Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in...
Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in ... NCAM-EC transgenic mice exhibited a striking reduction in synaptic puncta of GABAergic interneurons in the cingulate, frontal ... A novel transgenic mouse line was generated to identify consequences on cortical development and function of expressing soluble ... Transgenic mice were deficient in prepulse inhibition, which was restored by clozapine but not by haloperidol. Additionally, ...https://scholars.duke.edu/display/pub744580
Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired...
Transgenic lines were maintained by crossing heterozygous tg mice with non-tg C57BL/6 × DBA/2 F1 breeders. All mice were ... 2004a) Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw, Ind) mice. Proc Natl Acad Sci U S A 101:13363-13367 ... 2010) Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci ... The increased levels of BMP6 were accompanied by defects in hippocampal neurogenesis in AD patients and APP transgenic mice. In ...http://www.jneurosci.org/content/30/37/12252.long
Munin: Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity
Male transgenic mice displayed no differences in anxiety, but their locomotor activity increased compared to non-transgenic ... Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity. ... Our results were analyzed using Chi-square tests and homo- and heteroscedatic T-tests; Results Female transgenic mice displayed ... Conclusions Our results revealed anxiety-related traits and locomotor differences between transgenic mice expressing ...https://munin.uit.no/handle/10037/1243
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain | JCB
Increased KAI1 levels in AICD transgenic mice. (A) The AICD transgenic mice, but not the control or Fe.27 mice, show expression ... AICD transgenic mice. To examine the in vivo effects of AICD, we generated double transgenic mice expressing AICD and Fe65. The ... Brain membranes from two FeCγ.12 mice (lanes 2 and 3), APP-KO mice (lanes 4 and 5), and R1.40 transgenic mice expressing human ... we generated AICD transgenic mice, and found that AICD causes significant biologic changes in vivo. AICD transgenic mice show ...http://jcb.rupress.org/content/171/2/327.long
Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic β-Cells in Kir6.2G132S Transgenic Mice | Diabetes
B: Serum insulin levels of wild-type and Kir6.2G132S transgenic mice. Serum insulin levels of Kir6.2G132S transgenic mice were ... participate in the regeneration process of pancreatic β-cells in Kir6.2G132S transgenic mice. The Kir6.2G132S transgenic mouse ... and Kir6.2G132S transgenic mice. Blood glucose concentrations of Kir6.2G132S transgenic mice were significantly decreased with ... The number of mice is indicated in parentheses. *P , 0.05, **P , 0.01 compared with Kir6.2G132S transgenic mice at 4 weeks of ...http://diabetes.diabetesjournals.org/content/55/7/1930
Analysis of Immature (CD4-CD8-) Thymic Subsets in T-Cell Receptor αß Transgenic Mice - Semantic Scholar
... transgenic mice, in particular the earliest CD4-8stages. As expected, the transgenic TCR is expressed on the cell surface at an ... These mice produce increased numbers of CD4-8 mature T cells, all of which express the transgenic TCR, and small numbers of CD4 ... Furthermore, in contrast to other TCR o]/transgenic lines, TCR lineage cells appear to develop normally. ... in the context of H-2D into the genome of C57BL/6 mice, has many effects on the development and selection of T cells in both ...https://www.semanticscholar.org/paper/Analysis-of-Immature-CD4-CD8-Thymic-Subsets-in-T-C-Wilson-Pircher/4fa33320d7ee7863c482bd7ab343f398cfbc95dd
By comparison between the DEN-treated male transgenic mice (n=12) and non-transgenic littermate controls (n=8), we observed ... HCC was chemically-induced in the transgenic (TTR-V5-BRE) and non-transgenic littermates, bred with C57BL/6, by intraperitoneal ... of female transgenic mice (n=5) developed the malignancy.. For the paired tumoral and normal liver tissues, increased ... Female C57BL/6 mice are known to be less sensitive to DEN-treated carcinogenesis. We observed only 8.3% of the female non- ...http://clincancerres.aacrjournals.org/content/14/15_Supplement/A16
Hypertension in Transgenic Mice Expressing the Rac-1 Protein in Vascular Smooth Muscle | Hypertension
Hypertension in Transgenic Mice Expressing the Rac-1 Protein in Vascular Smooth Muscle. Mariana Morris, Marcelo Marialuisa, ... A novel transgenic mice has been generated which overexpresses the constitutively activated mutant form of human Rac 1 (Rac-CA ... Hypertension in Transgenic Mice Expressing the Rac-1 Protein in Vascular Smooth Muscle ... Hypertension in Transgenic Mice Expressing the Rac-1 Protein in Vascular Smooth Muscle ...http://hyper.ahajournals.org/content/36/Suppl_1/686.1
Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes | Diabetes
