Peloruside A is a microtubule-stabilizing agent isolated from a New Zealand marine sponge. Peloruside prevents growth of a panel of cancer cell lines at low nanomolar concentrations, including cell lines that are resistant to paclitaxel. Three xenograft studies in athymic nu/nu mice were performed to assess the efficacy of peloruside compared with standard anticancer agents such as paclitaxel, docetaxel, and doxorubicin. The first study examined the effect of 5 and 10 mg/kg peloruside (QD×5) on the growth of H460 non-small cell lung cancer xenografts. Peloruside caused tumor growth inhibition (%TGI) of 84% and 95%, respectively, whereas standard treatments with paclitaxel (8 mg/kg, QD×5) and docetaxel (6.3 mg/kg, Q2D×3) were much less effective (%TGI of 50% and 18%, respectively). In a second xenograft study using A549 lung cancer cells and varied schedules of dosing, activity of peloruside was again superior compared with the taxanes with inhibitions ranging from 51% to 74%, compared with ...http://mct.aacrjournals.org/content/early/2015/07/16/1535-7163.MCT-15-0167
Surface proteins of thymus-derived lymphocytes and bone-marrow-derived lymphocytes. Selective isolation of immunoglobulin and...
Accessible surface proteins of thymus-derived lymphocytes (T-cells) of normal CBA mice and bone-marrow-derived lymphocytes (B-cells) of congenitally athymic nu/nu mice were analysed. The surfaces of lymphocytes were radioiodinated by using the enzyme lactoperoxidase (EC 126.96.36.199), then solubilized either in acid-urea or in the non-ionic detergent Nonidet P-40. These lysates were then precipitated with antisera specific to either immunoglobulin or the θ-alloantigen in order to assess the presence of these surface markers. Comparable amounts of radioactivity in proteins specifically precipitable as immunoglobulin were obtained from T-lymphocytes and B-lymphocytes when the cells were disrupted by acid-urea. This immunoglobulin had mol. wt. approx. 180000 and was composed of light chains and μ-type heavy chains. When radioiodinated lymphocytes were solubilized with Nonidet P-40, 3-4% of radioiodinated high-molecular-weight protein of B-cells consisted of immunoglobulin, a result ...http://www.biochemj.org/content/140/3/345
A) Growth of MCF-7 tumours in athymic nude mice. Growt | Open-i
(A) Growth of MCF-7 tumours in athymic nude mice. Growth of MCF-7 tumours was inhibited by STX140 (5 mg kg−1 p.o.; daily) (*P|0.05) and STX140 (5 mghttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2600694_6604752f5&req=4
In Vivo Overexpression of IL-13 Receptor α2 Chain Inhibits Tumorigenicity of Human Breast and Pancreatic Tumors in...
In this study, we demonstrate that overexpression of IL-13Rα2 chain inhibits tumorigenicity of human breast and pancreatic tumor cells in nude mice. Although there was no difference in growth between vector only transfected cells and IL-13Rα2 chain transfected cells in vitro, in nude mice, tumorigenicity was impaired in IL-13Rα2 chain overexpressing tumors. The presence of inflammatory cells, particularly neutrophils were found to correlate with the lack of tumorigenicity or significant reduction in tumor growth rate. Neutrophils were found to produce IL-13 and IL-13 had modest antitumor effect in IL-13Rα2 overexpressing tumors. Moreover, IL-13Rα2 overexpressing tumor cells produced high level of IL-8 which has been shown to reduce tumorigenicity in several tumor models. To our knowledge this is the first report that implicates cytokine receptor chain in tumorigenesis.. It is of interest to note that stability of IL-13Rα2 chain expression ...http://jem.rupress.org/content/194/12/1743
"Virus in athymic nude mice." by castagnoli P. Ricciardi, M Lieberman et al.
