Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in...
Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification ... RESULTS. Fetuin-A-containing CPPs were only detectable in the serum of CKD patients. Inflammatory markers, oxLDL and BMP-2 ... METHODS. We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis ... Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts ...http://sro.sussex.ac.uk/41694/
Renal osteodystrophy - Wikipedia
... vascular or other soft-tissue calcification. Renal osteodystrophy may exhibit no symptoms; if it does show symptoms, they ... Low activated vitamin D3 levels are a result of the damaged kidneys' inability to convert vitamin D3 into its active form, ... and imaging methods (including measurement of bone-mineral density), bone biopsy has been, and still remains, the gold standard ... London GM (February 2009). "Bone-vascular axis in chronic kidney disease: a reality?". Clinical Journal of the American Society ...https://en.wikipedia.org/wiki/Renal_osteodystrophy
A role for the endothelium in vascular calcification. - PubMed - NCBI
METHODS AND RESULTS: In this study, we use 2 mouse models of vascular calcification, mice with gene deletion of matrix Gla ... Vascular calcification is a regulated process that involves osteoprogenitor cells and frequently complicates common vascular ... To determine whether the vascular endothelium contributes osteoprogenitor cells to vascular calcification. ... A role for the endothelium in vascular calcification.. Yao Y1, Jumabay M, Ly A, Radparvar M, Cubberly MR, Boström KI. ...https://www.ncbi.nlm.nih.gov/pubmed/23852538
Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion | Circulation Research
Methods and Results: Alexa488-labelled fetuin-A was internalized by human VSMCs, trafficked via the endosomal system and ... Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion. Alexander N Kapustin, Martijn L Chatrou, ... Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion. Alexander N Kapustin, Martijn L Chatrou, ... Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion. Alexander N Kapustin, Martijn L Chatrou, ...http://circres.ahajournals.org/content/early/2015/02/23/CIRCRESAHA.116.305012
Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome SecretionNovelty and Significance | Circulation...
Methods and Results: Alexa488-labeled fetuin-A was internalized by human VSMCs, trafficked via the endosomal system, and ... vascular calcification. Introduction. Vascular calcification is the accumulation of calcium phosphate salts in the medial and ... Proposed role of exosomes in vascular repair and calcification. Healthy contractile vascular smooth muscle cells (VSMCs) ... Importantly, healthy VSMCs efficiently prevent vascular calcification by expression of calcification inhibitors, some of which ...http://circres.ahajournals.org/content/116/8/1312
Activation of AKT by O-Linked N-Acetylglucosamine Induces Vascular Calcification in Diabetes MellitusNovelty and Significance |...
Methods and Results: Low-dose streptozotocin-induced diabetic mice exhibited increased aortic O-GlcNAcylation and vascular ... Results. Increased Vascular O-GlcNAcylation and Calcification in Diabetic Mice. Using low-dose streptozotocin injection-induced ... Administration of Thiamet-G in diabetic mice further enhances vascular O-GlcNAcylation, accelerated vascular calcification and ... which led to the decrease in vascular calcification.. The contribution of AKT O-GlcNAcylation to VSMC calcification was further ...http://circres.ahajournals.org/content/114/7/1094
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in MenHighlights | Arteriosclerosis, Thrombosis,...
Materials and Methods are available in the online-only Data Supplement.. Results. Baseline Characteristics. Tables I and II in ... 10 and vascular calcification.11 We have recently reported that sortilin plays a key role in the development of vascular ... Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016;126:1323-1336. ... The value of arterial calcification in the cardiovascular risk assessment is well established.13 Coronary artery calcification ...http://atvb.ahajournals.org/content/37/5/1005
Bone Gla Protein Increases HIF-1α-Dependent Glucose Metabolism and Induces Cartilage and Vascular Calcification |...
Methods and Results-We established an in vitro BGP-overexpression model in chondrocytes (ATDC5) and vascular smooth muscle ... The in vivo model of 1,25(OH)2D3-induced vascular calcification in rats revealed a correlation between calcification, elevated ... Bone Gla Protein Increases HIF-1α-Dependent Glucose Metabolism and Induces Cartilage and Vascular Calcification. Anna Idelevich ... Bone Gla Protein Increases HIF-1α-Dependent Glucose Metabolism and Induces Cartilage and Vascular Calcification ...http://atvb.ahajournals.org/content/early/2011/07/14/ATVBAHA.111.230904
Transglutaminase 2-Mediated Activation of β-Catenin Signaling Has a Critical Role in Warfarin-Induced Vascular Calcification |...
