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*  The polarized localization of Osh4 is dependent on PI4P | Open-i
Membrane Proteins/genetics/metabolism*. *Phosphatidylinositol Phosphates/metabolism*. *Receptors, Steroid/genetics/metabolism* ... Bottom Line: Phosphatidylinositol-4-phosphate (PI4P) is produced on both the Golgi and the plasma membrane.We show here that in ... Bottom Line: Phosphatidylinositol-4-phosphate (PI4P) is produced on both the Golgi and the plasma membrane.We show here that in ... Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4214785_3389fig3&req=4
*  Diffusion and dissociation of GAP1IP4BP bound to PtdIns | Open-i
Phosphatidylinositol 4,5-Diphosphate. *Phosphatidylinositol Phosphates/metabolism. *Protein Structure, Tertiary. *ras GTPase- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2654307_JCB_200809073_GS_Fig7&req=4
*  Frontiers | Transcriptomic Analysis in a Drosophila Model Identifies Previously Implicated and Novel Pathways in the...
... phosphatidylinositol signaling, endocytosis and hedgehog signaling in the latter. Transcriptome remodeling effect of AEDs was ... In the cell communication category, these pathways are inositol phosphate metabolism, phosphatidylinositol signaling, ... and inositol phosphate metabolism, phosphatidylinositol signaling, endocytosis, and hedgehog signaling in the latter. ... and the gene set belonging to cell communication enriched inositol phosphate metabolism, phosphatidylinositol signaling, ...
  https://www.frontiersin.org/articles/10.3389/fnins.2011.00161/full
*  1-phosphatidylinositol-4-phosphate 5-kinase - Wikipedia
This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. ... In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol-4-phosphate_5-kinase
*  1-phosphatidylinositol-5-phosphate 4-kinase - Wikipedia
This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase
*  DI-fusion In Chinese hamster ovary K1 cells dog and human thyrotropin...
Phosphatidylinositol 4,5-Diphosphate. Phosphatidylinositol Phosphates -- metabolism. Receptors, Thyrotropin -- physiology. ... In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol ... In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol ...
  http://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57697/Details
*  Inositol-tetrakisphosphate 5-kinase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Shears SB (1989). "The ...
  https://en.wikipedia.org/wiki/Inositol-tetrakisphosphate_5-kinase
*  Phosphatidylinositol-3,4-bisphosphate 4-phosphatase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Howell S, Barnaby RJ, Rowe ... whereas its two products are 1-phosphatidyl-1D-myo-inositol 3-phosphate and phosphate. This enzyme belongs to the family of ... 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate Thus, the two substrates of this enzyme are 1-phosphatidyl-myo-inositol ... In enzymology, a phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) is an enzyme that catalyzes the chemical ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol-3,4-bisphosphate_4-phosphatase
*  Phosphatidylinositol-3-phosphatase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, two ... Lips DL, Majerus PW (1989). "The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH ... phosphate Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 3-phosphate and H2O, whereas its two ... "Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3- ...
  https://en.wikipedia.org/wiki/Phosphatidylinositol-3-phosphatase
*  1-phosphatidylinositol 4-kinase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, the ... phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. ... phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644-6. doi:10.1038/332644a0. PMID 2833705. Barylko B; Gerber, SH; Binns ... In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction ATP + 1- ...
  https://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase
*  Phosphoinositide 5-phosphatase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, 4 ... whereas its two products are 1-phosphatidyl-1D-myo-inositol 4-phosphate and phosphate. This enzyme belongs to the family of ... 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo- ... phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, and phosphatidyl-inositol- ...
  https://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase
*  Inositol-tetrakisphosphate 1-kinase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, 3 ... Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ (1987). "Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by ... Balla T, Guillemette G, Baukal AJ, Catt KJ (1987). "Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate ...
  https://en.wikipedia.org/wiki/Inositol-tetrakisphosphate_1-kinase
*  DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis |...
They includes known cancer-associated pathways 'phosphatidylinositol phosphate metabolism' [20], 'prolactin receptor signalling ... The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489-501.View ArticlePubMedGoogle Scholar ...
  https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0443-z
*  Asara JM[au] - PubMed - NCBI
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. ... TSHB mRNA is linked to cholesterol metabolism in adipose tissue.. Moreno-Navarrete JM, Moreno M, Ortega F, Xifra G, Hong S, ... Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. ... MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Asara+JM%5Bau%5D&dispmax=50
*  Phosphite-induced changes of the transcriptome and secretome in Solanum tuberosum leading to resistance against Phytophthora...
