*  The effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and dependence was ... Morphine sulfate (7 mg/kg, i.p.) application for 5 days developed tolerance in animals. On 5th day, 30 min after the injection ... The results showed that the anti-nociceptive effect of morphine for acute pain markedly reduced, but slightly enhanced for ... of morphine, the acute and chronic pain was evaluated in diabetic and non-diabetic animals using hot plate and formalin test. ...
  http://ijpr.sbmu.ac.ir/article_155.html
*  Mr. Morphine - Erik Ringmar's web pages
Morphine. Mr. Morphine is a guy who suddenly appears after I've had 12.5 milliliters of that clear, opium-based, liquid my ... Morphine is a super hero like what you would find in an old Marvel Comic. He has a purple dress and a red cape, and he can fly ... Mr Morphine can do anything and deal with any problem. He looks out for me, fights my fights for me. Above all, he stands up to ... Morphine is dealing with the situation for me.. I've understood something important about drug addiction. Quite apart from the ...
  http://ringmar.net/index.php/2008/10/03/mr-morphine/
*  JCI - Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
... associated truncation in mE4M-B6 mice facilitated morphine tolerance and reduced morphine dependence without affecting morphine ... mE7M-B6 mutant mice lost morphine-induced receptor desensitization in the brain stem and hypothalamus, consistent with exon 7 ... In mE7M-B6 mice, the exon 7-associated truncation diminished morphine tolerance and reward without altering physical dependence ... Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. ...
  https://www.jci.org/articles/view/88760/sd/1
*  The Devious Side of Morphine Addiction in Canada - Drug Facts
The Devious Side of Morphine Addiction in Canada Posted By: drugfacts 0 Comment addiction, addiction to morphine ... Morphine can be melted in water and somewhat soluble in alcohol. Morphine sulfate looks similar to a feathery, white, cubical ... Morphine is significantly has more water-soluble than any other opioid in clinical use. Morphine has water coefficient of 1.42 ... Withdrawal from morphine causes nausea, tearing, yawning, chills, and sweating lasting up to three days. Morphine crosses the ...
  http://www.drugfacts.ca/prescription-drugs/the-devious-side-of-morphine-addiction-in-canada/
*  Optimizing the Use of Morphine in Pre-Term Neonates - Tabular View - ClinicalTrials.gov
Drug: Morphine Gestational Age, 29 weeks: A loading dose of 0.05 mg/kg I.V. morphine over 30-minutes, followed by a continuous ... Drug: Morphine Gestational Age,= 29 weeks: A loading dose of 0.1 mg/kg I.V. morphine over 30-minutes, followed by a continuous ... The decision to initiate morphine therapy will be based solely on clinical indications. Prior to morphine dosing, a biochemical ... Optimizing the Use of Morphine in Pre-Term Neonates. The safety and scientific validity of this study is the responsibility of ...
  https://clinicaltrials.gov/ct2/show/record/NCT00494429
*  Fan, X., Zhang, J., Zhang, X., Yue, W. and Ma, L. (2002) Acute and chronic morphine treatments and morphine withdrawal...
Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat ... Fan, X., Zhang, J., Zhang, X., Yue, W. and Ma, L. (2002) Acute and chronic morphine treatments and morphine withdrawal ...
  http://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=1022670
*  KEGG PATHWAY: Morphine addiction - Homo sapiens (human)
Morphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain ... Morphine addiction - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , ... Morphine can cause indirect excitation of VTA dopamine neurons by reducing inhibitory synaptic transmission mediated by ... The chronic use of morphine is characterized by adaptive changes in neurons and neuronal communication; such adaptations (e.g ...
  http://www.genome.jp/kegg-bin/show_pathway?hsa05032+5139
*  Biphasic Effects of Naloxone in the Rats Receiving Morphine Overdose A Place Preference Study
First, male Wistar rats (200-220 g) were received morphine (1-7.5 mg/Kg) for place conditioning and marginal dose of morphine ( ... The antagonist potentiates the expression of morphine-induced place preference on the dose of 0.05 and 0.4 mg/Kg while inhibits ... It could be concluded that the inhibition of opioid receptors may enhance or inhibit the expression of morphine reward ... Our results indicated that naloxone showed biphasic effects on the appearance of morphine-induced place preference. ...
  http://ijpr.sbmu.ac.ir/article_998.html
*  The effect of GABAB receptor activation within the ventral tegmental area on morphine-induced incentive sensitization in female...
