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*  Genetic Mechanism To Convert Cells into Insulin Producers Identiied
... a research team has found a way to convert another type of pancreas cell into the critical insulin-producing beta cells, which ... Some experts believe that even if the findings in mice translate to human tissue, scientists would need to find a way to turn ... Insulin-Secreting Tissues can be Regenerated by Stem Cells. Diabetes is a debilitating lifestyle disease that leads to a ... Liver Cells May Be Transformed As Insulin-Producing Beta Cells: Study. Scientists may have moved a step closer to developing a ...
  http://www.medindia.net/news/Genetic-Mechanism-To-Convert-Cells-into-Insulin-Producers-Identiied-56089-1.htm
*  RegenerativeMedicine.net - Article Archives
Vanderbilt University scientists have found evidence that the insulin-secreting beta cells of the pancreas, which are either ... Mouse Study Indicates Scientists Program Blood Stem Cells to Become Vision Cells Reprogramming Human Cells Without Inserting ... Brain Cell Special Class of T Cells Shown to Both Attack Cancer Cells and Enlist Other Immune Cells Sleep Deprivation Affects ... reported important findings about the microenvironment of the insulin-secreting beta cells and glucagon-secreting alpha cells, ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=8998&qCat=USN
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. ... We recently showed that triclosan strongly affects mast cell function2. In an effort to avoid use of an organic solvent, ... For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice ... Functional beta cell mass is determined by the anatomical beta cell mass as well as the ability of the beta cells to respond to ...
  https://www.jove.com/visualize/abstract/19956728/perk-regulates-proliferation-development-insulin-secreting-beta-cell
*  UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice - Healthcanal.com : Healthcanal.com
Hebrok has spent years trying to develop insulin-secreting beta cells, a part of the pancreas that is destroyed during the ... Got the 'drunchies'? New study shows how heavy drinking affects diet 07/19/2018 Nutrition ... Hebrok likens the quest for organ specific cells, including thymus cells and the elusive pancreatic beta cell, to an ... UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice. ...
  https://www.healthcanal.com/immune-system/38714-ucsf-scientists-use-human-stem-cells-to-generate-immune-system-in-mice.html
*  High-density lipoprotein, beta cells, and diabetes - Zurich Open Repository and Archive
... knowledge will be of importance to design therapeutic tools to preserve the proper functioning of the insulin-secreting cells ... of scientists in working on beta cells and diabetes to better define the cellular pathways activated by HDLs in beta cells. ... We discuss the capacity of HDLs to modulate endoplasmic reticulum stress and how this affects beta-cell survival. We also point ... Mouse-hovering a term displays its timeline, clicking it yields the associated documents. ...
  http://www.zora.uzh.ch/id/eprint/105128/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... the effect of specific transcellular interactions on the insulin secreting capacity and responsiveness of beta cells is ... The GIR is indicative of whole-body insulin action, as mice with enhanced insulin action require a greater GIR. The insulin ... Duchenne muscular dystrophy (DMD) is a severe genetic neuromuscular disorder that affects 1 in 3,500 boys, and is characterized ... The ability to measure cellular metabolism and understand mitochondrial dysfunction, has enabled scientists worldwide to ...
  https://www.jove.com/visualize/abstract/24748202/the-effects-propionate-valerate-on-insulin-responsiveness-for-glucose
*  The human gut microbiome and body metabolism: implications for obesity and diabetes.
... which is due to the specific destruction of the endocrine insulin-secreting pancreatic [beta] cells resulting in an ... and insulin resistance secondary to dysregulation of interleukin-1[beta] signaling (43). When gut microbiomes from these mice ... This was associated with increased insulin resistance, although the food intake was reduced. The metabolic syndrome affects 1 ... and metabolomics in metabolic diseases will enable scientists to mine large data sets for disease-contributing features. Large ...
  https://www.thefreelibrary.com/amp/The+human+gut+microbiome+and+body+metabolism%3A+implications+for...-a0369319761
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The pancreatic islet is a unique micro-organ composed of several hormone secreting endocrine cells such as beta-cells (insulin ... For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice ... We recently showed that triclosan strongly affects mast cell function2. In an effort to avoid use of an organic solvent, ... Functional beta cell mass is determined by the anatomical beta cell mass as well as the ability of the beta cells to respond to ...
