*  北京大学医学部机构知识库(IR@PKUHSC): AGEs mediated expression and secretion of TNF alpha in rail retinal microglia
... we attempted to confirm that AGEs induce the release of TNF alpha from rat retinal microglia using an in vitro microglia ... The degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. We have ... AGEs increased the protein secretion and mRNA expression of TNF alpha in cultured rat retinal microglia. These effects of AGEs ... AGEs-activated microglia showed an increase of NFkB p65 nuclear translocation. These observations indicated that ...
  http://ir.bjmu.edu.cn/handle/400002259/55593
*  JAIRO | A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates...
A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates ... Degeneration of Injured NeuronsA DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve ...
  http://jairo.nii.ac.jp/0002/00019186/en
*  Microglial pathology | Acta Neuropathologica Communications | Full Text
Diseased microglia are different from activated microglia, in that they are incapacitated cells whereas activated microglia are ... Microglia in the spinal cord of SOD G93A rats. A-C, double staining for microglia (Iba1) and neurons (NeuN) shows progressive ... Morphological heterogeneity of microglia in humans can be explained in part by the principle that microglia represent a stable ... Absence of activated microglia near neurons with Lewy bodies. Double-label immunostaining for microglia (Iba1, brown) and α- ...
  https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-014-0142-6
*  DGIST Scholar: Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia
Dendropanax Morbifera; M2 Polarization; Microglia; Neuroinflammation; NF-Kappa B. ISSN. 0192-415X. Abstract. Dendropanax ... These results strongly suggest that DMLE was able to counter the effects of LPS on BV2 cells via control of microglia ... Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia. Authors. Shim, HJ[Shim, ... Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia ...
  http://scholar.dgist.ac.kr/handle/20.500.11750/2728
*  Why Good Microglia Turn Bad-A Matter of Timing? | ALZFORUM
Initially, newly recruited microglia act to clear Aβ, but with time, they lose their ability to take up and degrade the peptide ... "We have found in the past that microglia can be both protective and detrimental, and I think this paper shows that at some ... Why Good Microglia Turn Bad-A Matter of Timing?. Quick Links. *Article ... The results offer a nuanced view of microglia action in AD, and suggest that anti-inflammatory therapy for the disease should ...
  http://www.alzforum.org/news/research-news/why-good-microglia-turn-bad-matter-timing
*  Neurophysiology Times - Neurophysiology @ NIMHANS
Mice depleted of microglia show no behavioral or cognitive abnormalities, revealing that microglia are not necessary for these ... Amoeboid microglia are a highly mobile phagocytic form that are active especially during development. Resting microglia have ... Surprisingly, extensive treatment results in elimination of ∼99% of all microglia brain-wide, showing that microglia in the ... Finally, we discovered that the microglia-depleted brain completely repopulates with new microglia within 1 week of inhibitor ...
  http://nphy.weebly.com/nphytimes/category/microglia
*  Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-β Protein in Alzheimer's Disease Brain | Stroke
... and HLA-DR for microglia (green, bottom right). Microglia are seen in the center of the Aβ deposits (arrow), which have no ... Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol ... microglia. Deposition of amyloid-β protein (Aβ) is one of the most salient pathological features in the AD brain. In addition ... Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett. 1990;119:32-36. ...
  http://stroke.ahajournals.org/content/28/10/1948
*  Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis | Journal of Cell Science
After stimulation of microglia with interferon-γ, we observe an upregulation of MHC class II in a subpopulation of microglia. ... Activation of microglia by IFNγ leads to an upregulation of MHC class II in a subpopulation of microglia. However, ... Because all these findings relied on cultured microglia, we wanted to verify that exosomes are also taken up by microglia in ... Next, we wanted to determine by which endocytic pathway microglia use to take up exosomes. Microglia are capable of different ...
  http://jcs.biologists.org/content/124/3/447
*  Rat microglial interleukin-3. - MyScienceWork
Total RNA prepared from purified microglia yielded a single PCR amplification product. Identity of the PCR product was ... it is hypothesized that the expression of a characteristic T cell feature in monocyte-derived microglia may be a partial ... Culture media conditioned by isolated microglia enhanced microglial proliferation above fresh media controls. IL-3 polypeptide ...
