Selected Studies on the Toxicity of Thimerosal Published in Peer Reviewed Scientific and Medical Journals
Effect of the sulfhydryl reagent thimerosal on cytosolic free Ca2+ and membrane potential of thymocytes. Gukovskaya AS, ... These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and ... Possible mechanisms regulating ATP- and thimerosal-induced Ca(2+) oscillations in the HSY salivary duct cell line. Tojyo Y, ... Effects of protein kinase C activation and inhibition on sperm-, thimerosal-, and ryanodine-induced calcium responses of human ...http://www.whale.to/vaccine/thim.html
Melatonin Modulates Hippocampus NMDA Receptors, Blood and Brain Oxidative Stress Levels in Ovariectomized Rats, The Journal of...
Blood and Brain Oxidative Stress Levels in Ovariectomized Rats, The Journal of Membrane Biology" on DeepDyve, the largest ... Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann's reagent ... New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose ... Oxidative stress has been proposed to explain the biological side effect of experimental menopause. Melatonin prevents ...https://www.deepdyve.com/lp/springer_journal/melatonin-modulates-hippocampus-nmda-receptors-blood-and-brain-g5pNnKq71A
The impact of grape proanthocyanidin extract on dexamethasone-induced osteoporosis and electrolyte imbalance | springermedizin...
Estimation of total protein bound and non-protein sulfhydryl groups in tissues with Ellman's reagent. Anal Biochem 25:192-205 ... Tian Y, Ma X, Yang C, Su P, Yin C, Qian A-R (2017) The impact of oxidative stress on the bone system in response to the space ... Fleisch H (1998) Bisphosphonates:Mechanisms of action. Endocr Rev 19:80-100 CrossRefPubMed ... Abdollahi M, Larijani B, Rahimi R, Salari P (2005) Role of oxidative stress in osteoporosis. Therapy 2:787-796 CrossRef ...https://www.springermedizin.de/the-impact-of-grape-proanthocyanidin-extract-on-dexamethasone-in/15727000
Sulfhydryl Redox State Affects Susceptibility to Ischemia and Sarcoplasmic Reticulum Ca2+ Release in Rat Heart | Circulation...
As expected, perfusion with sulfhydryl reagents produced a significant decrease in protein sulfhydryl concentration. Perfusion ... Although oxidative stress often has been associated with tissue injury, other studies have suggested that oxidative reactions ... We conclude that the pathogenetic mechanism of ischemic preconditioning involved the oxidation of intracellular sulfhydryl ... Sulfhydryl reagents trigger Ca2+ release from the sarcoplasmic reticulum of skinned rabbit psoas fibres. J Physiol. 1992;454: ...http://circres.ahajournals.org/content/83/9/908
Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice
... that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in ... Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to ... Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal ... Here, the oxidative damage in liver seems to occur without changes in Nrf2, HSP70, or NQO-1 protein levels (Figure 8). ...https://www.hindawi.com/journals/omcl/2016/8902954/
Topiramate and Vitamin E Modulate the Electroencephalographic Records, Brain Microsomal and Blood Antioxidant Redox System in...
Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann's reagent ... New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose ... Increased oxidative stress in epileptic children treated with propoic acid. Verrotti, A; Scardapane, A; Franzoni, E; Manco, R; ... Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy ...https://www.deepdyve.com/lp/springer_journal/topiramate-and-vitamin-e-modulate-the-electroencephalographic-records-fTfmiQGH1V
Colchicine Modulates Oxidative Stress in Serum and Neutrophil of Patients with Behçet Disease Through Regulation of Ca2+...
"Colchicine Modulates Oxidative Stress in Serum and Neutrophil of Patients with Behçet Disease Through Regulation of Ca2+ ... Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann's reagent ... New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose ... Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome ...https://www.deepdyve.com/lp/springer_journal/colchicine-modulates-oxidative-stress-in-serum-and-neutrophil-of-a9Lb8IViEI
Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 | Molecular and...
