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*  北京大学医学部机构知识库(IR@PKUHSC): AGEs mediated expression and secretion of TNF alpha in rail retinal microglia
... we attempted to confirm that AGEs induce the release of TNF alpha from rat retinal microglia using an in vitro microglia ... The degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. We have ... AGEs increased the protein secretion and mRNA expression of TNF alpha in cultured rat retinal microglia. These effects of AGEs ... AGEs-activated microglia showed an increase of NFkB p65 nuclear translocation. These observations indicated that ...
  http://ir.bjmu.edu.cn/handle/400002259/55593
*  JAIRO | A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates...
A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates ... Degeneration of Injured NeuronsA DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve ...
  http://jairo.nii.ac.jp/0002/00019186/en
*  Synergistic Destruction: How Vaccines and GMOs Converge to Fuel Autism and Neurodegenerative Conditions | Kinsei
In short, the microglia are the resident immune cells within the central nervous system. They are known to exist in two ... That "surveillance mode" role of the microglia, can be shifted into an inflammatory and destructive state where they secrete ... play key roles in determining the threshold by which the microglia may be shifted into the destructive activation state.(12) ... I touched on in the post was that maintaining sufficient levels of glutathione and SOD are critical for keeping the microglia ...
  http://kinseimindbody.com/synergistic-destruction-how-vaccines-and-gmos-converge-to-fuel-autism-and-neurodegenerative-conditions/?replytocom=6442
*  Why Good Microglia Turn Bad-A Matter of Timing? | ALZFORUM
Initially, newly recruited microglia act to clear Aβ, but with time, they lose their ability to take up and degrade the peptide ... "We have found in the past that microglia can be both protective and detrimental, and I think this paper shows that at some ... Why Good Microglia Turn Bad-A Matter of Timing?. Quick Links. *Article ... The results offer a nuanced view of microglia action in AD, and suggest that anti-inflammatory therapy for the disease should ...
  http://www.alzforum.org/news/research-news/why-good-microglia-turn-bad-matter-timing
*  Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-β Protein in Alzheimer's Disease Brain | Stroke
... and HLA-DR for microglia (green, bottom right). Microglia are seen in the center of the Aβ deposits (arrow), which have no ... Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol ... microglia. Deposition of amyloid-β protein (Aβ) is one of the most salient pathological features in the AD brain. In addition ... Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett. 1990;119:32-36. ...
  http://stroke.ahajournals.org/content/28/10/1948
*  The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood | The Journal of...
Adult microglia exhibit a CX3CR1-GFP+ CCR2-RFP−-expressing pattern, and microglia do not show significant CCR2RFP expression ... Juba considered microglia to be derived from invading mesodermal elements because microglia-like cells were also detected ... Microglia. In Cytology and Cellular Pathology of the Nervous System. Penfield W., ed. Paul B. Hoeber, New York, p. 481-584. ... The distribution of microglia and cell death in the fetal rat forebrain. Brain Res. Dev. Brain Res. 58: 1-12. ...
  http://www.jimmunol.org/content/188/1/29.full
*  Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis | Journal of Cell Science
After stimulation of microglia with interferon-γ, we observe an upregulation of MHC class II in a subpopulation of microglia. ... Activation of microglia by IFNγ leads to an upregulation of MHC class II in a subpopulation of microglia. However, ... Because all these findings relied on cultured microglia, we wanted to verify that exosomes are also taken up by microglia in ... Next, we wanted to determine by which endocytic pathway microglia use to take up exosomes. Microglia are capable of different ...
  http://jcs.biologists.org/content/124/3/447
*  Most recent papers with the keyword Telomere microglia | Read by QxMD
Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia ... and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, ... Mitotic activity of microglia suggests that they have limited life spans and rely on self-renewal to replace senescent cells. ... During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown ...
  https://www.readbyqxmd.com/keyword/61667
*  TAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation | The Journal of Immunology
Conditioned medium from TKO microglia cultures inhibits neuron stem cell proliferation and neuronal differentiation. IL-6 ... suggesting that IL-6 is a major downstream neurotoxic mediator under homeostatic regulation by TAM receptors in microglia. ... largely attributed to exaggerated inflammatory responses by microglia characterized by increased MAPK and NF-κB activation and ...
