*  Women Who Are Prescribed Combination Hormone Replacement Therapy Should Use Caution When Taking Apigenin Supplements, MU Study...
... the other two were given apigenin through a diet supplemented with apigenin. Researchers found that the mice that ingested ... "However, the mice that ingested apigenin began metabolizing it-which seemed to aggravate the situation causing very aggressive ... "We know that apigenin is effective when injected directly into the bloodstream, so intravenous supplements may still be a ... A new study shows that when the supplement apigenin is ingested in a diet at the same concentration as subjects received during ...
  https://www.healthcanal.com/female-reproductive/45108-women-who-are-prescribed-combination-hormone-replacement-therapy-should-use-caution-when-taking-apigenin-supplements-mu-study-finds.html
*  Prostate tumour growth suppressed by flavonoids
... slowed the growth of prostate cancer in mice, according to a new study.< ... Apigenin, a flavonoid found in herbs, fruits, and vegetables, ... In the study, apigenin was fed to two groups of mice. For one ... the feeding of apigenin started two weeks before prostate cancer was implanted in the mice. For another group, apigenin was fed ... Apigenin, a flavonoid found in herbs, fruits, and vegetables, slowed the growth of prostate cancer in mice, according to a new ...
  http://www.medindia.net/news/view_news_main.asp?x=5422
*  ABC DAILY HERBAL NUTRIPOWDER PLUS | Herbactive Health Clinic
The researchers also showed how, in mice, apigenin stops tumor growth and lowers the growth rate of dangerous cancer cells. But ... Apigenin, a compound found in parsley, has repeatedly been found to have strong anti-cancer properties. In fact, more than 600 ... The apigenin that is so abundant in parsley has been found to have remarkable anti-inflammatory and antioxidant properties as ... Other sources of apigenin include grapefruit, peppermint, thyme, raw celery, and rutabagas, as well as chamomile flower tea. ...
  https://herbactive.co.uk/daily-nutritional-herbal-powder.php
*  Subchronic Exposure of Apigenin Induces Hepatic Oxidative Stress in Male Rats
The weights of liver and spleen in apigenin treatment groups did not reveal statistically significant difference when compared ... apigenin can result in the reduction of T-AOC, thus leading to the oxidative damage of liver tissues. In contrast, in middle- ... CAT and GSH-Px in apigenin treatment groups were significantly lower than those in the control group (P , 0.05). In high-dose ... we investigated the effect of apigenin at various dosages on the hepatic oxidative stress of male rats. Totally 48 SD male rats ...
  http://www.scirp.org/journal/PaperInformation.aspx?paperID=44785
*  Phytochemicals for Prevention of Solar Ultraviolet Radiation- Induced Damages[Dagger] - Redorbit
These findings were reinforced by the observation that apigenin-induced G2/M arrest of cultured mouse keratinocytes was ... Apigenin Apigenin (5,7,4'-trihydroxyflavone) is a natural flavonoid present in the leaves, stems, fruits and vegetables of ... Li, B., D. H. Robinson and D. F. Birt (1997) Evaluation of properties of apigenin and [G-3H]apigenin and analytic method ... 85) examined the effects of apigenin on the cell cycle and indicated that apigenin induced a reversible G2/M arrest in cultured ...
  http://www.redorbit.com/news/science/1305781/phytochemicals_for_prevention_of_solar_ultraviolet_radiation_induced_damagesdagger/
*  Frontiers | Differential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult...
Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice. Eur. J. Pharmacol. 774, 50-54. ... male C57BL/6J mice did not alter GluN1 and GluN2A gene expression, but significantly decreased GluN2B and GluN2C levels in the ... Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. Neurobiol. ... and incubated for 2 h with horseradish peroxidase-conjugated goat anti-rabbit or anti-mouse secondary antibodies (1:2500-20,000 ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2017.00025/full
*  Anti-Cancer Foods and Supplements - page 2 | Life Extension
Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse ... Flavonoids apigenin and quercetin inhibit melanoma growth and metastic potential. Int J Cancer 87:595-600. ... Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver ... Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean ...
  http://www.lifeextension.com/Magazine/2003/2/report_cancer/Page-02
*  E-Cigarettes Are Like Vaporizing Windshield Washer Fluid | HubPages
In vivo and in vitro percutaneous absorption of cancer preventive flavonoid apigenin in different vehicles in mouse skin. Pharm ... and biotransformation on the chemopreventive activity of apigenin, a plant flavonoid, in mouse skin. Pharm Res 13(10):1530-4. ... van den Abbeel, E., van der Elst, J., van der Linden, M., and van Steirteghem, A. C. High survival rate of one-cell mouse ... Tuo, J., Loft, S., Thomsen, M. S., and Poulsen, H. E. Benzene-induced genotoxicity in mice in vivo detected by the alkaline ...