Ricciardi, castagnoli P.; Lieberman, M; Finn, O; Kaplan, D H.; and Leukemia, L I., "Virus in athymic nude mice." (1978). Subject Strain Bibliography 1978. 1049 ...https://mouseion.jax.org/ssbb1978/1049/
3254 Breast cancer is the most common malignancy among American women and is responsible for about 44,000 deaths annually in the United States. In 10% of breast cancer diagnoses, the cancer has already spread to distant organs in the body. Approximately 25% of breast cancers spread first to the bone and cause local osteolysis. We have synthesized a novel proteasome inhibitor (BU-32) which shows promising inhibitory activity against MDA-MB-231 cells in the human breast cancer xenograft nude mouse model. BU-32 exhibits strong cytotoxicity on a panel of cell lines - MDA-MB-231 (IC50 5.8 nM), SKBR3 (IC50 5.7 nM) and MCF-7 cells (IC50 5.8 nM). BU-32 down- regulated a wide array of angiogenic marker genes and up-regulated apoptotic markers including Bid and Bax. Incubation of MDA-MB-231 with BU-32 resulted in the accumulation of cell cycle inhibitor proteins p21 and P27 as well as stabilization of tumor suppressor protein p53. It also resulted in a dose-dependent inhibition of all three proteasome ...http://cancerres.aacrjournals.org/content/68/9_Supplement/3254
In this report, we have examined the role of the NT-trk receptor axes in the development and progression of human prostatic carcinoma and PDAC-derived xenografts in nude mice and the consequences of disrupting trk-mediated signaling in these tumor types using a mixture of NT neutralizing antibodies (anti-NGF, anti-BDNF, anti-NT-3, and anti-NT-4/5). We provide evidence that the NT-trk receptor axes are involved in the growth of TSU-Pr1 and PC-3 prostatic carcinoma and AsPC-1 PDAC xenografts. Treatment with the anti-NT antibody mixture inhibited significantly the growth of TSU-Pr1 and AsPC-1 tumor xenografts over a 15-day period and was generally well tolerated. In addition, treatment of nude mice bearing PC-3 tumors with the antibody mixture (400 μg) caused significant tumor regression. The mixture of NT neutralizing antibodies did not inhibit the growth of either the SK-OV-3 or CFPAC xenografts, although each cell line expressed the ...http://clincancerres.aacrjournals.org/content/8/6/1924
"Fetal isoenzymes expression of heterotransplanted hela cells in nude m" by R M. Singer, E M. Leahy et al.
Singer, R M.; Leahy, E M.; and Gershwin, M E., "Fetal isoenzymes expression of heterotransplanted hela cells in nude mice." (1980). Subject Strain Bibliography 1980. 447 ...http://mouseion.jax.org/ssbb1980/447/
"Circulating immune complexes in sera of nude mice bearing human neurob" by J Cyong, W Brandeis et al.
Cyong, J; Brandeis, W; Helson, L; Good, R A.; and Day, N K., "Circulating immune complexes in sera of nude mice bearing human neuroblastoma cells. Abstr." (1980). Subject Strain Bibliography 1980. 2029 ...http://mouseion.jax.org/ssbb1980/2029/
3973 Fibroblast growth factor 8 (FGF8) is involved in regulation of growth of breast and prostate cancer cells which preferentially metastasize to bone. We have previously shown that overexpression of FGF8 (isoform b) in breast cancer cells increases tumor growth and angiogenesis in nude mice. Here we studied the role of FGF8 in formation of breast cancer metastasis in bone. MDA-MB-231 human breast cancer cells forming osteolytic bone metastases were transfected with FGF8 isoforms a, b and e. The in vitro proliferation and invasion of FGF8-transfected MDA-MB-231 cells did not differ from those of vector-transfected control cells (MDA-MB-231-Mock cells), nor did the growth rate of the orthotopical tumors in nude mice. However, when the cells were injected intracardially into nude mice micro x-ray analysis in vivo and histomorphometry of long bones ex vivo showed that FGF8-transfected MDA-MB-231 cells, ...http://cancerres.aacrjournals.org/content/66/8_Supplement/935.2
Obesity has been identified as one of the risk factor for breast cancer progression. However the mechanisms underlying this link are not completely understood. Specifically, breast cancer patients who are overweight, obese or have excess abdominal fat have increased risk of local or distant (metastasis) recurrence and cancer related death. Furthermore, breast cancer patients gain weight during treatment, especially those who receive hormone depletion therapies, are at increased risk of developing obesity and metabolic syndrome in surviving patients. Importantly, the presence of obesity may influence the resistance of breast cancer to existing treatments, such as aromatase inhibitors (AIs). In an effort to understand the effect of obesity on the growth of hormone dependent breast cancer tumors, we fed ovariectomized athymic nude mice a diet containing 45% kcal fat (45% of the total calories coming from the fat in the diet) and low fat (10% kcal fat) diet. We saw that ...http://cancerres.aacrjournals.org/content/74/19_Supplement/621
"T lineage lymphocytes in nude mice born from homozygous nu/nu parents." by F Loor, H Amstutz et al.