  https://www.mysciencework.com/publication/show/rat-microglial-interleukin-3-4ddf9b1c
*  Team:UCL - 2013.igem.org
We have devised a genetic circuit for transfection into microglia, a novel chassis in which standard assembly has never been ... We have devised a genetic circuit for transfection into microglia, a novel chassis in which standard assembly has never been ... as well as to support and protect endangered neurons from microglia-mediated neuroinflammation. ... as well as to support and protect endangered neurons from microglia-mediated neuroinflammation. ...
  http://2013.igem.org/wiki/index.php?title=Team:UCL&diff=317285&oldid=58340
*  Group Barragan contributes to a publication in Nature Immunology - Department of Molecular Biosciences, The Wenner-Gren...
We found that glioma-induced microglia conversion was coupled to a reduction in the basal activity of microglial caspase-3 and ... Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Xianli Shen, Miguel A Burguillos, ... Repression of glioma NOS2 expression in vivo led to a reduction in both microglia recruitment and tumor expansion, whereas ... Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ...
  http://www.su.se/mbw/about-us/news/new-publications/group-barragan-contributes-to-a-publication-in-nature-immunology-1.297227
*  C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation - WRAP: Warwick...
Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond ... nonramified microglia. In this study, we demonstrate that cultured microglial cells respond to extrinsic C1q with a marked ... that C1q synthesized and released by activated microglia is likely to contribute in an autocrine/paracrine way to maintain and ... an activation and differentiation process similar to the proinflammatory response of microglia to exposure to ...
  http://wrap.warwick.ac.uk/28526/
*  Modulation of microglial phenotypes by CD200
Microglia are the principal immune cells of the CNS continually surveying their micro-environment for endogenous and exogenous ... Recent studies have suggested that activated microglia, like macrophages, adopt different phenotypes depending on the stimulus ... IFNy induces classical activation of microglia, whereas IL-4 induces an alternative activation state. A deactivation state has ...
  http://www.tara.tcd.ie/handle/2262/78883
*  Scientific Study
In the study, the specific observed activity of the microglia was an increase in engulfing of amyloid beta proteins. The end ... GABA receptors connect to microglia via astrocytes. Astrocytes modulate microglial activity, and their behavior is affected via ... This release, along with other signals from astrocytes, triggers anti-neuroinflammation and engulfing activity in microglia ... increasing the activity of microglia could help fight a possible Alzheimer's disease causing infection. ...
  http://www.abelardresearch.com/category/scientific-study/
*  Microglia in Alzheimer's Disease
... Ying Li,1,2 Meng-Shan Tan,3 Teng Jiang,4 and Lan Tan1,3,4 ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ... M. Kitazawa, T. R. Yamasaki, and F. M. LaFerla, "Microglia as a potential bridge between the amyloid β-peptide and tau," Annals ... E. P. Azevedo, J. H. Ledo, G. Barbosa et al., "Activated microglia mediate synapse loss and short-term memory deficits in a ...
  https://www.hindawi.com/journals/bmri/2014/437483/ref/
*  A new role for microglia
... researchers at the UC Davis MIND Institute and their colleagues have found that microglia remove healthy neural progenitor ... Microglia are the immune component cell of the central nervous system. Similar to macrophages, microglia provide the brain's ... which our data shows increases the activation of microglia, and as a result microglia may take out too many progenitor cells in ... "Microglia are generated in the yolk sack and quickly become attracted to the proliferative zones in the brain, colonize that ...
  http://www.ucdmc.ucdavis.edu/publish/news/research/7443
*  WikiGenes - Microglia
Associations of Microglia with chemical compounds. *Peritoneal macrophages and neonatal microglia from Lewis and BN rats are ... Using primary cultures of microglia, we show that IFN-gamma enhanced clearance of Abeta, microglia, and T cell motility, and ... Analytical, diagnostic and therapeutic context of Microglia. *TGF-beta 1 expression increases in astrocytes and microglia in ... Because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, ...
