*  K194 | Fanconi Anemia Complementation Group F (FANCF)- Cloud-Clone Corp.
FANCF was found predominantly in the nucleus, where it complexes with FANCA, FANCC, and FANCG . These interactions were detected in wildtype and FANCD (FANCD2) lymphoblasts, but not in lymphoblasts of other FA complementation groups. The authors hypothesized that each of the FA proteins, except FANCD, is required for complex formation, and that the multiprotein FA complex serves a nuclear function to maintain genomic integrity.FANCF gene encodes a polypeptide with homology to the prokaryotic RNA-binding protein ROM. The region of homology with ROM comprises the N terminus of the prokaryotic protein, which is the region involved in RNA binding. The homologous region in FANCF is predicted to form an alpha-helical structure.
*  Fanconi anemia complementation group proteins | definition of Fanconi anemia complementation group ...
Looking for online definition of Fanconi anemia complementation group proteins in the Medical Dictionary? Fanconi anemia complementation group proteins explanation free. What is Fanconi anemia complementation group proteins? Meaning of Fanconi anemia complementation group proteins medical term. What does Fanconi anemia complementation group proteins mean?
*  Fanconi anemia group F protein elisa and antibody
Shop Fanconi anemia group F protein ELISA Kit, Recombinant Protein and Fanconi anemia group F protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
*  Plus it
We then examined the levels of mRNA of five FA genes (FANCA, FANCC, FANCE, FANCF, and FANCG) in nine CC cell lines. The FANCA, FANCC, FANCE, and FANCG genes showed no evidence of decreased expression (data not shown). However, the FANCF gene showed a down-regulated expression in all three cell lines (SiHa, SW756, and ME-180) that exhibited promoter hypermethylation (Fig. 2A) ⇓ . In addition, three other cell lines (C-4I, MS751, and HeLa), which did not show promoter methylation, also showed down-regulated FANCF mRNA compared with normal cervix (Fig. 2A ⇓ ; Table 1 ⇓ ). Overall, six of nine (66.6%) cell lines exhibited FANCF gene down-regulation. Thus, the present results suggest that FANCF is inactivated by mechanisms other than complete methylation of its promoter such as partial methylation or mutation. To evaluate the latter possibility, we examined mutations in the coding region in a panel of 16 methylated and 16 unmethylated CC. No nonsense or frameship mutations could ...
*  WikiGenes - FANCF - Fanconi anemia, complementation group F
The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
*  fanca, Fanconi anemia, complementation group A - Creative Biogene
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript ...
*  Plus it
4995 Fanconi anemia (FA) is a cancer-susceptibility syndrome characterized by hypersensitivity to DNA crosslinking agents, such as cisplatin and mitomycin C. All 9 known FA proteins cooperate with breast/ovarian cancer susceptibility gene products (BRCA1 and BRCA2) in a common DNA damage-activated signaling pathway called the Fanconi anemia(FA)-BRCA pathway. Seven FA proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL) are components of a multi-subunit ubiquitin ligase complex (FA complex) required for monoubiquitination of FANCD2. After DNA damage, FANCD2 is monoubiquitinated and targeted to BRCA1/BRCA2-containing nuclear foci in an ATR kinase-dependent fashion. Importantly, the pathway is inactivated in a wide variety of human cancers by methylation of the FANCF gene. This inactivation causes cisplatin sensitivity in some ovarian cancer cell lines, suggesting an important role of the pathway in ...
*  Gene Therapy for Fanconi Anemia - Tabular View - ClinicalTrials.gov
PRIMARY OBJECTIVES:. I. To determine the safety of lentiviral gene transfer for patients with Fanconi anemia complementation group A.. SECONDARY OBJECTIVES:. I. To determine the feasibility and efficacy of filgrastim (G-CSF) and plerixafor mobilization in FA patients.. II. To determine the feasibility and efficacy of lineage depletion of bone marrow or mobilized apheresis product.. III. To determine the transduction efficiency for human FA patient hematopoietic progenitor cells transduced with a clinical grade lentiviral vector encoding the gene for Fanconi anemia complementation group A.. IV. To determine if gene transfer using the clinical grade vector will result in phenotypic correction of gene modified cells by in vitro assays.. V. To determine if infusion of FANCA gene-modified cells will result in engraftment and persistence of gene-modified cells and improvement in ...
*  Fanconi Anemia Therapeutics Market - Technology & Market Analysis - 2016 to 2020 | Healthcare
Before It's News). Fanconi Anemia Therapeutics market report covers research informatics related to Fanconi Anemia Therapeutics clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Fanconi Anemia Therapeutics clinical trials and for research professionals.. The report, "Fanconi Anemia Therapeutics Global Clinical Trials Review, H2, 2016″ provides an overview of Fanconi Anemia Therapeutics clinical trials scenario. This report provides top line data relating to the clinical trials on Fanconi Anemia Therapeutics. Report includes an overview of trial numbers and their average enrolment in top countries conducted across the globe. The report also offers coverage of disease clinical ...
*  The Fanconi anemia/BRCA2 pathway in pancreatic cancer
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. ...