This may be the mechanism of stress sensing by Keap1. The model structure of the Skp1-Cul1-F-box protein (SCF) E3 ligase ... Chemical reagents.MG132, tert-butyl hydroquinone (tBHQ), 15d-prostaglandin J2 (15d-PGJ2), and cycloheximide (CHX) were ... Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against ... The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ...https://mcb.asm.org/content/26/1/221?ijkey=d7d3bc72b772cbc6b899c96b347f9ebf00a7a9f0&keytype2=tf_ipsecsha
The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968; 25: ... The studied doses of ketamine led to oxidative stress by increasing the amount of adrenaline. Thiopental increased oxidative ... Free radical mechanisms in the central nervous system: an overview. Int J Neurosci 1988; 40: 13-8.. Jesberger JA. Oxygen free ... However, when used alone ketamine and thiopental led to oxidative stress in the striatum, heart, and bronchial tissues. ...https://www.termedia.pl/The-effects-of-ketamine-and-thiopental-used-alone-or-in-combination-on-the-brain-heart-and-bronchial-tissues-of-rats,19,27428,0,1.html
Tetrahydrocurcumin Potentially Attenuates Arsenic Induced Oxidative Hepatic Dysfunction in Rats | OMICS International
The values are expressed as nmol/min/ mg protein.. Determination of lipid peroxidation and oxidative stress markers: Lipid ... This could be due to the ability of THC to protect the sulfhydryl group from oxidative damage through the inhibition of lipid ... lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275 ... From earlier findings, arsenic exert its toxic effects through variety of mechanisms in which most noticeable one is the excess ...https://www.omicsonline.org/tetrahydrocurcumin-potentially-attenuates-arsenic-induced-oxidative-hepatic-dysfunction-in-rats-2161-0495.1000-168.php?aid=19968
Frontiers | Taurine: A Potential Ergogenic Aid for Preventing Muscle Damage and Protein Catabolism and Decreasing Oxidative...
Oxidative stress marker levels, and 24 hour urinary nitrogen, creatinine, and urea excretion were measured before and after 8 ... Oxidative stress marker levels, and 24 hour urinary nitrogen, creatinine, and urea excretion were measured before and after 8 ... but was effective in increasing taurine plasma levels and decreasing oxidative stress markers, which suggests that taurine may ... The aim of this study was to evaluate the effects of taurine and chocolate milk supplementation on oxidative stress and protein ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00710/full
Retino-protective effect of Bucida buceras against oxidative stress induced by H2O2 in human retinal pigment epithelial cells...
The mechanism of Bucida buceras extract is believed to be associated with their antioxidant capacity to protect cells against ... oxidative stress. A comparative oxidative stress H2O2-induced was performed by addition and enzymatic generation using glucose ... These findings suggest that Bucida buceras could protect RPE against ocular pathogenesis associated with oxidative stress ... and oxidative stress biomarkers (H2O2, GSH, CAT, GPx and FRAP). Bucida buceras L. extract is believed to be associated with the ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0765-6
Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J ... The important observation in this study is that the large sulfhydryl reagent MTSET accesses the mutated βS518C degenerin site ... Mechanisms of peroxynitrite-induced injury to pulmonary surfactants. Am J Physiol Lung Cell Mol Physiol 265: L555-L564, 1993. ... Oxidative stress and ion transport.. Oxidative stress occurs in many lung diseases and is characterized by an imbalance in ...http://ajplung.physiology.org/content/305/9/L595
Cellular defense mechanisms that might be expected to protect against oxidative stress (e.g., GSH or ascorbate) could actually ... Treatment of TPH with dopamine. The TPH-fusion protein (∼15 μg of protein per tube) was treated with varying concentrations of ... After incubations, enzyme samples were washed free of all test reagents by washing the enzyme in 50 vol of 50 mm Tris-HCl, pH ... 1989b) Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites. Eur J ...http://www.jneurosci.org/content/18/18/7111
Spring2008poster | Cal State LA
This current study will hopefully lend greater insight into how cells cope with oxidative stress mediated by hydrogen peroxide ... a protein that is predominant in liver and kidneys and responsible for the detoxification of heavy metals.1 The exact mechanism ... Oxidizers can increase or decrease the function of target proteins by oxidizing protein sulfhydryl groups. It is believed that ... reverse transcribed and subjected to real time PCR using Trizol reagent, transcriptase kit and SYBR GREEN chemistry with probes ...http://www.calstatela.edu/centers/moreprograms/fall2008poster.html
The Effect of Chromium and Boron on the Lipid Peroxidation and Antioxidant Status (In Experiment)
Tussue sulfhydryl groups. Arch Biochem Biophus. 1959;82:70-7.. *Lowry OH, Rosebough NJ, Farr AL, et al. Protein measurement ... In fact, oxidative stress develops when the levels of antioxidants lowered. Moreover, antioxidants can protect cells from free ... Oxidative mechanism in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol. 2001;20:77-88. ... Total lipids were determined using a set of reagents 'Lachema' (Czech Republic); the content of protein-by the method of Lowry ...https://www.tsijournals.com/articles/the-effect-of-chromium-and-boron-on-the-lipid-peroxidation-and-antioxidant-status-in-experiment.html
Hypochlorous acid - Wikipedia
The HClO mechanism of sulfhydryl oxidation is similar to that of chloramine, and may only be bacteriostatic, because once the ... Hsp33, a chaperone known to be activated by oxidative heat stress, protects bacteria from the effects of HOCl by acting as a ... Chlorinated amino acids rapidly decompose, but protein chloramines are longer-lived and retain some oxidative capacity. Thomas ... Unangst, P. C. "Hypochlorous Acid" in Encyclopedia of Reagents for Organic Synthesis (Ed: L. Paquette) 2004, J. Wiley & Sons, ...https://en.wikipedia.org/wiki/Hypochlorous_acid
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor...