Methods and Results-Warfarin-induced calcification in rat A10 VSMCs is associated with the activation of β-catenin signaling ... Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification. J Intern Med. 2006;260:192-210. ... Results. Warfarin Promotes Calcification in Cultured VSMCs. Previous studies have shown that warfarin induces calcification of ... Because vascular calcification can potently be promoted by oxidative stress,37 we examined the possibility that warfarin ...http://atvb.ahajournals.org/content/32/1/123
US Patent # 6,407,141. Oxalic acid or oxalate compositions and methods for vascular disorders, diseases, and calcerous...
... and methods of treatment and prevention of warm-blooded animals including humans and pets for vascular diseases, disorders, and ... Plaque results when calcification takes place in the cholesterol developed gummy substances in the inner lining of the arteries ... 8. A method of treating vascular diseases, plaque, microbial infections, fatty buildup, and calcification in patients sensitive ... A method for treating vascular diseases, plaque, microbial infections, fatty buildup, and calcerous conditions of the vascular ...http://patents.com/us-6407141.html
Vitamin K in hand osteoarthritis: results from a randomised clinical trial | Annals of the Rheumatic Diseases
... versus placebo on bone loss and vascular calcification among older adults regardless of their vitamin K status. At the final 3- ... Methods: This was an ancillary study to a randomised controlled trial assessing the effects of phylloquinone supplementation ( ... Results: This ancillary study had 378 participants (193 in vitamin K arm, 185 in placebo arm). There were no effects of ...http://ard.bmj.com/content/67/11/1570
Vascular Calcification and Osteoprotegrin in Chronic Kidney Disease - FullText - American Journal of Nephrology 2017, Vol. 46,...
The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods ... Vascular Calcification and Osteoprotegrin in Chronic Kidney Disease. Lenhard M.J.a, c · Maser R.E.a, b Author affiliations a ... This may be due in part to excess vascular calcification (VC), particularly coronary artery calcification (CAC). Worsening ... In vascular smooth muscle cells, receptor activator of nuclear factor-κβ ligand appears to promote calcification, whereas the ...https://content.karger.com/Article/FullText/477381
Clinical research in individual information of celiac artery CT imaging and gastric cancer surgery.
... course and anatomical variations of the celiac artery and vascular calcifications in 102 gastric cancer patients. RESULTS: (1) ... METHODS: Preoperative 64-MSCTA was performed to observe the origin, ... course and anatomical variations of the celiac artery and vascular calcifications in individual patient with gastric cancer. It ... METHODS: Preoperative 64-MSCTA was performed to ob ...http://www.biomedsearch.com/nih/Clinical-research-in-individual-information/23359186.html
Sequential Activation of Matrix Metalloproteinase 9 and Transforming Growth Factor β in Arterial Elastocalcinosis |...
The breaks in the elastic network of the vascular wall perfectly matched the kinetic defined by vascular calcification. As ... Methods and Results- Elastocalcinosis was induced in vivo and ex vivo using warfarin. Hemodynamic parameters, calcium ... Objective- Isolated systolic hypertension is associated with increased elastase activity, vascular calcification, and vascular ... a protein able to prevent calcification. Recently, undercarboxylated MGP was associated with vascular calcification in patients ...http://atvb.ahajournals.org/content/28/5/856
Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status | SpringerLink
Zittermann A, Koerfer R (2008) Protective and toxic effects of vitamin D on vascular calcification: clinical implications. Mol ... Methods. The study was conducted in Halle (Saale), Germany (51o northern latitude) as a placebo-controlled, double-blinded, ... Results. Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation, although ... Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL ...https://link.springer.com/article/10.1007/s00394-015-1106-8
Advanced Coronary and Carotid Arteriopathy in Young Adults With Childhood-Onset Chronic Renal Failure | Circulation
Results. Coronary Artery Calcifications. Significant calcification of coronary arteries (calcium score ,1) was noted in 34 of ... 14 Such an action could explain the preferential calcification of the media layer in uremia. Notably, vascular calcifications ... Methods and Results- We used novel noninvasive technologies to screen for coronary and carotid artery disease in 39 patients ... Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol Dial Transplant. 2000; 15: 1014-1021. ...http://circ.ahajournals.org/content/106/1/100
Characterization of Phosphate Transport in Rat Vascular Smooth Muscle Cells | Arteriosclerosis, Thrombosis, and Vascular Biology
Methods and Results- Primary cultures of VSMCs express both high affinity Na-dependent and Na-independent components of Pi ... Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic ... Characterization of Phosphate Transport in Rat Vascular Smooth Muscle Cells. Implications for Vascular Calcification. Ricardo ... Molecular mechanisms of vascular calcification. Lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 2006; 26: 1423- ...http://atvb.ahajournals.org/content/27/5/1030
Cortistatin Inhibits Migration and Proliferation of Human Vascular Smooth Muscle Cells and Decreases Neointimal Formation upon...