  https://hubpages.com/health/E-Cigarettes-Are-Like-Vaporizing-Windsheild-Washer-Fluid
*  School of Medicine Masters and PhD Research Projects Tickets, Fri, 08/12/2017 at 3:00 pm | Eventbrite
Apigenin and curcumin decreased the number of activated (Iba1+) microglia in the GFAP-IL6 mouse by , 40%. Apigenin improves ... in the live mouse by positron emission tomography (PET). Potential for translation: a) If the utility of apigenin and curcumin ... Laboratory mouse models can assist in understanding the complex relationship of genes and environment (e.g. chronic cannabis ... This will be assessed using a variety of methods in transgenic mice, ranging from in vivo electroretinographic recordings, to ...
  https://www.eventbrite.com.au/e/school-of-medicine-masters-and-phd-research-projects-tickets-40894656017
*  PPAR: The Portrait of a Target Ally to Cancer Chemopreventive Agents
investigated apigenin, chrysin, and kaempferol in mouse macrophages and found that these flavonoids stimulated PPARγ ... mice," International Journal of Cancer, vol. 119, no. 10, pp. 2339-2346, 2006. View at Publisher · View at Google Scholar · ... by flavonoids in mouse macrophages," FEBS Letters, vol. 496, no. 1, pp. 12-18, 2001. View at Publisher · View at Google Scholar ... In the most widely used preclinical model of sporadic colon carcinogenesis, the azoxymethane-treated mice, activation of PPARγ ...
  https://www.hindawi.com/journals/ppar/2008/436489/
*  Altered Microbiome Contributes to Exaggerated Post-Diet Weight Regain in Mice | The Scientist Magazine®
... affecting the exchange of metabolites between a mouse and its resident bugs, researchers report. ... They also linked the metabolic health of mice to levels of the dietary flavonoids apigenin and naringenin, among other ... ran a series of experiments using a mouse model of recurrent obesity. The composition of a mouse's microbiome is predictive of ... See "How Diet Influences Host-Microbiome Communication in Mice". There is hope, however. Segal and colleagues also reported ...
  https://www.the-scientist.com/?articles.view/articleNo/47597/title/Altered-Microbiome-Contributes-to-Exaggerated-Post-Diet-Weight-Regain-in-Mice/
*  Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells | SpringerLink
Sup-pression of inducible cycooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse ... in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity. The inhibitory ...
  https://link.springer.com/article/10.1023/B:MCBI.0000044364.73144.fe
*  Natural Prostate Cancer Prevention - page 3 | Life Extension
Administering apigenin to mice-beginning either two weeks before, or two weeks after, inoculation with the cells-inhibited the ... Apigenin In studies on human cancer cells, scientists observed that the vegetable extract apigenin inhibits angiogenesisand ... Tumors in control mice that received a placebo solution showed unrestricted growth. But tumors in mice that received the ginger ... 182 A liquid suspension containing either apigenin or placebo was given to the mice daily, via a gastric tube, for eight or ten ...
  http://www.lifeextension.com/Magazine/2013/12/A-Natural-Arsenal-for-Prostate-Cancer-Prevention/Page-03
*  Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity | Chinese Medicine | Full Text
Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res. 1997 ... The effect of apigenin (20 μΜ) treatment on Bax protein levels. D. The effect of apigenin (20 μΜ) treatment on Bax/Bcl-2 ratio ... The effect of apigenin on apoptosis-related proteins. A. The effect of apigenin (20 μΜ) treatment on sFas protein levels. ... The effect of apigenin on cell viability and induction of apoptosis. A. The cytotoxic and antiproliferative effect of apigenin ...
  https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-8-9
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
Hashimoto, Y., Maxam, A. M., and Greene, M. I. (1986). T-cell antigen-receptor genes in autoimmune mice. Proc. Natl. Acad. Sci ... Kiraly, A. J., Soliman, E., Jenkins, A., and Van Dross, R. T. (2016). Apigenin inhibits COX-2, PGE2, and EP1 and also initiates ... THC reduced the growth of Trib3+/+ xenograft tumors; however, this effect was not seen in mice engrafted with Trib3−/− cells ( ... In the context of behavior, 2-AG has been shown to reduce locomotor activity in CB1/CB2 double knockout mice (Sigel et al., ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  A preliminary report on oral glucose tolerance and antinociceptive activity tests conducted with methanol extract of Xanthosoma...
