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*  15-Hydroxyeicosatetraenoic acid - Wikipedia
Metabolized in skin epidermis by Epidermis-type lipoxygenase 3 (eLOX3, encoded by the ALOXE3 gene) to make two products, ... inhibitor of 12-lipoxygenase but not other human lipoxygenases. This effect could also have anti-inflammatory and anti- ... an arachidonate lipoxygenase product". Biochimica et Biophysica Acta. 1136 (3): 247-52. doi:10.1016/0167-4889(92)90113-p. PMID ... EXC4 is further metabolized by removal of the γ-L-glutamyl residue to form EXD4 which is in turn further metabolized by removal ...
  https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
*  The Role of PPAR Receptors and Leukotriene Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer
J. Ghosh and C. E. Myers, "Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human ... C. D. Funk, "The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase- ... The third pathway for metabolizing arachidonic acid, the lipoxygenase pathway catalyzes the incorporation of one oxygen ... J. Ghosh and C. E. Myers, "Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells ...
  https://www.hindawi.com/journals/ppar/2008/827096/
*  ALOX15B - Wikipedia
Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene. ALOX15B, also known as 15- ... Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM (2003). "Reduced 15S-lipoxygenase-2 ... Krieg P, Marks F, Fürstenberger G (May 2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1 ... it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13- ...
  https://en.wikipedia.org/wiki/ALOX15B
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
... sequence indetity to mouse Arachidonate 8-lipoxygenase. Mouse e-12LO metabolizes arachidonic acid predominantly to 12(S)-HETE ... 12-lipoxygenase gene, see lipoxygenase#mouse lipoxygenases) are resistant to a) streptozotocin-induced, b) high fat diet- ... In humans, Arachidonate 12-lipoxygenase (12-LO, 12-LOX, ALO12, or platelet type 12-lipoxygenase) is encoded by the ALOX12 gene ... Arachidonate 12-lipoxygenase, 12R type, also termed 12RLOX and encoded by the ALOX12B gene, is expressed primarily in skin and ...
  https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
*  Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators | The Journal of Immunology
Of importance, lipoxygenases can initiate the biosynthesis of resolvins (both E- and d-series), as well as protectins and ... In turn, PGH2 is metabolized to PGs and thromboxanes via specific synthases (top panel). ASA-mediated acetylation of COX ... In the example shown here, epithelial cell COX-2 generates 18-HEPE from dietary EPA and PMN-expressed 5-lipoxygenase (5-LO), ... In addition to the arachidonate-derived lipoxins and ATLs, bioactive SPMs are also biosynthesized from the ω-3 polyunsaturated ...
  http://www.jimmunol.org/content/187/7/3475
*  The essential essential fatty acids, linoleic acid and arachidonic acid play - Genomics Proteomics and Bioinformatics
Nevertheless, whether COX-3 is normally involved with tumorigenesis is normally unidentified [13]. Lipoxygenases Lipoxygenases ... Five Lipoxygenase 123714-50-1 manufacture Activating Proteins (FLAP), which really is a 18 kDa membrane-bound proteins, has an ... which is normally then additional metabolized to prostaglandin E2 (PGE2), PGF2, PGD2 and various other eicosanoids [5,6]. COX-1 ... have regiospecificity during connections with substrates and upon this basis have already been specified as arachidonate 5-, 8 ...
  http://www.bioinf.org/index.php/2018/08/10/the-essential-essential-fatty-acids-linoleic-acid-and-arachidonic-acid-play/
*  Lipoxygenase - Wikipedia
Arachidonate 12-lipoxygenase, 12R type (ALOX12B), also termed 12R-lipoxygenase, 12R-LOX, and 12R-LO. It metabolizes arachidonic ... LipOXygenases DataBase Lipoxygenases iron-binding region in PROSITE PDB: 1YGE​ - structure of lipoxygenase-1 from soybean ( ... Arachidonate 12-lipoxygenase (ALOX12) (EC 1.13.11.31InterPro: IPR001885), also termed 12-lipoxygenase, platelet type platelet ... There are several lipoxygenase structures known including: soybean lipoxygenase L1 and L3, coral 8-lipoxygenase, human 5- ...
  https://en.wikipedia.org/wiki/Lipoxygenase
*  Patente WO2005102356A1 - Carotenoid analogs or derivatives for the inhibition and amelioration of ... - Google Patentes
The term "5-lipoxygenase", or "5-LO" generally refers to one member of this class of enzymes that has lipoxygenase and ... 5-LO, FLAP, and Phospholipase A2 (which catalyzes release of arachidonate from phospholipids) form a complex in association ... Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small ... 2004 are each incorporated herein). The current state of knowledge suggests that lipoxygenases, cyclooxygenases, and cytochrome ...