Loor, F; Amstutz, H; Hagg, L; Mayor, K S.; and Roelants, G E., "T lineage lymphocytes in nude mice born from homozygous nu/nu parents." (1976). Subject Strain Bibliography 1976. 3297 ...https://mouseion.jax.org/ssbb1976/3297/
Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor...
Abstract A human lung cancer (OTUK-tumor) was transplanted serially to nude mice, which invariably developed a marked neutrophilia. In order to analyze this phenomenon, in vitro ag..https://www.omicsonline.org/references/demonstration-of-granulopoietic-factors-in-the-plasma-of-nude-mice-transplanted-with-a-human-lung-cancer-and-in-the-tumor-tissue-1099838.html
Assay of Tumorigenicity in Nude Mice
... in assays of cell transformation, tumorigenesis, invasion and wound healing of cell and tissue culture associated techniqueshttp://www.biocyclopedia.com/index/cell_biology_methods/assay_of_tumorigenicity_in_nude_mice.php
"Twenty-three new human tumor lines established in nude mice." by J Fogh, T Orfeo et al.
Fogh, J; Orfeo, T; Tiso, J; Sharkey, F E.; Fogh, J M.; and Daniels, W P., "Twenty-three new human tumor lines established in nude mice." (1980). Subject Strain Bibliography 1980. 1235 ...http://mouseion.jax.org/ssbb1980/1235/
miR-211 reduces EOC tumorigenesisin vivo.A. Nude mice w | Open-i
miR-211 reduces EOC tumorigenesisin vivo.A. Nude mice were implanted with OVCAR3 cells stably expressing miR-Ctrl or miR-211. Tumor volume was measured every fihttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4359570_12943_2015_322_Fig7_HTML&req=4
"Comparison of nude mice with the host species for evaluation of the tu" by C H. Evans and J A. Paolo
Evans, C H. and Paolo, J A., "Comparison of nude mice with the host species for evaluation of the tumorigenicity of guinea pig and hamster cells transformed in vitro by chemical carcinogens." (1976). Subject Strain Bibliography 1976. 613 ...http://mouseion.jax.org/ssbb1976/613/
Gentaur Molecular :Biochai \ cDNA Nude Mouse Normal Tissue Kidney \ C1N34142
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Definition for nude mouse
nude mouse definition: a mouse with an inherited problem that prevents all of them from developing locks also stops them from immunologically rejecting personal cells and tissues; popular in preclinical…https://www.azdictionary.com/definition/nude%20mouse
4791 Prostate cancer (PCA) remains the most commonly diagnosed visceral cancer in men with more than 230,000 newly diagnosed cases in 2005, and is the second leading cause of cancer deaths among US men. Epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) are potent mitogens that regulate proliferation and survival of PCA cells via autocrine and paracrine loops involving MAPK, Akt and NF-κB-mediated signaling pathways. Recently we showed that inositol hexaphosphate (IP6) inhibits human PCA DU145 xenograft growth in male nude mice, which was associated with its anti-proliferative and apoptotic effects in both in vivo and in vitro PCA systems; however, its mechanism of efficacy is not known completely. Here, we performed detailed mechanistic studies with IP6 to assess and define its effect on growth inhibition and apoptosis in human PCA PC3 cells cultured under serum or starved-condition without or with growth factor stimulation. Cell growth and proliferation ...http://cancerres.aacrjournals.org/content/66/8_Supplement/1125.2
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T84 ATCC ® CCL-248™ Homo sapiens colon; derived from metast
The T84 cell line is a transplantable human carcinoma cell line derived from a lung metastasis of a colon carcinoma in a 72-year-old male. Tumor tissue was inoculated subcutaneously and serially transplanted in BALB/c nude mice.https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/APC/CCL-248.aspx
T84 ATCC ® CCL-248™ Homo sapiens colon; derived from metast
The T84 cell line is a transplantable human carcinoma cell line derived from a lung metastasis of a colon carcinoma in a 72-year-old male. Tumor tissue was inoculated subcutaneously and serially transplanted in BALB/c nude mice.https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Colon/CCL-248.aspx
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Three Reasons You Shouldn't Use Heterozygous Nude Mice or Rats as Sentinels | Taconic Biosciences
The use of sentinel animals in research and production colonies is critical to facilitate health monitoring and maintain animal quality. Read the entire article.https://www.taconic.com/taconic-insights/quality/three-reasons-you-shouldnt-use-heterozygous-nude-mice-or-rats-as-sentinels.html