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*  cyclic gmp dependent protein kinases
Research Grants about cyclic gmp dependent protein kinases ... Cyclic GMP-dependent protein kinase II is a molecular switch ... Cyclic GMP-dependent protein kinase Ialpha inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle ... cyclic gmp dependent protein kinases. Summary. Summary: A group of enzymes that are dependent on cyclic GMP and catalyzes the ... cyclic nucleotide regulated protein kinases , cyclic gmp dependent protein kinases ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/cyclic/cyclic-gmp-dependent-protein-kinases-13214.html
*  CREB1 - Wikipedia
"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates ... "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and ... The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal ...
  https://en.wikipedia.org/wiki/CREB1
*  CGMP-dependent protein kinase - Wikipedia
"A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of ... Specifically, in smooth muscle tissue, PKG promotes the opening of calcium-activated potassium channels, leading to cell ... EC 2.7.11.12 Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System cGMP-Dependent Protein Kinases at the US ... cGMP-dependent protein kinase or Protein Kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP ...
  https://en.wikipedia.org/wiki/CGMP-dependent_protein_kinase
*  Discovery and development of phosphodiesterase 5 inhibitors - Wikipedia
Cyclic GMP binds to the cGMP-dependent protein kinase (PKG1) which phosphorylates several proteins that results in decreased ... cGMP binding proteins and protein kinase G (PKG). The effect on PKG reduces levels of calcium leading to relaxation of smooth ... Molecular Pharmacology 66, 144-152. Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_phosphodiesterase_5_inhibitors
*  Purkinje Cell Heterogeneity: Its Role in Organizing the Topography of the Cerebellar Cortex Connections | SpringerLink
Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proc. Natl Acad. Sci. USA, 78, 653- ... Jande, S.S, Maler, L, and Lawson, D.E.M. (1981): Immunocytochemical mapping of vitamin D-dependent calcium-binding protein in ... Phases in the maturation of Purkinje cells and the molecular layer. J. Comp. Neurol., 145, 399-464.Google Scholar ... Wassef, M, and Sotelo, C. (1984): Asynchrony in the expression of guanosine 3':5'-phosphate-dependent protein kinase by ...
  https://link.springer.com/chapter/10.1007/978-1-4612-2840-0_1
*  Role of cyclic GMP-dependent protein kinase type II in the brain - UBC Library Open Collections
Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain. J Neurochem. 64:2814-7 ... The large conductance, voltage-dependent, and calcium-sensitive K+ channel, Hslo, is a target of cGMP-dependent protein kinase ... PKG I cyclic GMP-dependent protein kinase type I PKG U cyclic GMP-dependent protein kinase type II pM pico Molar PMSF phenyl ... and cGMP-dependent protein kinases, protein kinase C , calmodulin-dependent protein kinase U and casein kinase LT. Eur J ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0092443
*  Thromboregulation - Wikipedia
In vivo phosphorylation of thromboxane by cyclic GMP-dependent protein kinase" (PDF). Journal of the Salk Institute for ... inhibition of cyclic AMP breakdown by cyclic GMP". Molecular Pharmacology. 37 (5): 671-681. Siess, Wolfgang; Eduardo, Lapetina ... G kinase). This kinase inhibits Gαq-phospholipase C-inositol 1,4,5-triphosphate signaling and the mobilization of calcium ... cAMP, cyclic adenosine monophosphate, phosphorylate messengers via protein kinase A (PKA). These signaling elements include ...
  https://en.wikipedia.org/wiki/Thromboregulation
*  Photoreceptors in Plant Photomorphogenesis to Date. Five Phytochromes, Two Cryptochromes, One Phototropin, and One Superchrome ...