  http://www.google.es/patents/WO2005102356A1?cl=en
*  Eicosanoid - Wikipedia
... is metabolized to the 3 double bond-containing analog of 5-HETE viz., 5-HETrE (see arachidonate 5-lipoxygenase#mead acid). ... Lipoxygenases (LOXs): 5-Lipoxygenase (5-LOX or ALOX5) initiates the metabolism of arachidonic acid to 5- ... The enzyme arachidonate 12-lipoxygenase (12-LO or ALOX12) metabolizes arachidonic acid to the S stereoisomer of 12- ... ALOX12B (i.e. arachidonate 12-lipoxygenase, 12R type) forms R chirality products, i.e. 12R-HpETE and 12R-HETE. Similarly, ...
  https://en.wikipedia.org/wiki/Eicosanoid
*  ALOX12B - Wikipedia
Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, 12R-LOX, and arachiconate lipoygenase 3, is a lipoxygenase-type ... Among the human lipoxygenases, ALOX12B is most closely (54% identity) related in amino acid sequence to ALOXE3 ALOX12B ... ALOX12B is also capable of metabolizing free linoleic acid to 9(R)-hydroperoxy-10(E),12(Z)-octadecadienoic acid (9R-HpODE) ... ALOX12B arachidonate 12-lipoxygenase, 12R type". Boeglin WE, Kim RB, Brash AR (June 1998). "A 12R-lipoxygenase in human skin: ...
  https://en.wikipedia.org/wiki/ALOX12B
*  Arachidonate 5-lipoxygenase - Wikipedia
In another pathway, ALOX5 may act in series with a second lipoxygenase enzyme, ALOX15, to metabolize AA to lipoxin A4 (LxA4) ... the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase ... Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms essential fatty acids (EFA) ...
  https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase
*  ALOX12 - Wikipedia
"Entrez Gene: ALOX12 arachidonate 12-lipoxygenase". Yamamoto S, Suzuki H, Ueda N (March 1997). "Arachidonate 12-lipoxygenases". ... ALOX12 is also distinguished from arachidonate 12-lipoxygenase, 12R type (ALOX12B), which metabolizes arachidonic acid to the R ... also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type ... arachidonate:oxygen 12-oxidoreductase, Delta12-lipoxygenase, 12Delta-lipoxygenase, C-12 lipoxygenase, leukotriene A4 synthase, ...
  https://en.wikipedia.org/wiki/ALOX12
*  Eoxin - Wikipedia
Arachidonate 5-lipoxygenase Arachidonate 15-lipoxygenase Leukotriene 15-Hydroxyicosatetraenoic acid Greene ER, Huang S, Serhan ... EXC4 is further metabolized by removal of the γ-L-glutamyl residue to form EXD4 which is in turn further metabolized by removal ... lipoxygenases (5-LOX, 12-LOX, 15-LOXa, 15-LOXb), and cytochrome P450s, respectively. These pathways are the target of approved ... The same pathways that metabolize arachidonic acid to eoxines have been shown to metabolize anandamide, N- ...
  https://en.wikipedia.org/wiki/Eoxin
*  ALOX15 - Wikipedia
... leukocyte-type arachidonate 12-lipoxygenase, or arachidonate omega-6 lipoxygenase. The second discovered human 15-lipoxygenase ... omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases". The ... Human ALOX15 metabolizes eicosapentaenoic acid to 15S-hydroperoxy-5Z,8Z,11Z,13E,17E-eicosapentaenoic acid (15S-HpEPA) and 15S- ... whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10. Kelavkar and Badr (1999) stated that the ...
  https://en.wikipedia.org/wiki/ALOX15
*  Essential fatty acid interactions - Wikipedia
Other lipoxygenases-8-LO, 12-LO and 15-LO-make other eicosanoid-like products. To act, 5-LO uses the nuclear-membrane enzyme 5- ... Lipoxygenase oxidation removes no C=C double bonds, and leads to the LK. After oxidation, the eicosanoids are further modified ... Phinney, SD; RS Odin; SB Johnson & RT Holman (March 1, 1990). "Reduced arachidonate in serum phospholipids and cholesteryl ... Or it may be metabolized to form eicosanoids, epoxyeicosatrienoic acids (EETs), neuroprotectin D or various endocannabinoids ( ...
  https://en.wikipedia.org/wiki/Essential_fatty_acid_interactions
*  Hepoxilin - Wikipedia
Human lipoxygenases) that also contains a very long chain fatty acid. In this pathway, ALOX12B metabolizes the esterified ... Muñoz-Garcia, A; Thomas, C. P.; Keeney, D. S.; Zheng, Y; Brash, A. R. (2014). "The importance of the lipoxygenase-hepoxilin ... and concurrently the 8Z double bond in this arachidonate moves to the 9E position to form the intermediate product, 12S- ... Muñoz-Garcia, A; Thomas, C. P.; Keeney, D. S.; Zheng, Y; Brash, A. R. (2014). "The importance of the lipoxygenase-hepoxilin ...
