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*  Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory...
... the cGMP-dependent protein kinase 1 (PrkG1) mediates this activity, as DRG neurons isolated from the kinase-deficient mouse ... Cyclic GMP has been proposed to regulate axonal development, but the molecular and cellular mechanisms underlying the formation ... 2005) Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of ... 2003) Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term ...
  http://www.jneurosci.org/content/29/5/1350
*  Biochemical cascade - Wikipedia
Sela-Abramovich, S; Chorev, E; Galiani, D; Dekel, N (Mar 2005). "Mitogen-activated protein kinase mediates luteinizing hormone- ... "Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes". Biology of ... These mechanisms are regulated by p16Ink4a-CDK4/6-Rb and p19Arf-p53-P21Cip1 signaling pathways. Embryonic stem cells have ... These proteins activate protein tyrosine kinase (PTK) that phosphorylates various proteins important for capacitation and ...
  https://en.wikipedia.org/wiki/Biochemical_cascade
*  cyclic gmp dependent protein kinases
Research Grants about cyclic gmp dependent protein kinases ... cGMP-dependent protein kinase I mediates the negative inotropic ... Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene ... cyclic gmp dependent protein kinases. Summary. Summary: A group of enzymes that are dependent on cyclic GMP and catalyzes the ... cyclic nucleotide regulated protein kinases , cyclic gmp dependent protein kinases ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/cyclic/cyclic-gmp-dependent-protein-kinases-13214.html
*  Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded ProteinsClinical Perspective | Circulation
cyclic GMP-dependent protein kinase. *desmin. *proteasome inhibitors. *proteins. Introduction. The ubiquitin-proteasome system ... UPS) mediates the degradation of most intracellular proteins and regulates diverse cellular processes, including protein ... Potential Mechanisms by Which PKG Enhances Proteasome Function. The 26S proteasome is composed of a 20S proteolytic core (where ... Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6. J Biol Chem. 2007;282: ...
  http://circ.ahajournals.org/content/128/4/365
*  Nicorandil - Wikipedia
Vrolix, M; Raeymaekers, L; Wuytack, F; Hofmann, F; Casteels, R (Nov 1, 1988). "Cyclic GMP-dependent protein kinase stimulates ... Takemoto, M; Sun, J; Hiroki, J; Shimokawa, H; Liao, JK (Jul 2, 2002). "Rho-kinase mediates hypoxia-induced downregulation of ... There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including ... "Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular ...
  https://en.wikipedia.org/wiki/Nicorandil
*  Nitrergic modulation of an oviposition digging rhythm in locusts | Journal of Experimental Biology
... inhibition of phospholipase-C activity via cyclic GMP-dependent protein kinase. Mol. Pharmacol. 47,517 -524. ... Vincent, J. F. V. and Wood, S. D. E. (1972). Mechanism of abdominal extension during oviposition in Locusta.Nature 235,167 -168 ... Bredt, D. S. and Snyder, S. H. (1989). Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. ... cGMP may in turn act upon cGMP-dependent protein kinase (PKG), which is thought to phosphorylate downstream target proteins or ...
  http://jeb.biologists.org/content/210/24/4448
*  Other chemical mediators | Pharmacology Education Project
... with downstream effects resulting from modulation of cGMP-dependent protein kinases (PKGs). It also opens ATP-dependent ... In normal physiology, NO binds to the haem group of guanylyl cyclase to increase intracellular cyclic GMP levels, with ... It also opens ATP-dependent potassium channels and mediates S-nitrosylation based protein modifications. Adverse effects of ... Eplerenone works by the same mechanism as spironolactone. This drug is used adjunctively in heart failure patients with low ...
  http://www.pharmacologyeducation.org/pharmacology/other-chemical-mediators
*  Insulin Induces the Release of Vasodilator Compounds From Platelets by a Nitric Oxide-G Kinase-VAMP-3-dependent Pathway | JEM
... in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA. 95:4888- ... The mechanism of dense granule secretion involves the G kinase-dependent association of syntaxin 2 with vesicle-associated ... The concept that adenosine mediates insulin-induced vasodilatation is supported by forearm blood flow data obtained in healthy ... Cyclic Guanosine-3′,5′ Cyclic Monophosphate Assay.. Cyclic guanosine-3′,5′ cyclic monophosphate (GMP) levels were determined in ...
  http://jem.rupress.org/content/199/3/347
*  Enhanced Recovery of Injury-Caused Downregulation of Paxillin Protein by eNOS Gene Expression in Rat Carotid Artery |...
