*  北京大学医学部机构知识库(IR@PKUHSC): AGEs mediated expression and secretion of TNF alpha in rail retinal microglia
... we attempted to confirm that AGEs induce the release of TNF alpha from rat retinal microglia using an in vitro microglia ... The degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. We have ... AGEs increased the protein secretion and mRNA expression of TNF alpha in cultured rat retinal microglia. These effects of AGEs ... AGEs-activated microglia showed an increase of NFkB p65 nuclear translocation. These observations indicated that ...
  http://ir.bjmu.edu.cn/handle/400002259/55593
*  JAIRO | A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates...
A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates ... Degeneration of Injured NeuronsA DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve ...
  http://jairo.nii.ac.jp/0002/00019186/en
*  Biology of microglia - Multiple Sclerosis - Derick Mussen Healthcare
a. Microglia in Normal and Injured CNSs. Microglia constitute a distinct glial population in the CNS [1-4]. Unlike neurons and ... c. Activation of Microglia through Surface Immune Receptors. By far the most potent activator of microglia and macrophages is ... In the mature CNS, microglia are ubiquitously present as highly ramified cells ('resting' microglia) [5,6]. They respond to ... of total brain microglia belong to this population of juxtavascular microglia [14]. The authors identified them as a mobile ...
  https://www.mussenhealth.us/multiple-sclerosis-3/ii-biology-of-microglia.html
*  DGIST Scholar: Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia
Dendropanax Morbifera; M2 Polarization; Microglia; Neuroinflammation; NF-Kappa B. ISSN. 0192-415X. Abstract. Dendropanax ... These results strongly suggest that DMLE was able to counter the effects of LPS on BV2 cells via control of microglia ... Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia. Authors. Shim, HJ[Shim, ... Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia ...
  http://scholar.dgist.ac.kr/handle/20.500.11750/2728
*  Why Good Microglia Turn Bad-A Matter of Timing? | ALZFORUM
Initially, newly recruited microglia act to clear Aβ, but with time, they lose their ability to take up and degrade the peptide ... "We have found in the past that microglia can be both protective and detrimental, and I think this paper shows that at some ... Why Good Microglia Turn Bad-A Matter of Timing?. Quick Links. *Article ... The results offer a nuanced view of microglia action in AD, and suggest that anti-inflammatory therapy for the disease should ...
  http://www.alzforum.org/news/research-news/why-good-microglia-turn-bad-matter-timing
*  Plus it
2004) Microglia promote the death of developing Purkinje cells. Neuron 41:535-547, doi:10.1016/S0896-6273(04)00069-8, pmid: ... 2013) Microglia actively regulate the number of functional synapses. PloS One 8:e56293, doi:10.1371/journal.pone.0056293, pmid: ... 2012) Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74:691-705, doi:10.1016 ... A, Low-magnification two-photon z-stack image of GFP-expressing microglia in layer II/III of a cortical brain slice. B, C, ...
  http://www.jneurosci.org/content/35/6/2417
*  Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-β Protein in Alzheimer's Disease Brain | Stroke
... and HLA-DR for microglia (green, bottom right). Microglia are seen in the center of the Aβ deposits (arrow), which have no ... Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol ... microglia. Deposition of amyloid-β protein (Aβ) is one of the most salient pathological features in the AD brain. In addition ... Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett. 1990;119:32-36. ...
  http://stroke.ahajournals.org/content/28/10/1948
*  The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood | The Journal of...
Adult microglia exhibit a CX3CR1-GFP+ CCR2-RFP−-expressing pattern, and microglia do not show significant CCR2RFP expression ... Juba considered microglia to be derived from invading mesodermal elements because microglia-like cells were also detected ... Microglia. In Cytology and Cellular Pathology of the Nervous System. Penfield W., ed. Paul B. Hoeber, New York, p. 481-584. ... The distribution of microglia and cell death in the fetal rat forebrain. Brain Res. Dev. Brain Res. 58: 1-12. ...
  http://www.jimmunol.org/content/188/1/29.full
*  Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis | Journal of Cell Science
After stimulation of microglia with interferon-γ, we observe an upregulation of MHC class II in a subpopulation of microglia. ... Activation of microglia by IFNγ leads to an upregulation of MHC class II in a subpopulation of microglia. However, ... Because all these findings relied on cultured microglia, we wanted to verify that exosomes are also taken up by microglia in ... Next, we wanted to determine by which endocytic pathway microglia use to take up exosomes. Microglia are capable of different ...