These changes were shown not to be due to phosphate depletion or acidification caused by phosphite treatment. Of the phosphite- ... We also observed changes in primary metabolism and cell wall-related processes. ... associated with lipid metabolism, phosphatidylinositol-4-phosphate kinase (PIP; DMP400032031) associated with cell wall ... phosphite and phosphate levels were measured in leaves to determine the effect of phosphite on phosphate uptake and metabolism ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-014-0254-y
*  Inositol-1,4-bisphosphate 1-phosphatase - Wikipedia
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, two ... 1D-myo-inositol 4-phosphate + phosphate Thus, the two substrates of this enzyme are 1D-myo-inositol 1,4-bisphosphate and H2O, ... whereas its two products are 1D-myo-inositol 4-phosphate and phosphate. This enzyme belongs to the family of hydrolases, ... Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5- ...
  https://en.wikipedia.org/wiki/Inositol-1,4-bisphosphate_1-phosphatase
*  John Asara | Harvard Catalyst Profiles | Harvard Catalyst
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018 May 03 ... Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. Proc Natl Acad Sci U S A. 2018 07 17; 115( ... Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans. Sci Rep ... Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2013 Jan 11; 339(6116):222-6. PMID ...
  https://connects.catalyst.harvard.edu/Profiles/display/Person/88579
*  PIK3CB Gene - GeneCards | PK3CB Protein | PK3CB Antibody
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta, including: function, proteins, disorders, pathways, ... Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.. Interacting Proteins for PIK3CB Gene. STRING ... Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3, ... Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3, ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=PIK3CB
*  Anti-PI3 Kinase p110 beta antibody [Y384] KO Tested Recombinant (ab32569)
Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.. * Sequence similarities. Belongs to the PI3/PI4-kinase ... Phosphatidylinositol 3 kinase catalytic beta polypeptide antibody. *Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa ... Metabolism. Developmental Biology. By research area. Immunology. Microbiology. Neuroscience. Signal Transduction. Stem Cells. ...
  https://www.abcam.com/pi3-kinase-p110-beta-antibody-y384-ab32569.html
*  UniProt: P48736
DR GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; ... ECO:0000269,PubMed:16127437, CC ECO:0000269,PubMed:7624799}. CC -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol ... DR GO; GO:0035004; F:phosphatidylinositol 3-kinase activity; TAS:UniProtKB. DR GO; GO:0046934; F:phosphatidylinositol-4,5- ... DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IDA:UniProtKB. DR GO; GO:0006661; P:phosphatidylinositol ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:P48736
*  Sphingolipid - Wikipedia
Brice SE, Alford CW, Cowart LA (March 2009). "Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate ... Additionally, modulation of sphingolipid metabolism by phosphatidylinositol (4,5)-bisphosphate signaling via Slm1p and Slm2p ... been shown between complex sphingolipid synthesis and cycling of phosphatidylinositol 4-phosphate by the phosphatidylinositol ... This forms ethanolamine phosphate and hexadecenal. Sphingolipids are commonly believed to protect the cell surface against ...
  https://en.wikipedia.org/wiki/Sphingolipid
*  Identification of Host Cell Factors Associated with Astrovirus Replication in Caco-2 Cells | Journal of Virology
... phosphatidylinositol and inositol phosphate metabolism, and RNA helicase activity decreased the amount of Yuc8 genomic RNA and ... The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication. Biochem Pharmacol 84: ... phosphatidylinositol (PI4KIII╬▓) and inositol phosphate (ITPR3) metabolism, and RNA helicase activity (DDX23) significantly ... Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at ...
  https://jvi.asm.org/content/89/20/10359
*  Pip4k2b MGI Mouse Gene Detail - MGI:1934234 - phosphatidylinositol-5-phosphate 4-kinase, type II, beta
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal. IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N- ... PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Orthology source: HomoloGene, HGNC ... J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53- ... interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5- ...
  http://www.informatics.jax.org/marker/MGI:1934234
*  Frontiers | Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation | Immunology
... metabolism and differentiation. Here, we discuss the impact of PIP5Ks on several T lymphocyte functions with a specific focus ... metabolism and differentiation. Here, we discuss the impact of PIP5Ks on several T lymphocyte functions with a specific focus ... and phosphatidylinositol 3,4,5-triphosphate (PIP3), which are essential for the activation of signalling pathways regulating ... and phosphatidylinositol 3,4,5-triphosphate (PIP3), which are essential for the activation of signalling pathways regulating ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00186/full
*  Frontiers | Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy | Immunology
In this context, targeting both tumor and T cell metabolism can beneficially enhance or temper immunity in an inhospitable ... In this context, targeting both tumor and T cell metabolism can beneficially enhance or temper immunity in an inhospitable ... phosphatidylinositol-3 kinase; PPP, pentose phosphate pathway; TCA, tricarboxylic acid; Teff, effector T cells; Th, helper T ... Targeting Metabolism for Efficient Immunotherapy. Targeting Glucose Metabolism. In tumors, T cell activation and proliferation ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.00353/full