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*  Mouse Model for Hepatocellular Carcinoma and Cholangiocarcinoma Originated from Mature Hepatocytes | Springer for Research &...
Targeting beta-catenin in hepatocellular cancers induced by coexpression of mutant beta-catenin and K-Ras in mice. Hepatology ... Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice. Sci Rep ... Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Oncogene 36(36 ... Butash KA, Natarajan P, Young A, Fox DK (2000) Reexamination of the effect of endotoxin on cell proliferation and transfection ...
  https://rd.springer.com/protocol/10.1007%2F978-1-4939-8961-4_20
*  c-Myc Antibody (9E10.3) [Allophycocyanin] (NBP2-47738APC): Novus Biologicals
Mouse Monoclonal Anti-c-Myc Antibody (9E10.3) [Allophycocyanin]. Validated: Flow. Tested Reactivity: Human, and more. 100% ... Beta Catenin Implications for Signaling. The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development ... c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety ... Anti-Mouse HRP Labeled Antibodies. *Anti-Mouse FITC Labeled Antibodies. *Anti-Mouse Biotin Labeled Antibodies ...
  https://www.novusbio.com/products/c-myc-antibody-9e103_nbp2-47738apc
*  Modeling the Influence of the E-Cadherin-[Beta]-Catenin Pathway in Cancer Cell Invasion: A Multiscale Approach - Redorbit
Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis. Development. 116:1011-1019. ... by promoting cell proliferation. Although the precise mechanisms which relate the beta-catenin nuclear translocation to cell ... all of them involving an upregulation of the soluble beta-catenin which overcomes the critical threshold c^sub T^. One case ... p120-catenin, beta-catenin, and beta-catenin. The alpha- catenin and beta-catenin then form a complex to link the actin ...
  http://www.redorbit.com/news/science/1529674/modeling_the_influence_of_the_ecadherinbetacatenin_pathway_in_cancer_cell/
*  Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling...
beta-Catenin mutation and its nuclear localization are confirmed to be frequent causes of Wnt signaling pathway activation in ... Immunolocalization of β-catenin and Lef-1 during postnatal hair follicle development in mice. Acta Histochem. 2012;114:773-8 ... Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem ... Our results suggest that Lef1 is a critical factor for the maintenance of the normal hair cycle and also might participate in ...
  http://www.medsci.org/v10p0738.htm
*  IJMS | Free Full-Text | Epidermal Stem Cells in Orthopaedic Regenerative Medicine | HTML
Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the ... Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev. Cell 2006, 11, 301-312. [Google Scholar] ... Regular articles: Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and ... ESCs are critical in the substitution of hair follicles. Epidermal cells from embryonic mouse skin, mixed with follicular ...
  http://mdpi.com/1422-0067/14/6/11626/htm
*  Aaron D. Gitler | Stanford Medicine Profiles
... and we demonstrate active Wnt/beta-catenin signaling in developing endocardial cushions suggesting pathways that have not been ... In a recent study, we used tissue-specific gene inactivation in mice to study the role of neurofibromin in heart development. A ... Our long-term goal is to identify the critical genes and cellular pathways affected by misfolded human disease proteins. ... Mutations that inactivate NF7 result in elevated levels of ras signaling and increased cell proliferation in some tissues. NF7 ...
  https://med.stanford.edu/profiles/aaron-gitler?tab=teaching
*  CTNNB1 | Beta-Catenin Antibody | Catenin beta-1 | Abgent
Beta-Catenin Antibody and Catenin beta-1 is available from Abgent for your research. Order your custom antibodies with us today ... and plays important roles in development, cellular proliferation, and differentiation (1). Beta-catenin is phosphorylated at ... Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as ... Mouse. Rabbit. Rat. Goat. chicken. Sheep. Hamster. Swine. Donkey. Guinea Pig. Horse. M. Mouse-Balb/c. Armenian Hamster. Mou. ...
  http://www.abgent.com/products/AJ1092a-Beta-Catenin-Antibody
*  Protocols and Video Articles Authored by Limor Landsman (Translated to Swedish)
... beta-Catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally ... β-catenin signaling and determined that it is a critical pathway in regulating mesenchyme survival and growth. Our study ... Elevated Hedgehog/Gli Signaling Causes Beta-cell Dedifferentiation in Mice Proceedings of the National Academy of Sciences of ... The long-term effects of VEGF include induction of proliferation and migration of endothelial cells, tube formation and ...
  https://www.jove.com/author/Limor_Landsman?language=Swedish
*  Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway | Clinical and...
