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*  Response of atrial flutter to overdrive atrial pacing and intravenous disopyramide phosphate, singly and in combination. | Heart
Ten patients who suffered spontaneous paroxysms of atrial flutter were investigated by electrophysiological techniques. Two had overt Wolff-Parkinson-White syndrome; three Lown-Ganong-Levine syndrome; and one a concealed accessory atrioventricular connection. Atrial flutter was initiated, at study, by right atrial pacing and electrograms from the right atrium and coronary sinus were observed for at least five minutes to ensure stable flutter in both atria. Atrial flutter was terminated by 2.5 s or 5 s bursts of atrial pacing at rates 10, 50, or 100 beats/min faster than the intrinsic flutter rate in only two patients. Atrial flutter, which was reinitiated in two patients, was then treated with intravenous disopyramide phosphate, 2 mg/kg body weight, infused over five minutes. In all 10 patients the atrial rate slowed from a mean of 310 +/- 39 beats/min to 217 +/- 27 beats/min and atrial flutter terminated in one case. Though the mean ventricular rate fell from 161 +/- 52 beats/min to 156 +/- ...
  http://heart.bmj.com/content/44/3/240
*  Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor...
We studied the interaction of disopyramide, quinidine, and procainamide with cardiac muscarinic receptors. In electrophysiological experiments, the effects of disopyramide, quinidine, procainamide, and atropine were determined on spontaneously depolarizing guinea pig right atria (GPRA) both in the presence and absence of pharmacologically induced (physostigmine) cholinergic stimulation. All four agents demonstrated a concentration-dependent antagonism of the negative chronotropic effects of physostigmine. The order of anticholinergic potency was atropine greater than disopyramide greater than quinidine greater than procainamide. The ability of disopyramide to antagonize the physostigmine induced slowing was stereoselective, (+)disopyramide greater than (-)disopyramide. In contrast, the ability of quinidine to antagonize the negative chronotropic effects of physostigmine was non-stereoselective, quinidine = ...
  http://circres.ahajournals.org/content/47/6/855
*  Disopyramide - Wikipedia
Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity. Disopyramide's Class 1a activity is similar to that of quinidine in that it targets sodium channels to inhibit conduction. Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current. This results in an increased threshold for excitation ...
  https://en.wikipedia.org/wiki/Disopyramide
*  Fatal Disopyramide Intoxication from Suicidal/Accidental Overdose
Disopyramide is an oral antiarrhythmic drug which reduces conduction velocity, prolongs duration of action potential and the effective refractory period, and exerts vagolytic properties. The drug is usually well absorbed orally. The principal use of the drug is to suppress ventricular extrasystoles with usual oral dosage of 100 to 200 mg every 6 h, until blood levels of 2 to 4 µg/mL are attained. The use of the drug for suicide is uncommon as it is a prescription drug.. Two cases of fatal disopyramide intoxication seen at the Los Angeles County Medical Examiner's Office will be discussed followed by a review of the literature of fatal suicidal disopyramide overdose. Case 1 was a 31-year-old male pharmacist with known history of depression and no history of heart disease. His decomposed remains were found with a suicide note and with several disopyramide tablets. At autopsy the blood level for disopyramide ...
  https://www.astm.org/DIGITAL_LIBRARY/JOURNALS/FORENSIC/PAGES/JFS11241J.htm
*  Disopyramide phosphate / disopyramide phosphate FDA New drug application 070139 global drug patent coverage, generic...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
  https://www.drugpatentwatch.com/p/NDA/070139
*  Disopyramide phosphate / disopyramide phosphate NDA 070102 international drug patent coverage, generic alternatives and...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
  https://www.drugpatentwatch.com/p/NDA/070102
*  disopyramide phosphate - Blink Price $125.73 | Blink Health
Find the Blink Price & Information for disopyramide phosphate - as low as $125.73 - pick up at your pharmacy (Rite Aid, Walmart & more). Price transparency and up to 80% savings.
  https://www.blinkhealth.com/disopyramide-phosphate
*  Drugs Five Years Later: Disopyramide | Annals of Internal Medicine | American College of Physicians
Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and atrial arrhythmias has been found to be similar to that of the other type I antiarrhythmic drugs, quinidine and procainamide. Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the sick sinus syndrome. The available data indicate that it can be used safely in patients with bundle branch block and firstdegree or type I second-degree atrioventricular block. Disopyramide has been found at times to precipitate ventricular tachycardia or ventricular fibrillation. Because this drug often causes decompensation in patients with congestive heart failure, it must be used very cautiously, if at all, in such patients. ...
  http://annals.org/aim/article/695402/drugs-five-years-later-disopyramide
*  Disopyramide (Oral Route) Description and Brand Names - Mayo Clinic
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. This is due to lowered blood pressure. Getting up slowly may help. This effect does not occur often at doses of disopyramide usually used; however, make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. If the problem continues or gets worse, check with your doctor.. Disopyramide may rarely cause hypoglycemia (low blood sugar) in some people. (See the Side Effects of This Medicine section below.) If these signs appear, eat or drink a food containing sugar and call your doctor right away.. This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well.. Disopyramide may cause dryness of the eyes, mouth, and nose. For temporary ...
  https://www.mayoclinic.org/drugs-supplements/disopyramide-oral-route/description/DRG-20063502?p=1
*  Disopyramide (Oral Route) Proper Use - Mayo Clinic
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. This is due to lowered blood pressure. Getting up slowly may help. This effect does not occur often at doses of disopyramide usually used; however, make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. If the problem continues or gets worse, check with your doctor.. Disopyramide may rarely cause hypoglycemia (low blood sugar) in some people. (See the Side Effects of This Medicine section below.) If these signs appear, eat or drink a food containing sugar and call your doctor right away.. This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well.. Disopyramide may cause dryness of the eyes, mouth, and nose. For temporary ...
  http://www.mayoclinic.org/drugs-supplements/disopyramide-oral-route/proper-use/drg-20063502?p=1
*  Disopyramide
DESCRIPTION Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. The ...
  http://www.egeneralmedical.com/rxlist00000020.html
*  Disopyramide dictionary definition | disopyramide defined
disopyramide definition: Noun (uncountable) 1. An antiarrhythmic medication used in the treatment of ventricular tachycardia....
  http://www.yourdictionary.com/disopyramide
*  Abstract 3905: Effects of Flecainide on Left Ventricular Pressure Gradient and Prognosis in Patients With Obstructive...
