Remodeling in asthma and COPD - differences and similarities - Sköld - 2010 - The Clinical Respiratory Journal - Wiley Online...
This leads to the activation, proliferation and contraction of fibroblasts in the connective tissue and increased extracellular ... Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor ... This suggests that besides destruction of the lung tissue, fibrotic mechanisms may occur in parallel. ... Inflammatory cells will be mentioned but mediators will not be discussed generally, because this is beyond the scope of this ...http://onlinelibrary.wiley.com/doi/10.1111/j.1752-699X.2010.00193.x/full
miR-133 and miR-30 Regulate Connective Tissue Growth Factor | Circulation Research
A well-organized extracellular matrix (ECM) is necessary to maintain strength and functional integrity of cardiac tissue and is ... to be an important mediator of tissue fibrosis.3,6-9 CTGF has thus emerged as a new target for the therapeutic intervention in ... fibrotic diseases. CTGF expression is induced by transforming growth factor (TGF)β and other prohypertrophic stimuli such as ... Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor ...http://circres.ahajournals.org/content/104/2/170
The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth
Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including ... connective tissue growth factor (CTGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), and mast cell ... "Autocrine transforming growth factor β stimulation of extracellular matrix production by fibroblasts from fibrotic human ... connective tissue growth factor (CCN2/CTGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF) appear ...https://www.hindawi.com/journals/mi/2013/639468/
Fibroblast-to-myofibroblast transition in bronchial asthma | SpringerLink
Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. Am J Respir Crit Care Med 173(1 ... the role of growth factors in triggering FMT is unquestionable and fundamental. Among all the identified pro-fibrotic factors, ... Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I ... Transforming growth factor-β1-induced expression of connective tissue growth factor is enhanced in bronchial fibroblasts ...https://link.springer.com/article/10.1007%2Fs00018-018-2899-4
Fibrosis - Wikipedia
... which deposit extracellular matrix into the surrounding connective tissue. This process of tissue repair is a complex one, with ... Other soluble mediators of fibrosis include CTGF, platelet-derived growth factor (PDGF), and Interleukin 4 (IL-4). These ... The most well characterized pro-fibrotic mediator is TGF beta, which is released by macrophages as well as any damaged tissue ... Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This ...https://en.wikipedia.org/wiki/Fibrosis
Signalling and regulation of collagen I synthesis by ET-1 and TGF-β1 - Horstmeyer - 2005 - The FEBS Journal - Wiley Online...
ET-1 further induced connective tissue growth factor (CTGF), as did TGF-β1, however, to lower levels. While rapid and sustained ... Is the door still open for the treatment of fibrotic diseases?, Life Sciences, 2014, 118, 2, 156. CrossRef ... tailoring the surface properties of biomaterials to modulate extracellular matrix, Scientific Reports, 2014, 4, 6325. CrossRef ... Mediators of Inflammation, 2013, 2013, 1. CrossRef ... An association of connective tissue growth factor (CTGF/CCN2) ...http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2005.05016.x/abstract
Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of Type I collagen ... One of the primary growth factors involved in the pulmonary fibrotic response is active TGF-β. Therefore, we determined the ... The importance of the ets family of transcription factors is apparent in extracellular matrix remodeling (12, 13) and lung ... Similar to active TGF-β, myofibroblasts are important mediators of fibrosis in response to bleomycin (21-23) and in patients ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3262682/
Effects of β-sitosterol derived from Artemisia capillaris on the activated human hepatic stellate cells and dimethylnitrosamine...
HSCs were activated by transforming growth factor-β (TGF-β) and the collagen-1 and α-smooth muscle actin (α-SMA) expressions ... Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human hepatic stellate cell (HSC) model and ... are activated and turned into the myofibroblastic cells and then join in synthesis and reorganization of connective tissue [16- ... Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human hepatic stellate cell (HSC) model and ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-363
Terminalia arjuna (Roxb.) Reverses the Molecular Signature of Fibrosis Induced by Isoproterenol in Rat Heart | Insight...
