*  ADME Services
Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe ... Our CYP and UGT inhibition services are conducted with Corning UltraPool® HLM 150 pooled human liver microsomes, drug probe ... Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated ... Using our well-known Corning Supersomes™ enzymes, human liver microsomes, or hepatocytes, we will evaluate enzyme-mediated ...
  https://www.corning.com/ru/ru/products/life-sciences/support-main/services/amde-services.html
*  Plus it
Human Liver Microsomes and Expression of UGT Proteins.. Human livers (HL 7, 10, 12, 13, and 40) were obtained from the human ... human liver microsomes. IV-IVE. in vitro-in vivo extrapolation. Ki. inhibitor constant. Km. Michaelis constant. UGT. UDP- ... Binding of codeine and inhibitors to human liver microsomes (1 mg/ml) in the absence and presence of bovine serum albumin (2% w ... Inhibition experiments with pooled HLM, prepared by mixing equal protein amounts of microsomes from the five livers used in the ...
  http://jpet.aspetjournals.org/content/334/2/609
*  IJMS | Free Full-Text | Inhibitory Effects of Dimethyllirioresinol, Epimagnolin A, Eudesmin, Fargesin, and Magnolin on...
... in human liver microsomes. Fargesin negligibly inhibited CYP1A2-catalyzed phenacetin O-deethylation, CYP2A6-catalyzed coumarin ... hydroxylation at 100 μM in human liver microsomes. Dimethyllirioresinol weakly inhibited CYP2C19 and CYP2C8 with IC50 values of ... enzyme activities in human liver microsomes were evaluated using liquid chromatography-tandem mass spectrometry to determine ... showed no the reversible and time-dependent inhibition of eight major CYP activities at 100 μM in human liver microsomes. These ...
  http://www.mdpi.com/1422-0067/18/5/952
*  AID 632143 - Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by...
Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by plate reader ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/632143
*  AID 724299 - Inhibition of CYP2C9 in pooled human liver microsomes assessed as reduction in enzyme-mediated (S)-warfarin 7...
Inhibition of CYP2C9 in pooled human liver microsomes assessed as reduction in enzyme-mediated (S)-warfarin 7-hydroxylation by ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/724299
*  AID 33221 - The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being...
The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/33221
*  Gentaur Molecular :SeraLab \ Beagle Liver Microsomes \ MIC-114
Beagle Liver Microsomes \ MIC-114 for more molecular products just contact us ... We have also other products like : Beagle Liver Microsomes Related products : Beagle Liver Microsomes ... MIC-114 Beagle Liver Microsomes Ask technical file .. Price. : Ask Price ! Product name : Beagle Liver Microsomes ... Index / SeraLab / Beagle Liver Microsomes / Product Detail : MIC-114 Beagle Liver Microsomes Related keywords: ...
  http://www.antibody-antibodies.com/product_det.php?id=2773966&supplier=search&name=Beagle%20Liver%20Microsomes%20
*  AID 754306 - Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins assessed per 0...
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins assessed per 0.5 mg of ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/754306
*  Liver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - JP
... microsomes & other liver subcellular fractionsLarge pooled lots for reproducible, long-term studiesFractions carefully isolated ... Table 1 - Relevant applications for liver subcellular fractions Metabolic Enzymes Liver Microsomes Liver S9 Fractions Liver ... Table 3 - Kinetic parameters for the GIBCO® 50 donor human liver microsome pool Isoform Metabolite Km(μM) Vmax (nmol/min/mg) ... Human microsome pools and subcellular fractions Subcellular fractions, derived from the endoplasmic reticulum of liver, contain ...
  https://www.thermofisher.com/jp/en/home/industrial/pharma-biopharma/drug-discovery-development/microsomes-s9-fractions-cytosol.html
*  JCI - Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.
Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.. S ... Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. Accordingly, ... 7-dehydrocholesterol into cholesterol by liver microsomes from seven controls and four Smith-Lemli-Opitz homozygous subjects. ... that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs ...
  https://www.jci.org/articles/view/118223
*  Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes | Springer for Research & Development
Incorporation of 14C into the phospholipid components of the liver microsomes isolated by a conventional method was determined ... Leyck S., Freundt K.J. (1978) Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes. In: Deutsche ... strongly with an inhibition of MFO as shown by a decrease in the O-demethylation of p-nitroanisol in prepared liver microsomes ... After 16 h the livers were subjected to extracorporeal perfusion for 1 h, the perfusate containing ca. 10 μCi u 14C glucose/100 ...
  https://rd.springer.com/chapter/10.1007/978-3-662-39532-5_76
*  Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. | Drug Metabolism & Disposition
Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Message Subject (Your Name) has forwarded a page ...
  http://dmd.aspetjournals.org/content/6/4/379
*  Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes - ZHANG - 2008 -...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7254.2008.00908.x/pdf
*  Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences | Drug Metabolism & Disposition
Liver Microsomes.. The liver tissue used in this study was obtained from mature male greyhound, beagle, and mixed-breed dogs ( ... Liver microsomes were diluted with phosphate buffer and 50 μl was added to each tube. Next, 100 μl of an NADPH-regenerating ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ...
  http://dmd.aspetjournals.org/content/27/11/1293
*  In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes | Drug Metabolism &...
human liver microsome. HPLC. high-performance liquid chromatography. LC-MS/MS. liquid chromatography-tandem mass spectrometry. ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ...
  http://dmd.aspetjournals.org/content/39/4/627.short
*  6 alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
... Araya, Z Uppsala ... Fourteen recombinant expressed cytochrome P450 (CYP) enzymes, human liver microsomes from different donors, and selective ... bile acid; 6 alpha-hydroxylation; CYP3A4; human liver; BILE-ACIDS; PIG-LIVER; METABOLISM; URINE; CYTOCHROME-P-450; ... The aim of the present study was to identify the enzymes in human liver catalyzing hydroxylations of bile acids. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:112787
*  AID 31223 - Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome - PubChem
BioAssay record AID 31223 submitted by ChEMBL: Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/31223
*  Identification of Cytochrome P450 Isoforms Involved in CitalopramN-Demethylation by Human Liver Microsomes | Journal of...
Human liver microsomes.. Human liver samples (n = 14) were obtained, as excess material removed during surgery on the liver, ... Assay with human liver microsomes.. The basic incubation medium contained 0.1 or 0.2 mg/ml microsomes, 0.5 mM NADP+, 2.0 mM ... in human liver microsomes.. The immunoinhibition of CIT N-demethylation was examined by preincubating human liver microsomal ... Kinetic profile of CIT N-demethylation in human liver microsomes.. Eadie-Hofstee plots for the N-demethylation of CIT (2.5-500 ...
  http://jpet.aspetjournals.org/content/280/2/927
*  Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine...
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine ... Human liver microsomal CYP2B6 activities were investigated using bupropion hydroxylation as probe substrate marker. The results ... In conclusion, the results from this study demonstrated that MAO inhibitors can inactivate human liver microsomal CYP2B6. The ... study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes ...
  http://www.sigmaaldrich.com/catalog/papers/25656918
*  Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver...
Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. ...
  http://jpet.aspetjournals.org/content/277/2/982
*  Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes |...
In the present investigation it was found that benzene was metabolized at a rate 20-65-fold higher in liver microsomes from ... The data indicate that benzene is metabolized mainly by the ethanol-inducible P-450 form in liver microsomes and that the ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes. ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes ...
  http://cancerres.aacrjournals.org/content/48/19/5387
*  Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.
... ... METHODS: Using pooled human liver microsomes, the in vitro inhibitory effects of isoniazid on CYP1A2 (phenacetin O-deethylation ... CYP2C19 and CYP3A4 in human liver microsomes. Co-administration of isoniazid and drugs that are primarily metabolised by these ...
  https://www.omicsonline.org/references/isoniazid-is-a-mechanismbased-inhibitor-of-cytochrome-p450-1a2-2a6-2c19-and-3a4-isoforms-in-human-liver-microsomes-1363160.html
*  AID 706454 - Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS...
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS analysis. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/706454
*  In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP...
In liver microsomes, phenolic glucuronidation was the highest in mice for T4 and in rats for T3 and lowest in monkeys for both ... In human liver microsomes, phenolic glucuronide was formed in higher amounts than acyl glucuronide for T4; in contrast, the ... Alamethicin (50 μg/mg protein) was mixed with liver microsomes for use in incubations. T4 or T3 in 5 μl of methanol was added ... To evaluate the effect of pH on the formation of T4 glucuronides, T4 was incubated with human liver microsomes at pH 6.8 and ...
  http://dmd.aspetjournals.org/content/35/12/2203