Methods and Results: SMCs from mouse carotid and human aortic arteries (hAoSMCs) and from human atherosclerotic plaques highly ... Cortistatin is elevated in plasma of patients suffering coronary heart disease and attenuates vascular calcification. ... Objective: To investigate the occurrence of vascular cortistatin and its effects on the proliferation and migration of SMCs in ... Cortistatin Inhibits Migration and Proliferation of Human Vascular Smooth Muscle Cells and Decreases Neointimal Formation upon ...http://circres.ahajournals.org/content/early/2013/04/17/CIRCRESAHA.112.300695
Lower serum magnesium is associated with vascular calcification in peritoneal dialysis patients: a cross sectional study | BMC...
In conclusion, our results support the assertion that Mg may inhibit vascular calcification, a condition that is highly ... This method of determining abdominal aortic calcification has been found to be a valid surrogate for assessing CAC (area under ... Patients with very little or no vascular calcification do not tend to develop vascular calcification over time and seem to ... If our results can be duplicated in large observational studies with repeated serum Mg and vascular calcification measurements ...https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0549-y
Results of Infrapopliteal Endovascular Procedures Performed in Diabetic Patients with Critical Limb Ischemia and Tissue Loss...
... vascular imaging, endovascular intervention, as well as prevention and treatment of vascular disease. ... and clinical studies focusing on vascular biology and physiology, ... International Journal of Vascular Medicine is a peer-reviewed, Open Access journal that publishes original research articles, ... Diabetic patients with infrapopliteal atherosclerosis frequently develop concentric continuous vascular wall calcifications, ...https://www.hindawi.com/journals/ijvm/2014/270539/
PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable...
Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med 2005;46:1278-84.PubMedGoogle Scholar ... had FDG uptake in at least one vascular bed. Following lifestyle changes that resulted in reduce LDL cholesterol and raised HDL ... No standard methods have been proposed, however, to robustly identify culprit lesions. In addition, different protocols between ... Vascular events during follow-up in patients with aortic arch atherosclerosis. Stroke 1997;28:36-9.PubMedCrossRefGoogle Scholar ...https://link.springer.com/article/10.1007%2Fs12350-011-9385-9
Leonardo da Vinci facts, information, pictures | Encyclopedia.com articles about Leonardo da Vinci
... calcification of vessels, and coronary vascular occlusion. He also returned briefly to an investigation of the structure of the ... In the case of the Magi altarpiece, however, the unfinished state may merely result from the fact that Leonardo left Florence ... His methods of illustration were particularly inventive: the bones of the thorax drawn orthographically; the cervical vertebrae ... His investigations into almost every field of known science in his time resulted in plans for everything from airplanes to air ...https://www.encyclopedia.com/people/literature-and-arts/european-art-1599-biographies/leonardo-da-vinci
Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients [Abstract]
Background: Vascular calcification (VC) is a key process associated with cardiovascular mortality in dialysis patients. ... Results: At baseline, 60% of the patients had detectable AAC on CXR. After 4 years, 77% had AAC. Patients with grade 1 and 2 ... Methods: 184 HD patients were enrolled and their annual posterior-anterior chest X-ray films (CXR) in 2009 and 2013 were ... Further investigation into the mechanistic roles of gelsolin in vascular calcification may provide new understanding of this ...http://www.medsci.org/v13p0092
Aortic Msx2-Wnt Calcification Cascade Is Regulated by TNF-α-Dependent Signals in Diabetic Ldlr−/− Mice | Arteriosclerosis,...
Methods and Results- HFD promoted obesity, hyperglycemia, and hyperlipidemia, and upregulated serum TNF-α in Ldlr−/− mice. ... Vascular Biology. Aortic Msx2-Wnt Calcification Cascade Is Regulated by TNF-α-Dependent Signals in Diabetic Ldlr−/− Mice. Ziyad ... Results. High-Fat Diets Induce TNF-α, Low-Grade Systemic Inflammation, and Medial Artery Calcification in Ldlr−/− Mice. The ... Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. 2004; 24: 1161-1170. ...http://atvb.ahajournals.org/content/27/12/2589
Abstract 18200: Sortilin Levels Correlated With Renal Function and Reduced by Strong Statins With Increased PCSK9 in Primary...
will result in the abstract being withdrawn and barred from presentation.. Atherosclerosis, Vascular Biology and Development ... Recent basic reports showed new aspects of Sortilin that it can bind to PCSK9, and also can enhance vascular calcification with ... Methods: A total of 62 patients (Male 33, Age 65±11 yrs) with primary dyslipidemia including 18 genetically confirmed ... Sortilin showed association with reduced renal function, and may associate with vascular calcification mechanism among chronic ...http://circ.ahajournals.org/content/134/Suppl_1/A18200