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*  Regulation of the bioavailability of CCR7 ligands - Enlighten: Theses
CCRL1, a member of the atypical chemokine receptor family, binds to CCL19, CCL21 and CCL25 and is proposed to be a scavenger of ... The coordinated migration of cells into and within tissues is mediated by chemokines, a family of small chemotactic cytokines ... After their secretion, chemokines can be controlled by proteases and interactions with atypical chemokine receptors that ... inflammation-driven DC migration defects observed in CCRL1 deficient mice were completely reversed by genetic deletion of CCL19 ...
  http://theses.gla.ac.uk/5904/
*  Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen | Journal of Hematology & Oncology |...
In vitro transwell experiment further confirmed that MIP-3β recruits T-ALL cells which express a high level of MIP-3β receptor ... By screening a panel of cytokines/chemokines, a higher level of MIP-3β was found in the splenic microenvironment than BM ... Co-culture experiment found that the splenic microenvironment more potently stimulated the proliferation and migration of T-ALL ... MILLIPLEX® MAP Multiplex Immunoassay was performed to measure cytokine/chemokine levels in different microenvironments. ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-014-0071-7
*  Chemokine C Receptor 7 Expression and Protection of Circulating CD8+ T Lymphocytes from Apoptosis | Clinical Cancer Research
4). The protective dose of chemokines (200 ng/mL) was selected after preliminary titrations; higher concentrations of CCL19 or ... The chemokine receptor, CCR7, is well known for its role in migration of T cells and mature dendritic cells to secondary ... CXCR4, a member of CXCR family, is involved in survival of CD4+ T cells. CXCR4 activation in CD4+ T cells by its ligand, ... Chemokine C Receptor 7 Expression and Protection of Circulating CD8+ T Lymphocytes from Apoptosis. Jeong-Whun Kim, Robert L. ...
  http://clincancerres.aacrjournals.org/content/11/21/7901
*  Stimulating Lymphotoxin β Receptor on the Dendritic Cells Is Critical for Their Homeostasis and Expansion | The Journal of...
The ligands of CCR7 include secondary lymphoid tissue chemokine (CCL21) and EBV-induced molecule-1 ligand chemokine (CCL19), ... These chemokines were found to control the migration of DCs from peripheral tissues to lymph nodes (6, 7, 8). ... a receptor expressed by T lymphocytes; TNFSF14) is a TNF family member that also binds to LTβR and two other distinct members ... The dominant receptor in the mobilization of DCs from the periphery to lymphoid tissues is thought to be chemokine receptor ...
  http://www.jimmunol.org/content/175/10/6997
*  Galectin-1-Matured Human Monocyte-Derived Dendritic Cells Have Enhanced Migration through Extracellular Matrix | The Journal of...
CCL19 (MIP-3β), a lymph node homing chemokine for DCs that is the cognate ligand for CCR7, a chemokine receptor highly ... Chemokines and chemokine receptors play crucial roles in targeting DCs both to sites of inflammation and back to the secondary ... Galectins are a family of highly conserved β-galactoside-binding lectins that function in cell growth regulation, cell-cell ... DC Matrigel migration assays. RPMI 1640 medium containing 10% FBS plus 200 ng/ml CCL19 (MIP-3β) was placed in the bottom of a ...
  http://www.jimmunol.org/content/177/1/216
*  Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding | The Journal of Immunology
CXCL13 enhances CCL19-mediated chemotaxis. Next, we used a transwell migration assay to test whether the enhanced receptor ... Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the ... A model for chemokine cooperativity. (A) In the absence of cooperative chemokines, CCL19/CCL21 binds to its seven-transmembrane ... All wild-type chemokines were obtained from PeproTech (London, U.K.). 125I-labeled CCL19 ([125I]-CCL19) was from Perkin Elmer ( ...
  http://www.jimmunol.org/content/192/8/3908
*  Chemokine‐guided cell migration and motility in zebrafish development | The EMBO Journal
This migration depends on the chemokines CCL19 and CCL21, which activate the receptor CCR7 on DCs. CCL21 gradient formation ... The recent sequence analysis of the zebrafish genome provided a comprehensive list of chemokine and chemokine receptor family ... Figure 1. Human and zebrafish chemokine and chemokine receptor genes. Chemokine genes are listed according to their subgroup ( ... Zebrafish models of chemokine‐guided single‐cell migration. Primordial germ cell migration. Primordial germ cells (PGCs), the ...