  https://www.jove.com/visualize/abstract/23077547/glucose-decouples-intracellular-ca2-activity-from-glucagon-secretion
*  David Hess | Robarts Research
... and to regenerate insulin-producing beta cells during diabetes. ... for his work include the use of transplanted human stem cells ... Hess's research is to understand the mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, ... Diabetes involves a progressive loss of insulin-secreting beta cells within islets of Langerhans, and affects ,250 million ... MRI tracking of transplanted iron-labeled mesenchymal stromal cells in an immune-compromised mouse model of critical limb ...
  http://www.robarts.ca/david-hess
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... this decrement develops from both an inability of beta cells to secrete insulin appropriately and the destruction of beta cells ... For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice ... The β-cells of the pancreatic islets of Langerhans are responsible for appropriately secreting insulin in response to elevated ... which significantly affects the pediatric population of patients due to their vulnerability to long-term immunosuppression. ...
  https://www.jove.com/visualize/abstract/24594640/ex-vivo-expanded-human-regulatory-t-cells-delay-islet-allograft
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... the effect of specific transcellular interactions on the insulin secreting capacity and responsiveness of beta cells is ... Humanized mice, stem cell transplantation, stem cells, in vivo animal imaging, T cells, cancer, animal model ... We recently showed that triclosan strongly affects mast cell function2. In an effort to avoid use of an organic solvent, ... Access to this online collection is currently provided to over 200 clinicians and scientists involved in type 1 diabetes ...
  https://www.jove.com/visualize/abstract/23861885/a-synthetic-model-human-beta-thalassemia-erythropoiesis-using-cd34
*  From Stem Cells to Billions of Human Insulin Producing Cells
"The biggest hurdle has been to get to glucose sensing, insulin secreting beta cells, and that's what our group has done." ... With human embryonic stem cells as a starting point, the scientists are for the first time able to produce, in the kind of ... "We've given these cells three separate challenges with glucose in mice and they've responded appropriately; that was really ... a condition that affects an estimated three million Americans at a cost of about $15 billion annually:. ...
  http://www.isscr.org/professional-resources/news-publicationsss/isscr-news-articles/article-listing/2014/10/09/from-stem-cells-to-billions-of-human-insulin-producing-cells
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... the effect of specific transcellular interactions on the insulin secreting capacity and responsiveness of beta cells is ... For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice ... We recently showed that triclosan strongly affects mast cell function2. In an effort to avoid use of an organic solvent, ... Functional beta cell mass is determined by the anatomical beta cell mass as well as the ability of the beta cells to respond to ...
  https://www.jove.com/visualize/abstract/22479612/isosteviol-has-beneficial-effects-on-palmitate-induced-cell
*  Stem cells: Therapy, controversy, and research
They are nonspecific cells that could become any kind of cell in the body. There is hope that they may be used in regenerative ... However, there is controversy about some uses of stem cells. Find out more. ... Stem cells are a type of cell that we all produce. ... cells-diabetic-patients-coaxed-develop-insulin-secreting-cells/ ... In mice and laboratory-grown cultures, the researchers successfully produced insulin-secreting cells from stem cells derived ...
  https://www.medicalnewstoday.com/articles/200904.php
*  You Must Know: Toxic Study List
Evidence that genistein increases rapid glucose-stimulated insulin secretion in both insulin-secreting cell lines and mouse ... 2006 Soy Genistein acutely stimulates insulin secretion in pancreatic beta-cells through cAMP-dependent protein kinase pathway ... 2005, De-masculinize male mice: John Hopkins School of Medicine: Exposure to endocrine disrupting chemicals adversely affects ... FDA Study: "FDA Scientists Against Soy" NIH scientists Drs. Doerge and Sheehan report, "Thus during pregnancy in humans, (soy) ...
  http://toxicstudylist.blogspot.com
*  Low thyroid hormone before birth alters growth and development of fetal pancreas
Levels of thyroid hormone in babies influence insulin-secreting cells of the pancreas, according to a new study published in ... Levels of thyroid hormone in babies influence insulin-secreting cells of the pancreas, according to a new study published in ... They also studied the rate of cell division and the number of beta cells, the cells of the pancreas that store and secrete ... The team of scientists from the UK, US, and Australia studied a sheep animal model of thyroid hormone deficiency before birth. ...
