-6642). Direct: 415-800-7777. info@myotonic.org ... a cell signaling molecule thought to play a role in the pathogenesis of myotonic dystrophy. The AMO clinical trial is a single- ...
  http://myotonic.org/interim-results-released-amo-pharma-clinical-trial
*  The DMPK gene of severely affected myotonic dystrophy patients...
The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat ... The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat. ... side of the CTG repeat in the DMPK gene of normal individuals and of patients affected with myotonic dystrophy, showing ...
  https://www.mysciencework.com/publication/show/the-dmpk-gene-of-severely-affected-myotonic-dystrophy-patients-is-hypermethylated-proximal-to-the-largely-expanded-ctg-repeat
*  Myotonic Dystrophy: A Personal Essay | Myotonic Dystrophy Foundation
Myotonic dystrophy is a form of muscular dystrophy, but it is rare and not well-researched. It is a disease that few will know ... The biggest barrier that will have a lasting impression on me is myotonic dystrophy. My father is afflicted with this horrific ... Have you ever heard of a disease called myotonic dystrophy? Most likely not, although you probably have heard of muscular ... Toll Free (US only): 86-MYOTONIC (866-968-6642). Direct: 415-800-7777. info@myotonic.org ...
  http://myotonic.org/myotonic-dystrophy-personal-essay
*  Myotonic Dystrophy (DM) Types 1 and 2
knockout and transgenic models of myotonic dystrophy type 1 to extend the RNA dominance hypothesis to congenital myotonic ... new molecules for study in myotonic dystrophy cell models which could lead to new therapeutic treatments for myotonic dystrophy ... Myotonic Dystrophy (DM) Types 1 and 2. Below we provide a few examples of the research being done here at the Center for ... A great website to visit for patients and families is the Myotonic Dystrophy Foundation site. There is a wealth of information ...
  http://neurogenetics.med.ufl.edu/research/myotonic-dystrophy-dm-types-1-and-2/
*  The myotonic dystrophies: diagnosis and management. - Nuffield Department of Clinical Neurosciences
... myotonic dystrophy type 1 (DM1), also known as 'Steinert's disease'; and (2) myotonic dystrophy type 2 (DM2), also known as ... DM1 is the most common form of adult onset muscular dystrophy whereas DM2 tends to have a milder phenotype with later onset of ... proximal myotonic myopathy. DM1 and DM2 are progressive multisystem genetic disorders with several clinical and genetic ... There are currently two clinically and molecularly defined forms of myotonic dystrophy: (1) ...
  https://www.ndcn.ox.ac.uk/publications/241728
*  Types of DM - Myogem Health Company
Myotonic Dystrophy Type 2 (DM2). The Myotonic Dystrophy Type 2 (DM2) known as well as PROMM (Proximal Myotonic Myopathy) - has ... Myotonic Dystrophy Type 1 (DM1) & Myotonic Dystrophy Type 2 (DM2). They are both caused by a genetic defect, on different genes ... Both Myotonic Dystrophy Type 1 (DM1) and Myotonic Dystrophy Type 2 (DM2) are characterized by skeletal and smooth muscle ... DM1 - Myotonic Dystrophy Type 1 is without any doubt the most common type and results from an abnormal DNA expansion in the ...
  https://myogemhealth.com/types-of-dm/
*  Efficacy and Tolerance of AVAPS Mode in Myotonic Dystrophy - Full Text View - ClinicalTrials.gov
... myotonic dystrophy Genetic and Rare Diseases Information Center resources: Myotonic Dystrophy Myotonia Atrophica Myotonic ... Myotonic Dystrophy. Muscular Dystrophies. Muscular Disorders, Atrophic. Muscular Diseases. Musculoskeletal Diseases. Myotonic ... Myotonic dystrophy type 1 is a myopathy with complex respiratory pattern and at risk to develop respiratory failure. Classical ... DM1 myotonic dystrophy. *One clinical signs dyspnea rest/effort, orthopnea, daytime sleepiness (Epworth, 10), morning headache. ...
  https://clinicaltrials.gov/ct2/show/NCT01530841
*  Abstract 17543: DMPK E Disrupts Sarcomere Structure by Inhibition of SRF Transcriptional Activity | Circulation
In a screen for MEF2 target genes, we have recently identified myotonic dystrophy protein kinase (DMPK) as a potential mediator ...
  http://circ.ahajournals.org/content/130/Suppl_2/A17543
*  A Cure for Kate | Myotonic Dystrophy Foundation
Their efforts are now focused on raising awareness and funds for myotonic dystrophy. They are encouraged by the news this year ... On Kate's 3-month birthday, she was diagnosed with congenital myotonic dystrophy. ... Toll Free (US only): 86-MYOTONIC (866-968-6642). Direct: 415-800-7777. info@myotonic.org ...
  http://www.myotonic.org/node/11
*  Targeting nuclear RNA for in vivo correction of myotonic dystrophy.