The WNT/beta-catenin pathway induces the transcription of genes involved in cell proliferation, i.e., MYC and CYCLIN D1. This ... PPAR gamma activation induces inhibition of beta-catenin pathway, while the activation of the canonical WNT/beta-catenin ... PPAR gamma is downregulated while the WNT/beta-catenin pathway is upregulated. In cancer cells, upregulation of the WNT/beta- ... Moreover, prostaglandin E2 by activating the canonical WNT pathway plays also a role in cancer. In addition in many cancer ...
  https://clintransmed.springeropen.com/articles/10.1186/s40169-017-0144-7
*  Frontiers | Functions of GSK-3 Signaling in Development of the Nervous System | Frontiers in Molecular Neuroscience
All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development ... All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development ... creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development ... creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2011.00044/full
*  c-Myc Antibody (CT14.G4) [HRP] (NBP2-34600H): Novus Biologicals
Mouse Monoclonal Anti-c-Myc Antibody (CT14.G4) [HRP]. Validated: WB, ELISA, IHC-Fr. Tested Reactivity: Human, Primate. 100% ... Beta Catenin Implications for Signaling. The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development ... in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in ... Anti-Mouse HRP Labeled Antibodies. *Anti-Mouse FITC Labeled Antibodies. *Anti-Mouse Biotin Labeled Antibodies ...
  https://www.novusbio.com/products/c-myc-antibody-ct14g4_nbp2-34600h
*  c-Myc Antibody [Alexa Fluor® 647] (NB600-336AF647): Novus Biologicals
Beta Catenin Implications for Signaling. The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development ... Myc up-regulates the expression of many genes involved in cell growth and proliferation such as ribosome biogenesis and protein ... When used to detect the c-Myc protein this antibody reacts with human and mouse. ... Pathways for c-Myc Antibody (NB600-336AF647). View related products by pathway. ...
  https://www.novusbio.com/products/c-myc-antibody_nb600-336af647
*  wunen and wunen-2
... a critical regulator of Wnt signaling. Loss of LPP3 results in a marked increase in beta-catenin-mediated TCF transcription, ... In mouse, ectopic PGCs are eliminated by apoptotic death. It will be interesting to see whether nonapoptotic pathways, mediated ... These data demonstrate that the Ppap2c gene is not essential for embryonic development or fertility in mice (Zhang, 2000b). ... If, however, no germ cells reach a gonad, compensatory proliferation is not possible and the adult ovary or testis will be ...
  http://www.sdbonline.org/sites/fly/sturtevant/wunen1.htm
*  Frontiers | A review of hedgehog signaling in cranial bone development | Physiology
As demonstrated from murine studies, expression of both SHH and IHH is critical to the formation and fusion of the cranial ... IHH expression is mainly found on the osteogenic fronts of the calvarial bones, and functions to induce cell proliferation and ... Unfortunately, neonatal lethality of deficient mice precludes a detailed examination of their postnatal calvarial phenotype. In ... signaling pathway is essential for mesodermal tissue patterning and differentiation. The Hedgehog family consists of three ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00061/full
*  Antioxidants
... through UNC-1999 beta-catenin appearance, most likely induces hyperplasia and medulloblastoma development through the Wnt ... Keywords: Knockout mouse Gene prioritization Gene selection Web tool Introduction Measuring RNA-seq data from the knockout mice ... This Wnt induced pathway may represent a definite subgroup of tumors which may be successfully modeled and molecularly targeted ... Nevertheless, accurate molecular subclassification of embryonal tumor subtypes will end up being critical for the introduction ...
  http://www.brain-tumor-cancer-information.com/category/antioxidants/
*  Frontiers | Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell...
Our understanding of T cell memory has been greatly aided by the development of TCR Tg mice and MHC tetrameric staining ... Development of CD8+ T cell memory is regulated by the transcriptional programs that control the differentiation and survival of ... Development of CD8+ T cell memory is regulated by the transcriptional programs that control the differentiation and survival of ... This review will focus on the recent progress made in our understanding of the mechanisms underlying the development of T cell ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2012.00404/full
*  Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt...