These include signaling components such as heterotrimeric G proteins, cyclic GMP, calcium nucleotide diphosphate kinase 2, and ... the Chory laboratory has shown that a phytochrome-binding protein, PKS1, is phosphorylated by phytochrome in a light-dependent ... Current work based on molecular genetic studies that rely heavily on photomorphogenic mutants has made significant progress in ... there was strong evidence that this protein was not only the photoreceptor and kinase for its own phosphorylation but a ...
  http://www.plantphysiol.org/content/125/1/85.full
*  PRKG1 - Wikipedia
"Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell ... "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase ... "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): ... of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha". ...
  https://en.wikipedia.org/wiki/PRKG1
*  Potassium Channel Function in Vascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
... cyclic GMP15 19 20 may activate KV channels in some blood vessels, and these channels may be inhibited by protein kinase C.21 ... Calcium-Activated K+ Channels. *Voltage-Dependent (Delayed Rectifier) K+ Channels. *ATP-Sensitive K+ Channels ... While molecular biological studies are revealing a large diversity in the subtypes of K+ channels that are normally expressed ... Endothelium-dependent hyperpolarization: beyond nitric oxide and cyclic GMP. Circulation. 1995;92:3337-3349. ...
  http://atvb.ahajournals.org/content/21/1/28
*  Biological functions of nitric oxide - Wikipedia
... cyclic GMP) from guanosine triphosphate (GTP). The soluble cGMP activates cyclic nucleotide-dependent protein kinase G (PKG or ... PKG is a kinase that phosphorylates a number of proteins that regulate calcium concentrations and calcium sensitization, ... The process involves the oxidation of NADPH and the reduction of molecular oxygen. The transformation occurs at a catalytic ... are calcium-dependent and produce low levels of this gas as a cell signaling molecule. The inducible isoform (NOS-2) is calcium ...
  https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide
*  Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System | Circulation Research
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient ... The molecular mechanisms of inhibition of G-protein-coupled responses by cGKI have yet to be elucidated. Furthermore, evidence ... Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile ... Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene ...
  http://circres.ahajournals.org/content/93/10/907.full
*  Table of Contents - May 01, 2001, 166 (9) | The Journal of Immunology
The Vasodilator-Stimulated Phosphoprotein Is Regulated by Cyclic GMP-Dependent Protein Kinase During Neutrophil Spreading ... MOLECULAR AND STRUCTURAL IMMUNOLOGY. *. You have accessRestricted access. Epitope Mapping of Antibodies to the C-Terminal ... Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy ... Fcα Receptor Cross-Linking Causes Translocation of Phosphatidylinositol-Dependent Protein Kinase 1 and Protein Kinase Bα to MHC ...
  http://www.jimmunol.org/content/166/9
*  The Toxoplasma Blog: November 2012
We also demonstrate that egress likely comes under a further level of control by cyclic GMP-dependent protein kinase and that ... Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.. Calcium signalling ... Using a chemical-genetic approach to specifically inhibit select calcium-dependent kinases (CDPKs), we instead demonstrate that ... Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, 30 Flemington Road, ...
  http://toxoplasmaparasite.blogspot.com/2012/11/
*  Nicorandil - Wikipedia
Vrolix, M; Raeymaekers, L; Wuytack, F; Hofmann, F; Casteels, R (Nov 1, 1988). "Cyclic GMP-dependent protein kinase stimulates ... Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the ... Kukovetz WR, Holzmann S, Pöch G (1992). "Molecular mechanism of action of nicorandil". J. Cardiovasc. Pharmacol. 20 (Suppl 3): ... "Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular ...
  https://en.wikipedia.org/wiki/Nicorandil
*  Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia
V. Sauzeau, H. Le Jeune, C. Cario-Toumaniantz et al., "Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA- ... cAMP activates protein kinase A (PKA) resulting in decreased calcium-calmodulin-dependent MLC phosphorylation and enhanced ... K. Riento and A. J. Ridley, "Rocks: multifunctional kinases in cell behaviour," Nature Reviews Molecular Cell Biology, vol. 4, ... "Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates ...
  https://www.hindawi.com/journals/anemia/2012/723520/
*  ITPR1 - Wikipedia
5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701-7. PMID ... "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): ... trisphosphate receptor with 4.1N protein in neurons". Molecular and Cellular Neurosciences. 22 (2): 271-83. doi:10.1016/s1044- ... Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol ...
  https://en.wikipedia.org/wiki/ITPR1
*  Calcium in biology - Wikipedia
... through a protein kinase C-dependent mechanism". Biochem J. 466 (2): 379-390. doi:10.1042/bj20140881. PMID 25422863. Milo, Ron ... Pugh Jr, E. N.; Lamb, T. D. (1990). "Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate ... Boron, Walter F.; Boulpaep, Emile L (2003). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. p. 867. ... which includes both protein-bound and free calcium. In contrast, ionized calcium is a measure of free calcium. An abnormally ...