... Posted August 6th, 2012. by Yannis Trakadis & filed under ... Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder characterized by myotonia, weakness, cardiac arrhythmias, ... Targeting nuclear RNA for in vivo correction of myotonic dystrophy.Wheeler et al. Nature. 2012 Aug 2;488(7409):111-5. PMID: ...
  https://ommbidblog.com/2012/08/06/targeting-nuclear-rna-for-in-vivo-correction-of-myotonic-dystrophy/
*  Get an MDF Toolkit | Myotonic Dystrophy Foundation
All community members who request a hard copy Toolkit will also receive Myotonic Dystrophy: The Facts, an easy-to-read book by ... And we'll send you monthly email updates that include articles on myotonic dystrophy, the latest medical advances, programs and ... How did you learn about the Myotonic Dystrophy Foundation?. --Select--. Web. Phone Inquiry. Partner Referral. Purchased List. ... Please tell us about your relationship to myotonic dystrophy. --Select--. Self or family member. Friend of family. Physician. ...
  http://myotonic.org/get-mdf-toolkit
*  Testing and Diagnosis | Myotonic Dystrophy Foundation
Diagnosis of myotonic dystrophy is not difficult once the disorder is suspected. However, the path to a correct diagnosis of ... Myotonic dystrophy can take multiple forms that affect a broad spectrum of systems. Individuals may visit several different ... There are three explanations as to why some individuals with myotonic dystrophy might not show symptoms of the disease:. * ... Prenatal testing, where the DNA of the fetus is checked for the presence of the myotonic dystrophy mutation, is also available ...
  http://myotonic.org/living-dm/testing-and-diagnosis
*  The possible aberrant function of MBNL1 with insulin receptor (IR-B) mRNA in myotonic dystrophy type I :: University of...
Myotonic Dystrophy (DM) a multi-systemic disorder, is the most common adult muscular dystrophy form. Among the pathological ... The possible aberrant function of MBNL1 with insulin receptor (IR-B) mRNA in myotonic dystrophy type I ... THE POSSIBLE ABERRANT FUNCTION OF MBNL1 WITH INSULIN RECEPTOR (IR-B) mRNA IN MYOTONIC DYSTROPHY TYPE I by Ana Marie E. Mangahas ... THE POSSIBLE ABERRANT FUNCTION OF MBNL1 WITH INSULIN RECEPTOR (IR-B) mRNA IN MYOTONIC DYSTROPHY TYPE I by Ana Marie E. Mangahas ...
  http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/156892/rec/14
*  MDF Staff Meets with NIAMS and NINDS | Myotonic Dystrophy Foundation
In November, Myotonic Dystrophy Foundation (MDF) staff met with the National Institute of Arthritis and Musculoskeletal and ... Toll Free (US only): 86-MYOTONIC (866-968-6642). Direct: 415-800-7777. info@myotonic.org ... senior leadership and program/policy staff to discuss research opportunities and federal support for myotonic dystrophy (DM). ...
  http://myotonic.org/mdf-staff-meets-niams-and-ninds
*  Myotonic Dystrophy - symptoms, Definition, Description, Demographics, Causes and symptoms, Diagnosis, Treatment
The International Myotonic Dystrophy Consortium (IDMC). 'New nomenclature and DNA testing guidelines for myotonic dystrophy ... congenital myotonic dystrophy, may appear in newborns of mothers who have DM1. Congenital myotonic dystrophy is marked by ... Myotonic dystrophy (DM), also called dystrophia myotonica, myotonia atrophica, or Steinert disease, is a common form of ... Myotonic dystrophy is an uncommon disease occurring in about one out of every 8,000 individuals. It is found worldwide. The ...
  http://www.healthofchildren.com/M/Myotonic-Dystrophy.html
*  Myotonic Dystrophy - Treatment
Myotonic dystrophy cannot be completely cured. However, several forms of treatment may be instituted to provide symptomatic ... Mild cases of myotonic dystrophy do not require any treatment. More severe cases might demand treatment with quinine, phenytoin ... My husband has Myotonic Dystrophy and finds cycling and swimming a lot easier than walking. The cycling he likes better due to ... Drugs for Myotonic Dystrophy. Vecuronium. This medication is a muscle relaxant, prescribed for relaxing muscles during surgery ...
  http://www.medindia.net/patients/patientinfo/myotonicdystrophy_treatment.htm
*  Myotonic Dystrophy (ebook) by Peter Harper | 9780191582783
Myotonic dystrophy is part of the group of muscular dystrophies. It is the commonest inherited muscular dystrophy and has a ... download and read Myotonic Dystrophy ebook online in EPUB format for iPhone, iPad, Android, Computer and Mobile readers. Author ... Myotonic dystrophy is part of the group of muscular dystrophies. It is the commonest inherited muscular dystrophy and has a ... Further explanation of the advances in basic understandingof myotonic dystrophy, and additional coverage of the new approaches ...
