*  Spontaneous Organ-Specific Th2-Mediated Autoimmunity in TCR Transgenic Mice | The Journal of Immunology
Both Th1 and Th2 cells generated from MBP-specific TCR Tg mice transfer EAE to RAG-1o/o mice and to αβ T cell-deficient mice (9 ... Spontaneous Organ-Specific Th2-Mediated Autoimmunity in TCR Transgenic Mice. Sophie Candon, Rebecca S. McHugh, Gilles Foucras, ... Spontaneous Organ-Specific Th2-Mediated Autoimmunity in TCR Transgenic Mice. Sophie Candon, Rebecca S. McHugh, Gilles Foucras, ... The A51 transgenic mice represent a unique model for autoimmune disease, and they illustrate that the in vivo response to a ...
  http://www.jimmunol.org/content/172/5/2917.long
*  Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain | JCB
Increased KAI1 levels in AICD transgenic mice. (A) The AICD transgenic mice, but not the control or Fe.27 mice, show expression ... AICD transgenic mice. To examine the in vivo effects of AICD, we generated double transgenic mice expressing AICD and Fe65. The ... Brain membranes from two FeCγ.12 mice (lanes 2 and 3), APP-KO mice (lanes 4 and 5), and R1.40 transgenic mice expressing human ... we generated AICD transgenic mice, and found that AICD causes significant biologic changes in vivo. AICD transgenic mice show ...
  http://jcb.rupress.org/content/171/2/327.long
*  STOP cassette: post #1
I plan to generate a new transgenic mouse where gene expression is prevented by upstream floxed STOP cassette: -promoter-loxP- ... STOP-loxP-transgene- Upon crossing to a CRE-recombinase expressing mouse line the STOP will be removed, leading to transgene ... Problem with Tamoxifen inducible Cre mouse Started by sprout, 21 Feb 2013 knockout mouse, transgenic mouse and 2 more... * 0 ... I plan to generate a new transgenic mouse where gene expression is prevented by upstream floxed STOP cassette:. -promoter-loxP- ...
  http://www.protocol-online.org/forums/topic/29848-stop-cassette/
*  Plus it
Although the doubly transgenic mice survive longer than T2/Onc2;RosaSB11 mice, they do eventually succumb to mainly ... Crossing of transposase and transposon transgenic mice yields experimental mice in which the transposon is mobilizing in the ... Crossing T2/Onc2 transgenics to Rosa26SB11 transgenics resulted in 5.6% to 12.5% doubly transgenic offspring depending on the ... Berns A, Breuer M, Verbeek S, van Lohuizen M. Transgenic mice as a means to study synergism between oncogenes. Int J Cancer ...
  http://cancerres.aacrjournals.org/content/65/21/9607
*  CSHLPress.com - HNF6 Rev-erb-alpha
"We showed that simply deleting the protein HNF6 in liver cells of adult transgenic mice fed normal laboratory chow leads to ...
  https://cshlpress.com/press.tpl?pag=HNF6_Rev-erb-alpha
*  Analysis of Immature (CD4-CD8-) Thymic Subsets in T-Cell Receptor αß Transgenic Mice - Semantic Scholar
... transgenic mice, in particular the earliest CD4-8stages. As expected, the transgenic TCR is expressed on the cell surface at an ... These mice produce increased numbers of CD4-8 mature T cells, all of which express the transgenic TCR, and small numbers of CD4 ... Furthermore, in contrast to other TCR o]/transgenic lines, TCR lineage cells appear to develop normally. ... in the context of H-2D into the genome of C57BL/6 mice, has many effects on the development and selection of T cells in both ...
  https://www.semanticscholar.org/paper/Analysis-of-Immature-CD4-CD8-Thymic-Subsets-in-T-C-Wilson-Pircher/4fa33320d7ee7863c482bd7ab343f398cfbc95dd
*  Plus it
By comparison between the DEN-treated male transgenic mice (n=12) and non-transgenic littermate controls (n=8), we observed ... HCC was chemically-induced in the transgenic (TTR-V5-BRE) and non-transgenic littermates, bred with C57BL/6, by intraperitoneal ... of female transgenic mice (n=5) developed the malignancy.. For the paired tumoral and normal liver tissues, increased ... Female C57BL/6 mice are known to be less sensitive to DEN-treated carcinogenesis. We observed only 8.3% of the female non- ...
  http://clincancerres.aacrjournals.org/content/14/15_Supplement/A16
*  Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes | Diabetes
HF, nontransgenic; ○, HF, transgenic; ▴, regular transgenic; ▵, regular, transgenic; ▪, transgenic; and □, nontransgenic. † ... HF, nontransgenic; ○, HF, transgenic; ▴, regular transgenic; ▵, regular, transgenic; ▪, transgenic; and □, nontransgenic. * ... Transgenic mice and dietary treatment.. GK gene locus transgenic animals (line 37) have been previously described (33,56). ... We have previously described the production and characterization of GK gene locus transgenic mice (56). These mice express and ...