Connective Tissue Growth Factor; ECM: Extracellular Matrix; GPCRs: G-Protein Coupled Receptors; GSH: Glutathione; ISO: ... Horn MA, Trafford AW (2016) Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling. J Mol Cell Cardiol ... Transforming Growth Factor β1; TFs: Transcription Factors.. Introduction. Cardiac Fibrosis is one of the leading causes of ... Isoproterenol; MMP: Matrix Metalloproteinase; NFÃ Â¸B: Nuclear Factor-Ã Â¸appa B; Nrf2: Nuclear factor erythroid related factor ...http://www.imedpub.com/articles/terminalia-arjuna-roxb-reverses-themolecular-signature-of-fibrosis-induced-byisoproterenol-in-rat-heart.php?aid=21258
Oryeongsan suppressed high glucose-induced mesangial fibrosis | BMC Complementary and Alternative Medicine | Full Text
Moreover, Oryeongsan promoted extracellular matrix degradation through disturbing transforming growth factor β (TGF-β)-Smad ... whereas suppressed HG-induced tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) expression. ... HG enhanced expression of fibrosis biomarkers such as collagen IV and connective tissue growth factor (CTGF), which was ... Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0542-6
UCD Dublin | Research | Medicine
Crean JK, Lappin D, Godson C, Brady HR; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic ... The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production ... Godson, C.; (2005) Invited Speaker: Taking insult from injury: lipoxins pro-resolution, anti-fibrotic mediators in renal ... Connective tissue growth factor antagonizes transforming growth factor-beta 1/Smad signalling in renal mesangial cells'. ...http://www.ucd.ie/research/people/medicine/professorcatherinegodson/
Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough
Other growth factors take part in prolonged fibrogenesis. CTGF (connective tissue growth factor) acts synergistically with TGF- ... transforming growth factor receptor-β1) and TGF-βR2. Therefore, there is a large pool of inactive TGF-β1 in the extracellular ... Figure 2: Fibrosis is a multicomponent pathology driven by multiple factors. Fibrotic diseases are driven by multiple factors ... Tissue injuries induce damages to resident cells which secrete inflammatory mediators which initiate an antifibrinolytic- ...https://www.hindawi.com/journals/sci/2014/340257/
Review. The lens as a model for fibrotic disease | Philosophical Transactions of the Royal Society B: Biological Sciences
IL-4 additionally heightens the production of TGFβ and connective tissue growth factor  and decreases IFN-γ. Secretion of ... The cytokine TGFβ is widely implicated as being a central mediator of the fibrotic response ; consequently, there is a great ... a pathological condition in which tissue structure is disrupted by production of excessive extracellular matrix (ECM)' [1,2]. ... Growth factors such as fibroblast growth factor (FGF), epidermal growth factor and platelet-derived growth factor (PDGF) can ...http://rstb.royalsocietypublishing.org/content/366/1568/1301
Modulation of angiotensin II signaling in the prevention of fibrosis | Fibrogenesis & Tissue Repair | Full Text
The presence of an autologous renin-angiotensin system has been demonstrated in almost all tissues of the body. It is now known ... This article reviews current knowledge on the role that angiotensin II plays in tissue fibrosis, as well as current and ... in a multitude of tissues outside of the cardiovascular and renal systems, including pulmonary fibrosis, intra-abdominal ... Rupérez M, Lorenzo O, Blanco-Colio LM, Esteban V, Egido J, Ruiz-Ortega M. Connective tissue growth factor is a mediator of ...https://fibrogenesis.biomedcentral.com/articles/10.1186/s13069-015-0023-z
Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor...
The aim of this study was to isolate and characterise renal fibroblasts from cadaverous kidney tissue of cats with and without ... Cortical fibroblast cultures were successfully established from the kidney tissue of cats with normal kidney function (FCF) and ... and connective tissue growth factor (CTGF) . TGF-β1 is a pro-fibrotic cytokine thought to be the primary mediator driving ... growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix ...https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1387-2
Co-upregulation of Transforming Growth Factor Beta-1 and Nitric Oxide Synthase in Keloid by comparison to normal human skin-A...
Mediators Inflamm 6573802.. *Gardner DL (1992) Pathological basis of the connective tissue diseases. London: Hodder & Staughton ... Verrecchia F, Mauviel A (2002) Transforming growth factor-beta signalling through the Smad pathway: role in extracellular ... Ding J, Tredget EE (2015) The role of chemokines in fibrotic wound healing. Adv Wound Care (New Rochelle) 4: 673-686. ... Fibrogenesis Tissue Repair 5: S29.. *Border WA, Nobel NA (1994) Transforming growth factor b in tissue fibrosis. N Engl J ...https://www.omicsonline.org/open-access/coupregulation-of-transforming-growth-factor-beta1-and-nitric-oxide-synthase-in-keloid-by-comparison-to-normal-human-skina-possibl.php?aid=93904
Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin...
Connective tissue growth factor: a mediator of TGF-␤ action on fibroblasts. Cytokine Growth Factor Rev 1997; 8:171-9. 36. Yuan ... is primarily associated with extracellular matrix production and up-regulation of platelet-derived growth factor (PDGF) ... is a mediator of the fibrotic effect of bleomycin at the transcriptional level and that the TGF␤ response element is required ... Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. ...https://www.docme.ru/doc/2165780/disruption-of-tumor-necrosis-factor-receptor-p55-impairs-..