  https://www.ebooks.com/665482/myotonic-dystrophy/harper-peter/
*  Myotonic Dystrophy Foundation Announces Two $100,000 Postdoctoral Fellowship Awards
The Myotonic Dystrophy Foundation (MDF) formally announces the first two $100,000 awards under its postdoctoral fellowship ... Foundation, Myotonic Dystrophy. "Myotonic Dystrophy Foundation Announces Two $100,000 Postdoctoral Fellowship Awards." Medical ... myotonic dystrophy.. Described as "the most variable of all diseases found in medicine", myotonic dystrophy can appear at any ... Myotonic Dystrophy", will investigate the molecular mechanisms underlying muscle weakness and wasting in myotonic dystrophy. ...
  https://www.medicalnewstoday.com/releases/136187.php
*  Myotonic Dystrophy | MD Australia
Myotonic dystrophy is a muscle condition that falls under the umbrella term 'muscular dystrophy'. The muscular dystrophies all ... What is congenital myotonic dystrophy?. Congenital myotonic dystrophy is the early childhood form of myotonic dystrophy. As the ... What is myotonic dystrophy?. Myotonic dystrophy is a muscle condition that falls under the umbrella term 'muscular dystrophy'. ... What is type 2 myotonic dystrophy (DM2). Type 2 myotonic dystrophy, also sometimes called 'PROMM' (proximal myotonic myopathy ...
  https://www.mda.org.au/disorders/overview/myt/
*  What are the treatment options for myotonic dystrophy? | Reference.com
Treatment options for myotonic muscular dystrophy include surgery, drug therapies or a treatment plan involving assisted ... Treatment of myotonic muscular dystrophy aims to prevent deformity of the spine and joints to maintain the patient's ability to ... Treatment options for myotonic muscular dystrophy include surgery, drug therapies or a treatment plan involving assisted ... What are the treatment options for someone with muscular dystrophy?. A: While there is no cure for muscular dystrophy, physical ...
  https://www.reference.com/health/treatment-options-myotonic-dystrophy-81c93ac2283c802e
*  Learning About Myotonic Dystrophy - National Human Genome Research Institute (NHGRI)
Additional Resources on Myotonic Muscular Dystrophy. What is myotonic dystrophy?. Myotonic dystrophy is an inherited type of ... cause myotonic dystrophy. Myotonic dystrophy Type 1 is caused by a mutation in the DMPK gene. Type 2 myotonic dystrophy is ... Myotonic Dystrophy Type 2 [ncbi.nlm.nih.gov]. From GeneTests. *Online Myotonic & Congenital Dystrophies Support Group ... Provides information on myotonic dystrophy.. *Myotonic Dystrophy [rarediseases.info.nih.gov]. Information from the Genetics and ...
  https://www.genome.gov/25521207/
*  Heart rate variability in myotonic dystrophy type 1 patients.
Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and reliable ... BACKGROUND: Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and ...
  http://www.biomedsearch.com/nih/Heart-rate-variability-in-myotonic/22406991.html
*  A repeated case: Expansions in RNA cause myotonic dystrophy
Researchers have determined that two types of myotonic dystrophy, the most common forms of muscular dystrophy in adults, can be ... The mutation in myotonic dystrophy type 1 (DM1) was identified in 1992 as an expansion of a repeat in the DMPK gene on ... Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. Science 293, 864-867 (August 3, 2001).. ... Myotonic dystrophy is an inherited disease that results in progressive muscle weakness and can cause eye cataracts, ...
  http://www.genomenewsnetwork.org/articles/08_01/Expansions_RNA.shtml
*  Abnormal ECG predict sudden death in myotonic dystrophy | News | Nursing Times
Severe abnormalities in ECG signatures are independent predictors of sudden death among myotonic dystrophy patients, a study ... Abnormal ECG predict sudden death in myotonic dystrophy. 19 June, 2008 By Richard Staines ... Severe abnormalities in ECG signatures are independent predictors of sudden death among myotonic dystrophy patients, a study ...
  https://www.nursingtimes.net/abnormal-ecg-predict-sudden-death-in-myotonic-dystrophy/1571052.article
*  Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry - Full Text View - ClinicalTrials.gov
Myotonic Dystrophy Facioscapulohumeral Muscular Dystrophy Muscular Dystrophy Myotonic Dystrophy Type 1 Myotonic Dystrophy Type ... Myotonic Dystrophy Type 1 Myotonic Dystrophy Type 2 Facioscapulohumeral Muscular Dystrophy Congenital Myotonic Dystrophy ... Myotonic Dystrophy. Muscular Dystrophies. Muscular Dystrophy, Facioscapulohumeral. Myotonic Disorders. Muscular Disorders, ... Congenital Myotonic Dystrophy PROMM (Proximal Myotonic Myopathy) Steinert's Disease Myotonic Muscular Dystrophy ...
  https://clinicaltrials.gov/ct2/show/NCT00082108?cond=%22Myotonic+dystrophy%22&rank=4