  https://en.wikipedia.org/wiki/Hepoxilin
*  Prostaglandin 2 biosynthesis and metabolism Pathway Map - PrimePCR | Life Science | Bio-Rad
... or by Epidermis-type lipoxygenase 3 (LOXE3) [10], [11] and Arachidonate 12-lipoxygenase, 12R type (ALOX12B) [10], [11]. COX-1 ( ... PGH2 is metabolized by a set of enzymes. Thromboxane A synthase 1 (platelet) (THAS) forms 12-hydroxyheptadeca-5,8,10-trienoic ... Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. ... Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/prostaglandin-2-biosynthesis-metabolism-fm
*  Unprecedented LipoxygenaseHydroperoxide Lyase Pathways in the Moss Physcomitrella patens.
Trapping experiments with dimethyl sulfide revealed that an arachidonate 12-LOX is involved in the transformations. Using this ... Communications Bioorganic Chemistry Unprecedented Lipoxygenase/Hydroperoxide Lyase Pathways in the Moss Physcomitrella patens ... which are not further metabolized by HPL.[3] In intact moss we found no endogenous hydroxylated fatty acids after reduction; ... and in higher plants this type of resistance is often mediated by lipoxygenases.[21] We are particularly interested in ...
  https://www.docme.ru/doc/1942201/unprecedented-lipoxygenasehydroperoxide-lyase-pathways-in..
*  Plus it
It has been known for some time that a number of different forms of cytochrome P450 are able to metabolize arachidonate. In the ... is metabolized to biologically active molecules by three pathways, cyclooxygenase, lipoxygenase, and cytochromes P450 ( ... and lipoxygenases (Capdevila and Falck, 2001). The different hydroxyeicosatetraenoic fatty acids (HETEs) and ... Family 2 P450s metabolize arachidonate primarily to EETs (Daikh et al., 1994; Wu et al., 1996; Keeney et al., 1998; Luo et al ...
  http://dmd.aspetjournals.org/content/32/8/840
*  Inhibition of Cytochrome P450ω-Hydroxylase | Circulation Research
28 Although CYP4A1 and CYP4A3 can metabolize AA to 20-HETE and 11,12-EET, CYP4A1 specifically metabolizes AA to 20-HETE with ... Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries. Circ ... Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000; 41: 163-181. ... blockade of the CYP pathway and a shift in AA substrate to other oxygenase pathways such as cyclooxygenases and lipoxygenases ...
  http://circres.ahajournals.org/content/95/8/e65
*  Functional Impact of Collagens on the Activity Directed by the Promoter of the α5 Integrin Subunit Gene in Corneal Epithelial...
Arachidonate 15-lipoxygenase in human corneal epithelium and 12- and 15-lipoxygenases in bovine corneal epithelium: comparison ... Discovery of a second 15S-lipoxygenase in humans. Proc Natl Acad Sci U S A. 1997 ; 94: 6148-6152. ... XV, XVII, and XVIII, laminin-111, laminin-332, laminin chains α3, β3, and γ2, as well as fibronectin, have been found to be ... a family of enzymes that comprises 19 proteins in human that are involved in maintaining cellular homeostasis by metabolizing ...
  https://iovs.arvojournals.org/article.aspx?articleid=2451413
*  ALOXE3 - Wikipedia
ALOXE3 arachidonate lipoxygenase 3". Schneider C, Brash AR (August 2002). "Lipoxygenase-catalyzed formation of R-configuration ... ALOX3E metabolizes 12R-HpETE to 8R-hydroxy-11R,12R-epoxy-eicosatrienoic acid and metabolizes 9R-HpODE to products that contain ... The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases ... Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by ...
  https://en.wikipedia.org/wiki/ALOXE3
*  Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury ...
... and arachidonate monoxygenases. The latter comprise a subset of the cytochrome P450 ... Eicosanoids are synthesized by heme-containing enzymes, including cyclooxygenases, lipoxygenases, ... lipoxygenases, and arachidonate monoxygenases. The latter, arachidonate hydroxylases and epoxygenases, comprise a subset of the ... Of the sixty-five Cyp genes assayed, sixteen arachidonate-metabolizing Cyps (Table 1A) and twelve other Cyps (Table 1C) were ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-303
*  Role of Lipoxygenase Metabolites of Arachidonic Acid in Enhanced Pulmonary Artery Contractions of Female Rabbits | Hypertension
Immunohistochemical study on arachidonate 5-lipoxygenase in porcine leukocytes and other tissues. J Histochem Cytochem. 1991;39 ... Although 5-HETE did not contract pulmonary arteries of either males or females, arachidonic acid is metabolized by 5-LO to the ... and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994;269:13979-13987. ... Related expression of arachidonate 12- and 15-lipoxygenases in animal and human lung tissue. Am J Physiol. 1991;261:L399-L405. ...
  http://hyper.ahajournals.org/content/57/4/825.long