HF, nontransgenic; ○, HF, transgenic; ▴, regular transgenic; ▵, regular, transgenic; ▪, transgenic; and □, nontransgenic. † ... HF, nontransgenic; ○, HF, transgenic; ▴, regular transgenic; ▵, regular, transgenic; ▪, transgenic; and □, nontransgenic. * ... Transgenic mice and dietary treatment.. GK gene locus transgenic animals (line 37) have been previously described (33,56). ... We have previously described the production and characterization of GK gene locus transgenic mice (56). These mice express and ...http://diabetes.diabetesjournals.org/content/50/3/622
Shirley ShiDu Yan | School of Pharmacy
Those novel transgenic AD-type mouse models greatly benefit the scientific AD communities. Some of these transgenic mouse ... We have developed a novel transgenic mouse model relevant to the pathogenesis of AD, such as transgenic mice expressing both ... She developed a novel transgenic mouse model relevant to AD and tested the role of RAGE and ABAD in Aβ-mediated cellular ... and first found that Aβ progressively accumulated in mitochondria of brains from AD patients and transgenic AD-type mouse model ...http://pharmacy.drupal.ku.edu/shirley-shidu-yan
Induction of Corneal Epithelial Hypertrophy by FGF-7 in a Binary Inducible Transgenic Mouse Model | IOVS | ARVO Journals
... transgenic mouse line that can be used to prepare the binary tetracycline inducible transgenic mouse lines by mating with tet-O ... mice were crossed with tet-OFGF7/FGF7 mice to produce compound heterozygous transgenic (KeraprrtTA/+•tet-OFGF7/+) mice, which ... Abstract: : Purpose: To establish a binary inducible transgenic mouse model that can be used to elucidate the roles of growth ... The expression pattern of K12 keratin is the same between the compound and simple transgenic mice. Conclusions: We have ...http://iovs.arvojournals.org/article.aspx?articleid=2418922
Protocols and Video Articles Authored by Tom L. Stephen
A Novel Transgenic Mouse Model of Breast Cancer' ... A Novel Transgenic Mouse Model of Breast Cancer Melanie R. ... We investigated which APC in the periphery and CNS mediates disease using transgenic mice with MHCII expression restricted to ... Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse ... cells have been demonstrated in the mouse tumor stroma, our results demonstrating that human breast TAMs expressed FAP were ...https://www.jove.com/author/Tom+L._Stephen
Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology | EMBO Reports
microglia transgenic mouse model. Introduction. A variety of transgenic mice have been generated to model cerebral amyloidosis ... transgenic control mice, whereas there was a significant threefold increase in microglia number in 8‐month‐old transgenic mice ... The present APPPS1‐21 mouse combines several advantages of previous transgenic lines. (i) Mice have been generated on a pure ... The oldest mice available to this study were three female 19‐month‐old mice. These mice showed a neocortical and hippocampal ...http://embor.embopress.org/content/7/9/940
PITX3+/IRES2-tTA-LNL mice were then crossed with Cre transgenic mice (Lakso et al., 1996) to generate PITX3+/IRES2-tTA mice in ... A53T transgenic mice developed profound motor disabilities. A53T transgenic mice developed normally and survived for the full ... 2A). For simplicity, the PITX3-IRES2-tTA/tetO-A53T double-transgenic mice were later referred as A53T transgenic mice without ... transgenic mice by crossbreeding PITX3-IRES2-tTA heterozygous knock-in mice with the E2 line of tetO-A53T transgenic mice that ...http://www.jneurosci.org/content/32/27/9248
Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of...
... mice. G-J: Fore and hind limbs of C57BL/6 (G and I) and D469del-COMP (H and J) mice. K and L: Front paws of C57BL/6 (K) and ... This inducible transgenic D469del-COMP mouse is the only in vivo model to replicate the critical cellular and clinical features ... Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of ... Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of ...https://www.ncbi.nlm.nih.gov/pubmed/22154935
KAKEN - Research Projects | Production of monoclonal antibody specific to HLA by utilizing HLA transgenic mice. (KAKENHI...
2)Transgenic mice acquired a tolerance to HLA molecules encoded for by transgene. 3)Transgenic mice acquired or lost immune ... DQw4 and DQw6 transgenic mice successfully. HLA molecules expressed in these transgenic mice were immunologicaly functional ... These transgenic mice were immunized intraperitoneally with human B lymphoblastoid cell lines expressing allogeneic HLA class ... Monoclonal antibody / Hybridoma / HLA / Allo-specificity / HLA transgenic mouse / Cell fusion / HLAアロ抗原 / HLAタイピング / ヒト主要組織適合抗原 ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01870026/
Abstract 122: Cardiac mTOR Preserves Cardiac Function Following Ex Vivo Ischemia-Reperfusion in Diet-Induced Obese Mice |...