A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue...
Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and ... MMPs digest ECM components and are considered important mediators of tissue remodeling [ 32, 33 ]. MMPs are regulated by their ... In addition, the expression of various genes encoding extracellular matrix proteins was upregulated. Fibrotic tenascin-C ... of the 3D collagen-matrices model with lung fibroblasts in investigating the airway remodeling process in connective tissue. ...http://paperity.org/p/85205146/a-3d-epithelial-mesenchymal-co-culture-model-of-human-bronchial-tissue-recapitulates
Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells | BMC Complementary and Alternative Medicine | Full...
... type I collagen and fibronectin in LTC-14 cells against transforming growth factor-beta stimulation. Though the values of ... curcumin and resveratrol significantly suppressed the mRNA and protein levels of several fibrotic mediators namely alpha-smooth ... We examined the anti-fibrotic effects of a variety of herbal constituents using a cellular platform, the LTC-14 cells, which ... Our findings suggest that the mentioned phenolic compounds may serve as anti-fibrotic agents in PSC-relating disorders and ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0789-y
The relationship between anti-vascular endothelial growth factor and fibrosis in proliferative retinopathy: clinical and...
... transforming growth factor β2 (TGFβ2), (B) connective tissue growth factor (CTGF) and (C) ciliary neurotrophic factor (CNTF) ... CTGF is a secreted protein that modulates the activity of many growth factors and extracellular matrix (ECM) proteins, leading ... 25 CTGF is also induced by growth factors such as VEGF and TGFβ.24 In PDR, the switch from neovascularisation to a fibrotic ... transforming growth factor β2 (TGFβ2), (B) connective tissue growth factor (CTGF) and (C) ciliary neurotrophic factor (CNTF) ...http://bjo.bmj.com/content/100/10/1443
Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats | Journal of Translational Medicine |...
Ruperez M, Lorenzo O, Blanco-Colio LM, Esteban V, Egido J, Ruiz-Ortega M: Connective tissue growth factor is a mediator of ... The papillary muscle was a prominent fibrotic site. In the left ventricle, mRNA levels of collagen1a (Col1a) (Figure 5C), ... TGFβ1 has been reported to be involved in fibroblast proliferation and extracellular matrix deposition. Gene expression of TGF ... transforming growth factor beta 1 (TGFβ1) (Figure 5D) and connective tissue growth factor (CTGF) (Figure 5E) were significantly ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-187
12th Meeting Abstracts - SPHINGOLIPID CLUB
... connective tissue growth factor (CTGF) and plasminogen activator inhibitor (PAI-1) and a reduced infiltration of macrophages. ... Paracrine factors are essential mediators of pathophysiological processes; their involvement in endothelial-intestinal tissue ... We found that SPHK2 protein and activity were upregulated in fibrotic renal tissue. Functionally, Sphk2 deficient (Sphk2-/-) ... Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring and loss ...http://www.sphingolipidclub.com/12th-meeting-abstracts/
La peau. M/S : médecine sciences - Érudit
... numerous paracrine factors, bio-active molecules and micro-environmental stimuli (growth factors, vasoactive peptides, balance ... Hypodermis is composed of adipocyte lobules defined by fibrous connective tissue septa. Hair follicle consists of 3 parts : the ... Isolation of cells from fibrotic tissue allows to define the fibrogenic differentiation acquired in vivo. The organotypic ... The intervention of soluble mediators such as TNFα, perforin/granzyme, or Fas-Ligand may be necessary for amplifying the ...https://www.erudit.org/fr/revues/ms/2006-v22-n2-ms1046/
Hepatic Fibrosis and Cirrhosis | SpringerLink
Liver fibrosis is the presence of scar tissue in the liver. Although it varies in location within the liver, especially in ... Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int. 2008;28(8):1065-79.PubMed ... Smad3 as a mediator of the fibrotic response. Int J Exp Pathol. 2004;85(2):47-64.PubMedCrossRefGoogle Scholar ... morphology of extracellular matrix in experimental rat liver fibrosis resembles that of normal developing connective tissue. ...https://link.springer.com/chapter/10.1007/978-1-4419-7107-4_30
Connective-tissue growth factor tacrolimus a soluble mediator that enhances and perpetuates the profibrotic effects of TGF-beta ... Tacrolimus ultimate result of the endothelial injury and inflammatory cascade is increased collagen and extracellular matrix ... tacrolimus other fibrotic skin disorders. ... Connective tissue growth factor gene expression in tissue ... and transforming growth factor-beta TGF-beta.. These cytokines and growth factors also increase fibroblast proliferation ...http://climateexchangeplc.com/psoriazis-tacrolimus.php