  https://www.pdn.cam.ac.uk/news/low-thyroid-hormone-before-birth-alters-growth-and-development-of-fetal-pancreas
*  DIABETES, FROM STEM CELLS TO INSULIN PRODUCERS
"The biggest hurdle has been to get to glucose sensing, insulin secreting beta cells, and that's what our group has done." ... "We've given these cells three separate challenges with glucose in mice and they've responded appropriately; that was really ... the scientists are for the first time able to produce, in the kind of massive quantities needed for cell transplantation and ... a condition that affects an estimated three million Americans at a cost of about $15 billion annually: With human embryonic ...
  https://ks-gopi.blogspot.com/2014/10/diabetes-from-stem-cells-to-insulin.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The pancreatic islet is a unique micro-organ composed of several hormone secreting endocrine cells such as beta-cells (insulin ... For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice ... which significantly affects the pediatric population of patients due to their vulnerability to long-term immunosuppression. ... This method is applicable to beta-cell lines, such as INS-1 cells, and to dissociated primary beta cells. It is based on ...
  https://www.jove.com/visualize/abstract/24621811/targeting-sur1abcc8-type-neuroendocrine-katp-channels-pancreatic
*  Frontiers | Role of Adaptor Proteins in Secretory Granule Biogenesis and Maturation | Endocrinology
Surprenant A. Correlation between electrical activity and ACTH/beta-endorphin secretion in mouse pituitary tumor cells. J Cell ... Direct identification of prohormone conversion site in insulin-secreting cells. Cell (1985) 42:671-81. doi:10.1016/0092-8674(85 ... Brefeldin A affects early events but does not affect late events along the exocytic pathway in pancreatic acinar cells. Proc ... Nevertheless, constitutive-like secretion has held many scientists' attention due to its potential link to cancer and metabolic ...
  https://www.frontiersin.org/articles/10.3389/fendo.2013.00101/full
*  WikiGenes - Igf2 - insulin-like growth factor 2
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell ... Overweight animals are hypophagic, suggesting that IGFII affects fat metabolism rather than feeding behavior in adult mice [5]. ... signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells ... Search thousands of articles and collaborate with scientists around the globe.. wikigene or wiki gene protein drug chemical ...
  https://www.wikigenes.org/e/gene/e/16002.html
*  BADERC Program Interest Areas
... or the susceptibility to the development of an autoimmune process that destroys the insulin-secreting beta cells of the ... beta cells in the adult mouse arise predominantly from the replication of preexisting beta cells, both in unstressed animals ... Type 2 diabetes affects 1/15 individuals of Caucasian ancestry over age 40, perhaps 1/10 individuals of African-American or ... C. Welt in collaboration with scientists at DECODE, are engaged in seeking the genes associated with the metabolic syndrome and ...
  http://baderc.org/programs.html
*  Immunomodulatory Effects Mediated by Dopamine
Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy ... β-cells and is cosecreted with insulin; this endogenous DA acts in an autocrine/paracrine manner on insulin-secreting β-cells ... affects proliferation and cytokine secretion in mouse splenocytes. This group demonstrated that L-DOPA increases the ... "Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion," The Journal of ...
  https://www.hindawi.com/journals/jir/2016/3160486/
*  Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells | Diabetes
Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells. Pharmacol Toxicol 2003;92:3-13. ... These findings establish cGKIα as an important signaling molecule that affects glucose metabolism in the mouse. ... Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and ... and by the Research Funding Programme for Young Scientists at the University of Tübingen to R.L. ...
  http://diabetes.diabetesjournals.org/content/60/1/148?with-ds=yes
*  Diabetes mellitus type 1 | Find Me A Cure
... they function quite like beta-islet cells, the insulin-secreting cells normally found in the pancreas. ... Indian scientists are using tissue engineering to give diabetes patients new insulin-making cells……...CLICK & SEE. ... from mice and placed them in a cocktail of appropriate biochemicals where they turn into insulin-secreting islet-like cells. ... Vitamin D affects your DNA through the vitamin D receptors (VDRs), which bind to specific locations of the human genome. ...
  https://findmeacure.com/tag/diabetes-mellitus-type-1/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... induce insulin expression in a mouse alpha cell line and provide a glimpse into potential intermediate cell states in beta-cell ... Type-1 diabetes (T1D) is an autoimmune disease in which insulin-secreting pancreatic beta cells are destroyed by the immune ... Its initial focus is to enable scientists to more effectively use the National Institutes of Health Roadmap Molecular Libraries ... Since we are particularly interested in how stereochemistry affects performance in biological assays, we prepared a ...
  https://www.jove.com/visualize?author=Paul+A+Clemons