*  Exbio antibodies - Mouse Monoclonal to alpha, beta-tubulin dimer TU-10 (IgM)
In vivo, microtubule dynamics vary considerably. Microtubule polymerization is reversible and a populations of microtubules in ... Microtubules have their intrinsic polarity; highly dynamic plus ends and less dynamic minus ends. Microtubules are required for ... In mammalian tissue culture cells microtubules have their minus ends anchored in microtubule organizing centers (MTOCs). The ... The microtubules are intracellular dynamic polymers made up of evolutionarily conserved polymorphic alpha/beta-tubulin ...
  http://www.exbio.cz/products/clone.py?idclone=CLO000000000000287
*  Microtubule Orientation in the Brassinosteroid Mutants lk, lka and lkb of Pea - Open Access Repository
Knowles, CL and Koutoulis, A and Reid, JB (2004) Microtubule Orientation in the Brassinosteroid Mutants lk, lka and lkb of Pea. ... the microtubules (MTs). This study adds to our. knowledge the fact that brassinolide (BL) can cause. MT realignment in azuki ... Microtubule Orientation in the Brassinosteroid Mutants lk, lka and lkb of Pea ...
  https://eprints.utas.edu.au/12566/
*  SLAIN Motif Family, Member 2 - CAGS
... recruiting it to the microtubule plus ends and thus ensuring microtubule elongation. ... Microtubules (MTs) are filamentous structures found throughout the cytoplasm of eukaryotic cells. They are polymers of tubulin ... Microtubules are also essential in several key cellular processes such as cell division and intracellular transport. ... Proteins that accumulate at the ends of growing microtubules, known as MT plus end-tracking proteins, play an important role in ...
  http://cags.org.ae/ctga/details.aspx?id=2443&se=Latest
*  Microtubule Self-Assembly Kinetics - Durham University
Microtubule assembly and disassembly is vital for many fundamental cellular processes. Our current understanding of microtubule ... This is because there is a shift in microtubule tip structure from relatively blunt at low free concentrations to relatively ... Together, our studies lead to a major revision of kinetic estimates of microtubule assembly, and provide a new perspective on ... Biomathematics Seminar: Microtubule Self-Assembly Kinetics. Presented by Davide Odde, University of Minnesota ...
  https://www.dur.ac.uk/mathematical.sciences/events/seminars/seminararchives/?seminar=3361
*  Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 |...
Effects of siRNA-induced CAPN6 knockdown on the association of GEF-H1 with microtubules and active Rac1. (A,B) Microtubule co- ... 5A,B). In this assay, the total amount of microtubules sedimented (stabilized microtubules) was the same in control and Capn6- ... The initial polarization of microtubule assembly is led by actin filaments, and conversely the polarized microtubules ... we have demonstrated that CAPN6 can bind to microtubules, mainly through domain III, and induce microtubule stabilization ...
  http://jcs.biologists.org/content/124/8/1214
*  CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content | JCB
... that bridge the transition zone microtubules with the membrane are missing from most cep290 doublet microtubules. Insets in C ... Microtubule-membrane interactions in Chlamydomonas flagella. In The Chlamydomonas Sourcebook. Volume 3. G.B. Witman, editor. ... Basal bodies and microtubules. J. Cell Biol. 38:403-425. doi:10.1083/jcb.38.2.403. ... I. Isolation and electrophoretic analysis of microtubules, matrix, membranes, and mastigonemes. J. Cell Biol. 54:507-539. doi: ...
  http://jcb.rupress.org/content/190/5/927
*  Dynein and Mast/Orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics | Journal of Cell...
... microtubules, cell cortex, centrosomes and microtubule plus-ends (Dujardin and Vallee, 2002; Hays et al., 1994; Pfarr et al., ... microtubule plus-end incorporation in the absence of both proteins (Mast and dynein) might be restored because microtubules are ... because plus-end microtubule polymerization was restored. To test this possibility, we analyzed the microtubule plus-end ... which does not contain the microtubule-binding domain) could be seen streaming poleward along spindle microtubules (Fig. 2B; ...
  http://jcs.biologists.org/content/122/14/2543
*  Nanoscale Force Generation and Rigidity of Isotypically Purified b-Tubulin Microtubules
Nanoscale Force Generation and Rigidity of Isotypically Purified β-Tubulin Microtubules. K Beinert and J A Tuszynski*. ... Microtubules are one of three cytoskeletal filaments found in eukaryotic cells, which exhibit a constant transition between ... We have investigated microtubule dynamics found in isotypically purified β-tubulin in order to understand how different ... The rate constants determined by our model were found to vary significantly between β-II, β-III, and β-IV microtubules. This ...