  http://emboj.embopress.org/content/early/2015/03/11/embj.201490105
*  Chemokine - Wikipedia
CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ... are constitutively produced in certain tissues and are responsible for basal leukocyte migration. These include: CCL14, CCL19, ... C6-CC chemokines). C6-CC chemokines include CCL1, CCL15, CCL21, CCL23 and CCL28. CC chemokines induce the migration of ... The cytokine family database - Chemokines at kumamoto-u.ac.jp The correct chemokine nomenclature at rndsystems.com. ...
  https://en.wikipedia.org/wiki/Chemokine
*  Ackr4 - Atypical chemokine receptor 4 - Mus musculus (Mouse) - Ackr4 gene & protein
... or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 ... Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9 ... resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) ... Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, ...
  http://www.uniprot.org/uniprot/Q924I3
*  Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm | JEM
1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J ... 1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic ... Naive T cells and dendritic cells colocalize in the T cell zones, through actions of chemokines such as CCL19 (macrophage ... B cell activator belonging to the TNF family (BAFF), a newly identified cytokine for B cell responses (30), is one possibility. ...
  http://jem.rupress.org/content/192/11/F31
*  CCL19 - Wikipedia
Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of ... Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ... 2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines ... This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It ...
  https://en.wikipedia.org/wiki/CCL19
*  Plus it
Because chemokines are major players in the promotion of inflammation and cellular migration, the chemokine receptor US28 was ... ORF74 binds to a broad range of human chemokines from the CXC family (CXCL1, 2, 3, 4, 5, 6, 7, 8, 10, and 12) and CC family ( ... U12 from HHV-6 and HHV-7 bind the CC chemokines CCL2, CCL3, CCL4, and CCL5 (Isegawa et al., 1998) and CCL17, CCL19, CCL21, and ... Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src ...
  http://molpharm.aspetjournals.org/content/76/4/692
*  Human CCR7 Stable Cell Line-HEK293T Gαqi5 - Creative Biogene
This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and ... The protein encoded by this gene is a member of the G protein-coupled receptor family. ... The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by ... The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene ...
  https://www.creative-biogene.com/Human-CCR7-Stable-Cell-Line-HEK293T-G%CE%B1qi5-CSC-RG1719-1373011-11.html
*  CCL19 - C-C motif chemokine 19 precursor - Homo sapiens (Human) - CCL19 gene & protein
Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for ... May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. ... Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. ... help/family_and_domains_section' target='_top'>More...,/a>,/p>Family & Domainsi. ,p>This subsection of the 'Family and domains ...
  https://www.uniprot.org/uniprot/Q99731
*  Plus it
... there are NK cell-recruiting chemokines produced, like CCL5, CXCL10, and CCL19. Different chemokines and chemokine receptors ... D, because of migration of both cell types into the lymph node and also the presence of lymph node-residing NK cells, NK-DC ... Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 2001;276:37692-9. ... family (40, 41). The NK cell-activating receptors NKp30 and NKp46 are also involved in NK-DC cross-talk (42-44). Moreover, 2B4 ...
  http://clincancerres.aacrjournals.org/content/20/5/1095
*  The Multiple Personalities of the Chemokine Receptor CCR7 in Dendritic Cells | The Journal of Immunology
Nitric oxide and cGMP protein kinase (cGK) regulate dendritic cell migration toward the lymph node-directing chemokine CCL19. ... Differences in the functions elicited by stimulating CCR7 with CCL19 or CCL21 in DCs. The chemokines CCL19 and CCL21 were found ... 4 Abbreviations used in this paper: DC, dendritic cell; βγ, βγ subunits of G protein; cGK, cGMP protein kinase; Gi, Gi family ... Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of ...
  http://www.jimmunol.org/content/176/9/5153
*  Choreography of Cell Motility and Interaction Dynamics Imaged by Two-Photon Microscopy in Lymphoid Organs
Zlotnik A, Yoshie O, Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol ... FRCs secrete the chemokines CCL19, CCL21, and CXCL12 and stain most strongly for surface-bound CCL21 in the paracortex (25, 57 ... Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001;412:826-31. [PubMed] ... by dissecting the signaling pathway that leads from chemokine to receptor (G protein-coupled receptor, or GPCR) to G protein ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2732400/?lang=en-ca
*  US20110081408A1 - Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms - Google...