  http://www.jimmunol.org/content/early/2013/11/15/jimmunol.1302229
*  "Neuron to microglia communication; a study of CX3CL1 signaling implica" by Joshua M. Morganti
The resident immune cells of the brain, microglia, act similarly to peripheral macrophages to protect the brain from insults, ... In the healthy brain neurons have several signaling systems that directly interact with microglia in order to maintain a ... This chemokine is found predominantly on neurons, while its cognate receptor CX3CR1 is found exclusively on microglia. There ... Neuron to microglia communication; a study of CX3CL1 signaling implications in cognitive function, inflammation, and ...
  http://scholarcommons.usf.edu/etd/4172/
*  Rat microglial interleukin-3. - MyScienceWork
Total RNA prepared from purified microglia yielded a single PCR amplification product. Identity of the PCR product was ... it is hypothesized that the expression of a characteristic T cell feature in monocyte-derived microglia may be a partial ... Culture media conditioned by isolated microglia enhanced microglial proliferation above fresh media controls. IL-3 polypeptide ...
  https://www.mysciencework.com/publication/show/rat-microglial-interleukin-3-4ddf9b1c
*  Fondation Recherches 3R / Projets / 3R-Project 137-13
Figure 1: Human monocyte-derived microglia in culture.. Figure 2: Expression of Iba1, a marker specific for microglia, by human ... Human microglia:. Human monocyte-derived microglia will be generated in-vitro using a published protocol (Etemad et al. 2012). ... The microglia will be isolated and cultured and then subjected to a comparative analysis. Monocyte- and brain-derived microglia ... Influence of beta amyloid on human microglia:. There is an abundance of evidence indicating that microglia are responsive to ...
  http://www.forschung3r.ch/fr/projects/pr_137_13.html
*  Past Recipients 2011
However, in microglia, there is a range of possible responses, including activation into either a pro-inflammatory (M1) or an ... Specifically, we hypothesize that activation of microglia at a low power density will induce an M1 microglial phenotype, while ...
  https://www.aslms.org/for-professionals/research-grants-awards/research-grants/aslms-research-grant/past-recipients-2011
*  C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation - WRAP: Warwick...
Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond ... nonramified microglia. In this study, we demonstrate that cultured microglial cells respond to extrinsic C1q with a marked ... that C1q synthesized and released by activated microglia is likely to contribute in an autocrine/paracrine way to maintain and ... an activation and differentiation process similar to the proinflammatory response of microglia to exposure to ...
  http://wrap.warwick.ac.uk/28526/
*  Modulation of microglial phenotypes by CD200
Microglia are the principal immune cells of the CNS continually surveying their micro-environment for endogenous and exogenous ... Recent studies have suggested that activated microglia, like macrophages, adopt different phenotypes depending on the stimulus ... IFNy induces classical activation of microglia, whereas IL-4 induces an alternative activation state. A deactivation state has ...
  http://www.tara.tcd.ie/handle/2262/78883
*  Cu(II) enhances the effect of Alzheimer's amyloid-β peptide on microglial activation | Journal of Neuroinflammation | Full Text
b Effect of Cu(II)-Aβ on the fraction of microglia exhibiting the activated morphology. Microglia were treated with Cu(II)-Aβ1- ... a The resting microglia (con) had branched processes, whereas microglia incubated with Cu(II)-Aβ1-40 (at 5 μΜ peptide ... stimulated microglia (Cu-CM), and (5) media previously conditioned by Cu(II)-Aβ1-40-stimulated microglia (Cu-Aβ-CM). Data are ... microglia might play a modulatory role via phagocytosis of Aβ plaques. In addition, microglia may exert protective functions ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0343-3
*  Microglia in Alzheimer's Disease
... Ying Li,1,2 Meng-Shan Tan,3 Teng Jiang,4 and Lan Tan1,3,4 ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ... M. Kitazawa, T. R. Yamasaki, and F. M. LaFerla, "Microglia as a potential bridge between the amyloid β-peptide and tau," Annals ... E. P. Azevedo, J. H. Ledo, G. Barbosa et al., "Activated microglia mediate synapse loss and short-term memory deficits in a ...
