Table of Contents | Cancer Research
Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone ... Interleukin 12 Stimulates IFN-γ-Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor ... Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA ... Inhibition of Lipocalin 2 Impairs Breast Tumorigenesis and Metastasis. Xiaohong Leng, Tian Ding, Hui Lin, Yan Wang, Limei Hu, ...http://cancerres.aacrjournals.org/content/69/22
Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and...
... inhibited STAT signaling was anticipated. STAT3 was originally discovered as a mediator of cytokine signaling pathways that ... Roles for the stem cell associated intermediate filament nestin in prostate cancer migration and metastasis. Cancer Res 2007;67 ... Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against ... We were surprised to note that even after inhibition of HIF-1α, NF-κB, and STAT3 signaling by silibinin in tumors, we observed ...http://cancerpreventionresearch.aacrjournals.org/content/2/1/74
In Vivo Overexpression of IL-13 Receptor α2 Chain Inhibits Tumorigenicity of Human Breast and Pancreatic Tumors in...
Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice. J. Clin. Invest. 97:2792- ... TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Curr. Biol. 8:1243-1252. ... Inhibition of proliferation and clonal growth of human breast cancer cells by interleukin 13. Cancer Res. 56:3583-3588. ... Interleukin 8 expression regulates tumorigenicity and metastasis in androgen-independent prostate cancer. Clin. Cancer Res. 6: ...http://jem.rupress.org/content/194/12/1743
Döppler H[au] - PubMed - NCBI
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic ... Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling.. Cowell CF, Döppler H, Yan IK, Hausser A, ... TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis ... Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=D%C3%B6ppler+H%5Bau%5D&dispmax=50
Frontiers | Inflammatory Gene Expression Upon TGF-β1-Induced p38 Activation in Primary Dupuytren's Disease Fibroblasts |...
Inhibition of p38 phosphorylation reversed these processes in vitro.Conclusions: TGF-β1 induced p38 phosphorylation in ND cells ... Inhibition of p38 phosphorylation reversed these processes in vitro. Conclusions: TGF-β1 induced p38 phosphorylation in ND ... Chirco, R., Liu, X. W., Jung, K. K., and Kim, H. R. (2006). Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev. ... and interleukin 1 receptor accessory protein (IL1RAP) that were found to be over-expressed. Inhibition of p38 phosphorylation ...https://www.frontiersin.org/articles/10.3389/fmolb.2015.00068/full
Pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells | Stem Cell Research & Therapy ...
... inhibition, respectively), while inhibition of the TGFβ pathway was found to promote the pro-inflammatory response ( ... GeneSpring 12.1 and DAVID tools were used for bioinformatic and signaling pathway analyses. Cell migration was assessed using a ... pathways, respectively. Interleukin-1β (IL1β) was measured using ELISA. MSCs exposed to secreted factors present in conditioned ... which was found to be positively regulated by FAK and MAPK signaling and negatively regulated by TGFβ signaling. Thus, our data ...https://stemcellres.biomedcentral.com/articles/10.1186/scrt325
P-selectin - Wikipedia
"Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase". Neoplasia. 13 (5): 445-52. doi: ... positive regulation of phosphatidylinositol 3-kinase signaling. • inflammatory response. • calcium-mediated signaling using ... Woltmann G, McNulty CA, Dewson G, Symon FA, Wardlaw AJ (May 2000). "Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion ... "Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway". Mol. Biol. Cell ...https://en.wikipedia.org/wiki/P-selectin
206Targeting the PD-1/PD-L1 signaling pathway for the treatment of OS lung metastasis. Add ... 431Inhibition of matrix metalloproteinases by cysteamine regulates tumor invasion and metastasis in mouse models of human ... 114Evaluation of AP-1 signaling by interleukin-13 in human glioblastoma cells. Add ... 385Impact of immune selection pressure on epithelial cell signaling pathway activation in a syngeneic pancreatic cancer model. ...https://www.eventscribe.com/2016/SITC/aaSearchByPosterDaySession.asp?h=Browse%20by%20Poster%20Day
Phosphoinositide-Specific Phospholipase C - Page 2 - Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors
Lastly they demonstrate that YKL-40 activates MAPK Akt and Wnt/β-catenin signaling pathways and regulates apoptosis pyroptosis ... Anti-α5 and anti-αV antibodies in combination produced a significant inhibition of the effect of fibronectin on IL-8 secretion ... These studies demonstrate that YKL-40/Chi3l1/BRP-39 binds to interleukin-13 receptor α2 (IL-13Rα2). They also demonstrate that ... signaling and regulates oxidant injury apoptosis pyroptosis inflammasome activation antibacterial responses melanoma metastasis ...http://rectalcancersite.com/category/phosphoinositide-specific-phospholipase-c/page/2/
Interferon Lambda: A New Sword in Cancer Immunotherapy
Both type I and type III IFNs stimulate common signaling pathways, consisting of the activation of Jak1 and Tyk2 kinases and ... L. Wang, W. Z. Wu, H. C. Sun et al., "Mechanism of interferon alpha on inhibition of metastasis and angiogenesis of ... In human, 3 distinct proteins called IFN-λ1, IFN-λ2, and IFN-λ3 have been identified [1, 2]. They are also named interleukin-29 ... Although the two IFNs act through an identical signaling pathway in the cell, the pattern of their activity seems to be ...https://www.hindawi.com/journals/jir/2011/349575/
Myeloid-Derived Suppressor Cells in Cancer | Springer for Research & Development
Rane, S. G., and Reddy, E. P. (2000). Janus kinases: components of multiple signaling pathways. Oncogene 19(49):5662-5679. ... Sgadari, C., Angiolillo, A. L., and Tosato, G. (1996). Inhibition of angiogenesis by interleukin-12 is mediated by the ... A correlation between GM-CSF gene expression and metastases in murine tumors. Int J Cancer 47:413-420.PubMedCrossRefGoogle ... direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 62(22):6659-6666.PubMedGoogle ...https://rd.springer.com/chapter/10.1007/978-0-387-69118-3_8
Restoration of Tumor Immunosurveillance via Targeting of Interleukin-13 Receptor-α2 | Cancer Research
metastasis. Introduction. Recent studies of the murine 15-12RM fibrosarcoma regressor and CT-26 colon carcinoma lung metastasis ... Inhibition of IL-13 induction of TGF-β1 in the CT-26 tumor model. If indeed IL-13 induces TGF-β1 production via IL-13Rα2 ... Effects of targeting IL-13Rα2 signaling on the growth of 15-12RM fibrosarcoma. To determine if the IL-13 induction of TGF-β1 ... one might predict that such production should be inhibited by administration of various agents that block this pathway at ...http://cancerres.aacrjournals.org/content/68/9/3467
The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages
... the inhibition of STAT-3 and NF-κB signaling pathways blocks the TAM-induced upregulation of B7-H1 on HCC cells . ... Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), and Interleukin 23 (IL-23), whereas they exhibit a HLA-. IL-. phenotype in ... and metastasis  (Figure 3). COX-2 has also been demonstrated to activate STAT-3 signaling pathway . In normal ... Targeting STAT-3 signaling pathway might be a hopeful approach in the treatment of HCC. Liu et al. demonstrated that blocking ...https://www.hindawi.com/journals/bmri/2013/187204/
Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation | JEM
All these antiapoptotic pathways are likely to synergize to promote the survival of cancer cells and facilitate metastasis. ... Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells. J. Exp. Med. 189:1939-1946. doi: ... Blocking OX40L prevented the expansion of IL13+CD4+ or TNF+CD4+ T cells by TSLP-primed mDCs (,50% inhibition; Fig. S2 A), mDCs ... In the presence of IL-12, OX40L signaling instead promotes the development of Th1 cells that, like inflammatory Th2 cells, ...http://jem.rupress.org/content/early/2011/02/17/jem.20102131
Leukotriene B4 receptor 2 - Wikipedia
MMP2 pathway to promote the metastasis of SKOV-3 and CAOV-3 cancer cells in mice and may act similarly to promote metastases in ... 12-HHT stimulates the PC3 human prostate cancer cell line to activate several pro-growth and/or pro-survival signaling pathways ... Inhibition of BLT2 receptors by LY255283 but not of BLT1 receptors by U75302 and suppression of BLT2 receptors by siRNA ... BLT2 receptor knockout mice exhibit attenuated ovalbumen-induced allergic airway eosinophilia and Interleukin 13 (IL-13) ...https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2
Browsing by Degree "Cancer Biology"
... have identified the Ser112 and Ser136 residues of BAD as the convergence point for several survival signaling pathways ... LOCO-REGIONALLY TARGETING INTERLEUKIN-13 RECEPTOR ALPHA-2 AND MAXIMIZING THERAPEUTIC ACCESS TO GLIOBLASTOMAS USING BIOMARKER ... IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR ... We investigated whether Astaxanthin was effective against invasion and metastasis of triple-negative breast cancer (TNBC) ... ...https://wakespace.lib.wfu.edu/browse?value=Cancer+Biology&type=degree
DETERMINING AGE RANGES OF SKIN SAMPLES - DERMTECH INTERNATIONAL