Clevers H,Wnt/beta-catenin signaling in development and diseaseCellYear: 200612746948010.1016/j.cell.2006.10.01817081971. ... levels and concurrently attenuated the downstream Akt/Wnt signaling pathways that play a critical role in cell proliferation. ... catenin antibody, rabbit polyclonal anti-GSK3? antibody, mouse monoclonal anti-cyclin D1 antibody, goat polyclonal anti-?-actin ... catenin pathway [23]. The Wnt/?-catenin pathway plays a central role in elevating colonocyte proliferation [24] and suppressing ...
  http://www.biomedsearch.com/nih/Resveratrol-suppresses-IGF-1-induced/20504360.html
*  Produktübersicht anti-WNT4 Antikörper
... and beta-catenin (zeige CTNNB1 Antikörper) have roles in the signaling pathway during ovarian differentiation in mice. ... beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up- ... WNT4 drives a novel signaling pathway in ILC (zeige CCL27 Antikörper) cells, with a critical role in estrogen-induced growth ... Estimated diversity of messenger RNAs in each murine spermatozoa and their potential function during early zygotic development ...
  http://www.antikoerper-online.de/wnt-signalweg-pathway-10/wnt4-antibody-5575/
*  Colon Cancer Oncogene Discovered ( CDK8 is frequently amplified in these...)
They were required for cellular proliferation, critical to regulating the WNT/beta-catenin signaling pathway known to be ... Vaccine Stops Colon Cancers Spread in Mice. 10. Social, Health Care Factors Drive Colon Screen Disparities. 11. Caris ... 14 (HealthDay News) -- Researchers have identified a new genetic player in the development of colon cancer. ... It turns out that kinases tend to play key roles in the biochemical pathways that often go haywire in cancer, so they are ...
  http://www.bio-medicine.org/medicine-news-1/Colon-Cancer-Oncogene-Discovered-26412-1/
*  Protocols and Video Articles Authored by Michelle Van Scoyk (Translated to Russian)
Sep, 2006 , Pubmed ID: 16835228 The Wnt pathway is critical for normal development, and mutation of specific components is seen ... Wnt-7a and Fzd-9 induced both cadherin and Sprouty-4 expression and stimulated the JNK pathway, but not beta-catenin/T cell ... A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival ... mice treated with iloprost had reduced lung tumors and increased Fzd 9 expression. These studies define a novel paradigm, ...
  https://www.jove.com/author/Michelle_Van+Scoyk?language=Russian
*  C-Met - Wikipedia
The beta-catenin pathway, a key component of the Wnt signaling pathway, translocates into the nucleus following MET activation ... However, MET is not essential for heart development, since α-MHCMet-KO mice show normal heart development. MET is normally ... The RAS pathway mediates HGF-induced scattering and proliferation signals, which lead to branching morphogenesis. Of note, HGF ... Furthermore, MET is required for such critical processes as liver regeneration and wound healing during adulthood. HGF/MET axis ...
  https://en.wikipedia.org/wiki/C-Met
*  Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target
induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway," Journal of ... and low-grade endometrioid cancers are associated with mutations in the beta-catenin gene, CTNNB1, PTEN, and PI3CA and mucinous ... Angiogenesis is also critical for ascites development and metastasis in ovarian cancer. The role of chemokines in tumor ... In mice lacking CXCL12, the colonization of gonads by PGCs is impaired [103]. CXCR4 is expressed in mouse germ cells; whereas ...
  https://www.hindawi.com/journals/jo/2010/426956/
*  Frontiers | Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption | Immunology
TRAF3 protein levels decrease in bone and bone marrow during aging in mice and humans. Development of drugs to prevent TRAF3 ... Mice with TRAF3 conditionally deleted in mesenchymal cells also develop early onset osteoporosis due to a combination of ... Mice genetically engineered to have TRAF3 deleted in osteoclast precursors and macrophages develop early onset osteoporosis, ... Chloroquine also inhibits bone destruction induced by ovariectomy and parathyroid hormone in mice in vivo. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.02263/full
*  WNT Signaling and Colorectal Cancer | SpringerLink
... and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of... ... The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, ... beta-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated reprogramming of somatic cells to pluripotency. Cell ... The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor ...
  https://link.springer.com/article/10.1007/s11888-017-0354-9
*  Produktübersicht anti-WNT2 Antikörper
It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review) ... Wnt2 complements Wnt/beta-catenin (zeige CTNNB1 Antikörper) signaling in regulating colorectal cancer cell proliferation. ... We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk ... show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for ...
  http://www.antikoerper-online.de/wnt-signalweg-pathway-10/wnt2-antibody-7762/