  https://www.hindawi.com/journals/bmri/2014/437483/ref/
*  Microglia actions in Alzheimer's disease | SpringerLink
... combined with studies in mouse models has highlighted microglia, the brain's intrinsic myeloid cells,... ... The identification of microglia-associated, neurological disease-causing mutations in patients, ... Streit WJ (2004) Microglia and Alzheimer's disease pathogenesis. J Neurosci Res 77:1-8. doi: 10.1002/jnr.20093 PubMedGoogle ... Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318PubMedGoogle Scholar ...
  https://link.springer.com/article/10.1007%2Fs00401-013-1182-x
*  Traçando o microglia do cérebro
O Microglia é sabido para ser importante para a função do cérebro. As pilhas imunes foram encontradas para proteger o cérebro ... "Este o microglia é muito inflamatório comparado com o microglia normal," diz Hammond. "Poderia ser um subconjunto patológico ... Bisbilhotar no microglia ao longo do tempo. Começando com ratos, Hammond e seus colegas arranjaram em seqüência o RNA de um ... Traçando o microglia. Hammond foi então uma etapa mais. Cobriu as classificações em um mapa do cérebro, para ver como as ...
  https://www.news-medical.net/news/20181206/19085/Portuguese.aspx
*  JCI - Microglia in steady state
In addition to their function as a resident immune cell in the CNS parenchyma, microglia display a variety of other functions ... Microglia modulate wiring and patterning in the developing CNS by regulating apoptosis of neuronal subpopulations, releasing ... In addition to this well-accepted function, recent findings point to major roles for microglia in instructing and regulating ... and how microglia help to maintain tissue homeostasis in the CNS. ... Homeostatic function of microglia in the developing and adult ...
  https://www.jci.org/articles/view/90602/figure/1
*  JCI - Microglia in prion diseases
At an early stage of prion infection and PrPSc aggregation, microglia are activated by PrPSc. Microglia then acquire a ... Here, we argue that microglia play an overall neuroprotective role in prion pathogenesis. Several microglia-related molecules, ... This damage may trigger microglia to switch to a proinflammatory phenotype with secretion of TNF-α, IL-1β, and IL-6. Such ... Moreover, studies on the role of microglia in prion disease could deepen our understanding of neuroinflammation in a broad ...
  https://www.jci.org/articles/view/90605/figure/1
*  Changing Face of Microglia | Science
Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored. ... Microglia are resident brain cells that sense pathological tissue alterations. They can develop into brain macrophages and ... Experimental studies support the idea that microglia have a role in the maintenance of synaptic integrity. Analogous to ... However, expression of immune proteins by microglia is not synonymous with inflammation, because these molecules can have ...
  http://science.sciencemag.org/content/330/6005/783
*  A new role for microglia
... researchers at the UC Davis MIND Institute and their colleagues have found that microglia remove healthy neural progenitor ... Microglia are the immune component cell of the central nervous system. Similar to macrophages, microglia provide the brain's ... which our data shows increases the activation of microglia, and as a result microglia may take out too many progenitor cells in ... "Microglia are generated in the yolk sack and quickly become attracted to the proliferative zones in the brain, colonize that ...
  http://www.ucdmc.ucdavis.edu/publish/news/research/7443
*  WikiGenes - Microglia
Associations of Microglia with chemical compounds. *Peritoneal macrophages and neonatal microglia from Lewis and BN rats are ... Using primary cultures of microglia, we show that IFN-gamma enhanced clearance of Abeta, microglia, and T cell motility, and ... Analytical, diagnostic and therapeutic context of Microglia. *TGF-beta 1 expression increases in astrocytes and microglia in ... Because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, ...
  https://www.wikigenes.org/e/mesh/e/13571.html
*  The Role of Microglia in Diabetic Retinopathy
U. K. Hanisch, "Microglia as a source and target of cytokine activities in the brain," in Microglia in the Regenerating and ... J. Gehrmann, R. B. Banati, and G. W. Kreutzberg, "Microglia in the immune surveillance of the brain: human microglia ... The Role of Microglia in Diabetic Retinopathy. Jeffery G. Grigsby,1 Sandra M. Cardona,2 Cindy E. Pouw,3 Alberto Muniz,2 Andrew ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ...
  https://www.hindawi.com/journals/joph/2014/705783/ref/