... whether NO upregulates paxillin through a cyclic GMP-dependent protein kinase pathway or through inhibition of paxillin protein ... mediates protein-protein interactions.6 Tyrosine phosphorylation of paxillin is associated with cytokines, mitogenic peptides, ... Exploring the mechanism of paxillin protein downregulation would be crucial to the understanding of NO-mediated upregulation of ... Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype. J Vasc Res. 1997;34:245-259. ...
  http://atvb.ahajournals.org/content/19/1/147.long
*  Gaseous signaling molecules - Wikipedia
"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype". Journal of Vascular Research. 34 (4): 245 ... Lincoln, T. M.; Cornwell, Taylor (March 1990). "cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in ... A mechanism for control of protein function". The Journal of Biological Chemistry. 276 (17): 13635-13643. doi:10.1074/jbc. ... which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes ...
  https://en.wikipedia.org/wiki/Gaseous_signaling_molecules
*  Plus it
Purification and characterization of 3′:5′-cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 73: 3918-3922, 1976. ... 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein ... 20-HETE stimulates Ca2+ release from IP3 receptors potentially through a PLA2 or G protein-coupled receptor-dependent mechanism ... cGMP-dependent protein kinase and the regulation of vascular smooth muscle cell gene expression: possible involvement of Elk-1 ...
  http://ajpheart.physiology.org/content/310/9/H1107
*  Frontiers | COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs | Oncology
However, the precise mechanisms by which NSAIDs exert their antiproliferative effects are still a matter of debate. Numerous ... Numerous other studies have shown that NSAIDs can act through COX-independent mechanisms. This review provides a detailed ... However, the precise mechanisms by which NSAIDs exert their antiproliferative effects are still a matter of debate. ... other studies have shown that NSAIDs can act through COX-independent mechanisms. This review provides a detailed description of ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00181/full
*  IJMS | Free Full-Text | Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens |...
Here, we discuss the current understanding of existing quorum sensing mechanisms and present important inhibitory strategies ... With better understanding of bacterial communication networks and mechanisms, many quorum quenching methods have been developed ... Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for coordination of population-wide phenotypes ... The protein bpiB09 was identified through metagenomic analysis as an NADP-dependent reductase, suggesting that AHLs are not the ...
  http://www.mdpi.com/1422-0067/14/8/16570/htm
*  Protocols and Video Articles Authored by Elizabeth Boon (Translated to Turkish)
The cognate response regulator, a protein annotated as a cyclic-di-GMP processing enzyme that we have named HarR (H-NOX- ... These data provide a detailed molecular mechanism for NO regulation of c-di-GMP signaling and biofilm formation. ... In characterizing these kinases, we effectively double the number of kinetically characterized histidine kinases that have been ... protein in the biofilm-dwelling bacterium Shewanella woodyi mediates NO-induced biofilm dispersal. In S. woodyi, H-NOX (SwH-NOX ...
  https://www.jove.com/author/Elizabeth_Boon?language=Turkish
*  Biological functions of nitric oxide - Wikipedia
... cyclic GMP) from guanosine triphosphate (GTP). The soluble cGMP activates cyclic nucleotide-dependent protein kinase G (PKG or ... A similar mechanism is thought to protect the skin from fungal infections, where nitrate in sweat is reduced to nitrite by skin ... NO also partially mediates macrophage cytotoxicity against microbes and tumor cells. Besides mediating normal functions, NO is ... PKG is a kinase that phosphorylates a number of proteins that regulate calcium concentrations and calcium sensitization, ...
  https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide
*  Two Forms of Learning following Training to a Single Odorant in Caenorhabditis elegans AWC Neurons | Journal of Neuroscience
2003) Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans. Development 130:1089-1099. ... The cGMP-dependent kinase egl-4 mediates associative memory formation. Work by the Bargmann and L'Etoile groups has highlighted ... are dependent on a memory that associates starvation with the odor and can be blocked by a serotonergic mechanism, the adapted ... 2002) The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans. Neuron 36:1079-1089. ...
  http://www.jneurosci.org/content/32/26/9035.full
*  Martin Kruse
effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase. and RGS2. Basic Res Cardiol 105: 583-95. ... Birnbaumer L, Pongs O, Kuhn M (2011). A cardiac pathway of cyclic GMP-independent. signaling of guanylyl cyclase A, the ... cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. ... JM, and Kuhn M (2010). Novel insights into the mechanisms mediating the local antihypertrophic. ...