The Nuclear Matrix Protein, NRP/B, Enhances Nrf2-Mediated Oxidative Stress Responses in Breast Cancer Cells ... Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress ... strongly suggested that the initially formed mixed disulfide between reagent and protein was rapidly reduced by another highly ... all can modify sulfhydryl groups by alkylation, oxidation, or reduction. Recognition of these properties suggested that cells ...http://www.pnas.org/content/101/7/2040
Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in...
The effects of DES on the anti-oxidant system, non-protein sulfhydryl (NP-SH) content, nitric oxide (NO)level, cyclooxygenase-2 ... The compound up regulated heat shock protein-70 (HSP-70) and down regulated Bax protein expression in the ulcerated tissue. DES ... COX-2) enzyme activity, bcl-2-associated X (Bax) protein expression and Helicabacter pylori (H pylori) were also investigated. ... activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect. ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-13-183
NADH dehydrogenase (ubiquinone) - Wikipedia
The A-form of complex I is insensitive to sulfhydryl reagents. It was found that these conformational changes may have a very ... Superoxide is a reactive oxygen species that contributes to cellular oxidative stress and is linked to neuromuscular diseases ... Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) NDUFS2 - NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme ... An antiporter mechanism (Na+/H+ swap) has been proposed using evidence of conserved Asp residues in the membrane arm. The ...https://en.wikipedia.org/wiki/NADH_dehydrogenase_(ubiquinone)
An Animal Model to Study the Molecular Basis of Tardive Dyskinesia | SpringerLink
... enhanced oxidative stress, there was a significant increase in cellular markers of inflammation and apoptotic protein (caspase- ... Lowry, O.H. (1951) Protein measurements with the Folin-phenol reagent. J. Biol. Chem. 193, 265-275PubMedGoogle Scholar ... Ellman, G.L. (1959) Tissue sulfhydryl groups. Arch. of Biochemi. Biophy. 82, 70-77.CrossRefGoogle Scholar ... Wills, E.D. (1966) Mechanism of lipid peroxide formation in animal tissues. Biochem. Jour. 99, 667-676.Google Scholar ...https://link.springer.com/protocol/10.1007%2F978-1-61779-458-2_12
The effects of hesperidin on idiopathic pulmonary fibrosis evaluated by histopathologial-biochemical and micro-computed...
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968; 25: ... Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem 2015; 97: 55-74. ... Imbalances in this mechanism result in exposure to free radicals with an inadequate defense mechanism, and may lead to ... Interstitial inflammation, advanced oxidative stress, and abnormal antioxidant activity were demonstrated to be the main causes ...http://www.alliedacademies.org/articles/the-effects-of-hesperidin-on-idiopathic-pulmonary-fibrosis-evaluated-by-histopathologialbiochemical-and-microcomputed-tomography-e.html
Frontiers | The hydrogen peroxide-sensitive proteome of the chloroplast in vitro and in vivo | Plant Science
By using methyl viologen that induces oxidative stress in vivo, mostly the same primary targets of oxidation were identified ... of available protein thiols which allowed for the identification of the primary targets of oxidation. The chosen redox ... By using methyl viologen that induces oxidative stress in vivo, mostly the same primary targets of oxidation were identified ... of available protein thiols which allowed for the identification of the primary targets of oxidation. The chosen redox ...https://www.frontiersin.org/articles/10.3389/fpls.2013.00054/full
Ameliorative Effects of Acacia Honey against Sodium Arsenite-Induced Oxidative Stress in Some Viscera of Male Wistar Albino Rats
It has also been reported that arsenic induces oxidative stress by multiple mechanisms . Chronic arsenic exposure through ... Chemicals and Reagents. Sodium arsenite (5 mg/kg body weight) equivalent to two-tenth of the oral LD50 was used  in all ... By using Auto Analyzer Hitachi Roche 7020 (902, Japan Inc.), the total protein contents of the tissues were determined based on ... and exerts cellular toxicity by binding to sulfhydryl groups which results in enzyme inhibition. During arsenic metabolism, ...https://www.hindawi.com/journals/bri/2013/502438/
... resulted in concentration-dependent oxidation of protein sulfhydryl groups, dimer and trimer formation, protein fragmentation, ... 2000) How urine analysis reflects oxidative stress-nitrotyrosine as a potential marker. Clin Chim Acta 297:207-216. ... TNM is a reagent that oxidizes sulfhydryl groups at pH 6 and pH 8, but selectively nitrates tyrosine residues at pH 8, and this ... Oxidation of critical sulfhydryl groups by ONOO−has been proposed as the mechanism for its inhibitory actions on several ...http://molpharm.aspetjournals.org/content/63/1/136