It has been reported that disopyramide, a type I antiarrhythmic drug, may reduce left ventricular pressure gradient (LVPG) and improve symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM). In some patients, however, disopyramide therapy should be withdrawn because of anti-cholinergic side effects such as dry mouth, constipation, and difficulty in micturition. Flecainide, other type I antiarrhythmic drug, has been approved on the United States for oral administration to treat patients with ventricular and supraventricular arrhythmias, without vagolytic side effects. However, it is still unclear whether flecainide is effective for improvement of LVPG and long-term prognosis in patients with obstructive HCM. In this study, therefore, we evaluate a long-term efficacy of flecainide for LVPG and mortality in patients with obstructive HCM, in comparison to disopyramide.. Methods: In 484 patients with HCM who were diagnosed and followed-up in our ...
  http://circ.ahajournals.org/content/120/Suppl_18/S884.2
*  Disopyramide 50mg/5ml solution for injection ampoules | LloydsPharmacy
Great price on Disopyramide 50mg/5ml solution for injection ampoules. FREE delivery options available. Trusted service, convenient and safe shopping online
  http://www.lloydspharmacy.com/en/disopyramide-50mg-5ml-solution-for-injection-ampoules
*  Disopyramide Sustained-Release Capsules Information - Drugs.com
Easy to read patient leaflet for Disopyramide Sustained-Release Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
  https://www.drugs.com/cdi/disopyramide-sustained-release-capsules.html
*  Disopyramide Generic 100 Mg
As this eMedTV page explains, a doctor may prescribe 100 mg of generic disopyramide capsules to treat certain heart rhythm problems. This article takes a brief look at the generic versions of this medication and offers a link to more detailed information.
  http://heart.emedtv.com/disopyramide/disopyramide-generic-100-mg.html
*  What Is Disopyramide Used For?
As this eMedTV article explains, disopyramide is used for treating serious heart rhythm problems in adults. This page takes a detailed look at how this medication works, who it is approved for, and whether it can be prescribed for unapproved reasons.
  http://heart.emedtv.com/disopyramide/what-is-disopyramide-used-for.html
*  Disopyramide 100mg capsules | LloydsPharmacy
Great price on Disopyramide 100mg capsules. FREE delivery options available. Trusted service, convenient and safe shopping online
  http://www.lloydspharmacy.com/en/disopyramide-100mg-capsules
*  disopyramide | C21H29N3O - PubChem
disopyramide | C21H29N3O | CID 3114 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
  https://pubchem.ncbi.nlm.nih.gov/compound/disopyramide
*  Disopyramide Medicare Coverage and Co-Pay Details - GoodRx
Medicare coverage and pricing details for Disopyramide. Learn more about Medicare prescription drug plans and savings with GoodRx.
  https://www.goodrx.com/disopyramide/medicare-coverage
*  Plus it
The antiarrhythmic, electrophysiologic and hemodynamic effects of a new antiarrhythmic agent, ACC-9358, were evaluated. In anesthetized dogs, ACC-9358 converted ouabain-induced ventricular tachycardia to normal sinus rhythm at a cumulative dose equal to encainide or flecainide and less than disopyramide. In 24-hr coronary artery ligated dogs, ACC-9358 suppressed spontaneous ventricular arrhythmias for up to 6 hr after oral or i.v. administration. The antiarrhythmic effect and plasma concentrations of ACC-9358 correlated well for both oral (r = 0.88) and i.v. (r = 0.87) administration. ACC-9358, flecainide and disopyramide were equieffective in converting crush-stimulation-induced atrial flutter in anesthetized dogs to normal sinus rhythm. In alpha-chloralose-anesthetized, closed-chest dogs, ACC-9358 slowed impulse conduction through the atria, atrioventricular node, His-Purkinje system and ventricles and prolonged atrial functional refractory period. In ...
  http://jpet.aspetjournals.org/content/243/3/1225
*  Major side effects of class I antiarrhythmic drugs
The side effect profile ofhas been well established. Anticholinergic symptoms are most common, but cardiac toxicity is of greatest concern. In particular, the negative inotropic activity and proarrhythmic potential of disopyramide limits its use in s
  https://www.uptodate.com/contents/major-side-effects-of-class-i-antiarrhythmic-drugs
*  CiNii 論文 - Chronotropic, Inotropic, Dromotropic and Coronary Vasodilator Effects of Bisaramil...
The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.. ...
  https://ci.nii.ac.jp/naid/10008195458
*  DMOZ - Health: Pharmacy: Drugs and Medications: D: Disopyramide
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
  http://dmoztools.net/Health/Pharmacy/Drugs_and_Medications/D/Disopyramide/
*  DAILY QUIZ-1 - Pharmacognize Blog
1. Which of the following anti-arrhythmic drug is having Iodine? a. Disopyramide b. Flecainide c. Amiodarone d. Quinidine 2. The quality of Coca leaves is
  http://pharmacognizeblog.com/2016/10/23/daily-quiz/