  http://jcs.biologists.org/content/124/3/447
*  "Neuron to microglia communication; a study of CX3CL1 signaling implica" by Joshua M. Morganti
The resident immune cells of the brain, microglia, act similarly to peripheral macrophages to protect the brain from insults, ... In the healthy brain neurons have several signaling systems that directly interact with microglia in order to maintain a ... This chemokine is found predominantly on neurons, while its cognate receptor CX3CR1 is found exclusively on microglia. There ... Neuron to microglia communication; a study of CX3CL1 signaling implications in cognitive function, inflammation, and ...
  http://scholarcommons.usf.edu/etd/4172/
*  Rat microglial interleukin-3. - MyScienceWork
Total RNA prepared from purified microglia yielded a single PCR amplification product. Identity of the PCR product was ... it is hypothesized that the expression of a characteristic T cell feature in monocyte-derived microglia may be a partial ... Culture media conditioned by isolated microglia enhanced microglial proliferation above fresh media controls. IL-3 polypeptide ...
  https://www.mysciencework.com/publication/show/rat-microglial-interleukin-3-4ddf9b1c
*  Fondation Recherches 3R / Projets / 3R-Project 137-13
Figure 1: Human monocyte-derived microglia in culture.. Figure 2: Expression of Iba1, a marker specific for microglia, by human ... Human microglia:. Human monocyte-derived microglia will be generated in-vitro using a published protocol (Etemad et al. 2012). ... The microglia will be isolated and cultured and then subjected to a comparative analysis. Monocyte- and brain-derived microglia ... Influence of beta amyloid on human microglia:. There is an abundance of evidence indicating that microglia are responsive to ...
  http://www.forschung3r.ch/fr/projects/pr_137_13.html
*  Group Barragan contributes to a publication in Nature Immunology - Department of Molecular Biosciences, The Wenner-Gren...
We found that glioma-induced microglia conversion was coupled to a reduction in the basal activity of microglial caspase-3 and ... Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Xianli Shen, Miguel A Burguillos, ... Repression of glioma NOS2 expression in vivo led to a reduction in both microglia recruitment and tumor expansion, whereas ... Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ...
  http://www.su.se/mbw/about-us/news/new-publications/group-barragan-contributes-to-a-publication-in-nature-immunology-1.297227
*  C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation - WRAP: Warwick...
Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond ... nonramified microglia. In this study, we demonstrate that cultured microglial cells respond to extrinsic C1q with a marked ... that C1q synthesized and released by activated microglia is likely to contribute in an autocrine/paracrine way to maintain and ... an activation and differentiation process similar to the proinflammatory response of microglia to exposure to ...
  http://wrap.warwick.ac.uk/28526/
*  Modulation of microglial phenotypes by CD200
Microglia are the principal immune cells of the CNS continually surveying their micro-environment for endogenous and exogenous ... Recent studies have suggested that activated microglia, like macrophages, adopt different phenotypes depending on the stimulus ... IFNy induces classical activation of microglia, whereas IL-4 induces an alternative activation state. A deactivation state has ...
  http://www.tara.tcd.ie/handle/2262/78883
*  Scientific Study
In the study, the specific observed activity of the microglia was an increase in engulfing of amyloid beta proteins. The end ... GABA receptors connect to microglia via astrocytes. Astrocytes modulate microglial activity, and their behavior is affected via ... This release, along with other signals from astrocytes, triggers anti-neuroinflammation and engulfing activity in microglia ... increasing the activity of microglia could help fight a possible Alzheimer's disease causing infection. ...
  http://www.abelardresearch.com/category/scientific-study/
*  Microglia in Alzheimer's Disease
... Ying Li,1,2 Meng-Shan Tan,3 Teng Jiang,4 and Lan Tan1,3,4 ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ... M. Kitazawa, T. R. Yamasaki, and F. M. LaFerla, "Microglia as a potential bridge between the amyloid β-peptide and tau," Annals ... E. P. Azevedo, J. H. Ledo, G. Barbosa et al., "Activated microglia mediate synapse loss and short-term memory deficits in a ...
  https://www.hindawi.com/journals/bmri/2014/437483/ref/
*  A new role for microglia
... researchers at the UC Davis MIND Institute and their colleagues have found that microglia remove healthy neural progenitor ... Microglia are the immune component cell of the central nervous system. Similar to macrophages, microglia provide the brain's ... which our data shows increases the activation of microglia, and as a result microglia may take out too many progenitor cells in ... "Microglia are generated in the yolk sack and quickly become attracted to the proliferative zones in the brain, colonize that ...