*  HES1 is a novel interactor of the Fanconi anemia core complex | Blood Journal
Although the FA pathway has been linked to DNA-damage responses, the specific biochemical function of each FA protein (separately or in the context of the FA complex/pathway) remains unclear. In particular, functions that would explain the disease phenotype, stem cell defects leading to bone marrow failure, and developmental abnormalities have been elusive. Our data presented here provide the first evidence linking FA proteins to HES1, a protein involved in stem cell function and developmental processes. We found that FA core complex components (FANCA, FANCG, FANCF, and FANCL) interact directly with HES1 and are present in HES1 immunocomplexes, implying that HES1 is a novel FA core complex interacting protein. We also found that HES1 is detected in immunocomplexes using antibodies directed against multiple FA core complex proteins (FANCA, FANCG, and FANCC), whereas reciprocal immunoprecipitation using anti-HES1 antibodies ...
*  FANCE Gene - GeneCards | FANCE Protein | FANCE Antibody
Complete information for FANCE gene (Protein Coding), Fanconi Anemia Complementation Group E, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  Henning Willers, MD - Department of Radiation Oncology - Massachusetts General Hospital, Boston, MA
Wang M, Kern A, Hülskötter M, Greninger P, Singh A, Pan Y, Chowdhury D, Krause M, Baumann M, Benes C, Efstathiou J, Settleman J, Willers H. EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res 2014;74:2825-34. Liu Q, Wang M, Kern A, Khaled S, Han J, Yeap B, Hong T, Settleman J, Benes C, Held K, Efstathiou J, Willers H. Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers. Mol Cancer Res 2015;13:713-20. Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Biggs P, Paganetti H, Efstathiou J, Lu HM, Held K, Willers H. Lung Cancer Cell Line Screen Links Fanconi Anemia/BRCA Pathway Defects to Increased RBE of Proton Radiation. IJROBP 2015;91:1081-9. Al-Halabi H, Paetzold P, Sharp G, Olsen C, Willers H. A Contralateral Esophagus-Sparing Technique to Limit Severe Esophagitis Associated With Concurrent High-Dose Radiation and Chemotherapy in Patients With Thoracic ...
*  Fanconi Anemia Research Community - OpenWetWare
Welcome to the Fanconi Anemia Research Community ,wikionly,wiki,/wikionly,,nonwikionly,website.,/nonwikionly,. We are researchers interested in understanding how the Fanconi anemia proteins contribute to the maintenance of genomic stability with the goal of developing better treatments for Fanconi patients. Because this is a wiki, you can add a website for your lab, find out about other labs doing Fanconi research, start or participate in discussions, find out about research materials, post results for other researchers to see, and more. To begin, you'll need an OpenWetWare account. See this page to sign up. Need help? Consult the getting started tutorial. ...
*  FANCA Gene - GeneCards | FANCA Protein | FANCA Antibody
Complete information for FANCA gene (Protein Coding), Fanconi Anemia Complementation Group A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  Fanconi Anemia 101: A Primer for Scientists | Fanconi Anemia Research Fund
This video presentation of fundamental Fanconi anemia information, or "FA 101", was recorded at the Fanconi Anemia Research Fund's 21st Annual Scientific Symposium, held in Baltimore, Maryland in 2009. The presentation runs about one hour and 25 minutes in length.. ...
*  FANCB Gene - GeneCards | FANCB Protein | FANCB Antibody
Complete information for FANCB gene (Protein Coding), Fanconi Anemia Complementation Group B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  FANCE: the link between Fanconi anaemia complex assembly and activity | The EMBO Journal
Genetic predisposition to cancer is commonly precipitated by mutations in genes that result in chromosome breakage. Studies of the inherited chromosomal instability diseases have led to the discovery of some of these genes, and the characterization of their products has profoundly contributed to the understanding of pathways that maintain genetic integrity (Patel et al., 1998; Moynahan et al., 1999; Scully and Livingston, 2000; Kinzler and Vogelstein, 2001). Fanconi anaemia (FA) is an autosomal recessive chromosomal breakage disease that results in developmental abnormalities, growth retardation, bone marrow failure and a marked predisposition to cancer (Auerbach et al., 2001; Joenje and Patel, 2001). The spontaneous chromosome breakage seen in FA cells is greatly potentiated upon exposure to agents that cross‐link DNA (Auerbach and Wolman, 1976; Ishida and Buchwald, 1982). However, despite the cloning of the majority of the genes mutated in this disease, their precise ...
*  Probes for FANCF | In Situ Hybridization, RNA-ISH | ACDBio
For Research Use Only. Not for diagnostic use. Refer to appropriate regulations. RNAscope is a registered trademark; and HybEZ, EZ-Batch and DNAscope are trademarks of Advanced Cell Diagnostics, Inc. in the United States and other countries. All rights reserved. ©2016 Advanced Cell Diagnostics, Inc.. ...
*  Fanconi Anemia; Anemia, Fanconi
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
*  Eisele, David W.
Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL; journal for oto-rhino-laryngology and its related specialties. 2007 ...
*  OriGene - FANCG (NM 004629) cDNA Clone
FANCG - FANCG (untagged)-Human Fanconi anemia, complementation group G (FANCG) available for purchase from OriGene - Your Gene Company.
*  AID 758814 - Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assay - PubChem
BioAssay record AID 758814 submitted by ChEMBL: Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assay.
*  OriGene - FANCC (NM 000136) shRNA
FANCC - FANCC - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector shRNA available for purchase from OriGene - Your Gene Company.
*  ADC 9001 Advanced Design Consulting USA, Inc.
ADC's innovative solutions leverage its expertise in precision robotics, sub-micron positioning systems, and optical subsystems to enhance the capabilities and productivity of its customers' manufacturing, engineering and research applications.