*  FGF12 knockout cell line
Fast delivery of FGF12 knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. ... How are Hap1 knockout cell lines generated?. HAP1 knockouts are engineered using the CRISPR-Cas9 system to introduce frameshift ... How are HAP1 knockouts validated?. All HAP1 knockout cell lines are validated by PCR amplification and Sanger Sequencing to ... FGF12 HAP1 knockout Cell Culture. Biosafety Level. 1 Media Type. IMDM, 10% FCS Freeze Medium. IMDM, 20% FCS, 10% DMSO Revival. ...
  https://www.horizondiscovery.com/human-fgf12-knockout-cell-line-hzghc2257
*  Biology-Online • View topic - Knockout mice
If one parent is a wild-type mouse and the other is a homozygous knockout mouse, their offspring will be heterozygous at the ... Knockout mice. by cassieconte » Tue Feb 05, 2013 4:54 pm Can someone please explain how it is possible to have a heterozygous ... knock out mouse? If a gene is 'knocked-out,' how can the mouse be heterozygous for the gene? Will the mouse still produce ... If there is some of the protein made, the mouse is a knock-down and not a knock-out. Watch out for the other meaning of ...
  http://www.biology-online.org/biology-forum/post-149536.html
*  Knockout Mouse Catalog | Drug Development | genOway
Ready-to-use Knockout mouse models for target discovery and confirmation, in vivo compound specificity, MOA and clinical ... Custom Mouse Models. Custom Rat Models. Custom Cell Models. Catalog Models. *Off-the-Shelf Knockouts *Overview ... We offer you ready-to-use Knockout mouse models that perfectly fit into any tight schedule. ... I started this project with no personal experience in creating knockout mice. My early discussions with your scientists and ...
  https://www.genoway.com/services/catalog/knockout-mouse.htm?
*  Hyperplastic Gastric Tumors with Spasmolytic Polypeptide-Expressing Metaplasia Caused by Tumor Necrosis Factor-α-Dependent...
... we introduced a knockout mutation of Rag2 gene into the K19-C2mE mice to generate Rag2 (−/−) K19-C2mE mice that lack T and B ... The K19-C2mE mice were crossed with respective knockout mouse strains to generate Tnf (−/−) K19-C2mE, Il1r1 (−/−) K19-C2mE, and ... Suppression of gastric tumorigenesis by Tnf knockout mutation. In the glandular stomach of K19-C2mE mice, expression is ... Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 2000 ...
  http://cancerres.aacrjournals.org/content/65/20/9147
*  Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task - pdf descargar
Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task. . Biblioteca virtual ... In this study, we conducted a series of behavioral analyses on Capsr3-knockout KO mice and equivalent wild-type WT mice to ... In the late phase, the performance of the Caspr3-KO mice caught up to the level of WT mice, suggesting that the deletion of ... Correction: Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of ...
  http://libros.duhnnae.com/2017/jun9/149853141056-Caspr3-Deficient-Mice-Exhibit-Low-Motor-Learning-during-the-Early-Phase-of-the-Accelerated-Rotarod-Task.php
*  Inducible Knockout Mouse | Genome Engineering | genOway
Use an inducible Knockout mouse to inactivate your gene in an age-specific manner, and enable studies at defined development ... Inducible Knockout Mouse Model An inducible Knockout mouse defines a conditional biological model in which the target gene of ... Custom Knockout Mouse Services at genOway. genOway provides a one-stop solution for the design, creation and analysis of your ... Four mouse Knockout production options are available. All options include the same dedicated customer support. ...
  https://www.genoway.com/services/customized-mouse/knockout-models/conditional-ko-time.htm
*  Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis | Blood Journal
E) Viability of the cdc42 knockout primary mice and the bone marrow transplant recipient mice is depicted by the Kaplan-Meier ... Primary MxTgcdc42f/f (f/f) mice, n = 16; WT mice with f/f bone marrow reconstitution, n = 6; mice with WT bone marrow ... Mice. Mx1-Cre;cdc42flox/flox mice were generated as previously described and maintained on a 129/C57BL/6 mixed background in ... In previous studies using a Cdc42GAP knockout, Cdc42 gain-of-activity mouse model, we have shown that constitutively increased ...
  http://www.bloodjournal.org/content/110/12/3853?sso-checked=true
*  Van Remmen, Holly
Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in ... The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse ... Using a mouse model of sarcopenia, we're looking specifically at the role of oxidative stress, or free radicals, in the long- ... Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Nov 5;455:103-14. PMCID: ...
  https://omrf.org/research-faculty/scientists/van-remmen-holly/
*  004361 - B6.129-Xrcc5|tm1Nus|/J
... knock-out mice exhibit growth deficiency including decreased size of spleen, lymph nodes and thymus with curtailed T cell and B ... These Xrcc5 knock-out mice exhibit growth deficiency including decreased size of spleen, lymph nodes and thymus with curtailed ... JAX® Mice, Products & Services Conditions of Use. "MICE" means mouse strains, their progeny derived by inbreeding or ... Mice that are homozygous for the targeted mutation are viable, fertile, but are 40-60% the size of normal mice. No Xrcc5 ...
  https://www.jax.org/strain/004361
*  Caspase-7 was regarded as redundant with caspase-3 because these related cystein - How NF-B is activated: the role of the IB...
