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*  N-Ethyl-3-piperidyl benzilate - Wikipedia
Muscarinic acetylcholine receptor modulators. mAChRs. Agonists. *77-LH-28-1. *AC-42 ... Radiolabelled versions of this drug have been used in scientific research to map the distribution of muscarinic acetylcholine ... propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[11C] ...
  https://en.wikipedia.org/wiki/N-Ethyl-3-piperidyl_benzilate
*  Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem...
AC-42) and the muscarinic M1 receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol 69: ... Porter AC, Bymaster FP, DeLapp NW, Yamada M, Wess J, Hamilton SE, Nathanson NM, and Felder CC (2002) M1 muscarinic receptor ... Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using ... Scarr E, Keriakous D, Crossland N, and Dean B (2006) No change in cortical muscarinic M2, M3 receptors or [35S]-GTPγS binding ...
  http://jpet.aspetjournals.org/content/325/3/869
*  Muscarinic Acetylcholine Receptor M1/CHRM1 Proteins: Novus Biologicals
Browse our Muscarinic Acetylcholine Receptor M1/CHRM1 Protein catalog backed by our Guarantee+. ... Muscarinic Acetylcholine Receptor M1/CHRM1 Proteins available through Novus Biologicals. ... Applications: AC. view datasheet<\/a>","Price":"Price Not Shown"}'>. compare. (select up to 3 products from this page to ...
  https://www.novusbio.com/product-type/peptides-and-proteins?related_diseases=Depressive%20Disorder&common_name=Muscarinic%20Acetylcholine%20Receptor%20M1/CHRM1
*  Pulmonology Xagena News
... a combination long-acting muscarinic antagonist ( LAMA ) / long-ac ... ...
  http://www.pulmonologynews.net/page/4
*  Pulmonology Xagena News
... a combination long-acting muscarinic antagonist ( LAMA ) / long-ac ... ... Dual bronchodilation with a long-acting beta2-agonist ( LABA ) and long-acting muscarinic antagonist ( LAMA ) is recommended ...
  http://www.pulmonologynews.net/?q=LABA
*  Publications & References
AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal ... Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.. ... AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal ... Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.. ...
  https://www.discoverx.com/tools-resources/publications-references?page=12
*  Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions |...
Cheng K, Shang AC, Drachenberg CB, et al. Differential expression of M3 muscarinic receptors in progressive colon neoplasia and ... East JE, Atkin WS, Bateman AC, et al. British Society of Gastroenterology position statement on serrated polyps in the colon ... Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells. Biochem ... Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human ...
  https://link.springer.com/article/10.1007/s10620-018-5000-0
*  Activation of Muscarinic Acetylcholine Receptors Enhances the Release of Endogenous Cannabinoids in the Hippocampus | Journal...
Dolphin AC. (1995) Voltage-dependent calcium channels and their modulation by neurotransmitters and G proteins. Exp Physiol 80: ... 1995) Muscarinic receptors modulate N-, P-, and L-type Ca2+ currents in rat striatal neurons through parallel pathways. J ... 1996) Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a ... 2002) Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. ...
  http://www.jneurosci.org/content/22/23/10182
*  US20050203134A1 - Biphenyl compounds useful as muscarinic receptor antagonists - Google Patents
The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions ... To measure the ability of a test compound to block oxotremorine-inhibited AC activity, 25 μL forskolin and oxotremorine (25 μM ... Accordingly, a need exists for new muscarinic receptor antagonists. In particular, a need exists for new muscarinic receptor ... In this embodiment, a biological system or sample comprising a muscarinic receptor is contacted with a muscarinic receptor- ...
  https://patents.google.com/patent/US20050203134A1/en
*  CiNii 論文 - Sleep-Predominant Lowering of Ambulatory Blood Pressure by Bedtime Inhalation of a...