... reduced the morphine effects. The results indicated that activation of GABAB receptors within the VTA in morphine-sensitized ... Five days later, the animals were conditioned with an ineffective dose of morphine in a two compartment un-biased apparatus. ... In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive ... The results indicated that morphine administration to the animals in three consecutive days produces sensitization in which low ...
  http://ijpr.sbmu.ac.ir/article_121.html
*  DailyMed - MORPHINE SULFATE - morphine sulfate solution
Do not take morphine sulfate oral solution if you:. * are allergic to morphine, morphine salts or any of the ingredients in ... Conversion from Parenteral Morphine to Oral Morphine Sulfate For conversion from parenteral to oral morphine sulfate, anywhere ... Morphine sulfate is contraindicated in patients with known hypersensitivity to morphine, morphine salts, or any components of ... MORPHINE SULFATE (UNII: X3P646A2J0) (MORPHINE - UNII:76I7G6D29C). MORPHINE SULFATE. 20 mg in 1 mL. ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5e29ebe-0e74-4ba7-a16c-e3199cc70c11
*  Morphine is an opioid analgesic drug commonly used for pain relief - Aurora Kinases as Druggable Targets in Cancer Therapy
Morphine is an opioid analgesic drug commonly used for pain relief in cancer patients. demonstrate that morphine contributes to ... 5) nalmefene (= 5) morphine (= 5) or nalmefene plus morphine (= 5) right after tumor cell implantation. Due to the potential ... Morphine is an opioid analgesic drug commonly used for pain relief. August 19, 2016. GAT ... PubMed] 12 Fujioka N Nguyen J Chen C Li Y Pasrija T Niehans G Johnson KN Gupta V Kratzke RA Gupta K. Morphine-induced epidermal ...
  http://www.exposed-skin-care.net/2016/08/19/morphine-is-an-opioid-analgesic-drug-commonly-used-for-pain-relief/
*  MORPHINE SULFATEEXTENDED-RELEASE TABLETSCII15 mg, 30 mg, 60 mg, 100 mg, 200 mg*200 mg for use in opioid...
Conversion from Conventional Oral Morphine to Morphine Sulfate Extended-Release Tablets. A patient's daily morphine requirement ... mg of morphine IM for every 6 mg of morphine as morphine sulfate extended-release tablets. Of course, the IM 24-hour dose would ... morphine vary. Some authorities suggest that a dose of oral morphine only three times the daily parenteral morphine requirement ... plasma morphine concentrations are related to the morphine dose. In non-tolerant individuals, plasma morphine concentration- ...
  http://rxdrugsinfo.com/drug-info-label/morphine-sulfate
*  Neuropathic Pain Aided by Morphine + Epilepsy Medication
The pain relief brought about by morphine can diminish over time. In this study, when carbamazepine was added to the morphine ... When morphine is used in combination with carbamazepine, which prevents epileptic seizures, this loss of drug efficacy may be ... Neuropathic Pain Aided by Morphine + Epilepsy Medication. Scientists studying induced nerve injury in rodents have found that ... News Neuropathic Pain Aided by Morphine + Epilepsy Medication ... "the dampening of the analgesic effects of morphine on ...
  https://www.painweek.org/news_posts/neuropathic-pain-aided-by-morphine-epilepsy-medication.html
*  Resveratrol May Preserve Pain-Relieving Effects of Morphine | International Anesthesia Research Society
In morphine-tolerant rats, the pain-relieving response to morphine was about 20 percent of normal. In rats receiving ... After inducing morphine tolerance in rats, the researchers tested the animals' spinal cord responses to morphine, with or ... particularly for patients who need long-term morphine administration and for morphine-tolerant patients who require better pain ... Morphine and related opioid drugs play an important role in the treatment of severe pain, including cancer pain and other ...
  http://www.iars.org/resveratrol_may_preserve_pain-relieving_effects_of_morphine/?Archive=y%3Fprint%3Dy&pg=9&F_All=y?print=y
*  Spinal Nitric Oxide Mediates Antinociception from Intravenous Morphine | Anesthesiology | ASA Publications
Figure 1. Effect of intravenously administered morphine alone on paw withdrawal response to noxious heat. Morphine (2.5 mg/kg) ... Figure 1. Effect of intravenously administered morphine alone on paw withdrawal response to noxious heat. Morphine (2.5 mg/kg) ... Figure 1. Effect of intravenously administered morphine alone on paw withdrawal response to noxious heat. Morphine (2.5 mg/kg) ... Figure 1. Effect of intravenously administered morphine alone on paw withdrawal response to noxious heat. Morphine (2.5 mg/kg) ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1946998
*  COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE...
COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE ... COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE ... COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE ... COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE ...
  http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/93749-engb-93749
*  Phosphoproteomics and Bioinformatics Analyses of Spinal Cord Proteins in Rats with Morphine Tolerance
However, repeated neuraxial administration of morphine may still lead to morphine tolerance. Methods To better understand the ... Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can ... We confirmed tolerance by measuring paw withdrawal latencies and maximal possible analgesic effect of morphine on day 5. We ... Conclusions Repeated morphine administration may affect multiple biological networks by altering protein phosphorylation. These ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083817
*  Brain Sciences | Free Full-Text | The Neurodevelopmental Impact of Neonatal Morphine Administration | HTML
Morphine increases apoptosis in human microglial cells, and animal studies demonstrate long-term changes in behavior, brain ... function, and spatial recognition memory following morphine exposure. This comprehensive review examines existing preclinical ... 3 days of age who were randomized to receive continuous morphine (n = 73) or placebo (n = 77), with open-label morphine used ... morphine administration regimens. Other groups were also treated with naloxone in addition to morphine. Brain tissue was ...
  http://www.mdpi.com/2076-3425/4/2/321/htm
*  Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... When the doses of morphine (mg/kg per injection) were subcutaneously given into mice as pretreatment twice daily for 2 days ( ... Tolerance to i.t. morphine was significantly suppressed by i.t. injection of pifithrin-alpha (1 and 10nmol), an inhibitor of ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
*  Morphine
... HCI. Topic: morphine. This sight is in the makings for now. It will eventually show a report on Morphine showing ...
  http://www.angelfire.com/planet/carrbin/morphine/index.blog
*  Sister Morphine - Wikipedia
"Sister Morphine" is a song written by Marianne Faithfull, Mick Jagger and Keith Richards. Faithfull released the original ... In some territories such as the Netherlands, Italy and Japan, "Sister Morphine" appeared on the A-side.[3] In addition, the ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Sister_Morphine&oldid=835104387" ...
  https://en.wikipedia.org/wiki/Sister_Morphine
*  Morphine methylbromide - Wikipedia
Morphine methylbromide (Morphine methobromide, Morphine bromomethylate, Morphosan) a derivative of morphine. It is an opioid ... It is a salt of morphine with a freebase conversion ratio of 0.75.controlled substance.[1] [2] [3] ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Morphine_methylbromide&oldid=768973364" ...
  https://en.wikipedia.org/wiki/Morphine_methobromide
*  Morphine History
Morphine and other opiates have been known to mankind for centuries. Applications of the drug have been varied ranging from ... Morphine as a medicine. Morphine soon began to gain popularity as a pain reliever. The drug was commercially produced in the ... Soldiers who had been injured during war became some of the first people to develop morphine addiction and morphine dependence ... Morphine restriction. During the mid-19th century, both opium and cocaine addiction were on the rise and laudanum (an opium ...
  https://www.news-medical.net/health/Morphine-History.aspx
*  Morphine
... is a type of painkiller used for moderate to severe pain. It is classified as a strong opioid analgesic (also ... This is because morphine is a controlled drug.. *Do not just stop taking morphine suddenly as you will probably suffer from ... Before taking morphine, make sure that your Doctor is aware if any of the following apply to you:. *If you have heart, liver or ... Morphine is used to relieve moderate to severe pain and also in easing severe coughs. It works by affecting the nerves and ...
  https://www.sportsinjuryclinic.net/treatments-therapies/drugs/morphine
*  morphine | drug | Britannica.com
Morphine was isolated from opium by the German chemist F.W.A. Sertürner... ... morphine: Narcotic analgesic drug used in medicine in the form of its hydrochloride, sulfate, acetate, and tartrate salts. ... The cause of death in morphine overdoses is usually respiratory failure. Nausea is caused by morphine's stimulation of the ... Morphine, narcotic analgesic drug used in medicine in the form of its hydrochloride, sulfate, acetate, and tartrate salts. ...
  https://www.britannica.com/science/morphine