For instance eye lenses of caspase-7 knockout mice are grossly normal whereas those of caspase-3 deficient mice display marked ... Finally caspase-7 lacking mice are resistant to endotoxemia whereas caspase-3 knockout mice are vulnerable. These findings ... Oddly enough C57BL/6 mice deficient for both caspase-3 and -7 perish shortly after delivery while mice missing only caspase-3 ... Caspase-7?/? MEFs are more resistant to FasL- and UV-induced apoptosis than caspase 3?/? MEFs although double knockout MEFs are ...
  http://cancercurehere.com/?p=2125
*  Knockout mouse | medical research | Britannica.com
Knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or ... Knockout mouse models also give a better understanding of the role of similar genes involved in human diseases. Knockout mouse ... Generation of knockout mice. Technologies used to generate knockout mice include homologous recombination (or gene targeting) ... In order to generate a pair of true knockout mice (homologous knockouts), the mice must be bred over several generations. ...
  https://www.britannica.com/topic/knockout-mouse
*  Safe Knockout Mouse | Knockout Engineering | genOway
Safe Knockout to generate both conventional and tissue-specific Knockout mice from a single project, and substantially save ... Safe Knockout Mice. Generating both conventional (constitutive) and tissue-specific Knockout mouse models with the same gene ... technology that allows us to generate both conventional and tissue-specific KO mice from a single project. This innovative ...
  https://www.genoway.com/services/customized-mouse/knockout-models/safe-ko.htm
*  Knockout Mice Help Researchers Find Ways To Knockout Incontinence - Redorbit
When the researchers tested the bladders of the integrin knockout mice, they found the bladders were constantly squeezing and ... They also found that the mice overfilled their bladders and took much longer to urinate than the normal mice. ... while the second group of mice was normal. Both groups of mice had normal appearing bladders, but the group without the ... The research team tested two groups of mice. One group were genetically modified to be missing an important member of the ...
  http://www.redorbit.com/news/health/1112780817/bladder-incontinence-study-of-the-epithelium-and-integrins-020913/
*  Medical Xpress - knockout mice
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
  https://medicalxpress.com/tags/knockout+mice/sort/popular/1d/
*  Frontiers | Urea Transporter Physiology Studied in Knockout Mice | Physiology
Over the past few years, multiple UT knockout mouse models have been generated enabling us to explore the physiological roles ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... Since UT-B has a wide distribution, multiple phenotypic abnormalities were found in UT-B null mice, such as defective urine ...
  https://www.frontiersin.org/articles/10.3389/fphys.2012.00217/full
*  Knockout Mouse Phenotyping | NIH Common Fund
NIH…Turning Discovery Into Health®. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892. U.S. Department of Health and Human Services. ...
  https://commonfund.nih.gov/multimedia/videos/knockout-mouse-phenotyping
*  SAP/Sh2d1A Knockout Mouse | Taconic Biosciences
The SAP Knockout mouse was generated in 2001 by Michael J. Czar and Pamela Schwartzberg of the National Human Genome Research ... The SAP Knockout mouse was generated in 2001 by Michael J. Czar and Pamela Schwartzberg of the National Human Genome Research ... SAP protein is not present in these mice. The Sh2d1a gene is located on the X chromosome, so female knockouts are homozygous ... Homologous recombinants were screened and chimeric mice were bred to C57BL6/J mice. The line was backcrossed to C57BL/6J for 10 ...
  https://www.taconic.com/mouse-model/sapsh2d1a-knockout
*  Fam163b | Knockout Mouse | Research Models | Taconic Biosciences
See Taconic Bioscience's Constitutive Knock Out mouse, model # Fam163b ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as ... A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed ...
  https://www.taconic.com/knockout-mouse/fam163b-targeted
*  Napepld | Knockout Mouse | Research Models | Taconic Biosciences
See Taconic Bioscience's Constitutive Knock Out mouse, model # Napepld ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as ... A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed ... Mouse. Initial Publication:. http://www.ncbi.nlm.nih.gov/pubmed/14634025. http://www.ncbi.nlm.nih.gov/pubmed/16818490. http:// ...
  https://www.taconic.com/knockout-mouse/napepld-trapped
*  Jam3 | Knockout Mouse | Research Models | Taconic Biosciences
See Taconic Bioscience's Constitutive Knock Out mouse, model # Jam3 ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as ... A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed ... Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. ...
  https://www.taconic.com/knockout-mouse/jam3-targeted
*  Grem2 | Knockout Mouse | Research Models | Taconic Biosciences
See Taconic Bioscience's Constitutive Knock Out mouse, model # Grem2 ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as ... A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed ... Analysis of the mouse transcriptome based on functional annotation of 60, 770 full-length cDNAs. ...
  https://www.taconic.com/knockout-mouse/grem2-targeted
*  Knockout mouse - Wikipedia
A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or " ... The website for ordering ES cells and mice generated by TIGM Creating Knockout Mice for Targeting Vector from Knockout Mice ... Millions of knockout mice are used in experiments each year. There are several thousand different strains of knockout mice. ... Studying Gene Function: Creating Knockout Mice - a review from the Science Creative Quarterly The Knock Out Mouse Project (KOMP ...
  https://en.wikipedia.org/wiki/Knockout_mouse
*  International Knockout Mouse Consortium - Wikipedia
International Knockout Mouse Consortium Knockout Mouse Project (KOMP) Repository North American Conditional Mouse Mutagenesis ( ... The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem ... International Mouse Knockout Consortium (2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018 ... 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi: ...
  https://en.wikipedia.org/wiki/International_Knockout_Mouse_Consortium
*  Nucleoporin 85 - Wikipedia
A conditional knockout mouse line called Nup85tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi:10.1038/ ... "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452-64. ...
  https://en.wikipedia.org/wiki/Nucleoporin_85
*  Wrch1 - Wikipedia
A conditional knockout mouse line, called Rhoutm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. ...
  https://en.wikipedia.org/wiki/Wrch1