Tiotropium, a Novel Muscarinic M3 Receptor Antagonist, Improved Symptoms of Chronic Obstructive Pulmonary Disease Complicated ... SALISBURY AC Am J Cardiol 99, 636-641, 2007 被引用文献1件 ... Blood Pressure by Bedtime Inhalation of a Novel Muscarinic M3 ...
  https://ci.nii.ac.jp/naid/10021935123
*  Benadryl and Guaifenesin AC Drug Interactions - Drugs.com
A Moderate Drug Interaction exists between Benadryl and Guaifenesin AC. View detailed information regarding this drug ... Lonhala Magnair Lonhala Magnair (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator for... ...
  https://www.drugs.com/drug-interactions/benadryl-with-guaifenesin-ac-896-1617-719-18655.html
*  M1 and M3 Muscarinic Receptors Control Physiological Processing of Cellular Prion by Modulating ADAM17 Phosphorylation and...
Plated HEK293 cells stably transfected with empty pcDNA3 (Mock) or cDNAs encoding M1 (A-C) or M4 (B) muscarinic receptors were ... Influence of M1 muscarinic receptor activation on C1 formation in HEK293 cells. HEK293 cells overexpressing M1 muscarinic ... Muscarinic receptors activation does not affect PrPc trafficking in M1 or M3 stably transfected HEK293 cells. A, M1-expressing ... and that express high levels of endogenous muscarinic receptors (Hamilton and Nathanson, 2001). The nonselective muscarinic ...
  http://www.jneurosci.org/content/27/15/4083
*  Frontiers | The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock...
We showed that activation of adrenergic signaling increases AC-cAMP/PKA signaling, which mediates the increase in the SANC AP ... We showed that activation of adrenergic signaling increases AC-cAMP/PKA signaling, which mediates the increase in the SANC AP ... Eliminating AC-cAMP-PKA signaling abolished the core effect of autonomic receptor stimulation on the AP firing rate. ... We hypothesize that changes in AC-cAMP/PKA activity are crucial for mediating either decrease or increase in the AP firing rate ...
  https://www.frontiersin.org/articles/10.3389/fphys.2016.00419/full
*  Romilar AC and Triaminic Flu, Cough & Fever Drug Interactions - Drugs.com
A Moderate Drug Interaction exists between Romilar AC and Triaminic Flu, Cough & Fever. View detailed information regarding ... Yupelri Yupelri (revefenacin) is a long-acting muscarinic antagonist (LAMA) for the... ... Romilar AC (codeine/guaifenesin). Triaminic Flu, Cough & Fever (acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine ... Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin ...
  https://www.drugs.com/drug-interactions/romilar-ac-with-triaminic-flu-cough-fever-719-8060-40-16044.html
*  Muskarinski acetilholinski receptor M3 - Википедија, слободна енциклопедија
Bonner TI, Young AC, Brann MR, Buckley NJ (1990). „Cloning and expression of the human and rat m5 muscarinic acetylcholine ... Bonner TI, Buckley NJ, Young AC, Brann MR (1987). „Identification of a family of muscarinic acetylcholine receptor genes.". ... Acetylcholine receptors (muscarinic): M3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Entrez Gene: CHRM3 cholinergic receptor, muscarinic 3".. *^ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John ...
  https://sr.wikipedia.org/wiki/Muskarinski_acetilholinski_receptor_M3
*  Pharmacological Characterization of LY593093, an M1 Muscarinic Acetylcholine Receptor-Selective Partial Orthosteric Agonist |...
AC-42. 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]. 77-LH-28-1. 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)- ... muscarinic acetylcholine receptor. M1-5AChR. muscarinic; acetylcholine receptor subtypes 1-5. CHO. Chinese hamster ovary. GTPγ[ ... 2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor ... 2007) Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721-733. ...
  http://jpet.aspetjournals.org/content/338/2/622
*  Activation of Muscarinic and Nicotinic Acetylcholine Receptors in the Nucleus Accumbens Core Is Necessary for the Acquisition...
Email: gerald.zernig{at}uibk.ac.at. References. *↵ Acquas E, Marrocu P, Pisanu A, Cadoni C, Zernig G, Saria A, DiChiara G (2001 ... In another set of experiments, the acquisition of RMF reinforcement was tested in the presence of 10 μm of the muscarinic ACh ... Activation of Muscarinic and Nicotinic Acetylcholine Receptors in the Nucleus Accumbens Core Is Necessary for the Acquisition ... Activation of Muscarinic and Nicotinic Acetylcholine Receptors in the Nucleus Accumbens Core Is Necessary for the Acquisition ...