  http://www.ucdmc.ucdavis.edu/publish/news/research/7443
*  WikiGenes - Microglia
Associations of Microglia with chemical compounds. *Peritoneal macrophages and neonatal microglia from Lewis and BN rats are ... Using primary cultures of microglia, we show that IFN-gamma enhanced clearance of Abeta, microglia, and T cell motility, and ... Analytical, diagnostic and therapeutic context of Microglia. *TGF-beta 1 expression increases in astrocytes and microglia in ... Because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, ...
  https://www.wikigenes.org/e/mesh/e/13571.html
*  Bidirectional Microglia-Neuron Communication in the Healthy Brain
The role of microglia during injury and disease has been studied for a few decades. However, the dynamics of microglia-neuron ... 3. The Microglia-to-Neuron Communication Axis. By far, the literature is more extensive on the neuron-to-microglia ... Using microglia ablation strategies, recent studies also shed new light on the role of microglia in synaptic transmission. ... Microglia Cells Contribute to Neuronal Circuitry Establishment. In addition to the possibility that microglia are involved in ...
  https://www.hindawi.com/journals/np/2013/456857/
*  The Biphasic Role of Microglia in Alzheimer's Disease
C. K. Combs, J. Colleen Karlo, S. C. Kao, and G. E. Landreth, "β-amyloid stimulation of microglia anti monocytes results in TNF ... Y. Doi, T. Mizuno, Y. Maki et al., "Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid β ... K. Biber, H. Neumann, K. Inoue, and H. W. G. M. Boddeke, "Neuronal 'On' and 'Off' signals control microglia," Trends in ... A. M. Floden, S. Li, and C. K. Combs, "β-Amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor ...
  https://www.hindawi.com/journals/ijad/2012/737846/ref/
*  The Controversial Role of Microglia in Malignant Gliomas
This is antagonized by inactivation of microglia as well as by Wnt signaling inhibition. Therefore, microglia were shown to be ... As such, many investigators use the more general term "microglia/macrophages" instead of microglia alone. CD163, CD200, CD204, ... The GSC-conditioned medium polarized the microglia/macrophage to an M2 phenotype, inhibited microglia/macrophage phagocytosis, ... microglia invade the tumor. The microglia then secrete a variety of factors that degrade the CNS matrix. The glioma cells ...
  https://www.hindawi.com/journals/jir/2013/285246/
*  Neher Inflammed Microglia | Microglia | Neurodegeneration
Neher Inflammed Microglia - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Glial cells are the ... Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration Jonas J. Neher *, Urte Neniskyte and ... When microglia were then allowed to interact with these neurons, the neurons were phagocytosed and thus killed. However, if the ... Microglia have been shown to contribute to neuronal loss in an Alzheimer's mouse model (Fuhrmann et al., 2010). Two-photon ...
  https://www.scribd.com/document/153560976/Neher-Inflammed-Microglia
*  Macrophages and Microglia in Brain Malignancies | IntechOpen
Macrophages and Microglia in Brain Malignancies. By Cristina Riccadonna and Paul R Walker ... Cristina Riccadonna and Paul R Walker (March 30th 2012). Macrophages and Microglia in Brain Malignancies, Tumor ... Cristina Riccadonna and Paul R Walker (March 30th 2012). Macrophages and Microglia in Brain Malignancies, Tumor ... iframe src='http://www.intechopen.com/embed/tumor-microenvironment-and-myelomonocytic-cells/macrophages-and-microglia-in-brain- ...
  https://www.intechopen.com/books/tumor-microenvironment-and-myelomonocytic-cells/macrophages-and-microglia-in-brain-malignancies/
*  Signaling Pathways Controlling Microglia Chemotaxis
CD36 on the microglia cell surface have been implicated in the innate immune response and chemotaxis of microglia to β-amyloid ... Microglia are the primary mediators of innate immune response in the brain to infection, injury, and diseases. Microglia are ... Stimulation of microglia with stromal cell-derived factor-1 (SDF-1) via CXC chemokine receptor 4 (CXCR4) induces microglia ... Role of Protein Kinase A (PKA) in the regulation of microglia chemotaxis. The role of PKA for microglia activation has been ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5386953/