  https://www.wikigenes.org/e/mesh/e/13571.html
*  Bidirectional Microglia-Neuron Communication in the Healthy Brain
The role of microglia during injury and disease has been studied for a few decades. However, the dynamics of microglia-neuron ... 3. The Microglia-to-Neuron Communication Axis. By far, the literature is more extensive on the neuron-to-microglia ... Using microglia ablation strategies, recent studies also shed new light on the role of microglia in synaptic transmission. ... Microglia Cells Contribute to Neuronal Circuitry Establishment. In addition to the possibility that microglia are involved in ...
  https://www.hindawi.com/journals/np/2013/456857/
*  The Controversial Role of Microglia in Malignant Gliomas
This is antagonized by inactivation of microglia as well as by Wnt signaling inhibition. Therefore, microglia were shown to be ... As such, many investigators use the more general term "microglia/macrophages" instead of microglia alone. CD163, CD200, CD204, ... The GSC-conditioned medium polarized the microglia/macrophage to an M2 phenotype, inhibited microglia/macrophage phagocytosis, ... microglia invade the tumor. The microglia then secrete a variety of factors that degrade the CNS matrix. The glioma cells ...
  https://www.hindawi.com/journals/jir/2013/285246/
*  Neher Inflammed Microglia | Microglia | Neurodegeneration
Neher Inflammed Microglia - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Glial cells are the ... Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration Jonas J. Neher *, Urte Neniskyte and ... When microglia were then allowed to interact with these neurons, the neurons were phagocytosed and thus killed. However, if the ... Microglia have been shown to contribute to neuronal loss in an Alzheimer's mouse model (Fuhrmann et al., 2010). Two-photon ...
  https://www.scribd.com/document/153560976/Neher-Inflammed-Microglia
*  Signaling Pathways Controlling Microglia Chemotaxis
CD36 on the microglia cell surface have been implicated in the innate immune response and chemotaxis of microglia to β-amyloid ... Microglia are the primary mediators of innate immune response in the brain to infection, injury, and diseases. Microglia are ... Stimulation of microglia with stromal cell-derived factor-1 (SDF-1) via CXC chemokine receptor 4 (CXCR4) induces microglia ... Role of Protein Kinase A (PKA) in the regulation of microglia chemotaxis. The role of PKA for microglia activation has been ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5386953/
*  Histonet] microglia/philosophy OT
... From:. koellingr@comcast.net. Is a very long answer to Carl as well as some philosophy so ... At first I was going to say I made an error and that RCA-1 could only be used on human microglia but a few papers I see uses ... And if you are in rat there are the famous OX series OX-41,42,11 that stain microglia but others know much more about them than ... EM of microglia staining with 'other' antibodies. I found them in 4-5 minutes in PubMed and I HATE, HATE, HATE computers ( ...
  http://www.histosearch.com/histonet/Jun07A/Histonetmicroglia.philoso.html
*  Microglia, SEM - Stock Image C028/8612 - Science Photo Library
Coloured scanning electron micrograph (SEM) of protective cells of the human immune system known as a microglia. Microglia ... Dendritic cells found in the central nervous system are known as microglia, in the upper layer of the skin (the epidermis) they ... Coloured scanning electron micrograph (SEM) of protective cells of the human immune system known as a microglia. Microglia ... Dendritic cells found in the central nervous system are known as microglia, in the upper layer of the skin (the epidermis) they ...
  http://www.sciencephoto.com/media/718368/view
*  Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia | Journal of Neuroscience
... microglia. Microarray analysis on ex vivo sorted microglia from ipsilateral male mouse cortex following a transient in vivo ... Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia. Ashley McDonough, Richard V. Lee, Shahani Noor ... Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia. Ashley McDonough, Richard V. Lee, Shahani Noor ... To determine the effects of 'ischemia/reperfusion-like' conditions on microglia we carried out genomic analyses on wild-type ( ...
  http://www.jneurosci.org/content/early/2017/07/26/JNEUROSCI.0725-17.2017