  http://diabetes.diabetesjournals.org/content/50/3/622
*  Shirley ShiDu Yan | School of Pharmacy
Those novel transgenic AD-type mouse models greatly benefit the scientific AD communities. Some of these transgenic mouse ... We have developed a novel transgenic mouse model relevant to the pathogenesis of AD, such as transgenic mice expressing both ... She developed a novel transgenic mouse model relevant to AD and tested the role of RAGE and ABAD in Aβ-mediated cellular ... and first found that Aβ progressively accumulated in mitochondria of brains from AD patients and transgenic AD-type mouse model ...
  http://pharmacy.drupal.ku.edu/shirley-shidu-yan
*  Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology | EMBO Reports
microglia transgenic mouse model. Introduction. A variety of transgenic mice have been generated to model cerebral amyloidosis ... transgenic control mice, whereas there was a significant threefold increase in microglia number in 8‐month‐old transgenic mice ... The present APPPS1‐21 mouse combines several advantages of previous transgenic lines. (i) Mice have been generated on a pure ... The oldest mice available to this study were three female 19‐month‐old mice. These mice showed a neocortical and hippocampal ...
  http://embor.embopress.org/content/7/9/940
*  Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of...
... mice. G-J: Fore and hind limbs of C57BL/6 (G and I) and D469del-COMP (H and J) mice. K and L: Front paws of C57BL/6 (K) and ... This inducible transgenic D469del-COMP mouse is the only in vivo model to replicate the critical cellular and clinical features ... Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of ... Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of ...
  https://www.ncbi.nlm.nih.gov/pubmed/22154935
*  Abstract 122: Cardiac mTOR Preserves Cardiac Function Following Ex Vivo Ischemia-Reperfusion in Diet-Induced Obese Mice |...
... we used transgenic mice with cardiac-specific overexpression of mTOR (mTOR-Tg) as reported previously. mTOR-Tg and WT mice at 6 ... NCD-mTOR-Tg (n=11) mice, p,0.01]. Functional recovery after I/R was significantly lower in HFD-WT mice than NCD-WT mice ( ... mice. Body weight (BW) and heart weight (HW) were significantly higher in HFD mice than SCD mice (p,0.001 for BW in both ... was higher in HFD mice than NCD mice in both strains [185.8 ± 10.7 vs. 143.6 ± 5.0 mmHg, HFD-WT (n=11) vs. NCD-WT (n=10) mice, ...
  http://circres.ahajournals.org/content/111/Suppl_1/A122
*  Transgenic Mouse/ES Cell Shared Resource - Labnodes - The Vanderbilt Research Network
... over 2700 transgenic founder mice from over 750 different DNA constructs and 5000 chimeric mice from over 800 different mouse ... The Vanderbilt Transgenic Mouse/ES Cell Shared Resource (TMESCSR) provides services, consultation and collaborations to enable ... We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you. ... Prior to the discovery of the CRISPR/Cas system, the TMESCSR generated over 160 different gene-targeted mice. Since 2013, the ...
  https://labnodes.vanderbilt.edu/community/profile/id/8/member_id/10396
*  Alb-uPA Transgenic Mice
... The Digitized Atlas of Mouse Liver Lesions. Transgenic mice carrying an albumin promoter linked to ... An aged uPA transgenic mouse with an hepatocellular adenoma. There is evidence of toxic hepatopathy in the adjacent hepatic ... AL-TAg x AL-myc Dual Transgenic * Unique Lesions of Genetically Altered Mice ... A large and a small nodule of regenerating hepatocytes in an Alb-uPA transgenic mouse. ...
  https://www.niehs.nih.gov/research/resources/visual-guides/liverpath/unique/transgenic_mice/
*  Transgenic Mice Advice?
... Wolfgang Schechinger hubahopp at gmx.de Sat Dec 11 17:26:32 EST 2004 *Previous message: Transgenic ... Previous message: Transgenic Mice Advice? *Next message: Transgenic Mice Advice? * Messages sorted by: [ date ] [ thread ] [ ...
  http://www.bio.net/bionet/mm/methods/2004-December/098972.html
*  Transgenic Mice Advice?
... Wolfgang Schechinger hubahopp at gmx.de Sat Dec 11 14:34:00 EST 2004 *Previous message: Transgenic ... Previous message: Transgenic Mice Advice? *Next message: Transgenic Mice Advice? * Messages sorted by: [ date ] [ thread ] [ ...
  http://www.bio.net/bionet/mm/methods/2004-December/098960.html
*  Recent Articles | Transgenic Mice | The Scientist Magazine®
A transgenic mouse company is paying researchers who mention its animal models in scientific papers. ... Fluorescent calcium sensors in transgenic mice give a real-time readout of neuronal activity. ... Researchers develop mouse lines to help them see whether the maternal or paternal X chromosome is inactivated. ... Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells. ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/1960/tags/transgenic-mice/
*  Atherosclerosis in APOE*3-Leiden Transgenic Mice | Circulation
Mice. Transgenic mice expressing the human APOE*3-Leiden gene were generated and bred with C57Bl/6J females as described ... mice received standard mouse chow for 9 months. To label DNA-synthesizing cells, 6 transgenic animals of the 6-month diet group ... Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. J Biol Chem. 1993;268:10540-10545. ... Atherosclerosis in APOE*3-Leiden Transgenic Mice. From Proliferative to Atheromatous Stage. Esther Lutgens, Mat Daemen, Mark ...