... we used transgenic mice with cardiac-specific overexpression of mTOR (mTOR-Tg) as reported previously. mTOR-Tg and WT mice at 6 ... NCD-mTOR-Tg (n=11) mice, p,0.01]. Functional recovery after I/R was significantly lower in HFD-WT mice than NCD-WT mice ( ... mice. Body weight (BW) and heart weight (HW) were significantly higher in HFD mice than SCD mice (p,0.001 for BW in both ... was higher in HFD mice than NCD mice in both strains [185.8 ± 10.7 vs. 143.6 ± 5.0 mmHg, HFD-WT (n=11) vs. NCD-WT (n=10) mice, ...http://circres.ahajournals.org/content/111/Suppl_1/A122
Transgenic Mouse/ES Cell Shared Resource - Labnodes - The Vanderbilt Research Network
... over 2700 transgenic founder mice from over 750 different DNA constructs and 5000 chimeric mice from over 800 different mouse ... The Vanderbilt Transgenic Mouse/ES Cell Shared Resource (TMESCSR) provides services, consultation and collaborations to enable ... We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you. ... Prior to the discovery of the CRISPR/Cas system, the TMESCSR generated over 160 different gene-targeted mice. Since 2013, the ...https://labnodes.vanderbilt.edu/community/profile/id/8/member_id/10396
Alb-uPA Transgenic Mice
... The Digitized Atlas of Mouse Liver Lesions. Transgenic mice carrying an albumin promoter linked to ... An aged uPA transgenic mouse with an hepatocellular adenoma. There is evidence of toxic hepatopathy in the adjacent hepatic ... AL-TAg x AL-myc Dual Transgenic * Unique Lesions of Genetically Altered Mice ... A large and a small nodule of regenerating hepatocytes in an Alb-uPA transgenic mouse. ...https://www.niehs.nih.gov/research/resources/visual-guides/liverpath/unique/transgenic_mice/
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations | JEM
... mice were backcrossed onto C57BL/6 mice. Techniques of microinjection and generation of transgenic mice have been previously ... BAFF-Tg Mice.. Full-length murine BAFF was expressed in transgenic mice using the liver-specific alpha-1 antitrypsin promoter ... Expansion of the Peripheral Blood B Cell Compartment in BAFF-Tg Mice.. The transgenic mouse population was found to have more ... However, chronic exposure of the transgenic mice to BAFF led to changes not paralleled in mice injected for 4 d with ...http://jem.rupress.org/content/190/11/1697
Transgenic Mice Advice?
... Wolfgang Schechinger hubahopp at gmx.de Sat Dec 11 17:26:32 EST 2004 *Previous message: Transgenic ... Previous message: Transgenic Mice Advice? *Next message: Transgenic Mice Advice? * Messages sorted by: [ date ] [ thread ] [ ...http://www.bio.net/bionet/mm/methods/2004-December/098972.html
Transgenic Mice Advice?
... Wolfgang Schechinger hubahopp at gmx.de Sat Dec 11 14:34:00 EST 2004 *Previous message: Transgenic ... Previous message: Transgenic Mice Advice? *Next message: Transgenic Mice Advice? * Messages sorted by: [ date ] [ thread ] [ ...http://www.bio.net/bionet/mm/methods/2004-December/098960.html
NASA - Muscle Atrophy of Muscle Sparing in Transgenic Mice
... including 10 NASA mice, and 10 CASIS mice. The CASIS mice include 16 week-old C57Bl female mice, 5 wild type and 5 transgenic ... Muscle Atrophy of Muscle Sparing in Transgenic Mice (Rodent Research-1 (CASIS)) - 11.22.16. Overview , Description , ... A total of 10 mice, 5 wild type and 5 transgenic, are sent to the ISS to live in microgravity for 21 days. ... Researchers aim to look at the muscle atrophy and muscle sparing in the transgenic mice. ...https://www.nasa.gov/mission_pages/station/research/experiments/1824.html
Recent Articles | Transgenic Mice | The Scientist Magazine®
A transgenic mouse company is paying researchers who mention its animal models in scientific papers. ... Fluorescent calcium sensors in transgenic mice give a real-time readout of neuronal activity. ... Researchers develop mouse lines to help them see whether the maternal or paternal X chromosome is inactivated. ... Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells. ...https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/1960/tags/transgenic-mice/
Transgenic mouse models of Alzheimer's disease. - PubMed - NCBI
Transgenic mouse models of Alzheimer's disease.. Elder GA1, Gama Sosa MA, De Gasperi R. ... Transgenic mouse models now exist that mimic a range of Alzheimer's disease-related pathologies. Although none of the models ... Transgenic modeling has been pursued on the basis of the amyloid hypothesis and has taken advantage of mutations in the amyloid ... Modeling has been most aggressively pursued in mice, for which the techniques of genetic modification are well developed. ...https://www.ncbi.nlm.nih.gov/pubmed/20101721?dopt=Abstract