... extract of aerial parts led to dose-dependent and significant reductions in blood glucose levels in glucose-loaded mice. At ... by observed decreases in abdominal constrictions in intraperitoneally administered acetic acid-induced pain model in mice. ... Apigenin derivatives, vitexin and isovitexin have been reported in X. violaceum[1]. Apigenin has been reported to be able to ... Briefly, fasted mice were grouped into six groups of five mice each. The various groups received different treatments like ...
  https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-335
*  Vargastem - Varga Őssejt kutatás - Őssejt terápia
Yano, S., et al.: Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N Mice; In: Biochemical ... a flavonoidokban dúsított APIGENIN kivonat. Az apigenin gyulladásátló hatása révén (hasonlóan az ibuprofenhez) megelőzheti az ... Wang, B., et al.: Effect of Ganoderma triterpene on proliferation of dendritic cells from mouse spleen; In: Zhong Yao Cai, 2005 ... Nishizawa, K., et al.: Antidepressant-like effect of Cordyceps sinensis int he mouse tail suspension test; In: Biol. Pharm. ...
  http://www.vargastem.hu/rakellenes_ossejtterapia.html
*  Micelles of TPGS modified apigenin phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation. ...
In vivo, an effective inhibition of 72.9% was achieved upon oral administration to S180 carcinoma mice compared to 19.5% by Ap- ... Micelles of TPGS modified apigenin phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation. ... Mixed micelles were designed to increase oral bioavailability of Apigenin (Ap). The phospholipid (Ph) complex technology was ...
  https://www.sigmaaldrich.com/catalog/papers/24266259
*  Nutrients | Free Full-Text | The Effect of Gestational and Lactational Age on the Human Milk Metabolome | HTML
Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional ... Profiles in the Liver of High-Fat Diet-Induced Obese Mice. Previous Article in Special Issue. The Essentiality of Arachidonic ...
  http://www.mdpi.com/2072-6643/8/5/304/htm
*  Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231...
To investigate potential anticancer properties of apigenin on human breast cancer, ER-positive MCF-7 and... ... Apigenin is found in several dietary plant foods such as vegetables and fruits. ... Liao Y, Shen W, Kong G, Lv H, Tao W, Bo P (2014) Apigenin induces the apoptosis and regulates MAPK signaling pathways in mouse ... Moreover, toxicological safety of apigenin towards normal cells was evaluated in human lymphocytes. Cytotoxicity of apigenin ...
  https://rd.springer.com/article/10.1007/s00210-018-1486-4
*  Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype:...
Perrott KM, Wiley CD, Desprez PY, Campisi J (2017) Apigenin suppresses the senescence-associated secretory phenotype and ... Gibson HE, Reim K, Brose N, Morton AJ, Jones S (2005) A similar impairment in ca3 mossy fibre ltp in the r6/2 mouse model of ... Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A (2017) A new mouse model of ... To achieve that goal, we induced hypertension in young C57BL/6 mice by chronic (4 weeks) infusion of angiotensin II. We found ...
  https://link.springer.com/article/10.1007%2Fs11357-017-9981-y
*  Insulin-Like Growth Factor-I Axis as a Pathway for Cancer Chemoprevention | Clinical Cancer Research
... growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice. ... Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green ... The in vivo anticancer effects of silibinin were associated with an increased accumulation IGFBP-3 in mouse plasma (44). ... Tumor inhibitory effects of apigenin, a dietary flavonoid abundantly present in fruits and vegetables, were observed to be ...
  http://clincancerres.aacrjournals.org/content/12/19/5611?ijkey=8b2d63ccffe2f768fdcee61d0627fcf03cf5f229&keytype2=tf_ipsecsha
*  Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. | Sigma-Aldrich
Apigenin is a plant-derived flavonoid and has been reported to prevent bone loss in ovariectomized mice, but the role of ... eliminated the stimulating effects of apigenin. In addition, addition of SP600125 or SB203580 also blocked apigenin-induced ALP ... We found that apigenin treatment significantly increased the levels of p-JNK, p-p38 in hMSCs and addition of the inhibitors of ... Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways.. [Xue Zhang, ...
  https://www.sigmaaldrich.com/catalog/papers/25994505
*  Phytochemistry and antioxidant activity of Lallemantia iberica aerial parts
... apigenin (10) were isolated and identified from the ethyl acetate and methanol extracts. The antioxidant activity of the ethyl ... 33] Hui L, Hong-Bo L, Ming Z, Fang Y, Zhong-Xian Z, Zhi-Lan L. Effect of apigenin on the reproductive system in male mice. ... apigenin-7-O-glucoside (7), Luteolin (8), diosmetin (9), apigenin (10) were isolated and identified from the ethyl acetate and ...
  http://www.rjpharmacognosy.ir/article_15634.html
*  Apigenin and its impact on gastrointestinal cancers. - PubMed - NCBI
Apigenin has been shown to inhibit cell growth, sensitize cancer cells to elimination by apoptosis, and hinder the development ... Apigenin is able to reduce cancer cell glucose uptake, inhibit remodeling of the extracellular matrix, inhibit cell adhesion ... As such, apigenin may provide some additional benefit beyond existing drugs in slowing the emergence of metastatic disease. ... Apigenin (4',5,7-trihydroxyflavone, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many ...
  https://www.ncbi.nlm.nih.gov/pubmed/23197449