  http://circ.ahajournals.org/content/99/2/276
*  Carolina Worlshop on Gene Targeting and Transgenic Mice
... R. Wayne Litaker fleurs at cahaba.med.unc.edu Sat Apr 6 18:54:08 EST ... FOURTH ANNUAL 'GENE TARGETING IN ES CELLS AND TRANSGENIC MICE' WORKSHOP July 28 -- August 9, 1996 CAROLINA WORKSHOPS University ... Manipulating the Mouse Embryo by B. Hogan, et. al. (Cold Spring Harbor Laboratory, 1994) and Gene Targeting: A Practical ... A seminar series on the application of gene targeting and transgenics in various research areas will run concurrently with the ...
  http://www.bio.net/bionet/mm/bionews/1996-April/002961.html
*  Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice | PNAS
Transgenic APP[V717I] Mice. Transgenic mice (n = 4) were treated with BL (1 mg/kg) from weaning (age, 3 weeks) for 17 weeks. In ... transgenic mice. In a follow-up study using the APP[V717I]/PS1[A246E] AD transgenic mice, bryostatin significantly reduced the ... transgenic mice. In a more recently developed AD double-transgenic mouse, bryostatin was effective in reducing both brain Aβ40 ... Transgenic mice APP[V717I]/PS1[A246E]: Mortality. (A) Life table analysis of all mice. Both treated (n = 23) and untreated (n ...
  http://www.pnas.org/content/101/30/11141
*  Transgenic Mice Accumulate Human Tau in Degenerating Hippocampal Neurons | ALZFORUM
A handful of transgenic mouse strains exist that express various forms of tau, but they either die at a young age or differ ... transgenic mice with the deletion of lysine at position 280 would show early and extensive PHF formation, as this in vitro work ... Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci. 2002 Jan 1;22(1):133-41. ... Transgenic Mice Accumulate Human Tau in Degenerating Hippocampal Neurons. Quick Links. *Article ...
  http://www.alzforum.org/news/research-news/transgenic-mice-accumulate-human-tau-degenerating-hippocampal-neurons?id=348
*  Impaired Fertility in Transgenic Mice Overexpressing Betacellulin.
Successive matings of Btc transgenic males and females mice with wild-type mice revealed a decrease in litter size as compared ... Mice lacking Btc are viable, fertile and show no overt phenotype, but transgenic mice overexpressing Btc exhibit a whole array ... Betacellulin, Transgenic Mice, Fertility. Themengebiete:. 500 Naturwissenschaften und Mathematik , 590 Tiere (Zoologie) 500 ... The implantation of the Btc transgenic mice was delayed, but this was not the reason for the litter size reduction, because the ...
  https://edoc.ub.uni-muenchen.de/6575/
*  Impairment of Collateral Formation in Lipoprotein(a) Transgenic Mice | Circulation
Control mice indicates female nontransgenic mice; Lp(a) transgenic mice, female Lp(a) transgenic mice; Control gene, right ... transgenic mice were created by the mating of human apo(a) transgenic mice and human apoB transgenic mice.13,26-28⇓⇓⇓ Human apo ... The background of both mice was FVB mice. Lp(a) transgenic mice were created by breeding of both homotransgenic mice and ... transgenic mice. In Lp(a) transgenic mice, serum Lp(a) concentration was much higher in female mice (52.5±6.3 mg/dL, n=10) than ...
  http://circ.ahajournals.org/content/105/12/1491
*  Recent Articles | Transgenic Mice And Disease/Medicine | The Scientist Magazine®
Child Receives Transgenic Skin Over Most of His Body. By Ruth Williams , November 8, 2017 ... Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease. ... Infectious protein aggregates from the skin of human patients can cause disease in mice. ... tags: transgenic mice x disease/medicine x The Scientist. » transgenic mice and disease/medicine ...
  https://www.the-scientist.com/?articles.list/tagNo/1960,6/tags/transgenic-mice,disease-medicine/
*  Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice | Journal of Neuroscience
... of a single transgeniclacZ transgenic mouse, which served as a control (Fig.5 a), and the double transgenic lacZ-TK mouse (Fig ... Generation of transgenic mice. We generated transgenic mice expressing the herpes TK gene under the control of a human GFAP ... nlacZ transgenic mice. a, Central lobule of cerebellum from nlacZ transgenic mouse (control) treated with GCV at P3. b, Central ... Cerebella of nontransgenic mice were treated with GCV at P1 [a, e, i, m (column 1)], or transgenic mice were treated at either ...
  http://www.jneurosci.org/content/16/21/6908