  http://www.foresight.org/Conferences/AdvNano2004/Abstracts/Beinert/index.html
*  Plant microtubules | Journal of Cell Science
Similarly, a homologue of the microtubule-severing protein katanin p60 also plays an essential role in cortical microtubule ... which form crossbridges between adjacent microtubules and maintain microtubule spacing. It is a relative of the Dis1/TOG/ ... Microtubules in animal cells at interphase generally form highly organized radial arrays anchored by centrosomes. Plant ... Highly similar MAPs thus appear able to coordinate remarkably different microtubule organization strategies. ...
  http://jcs.biologists.org/content/115/7/e702
*  Yeast microtubules run out of Amo | Journal of Cell Science
... suggest that the interplay between the nucleus and microtubules is important for the regulation of microtubule dynamics. ... Microtubules play a central role in cell division and cell polarity in eukaryotic cells. Fission yeast represents a useful ... The phenotype of amo1Δ cells indicates that Amo1 helps to regulate microtubule growth, cell-end termination and cell polarity. ... However, Pardo and Nurse find no evidence that the loading of factors affecting microtubule dynamics is defective in amo1Δ ...
  http://jcs.biologists.org/content/118/8/e802
*  Plus it
The antitumor efficacy of some taccalonolides, which stabilize microtubules in a manner different from other microtubule ... Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity. A.L. Risinger, J. Li, M.J. Bennett ... AF and AJ caused aberrant mitotic spindles and bundling of interphase microtubules that differed from the effects of either ... AJ also distinctly affected microtubule polymerization in that it enhanced the rate and extent of polymerization in the absence ...
  http://cancerres.aacrjournals.org/content/early/2013/11/07/0008-5472.CAN-13-1346
*  MAPless microtubule dynamics | Journal of Cell Science
For example, the authors show that the persistent growth of microtubules does not require the activity of microtubule- ... Microtubules - polymers of tubulin - are important components of the cytoskeleton. They constantly cycle between periods of ... Overall, the authors' findings provide a foundation for a better understanding of microtubule dynamics. In addition, they ... associated proteins (MAPs) but is an inevitable consequence of a nucleated system of dynamic microtubules polymerizing in a ...
  http://jcs.biologists.org/content/119/22/e2204
*  MAP65 Coordinate Microtubule Growth during Bundle Formation
In cooperation with microtubule-associated proteins (MAPs), MTs form bundles endowing cells with specific mechanisms to control ... Microtubules (MTs) are highly dynamical structures that play a crucial role in cell physiology. ... Microtubules Is the Subject Area "Microtubules" applicable to this article? Yes. No. ... Microtubules (MTs) are highly dynamical structures that play a crucial role in cell physiology. In cooperation with microtubule ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056808
*  Colchicine effect on microtubules
Ligands; Microtubule-Associated Proteins/isolation & purification; Microtubule-Associated Proteins/metabolism; Microtubules/ ... Colchicine Inhibition of Microtubule. Pathogen via Copolymer. Formation*. (Possible for colchicine effect on microtubules, ... Main / Summer Savings / Colchicine effect on microtubules Mechanism of inhibition of microtubule polymerization by colchicine: ... Quantitation of the Antidepressant ofCD Complexon Microtubule. Infusion. Microtubule assembly at. Unlike cold or allergy sinus ...
  http://geptsite.info/summer-savings/colchicine-effect-on-microtubules.php
*  Microtubule plus-end binding protein EB1 is necessary for muscle cell differentiation, elongation and fusion | Journal of Cell...
The mutated EB1-GFP decorated microtubule plus-ends or the whole length of the microtubules depending on the expression level ( ... Considering that EB1 is the isoform necessary for microtubule stabilization in fibroblasts and that microtubule stabilization ... the staining appears to spread from the microtubule plus-ends to the total length of microtubules. We do not know whether this ... show the comet-like pattern and a finer punctate staining along microtubules (arrow). The microtubule plus-end EB1 comets are ...
  http://jcs.biologists.org/content/122/9/1401
*  Cell microtubules, anaglyph 3D - Stock Video Clip K003/4489 - Science Photo Library
This clip shows the microtubules of the cell's cytoskeleton, surrounded by proteins in the cytoplasm, with the motor protein ... Cell microtubules, anaglyph 3D animation. Clip 4 of 10. This clip forms part of an animation sequence showing protein ... microtubule, microtubules, modelled, molecular, molecule, molecules, motor protein, moving, nanoscale, protein, protein ... Caption: Cell microtubules, anaglyph 3D animation. Clip 4 of 10. This clip forms part of an animation sequence showing protein ...
  http://www.sciencephoto.com/media/477202/view
*  DSpace at IIT Bombay: Transcription factor NF-kappa B associates with microtubules and stimulates apoptosis in response to...
