*  Plus it
Human Liver Microsomes and Expression of UGT Proteins.. Human livers (HL 7, 10, 12, 13, and 40) were obtained from the human ... human liver microsomes. IV-IVE. in vitro-in vivo extrapolation. Ki. inhibitor constant. Km. Michaelis constant. UGT. UDP- ... Binding of codeine and inhibitors to human liver microsomes (1 mg/ml) in the absence and presence of bovine serum albumin (2% w ... Inhibition experiments with pooled HLM, prepared by mixing equal protein amounts of microsomes from the five livers used in the ...
  http://jpet.aspetjournals.org/content/334/2/609
*  IJMS | Free Full-Text | Inhibitory Effects of Dimethyllirioresinol, Epimagnolin A, Eudesmin, Fargesin, and Magnolin on...
... in human liver microsomes. Fargesin negligibly inhibited CYP1A2-catalyzed phenacetin O-deethylation, CYP2A6-catalyzed coumarin ... hydroxylation at 100 μM in human liver microsomes. Dimethyllirioresinol weakly inhibited CYP2C19 and CYP2C8 with IC50 values of ... enzyme activities in human liver microsomes were evaluated using liquid chromatography-tandem mass spectrometry to determine ... showed no the reversible and time-dependent inhibition of eight major CYP activities at 100 μM in human liver microsomes. These ...
  http://www.mdpi.com/1422-0067/18/5/952
*  AID 632143 - Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by...
Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by plate reader ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/632143
*  AID 724299 - Inhibition of CYP2C9 in pooled human liver microsomes assessed as reduction in enzyme-mediated (S)-warfarin 7...
Inhibition of CYP2C9 in pooled human liver microsomes assessed as reduction in enzyme-mediated (S)-warfarin 7-hydroxylation by ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/724299
*  AID 33221 - The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being...
The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/33221
*  Gentaur Molecular :SeraLab \ Beagle Liver Microsomes \ MIC-114
Beagle Liver Microsomes \ MIC-114 for more molecular products just contact us ... We have also other products like : Beagle Liver Microsomes Related products : Beagle Liver Microsomes ... MIC-114 Beagle Liver Microsomes Ask technical file .. Price. : Ask Price ! Product name : Beagle Liver Microsomes ... Index / SeraLab / Beagle Liver Microsomes / Product Detail : MIC-114 Beagle Liver Microsomes Related keywords: ...
  http://www.antibody-antibodies.com/product_det.php?id=2773966&supplier=search&name=Beagle%20Liver%20Microsomes%20
*  AID 754306 - Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins assessed per 0...
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins assessed per 0.5 mg of ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/754306
*  JCI - Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.
Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.. S ... Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. Accordingly, ... 7-dehydrocholesterol into cholesterol by liver microsomes from seven controls and four Smith-Lemli-Opitz homozygous subjects. ... that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs ...
  https://www.jci.org/articles/view/118223
*  Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes | Springer for Research & Development
Incorporation of 14C into the phospholipid components of the liver microsomes isolated by a conventional method was determined ... Leyck S., Freundt K.J. (1978) Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes. In: Deutsche ... strongly with an inhibition of MFO as shown by a decrease in the O-demethylation of p-nitroanisol in prepared liver microsomes ... After 16 h the livers were subjected to extracorporeal perfusion for 1 h, the perfusate containing ca. 10 μCi u 14C glucose/100 ...
  https://rd.springer.com/chapter/10.1007/978-3-662-39532-5_76
*  Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. | Drug Metabolism & Disposition
Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Message Subject (Your Name) has forwarded a page ...
  http://dmd.aspetjournals.org/content/6/4/379
*  Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes - ZHANG - 2008 -...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7254.2008.00908.x/pdf
*  Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences | Drug Metabolism & Disposition
Liver Microsomes.. The liver tissue used in this study was obtained from mature male greyhound, beagle, and mixed-breed dogs ( ... Liver microsomes were diluted with phosphate buffer and 50 μl was added to each tube. Next, 100 μl of an NADPH-regenerating ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ...
  http://dmd.aspetjournals.org/content/27/11/1293
*  6 alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
... Araya, Z Uppsala ... Fourteen recombinant expressed cytochrome P450 (CYP) enzymes, human liver microsomes from different donors, and selective ... bile acid; 6 alpha-hydroxylation; CYP3A4; human liver; BILE-ACIDS; PIG-LIVER; METABOLISM; URINE; CYTOCHROME-P-450; ... The aim of the present study was to identify the enzymes in human liver catalyzing hydroxylations of bile acids. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:112787
*  Identification of Cytochrome P450 Isoforms Involved in CitalopramN-Demethylation by Human Liver Microsomes | Journal of...