  http://www.jneurosci.org/content/26/22/6004.full
*  The Molecular Basis for Distinct β-Adrenergic Receptor Subtype Actions in Cardiomyocytes | Circulation Research
Early studies demonstrating that muscarinic receptors inhibit β-AR-stimulated AC activity66 67 68 led to the notion that a ... Chimeric muscarinic cholinergic: β-adrenergic receptors that activate Gs in response to muscarinic agonists. J Biol Chem. 1990; ... Whereas β2-ARs also can link to the activation of AC (in fact, they inherently couple to the activation of AC more effectively ... the abundance of transcripts for type V AC increases and for type VI AC decreases with age.58 61 In the context of recent ...
  http://circres.ahajournals.org/content/85/11/1101.long
*  Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?
Kruse AC, Hu J, Pan AC, et al. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 2012;482(7386):552- ... Haga K, Kruse AC, Asada H, et al. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature. ... muscarinic receptors, [22, 23] and several others [24-26] including the chemokine receptor CXCR4 [27]. In the recent years, ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3414077/
*  Frontiers | Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic...
Here we report that muscarinic acetylcholine receptor (M receptor) agonists, ACh and Oxotremorine (OXO-M), decreased the firing ... Here we report that muscarinic acetylcholine receptor (M receptor) agonists, ACh and Oxotremorine (OXO-M), decreased the firing ... M2-class receptors preferentially couple to Gαi proteins that inhibit adenylyl cyclase (AC) and downregulate intracellular cAMP ... Keywords: cholinergic interneurons, muscarinic receptor, HCN channel, scRT-PCR, muscarinic inhibitory. Citation: Zhao Z, Zhang ...
  https://www.frontiersin.org/articles/10.3389/fncel.2016.00071/full
*  Chrm4 - Muscarinic acetylcholine receptor M4 - Rattus norvegicus (Rat) - Chrm4 gene & protein
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown ... www.ebi.ac.uk/intact/">IntAct database,/a>. It is updated on a monthly basis. Each binary interaction is displayed on a ... Muscarinic acetylcholine receptor M4Add BLAST. 478. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.PROSITE-ProRule annotation. ,p>Manual validated information ...
  http://www.uniprot.org/uniprot/P08485
*  Sequestration of Human Muscarinic Acetylcholine Receptor hm1-hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2,...
E-mail: tsuga{at}m.u-tokyo.ac.jp. * ↵1 This work was supported in part by grants from the Ministry of Education, Science, and ... Sequestration of Human Muscarinic Acetylcholine Receptor hm1-hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, ... Sequestration of Human Muscarinic Acetylcholine Receptor hm1-hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, ... Sequestration of Human Muscarinic Acetylcholine Receptor hm1-hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, ...
  http://jpet.aspetjournals.org/content/284/3/1218
*  The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid...
Gukovskaya AC, *Brown RJ, *Pandol SJ, and *Muallem S. (1997) nNOS and Ca2+ influx in rat pancreatic acinar and submandibular ... muscarinic acetylcholine receptor. APM. apical plasma membrane. SNI-2011. cevimeline hydrochloride. PLC. phospholipase C. IP3. ... 1996) The nitric oxide/cGMP pathway couples muscarinic receptors to the activation of Ca2+ influx. J Neurosci 16:1702-1709. ... 1996) The interaction of enantiomers of aceclidine with subtypes of the muscarinic receptor. J Pharmacol Exp Ther 279:1335-1344 ...
  http://molpharm.aspetjournals.org/content/61/6/1423
*  The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular FunctionNovelty...
muscarinic acetylcholine receptor subtype M3. NO. nitric oxide. NOSTRIN. nitric oxide synthase traffic inducer. ... Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to ... M3muscarinic receptors mediate acetylcholine-induced pulmonary vasodilation in pulmonary hypertension. Biosci Trends. 2010;4: ... Connexins and M3 muscarinic receptors contribute to heterogeneous Ca(2+) signaling in mouse aortic endothelium. Cell Physiol ...
  http://circres.ahajournals.org/content/117/5/460.full
*  Hvordan kan jeg unngå astmaanfall
Kew KM, Evans DJW, Allison DE, Boyter AC. Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) ...
  https://nhi.no/sykdommer/lunger/astma/astma-rad/