It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and ... The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine ... that binds to a chemokine or chemokine receptor selected from the group consisting of CCL1, CCL4, CCL17, CCL19, CCL21, CCL22, ... Methods for prevention and treatment of inflammation using anti-chemokine antibodies Family Applications Before (5). ...
  https://patents.google.com/patent/US20110081408A1/en
*  Produktübersicht anti-CCBP2 Antikörper
This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. ... Mouse (Murine) Chemokine Binding Protein 2 (CCBP2) Interaktionspartner * a comprehensive model of CCL19 (zeige CCL19 Antikörper ... Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the ... CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts ...
  https://www.antikoerper-online.de/abstract/Chemokine+Binding+Protein+2+
*  Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response | The Journal of...
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of ... The lymphoid chemokines CCL19 (ELC) and CCL21 (SLC), expressed on the HEVs (6), induce changes in the affinity of LFA-1 on ... Receptor activator for NF-κB (RANK) ligand (RANKL), another member of the larger TNF family, also participates in LN ... Both T cells and DCs are attracted to the paracortical region by their expression of CCR7, the receptor for CCL19 and CCL21. ...
  http://www.jimmunol.org/content/183/4/2205.full
*  Neuro-Immune Crosstalk in CNS Diseases | SpringerLink
Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH (2002) The chemokine receptor CXCR2 ... Lauro C, Catalano M, Trettel F, Mainiero F, Ciotti MT, Eusebi F, Limatola C (2006) The chemokines CX3CL1 reduces migration and ... Alt C, Laschinger M, Engelhardt B (2002) Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the ... Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383- ...
  https://link.springer.com/chapter/10.1007%2F400_2009_6
*  Chemokines in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
The chemokines CCL19 and CCL21 bind the receptor CCR7 to direct the migration of T cells and DCs into lymph nodes, where these ... Chemokine-Like Functions of Macrophage Migration Inhibitory Factor. *Immune-Regulatory Chemokines CCL19 and CCL21 in Vascular ... atherosclerotic plaques and in monocyte/macrophages is regulated by the Rel proteins p50 and p65 belonging to the NF-κB family ... Chemokine-Like Functions of Macrophage Migration Inhibitory Factor. *Immune-Regulatory Chemokines CCL19 and CCL21 in Vascular ...
  http://atvb.ahajournals.org/content/28/11/1897.long
*  Lymphoid Hematopoiesis and Lymphocytes Differentiation and Maturation | IntechOpen
The thymus colonization by immature lymphocytes, also known as thymocytes, enrolls chemokines, mainly CC‐chemokine ligand 21 ( ... 12 family, contributes to STAT1 phosphorylation and T‐bet activation. T‐bet enhances the synthesis of the IL‐12 receptor, which ... Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and ... Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. European Journal of ...
  https://www.intechopen.com/books/lymphocyte-updates-cancer-autoimmunity-and-infection/lymphoid-hematopoiesis-and-lymphocytes-differentiation-and-maturation/
*  CCR7: Unifying Disparate Journeys to the Lymph Node | The Journal of Immunology
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of ... As data on chemokine biology emerged, it became clear that some chemokines were homeostatic (4), produced constitutively, ... highly potent family of polypeptides that regulated immune cell chemotaxis (3). Prior to this time, known chemoattractants were ... These ligands are now called CCL19 and CCL21 using the new, more facile nomenclature that Zlotnik and Yoshie (14) devised. The ...
  http://www.jimmunol.org/content/196/1/3
*  CCR7 Signals Are Essential for Cortex-Medulla Migration of Developing Thymocytes | JEM
... none of the chemokines or chemokine receptors that are involved in the regulation of the cortex-medulla migration of thymocytes ... Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 412:826-831. ... and CCL19-Ig. (H) CCL19-Ig staining profiles of DP thymocytes from 2C-TCR transgenic mice of positively selecting H-2k/b ... suggesting that G protein-coupled receptor signals, e.g., the signals via chemokine receptors, may be involved in the ...
  http://jem.rupress.org/content/200/4/493