One of these pathways involves the gene Sir2, a NAD+-dependent histone deacetylase. In yeast, Sir2 is required for genomic ... metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA). 34. 211452_x_at. leucine rich repeat (in FLII) ... Mutations that affect insulin-like signaling in worms, flies and mice are associated with extended lifespan. In yeast, Sir2 ... Almost conversely, SAPs activate factors (e.g., c-Jun) that promote both inhibition of procollagen synthesis and degradation of ...http://www.freepatentsonline.com/y2015/0259739.html
Prostaglandin EP3 receptor - Wikipedia
... interleukin 8, and MIP-1β trigger fever independently of EP3; and d) inhibition of the PGE2-EP3 pathway underlies the ability ... pathways that elevated cellular cytosolic Ca2+ which thereby regulate Ca2+-sensitive cell signaling molecules, and pathways ... However, some studies suggest an indirect pro-carcinogenic function for the EP3 receptor: The growth and metastasis of ... Gs and Gβγ components which proceed to activate cell signaling pathways that lead functional responses viz., pathways that ...https://en.wikipedia.org/wiki/Prostaglandin_EP3_receptor
Cancers | Free Full-Text | The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy | HTML
Cytotoxic ionizing radiation is known to trigger pro-inflammatory signaling cascades and immune activation secondary to cell ... or signaling through IFN-γ pathway constituents. In addition, the tumor may establish a locally immunosuppressive state by ... Chemo-immunotherapy with oxaliplatin and interleukin-7 inhibits colon cancer metastasis in mice. PLoS One 2014, 9, e85789. [ ... Immune-Mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast ...https://www.mdpi.com/2072-6694/6/4/1953/htm
Cancer Program Legacy Publication Resources
RESULTS: Aberrant mTOR signaling (phosphorylated-RPS6) was present in half of the cases, associated with IGF pathway activation ... We identified MAP3K8 (COT/TPL2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAFV600E cell lines. ... We found that solid tumors carrying the metastasis gene expression signature were most likely to be associated with metastasis ... Like cHLs, MLBCLs also had high levels of expression of the interleukin-13 (IL-13) receptor and downstream effectors of IL-13 ...http://portals.broadinstitute.org/cgi-bin/cancer/publications/pub_menu.cgi
Antibodies | Free Full-Text | Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted...
... thus interfering with cellular water homeostasis and intracellular signaling pathways, causing edema. Lethal factor is a zinc- ... Mathews, M.S.; Shih, E.C.; Zamora, G.; Sun, C.H.; Cho, S.K.; Kwon, Y.J.; Hirschberg, H. Glioma cell growth inhibition following ... Targeted protein toxins therefore have greatest potential for the treatment of residual disease and metastases in addition to ... A targeted toxin comprised of interleukin-13 and Pseudomonas exotoxin A showed synergistic cytotoxicity when combined with the ...http://mdpi.com/2073-4468/2/2/209/htm
All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in...
In our study, the effects of NF-κB activation or inhibition on TNFα/NOS2 induction are confirmed by ex vivo experiments. Our ... R. Y. C. Hsu, H. F. C. Chan, D. J. Spicer et al., "Liver metastasis 1 integrin-mediated cell adhesion and β cells increases LPS ... G. Kolios, K. L. Wright, J. D. Linehan, D. A. Robertson, and J. Westwick, "Interleukin-13 inhibits nitric oxide production in ... P. Hassanzadeh, "Colorectal cancer and NF-κB signaling pathway," Gastroenterology and Hepatology from Bed to Bench, vol. 4, no ...https://www.hindawi.com/journals/mi/2017/7353252/
Tumor microenvironment - Wikipedia
... such as interleukin 4 (IL-4) and interleukin 13 (IL-13). TAMs gather in necrotic regions of tumors where they are associated ... FasL inhibition also improves ACT efficacy. In ovarian cancer elevated VEGF levels and expression of the immune regulatory ... Destruction of the ECM also modulates the signaling cascades controlled by the interaction of cell-surface receptors and the ... Accordingly, IDO1 genetic deficiency is associated with reduced tumor burden and metastasis and enhanced survival in mouse ...https://en.wikipedia.org/wiki/Tumor_microenvironment
Frontiers | Diffuse intrinsic pontine glioma: poised for progress | Oncology
... "differential reprogramming of embryonic signaling organizers." They demonstrated involvement of two distinct oncogenic pathways ... 2008). Identification of Interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative ... 2006). Incidence and patterns of neuroaxis metastases in children with diffuse pontine glioma. J. Neurooncol. 77, 207-212. ... and p-glycoprotein inhibition (Greenberg et al., 2005). Most recently, convection-enhanced delivery has been used to deliver ...https://www.frontiersin.org/articles/10.3389/fonc.2012.00205/full