  https://www.bates.edu/neuroscience/martin-kruse/
*  Frontiers | Depolarization-Mediated Regulation of Alternative Splicing | Neuroscience
... in calcium signaling-mediated alternative splicing that have provided some insights into the important regulatory mechanisms. ... in calcium signaling-mediated alternative splicing that have provided some insights into the important regulatory mechanisms. ... the underlying mechanisms are not well understood. As calcium signaling in neurons plays a crucial role in essential neuronal ... the underlying mechanisms are not well understood. As calcium signaling in neurons plays a crucial role in essential neuronal ...
  https://www.frontiersin.org/articles/10.3389/fnins.2011.00141/full
*  Frontiers | Visualization of cyclic nucleotide dynamics in neurons | Frontiers in Cellular Neuroscience
Current and future fluorescent protein reporters will be essential to elucidate the role of cyclic nucleotide signaling ... Current and future fluorescent protein reporters will be essential to elucidate the role of cyclic nucleotide signaling ... Then we discuss a few examples of using cyclic nucleotide fluorescent biosensors to study regulation of neuronal function and ... Although there has been significant progress made in understanding how the specific signaling of cyclic nucleotide second ...
  https://www.frontiersin.org/articles/10.3389/fncel.2014.00395/full
*  Alveolar macrophage - Wikipedia
... through cyclic GMP-dependent mechanisms. NO prolongs the ability of human dendritic cells to internalize antigens at sites of ... protein kinase A (PKA) and the exchange proteins directly activated by cAMP (Epac-1 and -2). Epac-1 and PKA are both important ... cAMP/PKA/CREB axis mediates the inhibition of TNF-alpha release. The killing of phagocytosed bacteria by AMs is dependent upon ... The molecular mechanisms facilitating opsonin-dependent phagocytosis are different for specific opsonin/receptor pairs. For ...
  https://en.wikipedia.org/wiki/Alveolar_macrophage
*  Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain ... their mechanisms of action, and their locus in the spinal circuitry are still unclear. Here, we found that Protein Kinase G1 ( ... Our results further suggest that the RhoA-ROCK pathway, which is activated downstream of plexin B1, mediates these inhibitory ... The encoded protein displayed high homology to the MARK family of serine-threonine protein kinases and has recently been ...
  https://www.jove.com/author/Rohini_Kuner?language=Italian
*  Plus it
... and cyclic GMP (cGMP) production. PST also stimulates mitogen-activated protein kinase (MAPK) activity, which is responsible ... where the mechanisms are not Ca2+ dependent (32). These effects of PST were mainly due to the disruption of Ca2+-dependent ... and therefore mediates the glycogenolytic effect in the liver by increasing cytoplasmic free calcium and stimulating PKC, while ... Pancreastatin activates protein kinase C by stimulating the formation of 1, 2-diacylglycerol in rat hepatocytes. Biochem J 303 ...
  http://physiolgenomics.physiology.org/content/45/22/1060
*  Cysteine-674 of the Sarco/Endoplasmic Reticulum Calcium ATPase Is Required for the Inhibition of Cell Migration by Nitric Oxide...
24 NO activates guanylyl cyclase which produces cyclic GMP, and cyclic GMP subsequently activates protein kinase G that induces ... the SERCA-dependent mechanism described here defines a cyclic GMP-independent mechanism by which NO can limit such neointimal ... S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J Biol Chem. ... Indeed, loss of the cyclic GMP, protein kinase G system either in culture or in vivo29 would be expected to emphasize the role ...
  http://atvb.ahajournals.org/content/27/4/783
*  Plus it
1998) Cyclic-GMP-dependent protein kinase inhibits the Ras/mitogen-activated protein kinase pathway. Mol Cell Biol 18:6983-6994 ... 1999) Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric ... FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation ... Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ...
  http://www.jneurosci.org/content/21/11/3871
*  Endothelial Nitric Oxide Synthase Inhibits G12/13 and Rho-Kinase Activated by the Angiotensin II Type-1 Receptor |...
Hofmann F. The biology of cyclic GMP-dependent protein kinases. J Biol Chem. 2005; 280: 1-4. ... Lincoln TM, Dey N, Sellak H. Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the ... epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase ... Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular ...
  http://atvb.ahajournals.org/content/29/2/217.full