Human liver microsomes.. Human liver samples (n = 14) were obtained, as excess material removed during surgery on the liver, ... Assay with human liver microsomes.. The basic incubation medium contained 0.1 or 0.2 mg/ml microsomes, 0.5 mM NADP+, 2.0 mM ... in human liver microsomes.. The immunoinhibition of CIT N-demethylation was examined by preincubating human liver microsomal ... Kinetic profile of CIT N-demethylation in human liver microsomes.. Eadie-Hofstee plots for the N-demethylation of CIT (2.5-500 ...
  http://jpet.aspetjournals.org/content/280/2/927
*  Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine...
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine ... Human liver microsomal CYP2B6 activities were investigated using bupropion hydroxylation as probe substrate marker. The results ... In conclusion, the results from this study demonstrated that MAO inhibitors can inactivate human liver microsomal CYP2B6. The ... study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes ...
  http://www.sigmaaldrich.com/catalog/papers/25656918
*  Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver...
Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. ...
  http://jpet.aspetjournals.org/content/277/2/982
*  Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.
... ... METHODS: Using pooled human liver microsomes, the in vitro inhibitory effects of isoniazid on CYP1A2 (phenacetin O-deethylation ... CYP2C19 and CYP3A4 in human liver microsomes. Co-administration of isoniazid and drugs that are primarily metabolised by these ...
  https://www.omicsonline.org/references/isoniazid-is-a-mechanismbased-inhibitor-of-cytochrome-p450-1a2-2a6-2c19-and-3a4-isoforms-in-human-liver-microsomes-1363160.html
*  AID 706454 - Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS...
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS analysis. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/706454
*  In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP...
In liver microsomes, phenolic glucuronidation was the highest in mice for T4 and in rats for T3 and lowest in monkeys for both ... In human liver microsomes, phenolic glucuronide was formed in higher amounts than acyl glucuronide for T4; in contrast, the ... Alamethicin (50 μg/mg protein) was mixed with liver microsomes for use in incubations. T4 or T3 in 5 μl of methanol was added ... To evaluate the effect of pH on the formation of T4 glucuronides, T4 was incubated with human liver microsomes at pH 6.8 and ...
  http://dmd.aspetjournals.org/content/35/12/2203
*  Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation | Drug Metabolism ...
human liver microsomes. LC. liquid chromatography. MH+. protonated molecular ions. MS. mass spectrometry. MSn. multiple stage ... Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation. Yanlin Zhu, Fen ... Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation ... in human liver microsomes (HLM), and to identify the cytochrome P450 (P450) enzyme(s) involved in the M9 formation. Liquid ...
  http://dmd.aspetjournals.org/content/42/2/245
*  Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes |...
Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... When [3H]benzo[a]pyrene is incubated in vitro together with deproteinized salmon sperm DNA, NADPH, and mouse liver microsomes, ...
  http://molpharm.aspetjournals.org/content/14/2/306
*  Contribution of CYP3A4, CYP2B6, and CYP2C9 Isoforms toN-Demethylation of Ketamine in Human Liver Microsomes | Drug Metabolism &...
Liver to plasma concentration ratio of ketamine was taken into consideration. Pooled human liver microsomes and human ... Quentin, France). Human liver microsomes from seven donors and pooled microsomal preparations prepared from 20 livers were ... Ketamine (0.05 mM) was incubated with of human liver microsomes (0.5 mg/ml) obtained from seven donors. The livers showing ... average content of CYP3A4 was 146 pmol/mg of human liver microsomes and that of CYP2C9 was 89 pmol/mg of human liver microsomes ...
  http://dmd.aspetjournals.org/content/30/7/853
*  Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes | Drug...
The metabolic profile in dog liver microsomes was also different from human liver microsomes, with the contribution of 13X to ... 1 mg/ml dog or human liver microsomes, and 0.8 mM NADPH. For human liver microsomes, inhibitory effects of 1 μM ANF were also ... 0.8 mg/ml dog or human liver microsomes, and 0.8 mM NADPH. For human liver microsomes, inhibitory effects of 1 μM ANF were also ... 0.5 mg/ml dog or human liver microsomes, and 0.8 mM NADPH. For human liver microsomes, inhibitory effects of 1 μM ANF, human ...
  http://dmd.aspetjournals.org/content/36/9/1903
*  1 - Cara membaca forex factory dalam bahasa indonesia
There are three main approaches utilized in CYP isozyme identification in human liver microsomes (117,138,139): (I) metabolism ...
  http://forexsignalhere.com/cara-membaca-forex-factory-dalam-bahasa-indonesia.html