Using TN16, a known microtubule targeting agent, we found that microtubule dynamics plays a critical role in NF-kappa B- ... Transcription factor NF-kappa B associates with microtubules and stimulates apoptosis in response to suppression of microtubule ... microtubule interaction. Treatment of cells with low concentrations of TN16 (25 and 50 nM) that suppressed microtubule dynamics ... Here, we found that NF-kappa B is associated with polymeric tubulin and co-localized with microtubules in MCF-7 cells. ...
  http://dspace.library.iitb.ac.in/jspui/handle/100/17569
*  Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission | Journal of Cell Science
Finally, we show that central spindle microtubule reorganization is driven by localized microtubule buckling and breaking, ... Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission. John A. Schiel, Kristin Park, Mary ... Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission. John A. Schiel, Kristin Park, Mary ... Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission. John A. Schiel, Kristin Park, Mary ...
  http://jcs.biologists.org/content/early/2011/04/12/jcs.081448
*  NuMA-tic Motoring | Science
... a complex of the microtubule motor protein dynein and dynactin powers NuMA transport along microtubules to the polar region. ... During mitosis, two arrays of microtubules form the bipolar mitotic spindle in order to effect partitioning of the duplicated ... and a protein known as NuMA is needed to properly gather the ends of the microtubules at the poles. ... perhaps through binding of the individual microtubules to a NuMA multimer. Disruption of NuMA transport by addition of the ...
  http://science.sciencemag.org/content/288/5471/1551.2
*  Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. | Kaverina Lab
An organized microtubule array is essential for the polarized motility of fibroblasts. Dynamic microtubules closely interact ... Here, we examined the effect of focal adhesions on microtubule dynamics. We observed that the probability of microtubule ... We suggest that paxillin influences microtubule dynamics at focal adhesions by serving as a scaffold for a putative catastrophe ... Analysis of the dependence between the microtubule growth rate and catastrophe probability throughout the cytoplasm revealed ...
  https://medschool.vanderbilt.edu/kaverina-lab/publication/paxillin-dependent-stimulation-microtubule-catastrophes-focal-adhesion-sites
*  Astral microtubules - Wikipedia
Astral microtubules are a subpopulation of microtubules, which only exist during and immediately before mitosis. They are ... The turn-over rate of this population of microtubules is higher than any other population. The role of astral microtubules is ... The maintenance of astral microtubules is dependent on the integrity of centrosome. It is also dependent on several microtubule ... Astral microtubules develop in the actin skeleton and interact with the cell cortex to aid in spindle orientation. They are ...
  https://en.wikipedia.org/wiki/Astral_microtubules
*  Microtubule - Wikipedia
An astral microtubule is a microtubule originating from the MTOC that does not connect to a chromosome. Astral microtubules ... Both microtubule stabilizers and destabilizers can suppress microtubule dynamics. The drugs that can alter microtubule dynamics ... The mitotic spindle includes the spindle microtubules, microtubule-associated proteins (MAPs), and the MTOC. The microtubules ... In contrast to the 13 protofilaments of eukaryotic microtubules, bacterial microtubules comprise only five. Microtubules are ...
  https://en.wikipedia.org/wiki/Microtubule
*  Microtubule nucleation - Wikipedia
This method of microtubule-dependent microtubule nucleation leads to rapid amplification in microtubule number, and creates ... In cell biology, microtubule nucleation is the event that initiates de novo formation of microtubules (MTs). These filaments of ... The microtubule-binding protein doublecortin, in vitro, nucleates microtubules-acting by binding to the side rather than the ... ends from which microtubules can grow. In this fashion dynamic arrays of microtubules can be generated without the aid of the γ ...
  https://en.wikipedia.org/wiki/Microtubule_nucleation
*  Microtubules, assemble! | EurekAlert! Science News
Paulson School of Engineering and Applied Sciences have observed how microtubules and motor proteins assemble into macroscopic ... The answer lay not in the microtubules but in the behavior of the motor protein. Microtubules have plus and minus ends and ... "We know how motor proteins interact with microtubules but how do you go from individual microtubules and motor proteins to ... Microtubules are a critical component of the cytoskeleton, vital for cell division and, because of that, an excellent target ...
  https://www.eurekalert.org/pub_releases/2016-01/hjap-ma012816.php
*  Microtubule organizing center - Wikipedia
Organization of the microtubules at the MTOC, or centrosome in this case, is determined by the polarity of the microtubules ... Microtubule-organizing centers function as the site where microtubule formation begins, as well as a location where free-ends ... The microtubule-organizing center (MTOC) is a structure found in eukaryotic cells from which microtubules emerge. MTOCs have ... Within the cells, microtubule-organizing centers can take on many different forms. An array of microtubules can arrange ...
  https://en.wikipedia.org/wiki/Microtubule_organizing_center