  https://en.wikipedia.org/wiki/Calcium_in_biology
*  Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity
K. Mujoo, J. S. Krumenacker, and F. Murad, "Nitric oxide-cyclic GMP signaling in stem cell differentiation," Free Radical ... protein kinase C, cdc42, and Numb. N-cadherin is expressed in normal stem cell niche and is required for maintenance of ... which are constitutive and calcium-dependent, produce small amount of NO for very short period of time when activated. By ... R. G. Vries, M. Huch, and H. Clevers, "Stem cells and cancer of the stomach and intestine," Molecular Oncology, vol. 4, pp. 373 ...
  https://www.hindawi.com/journals/bmri/2017/9634172/
*  Biochemical cascade - Wikipedia
In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, ... "Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes". Biology of ... "Protein tyrosine kinase signaling during oocyte maturation and fertilization". Molecular reproduction and development. 78 (10- ... These proteins activate protein tyrosine kinase (PTK) that phosphorylates various proteins important for capacitation and ...
  https://en.wikipedia.org/wiki/Biochemical_cascade
*  US Patent # 9,611,278. Soluble guanylate cyclase activators - Patents.com
... are capable of modulating the body's production of cyclic guanosine monophosphate ('cGMP') and are generally suitable for the ... intracellular messenger which triggers a multitude of different effects via the modulation of cGMP-dependent protein kinases, ... Cyclic GMP (cGMP) is an important ... or with atorvastatin calcium (e.g. LIPTRUZET.RTM.); niacin in ... are essentially regulated by a family of low-molecular-weight factors which are formed enzymatically. The most important ...
  http://patents.com/us-9611278.html
*  Calcium and Potassium Channels in Experimental Subarachnoid Hemorrhage and Transient Global Ischemia
... as they are activated by cyclic GMP-dependent protein kinase (PKG), which is stimulated by the NO-induced increase of cGMP [22 ... S. Albarwani, L. T. Nemetz, J. A. Madden et al., "Voltage-gated K+ channels in rat small cerebral arteries: molecular identity ... S. Ansar and L. Edvinsson, "Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase ... 3.2 protein expression was much lower, 2.3 protein was confined to the surface of the vessel, and 1.3 protein was not ...
  https://www.hindawi.com/journals/srt/2012/382146/
*  http://ufdc.ufl.edu/UFE0041178/00001
... potassium activated adenosine triphosphatase through a mechanism involvi ng cyclic GMP and cyclic GMP dependent protein kinase ... The large conductance, voltage dependent, and calcium sensitive K+ channel, Hslo, is a target of cGMP dependent protein kinase ... The TM cells were incubated with the fluorescent dye Calcein AM (Molecular Probes) at a concentration of 1 M for 1 hour in a ... Butt E, Pohler D, Genieser HG, Huggins JP, Bucher B. Inhibition of cyclic GMP dependent protein kinase mediated effects by (Rp) ...
  http://ufdc.ufl.edu/UFE0041178/00001
*  Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... cyclic-ADPribose, arachidonic acid,diacylglycerol and calcium-calmodulin. The cyclic-AMP dependent protein kinases (PKA) are ... such as Proteins--Structure and Molecular Properties, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993). ...
  http://www.patentgenius.com/patent/6410294.html
*  James Ferrell | Stanford Medicine Profiles
... calcium and norepinephrine stimulation of membrane protein phosphorylation is mediated by calmodulin-dependent spectrin kinase ... cyclic AMP, or cyclic GMP. ... PROTEIN-KINASE BY RENATURATION MOLECULAR AND CELLULAR BIOLOGY ... a 42-kDa protein related to mitogen-activated protein kinase or microtubule-associated protein-2 kinase (MAP kinase) and a 34- ... The protein kinase Mos is responsible for the activation of MEK1 and p42 mitogen-activated protein kinase during Xenopus oocyte ...
  https://med.stanford.edu/profiles/james-ferrell