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*  Tranilast Suppresses Vascular Chymase Expression and Neointima Formation in Balloon-Injured Dog Carotid Artery | Circulation
Cell-to-cell interaction between fibroblasts and mast cells through regulation of stem cell factor (SCF)/c-kit expression is ... Because almost all mast cells are located in the adventitia, its density was expressed as total mast cell count in adventitia/ ... Chymase derives mainly from connective tissue-type mast cells. In the current study, mast cell density was markedly increased ... of which we focused on the development of vascular mast cells as the main source of chymase. In the adventitia, mast cell ...
  http://circ.ahajournals.org/content/99/8/1084
*  Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution
Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine proteases, graspases. ... Cell and molecular biology, immune system, mast cell, basophil, mast cell chymase locus, multigene tryptase locus, serine ... Rat and mouse mast cells express numerous different graspases, whereas human and dog mast cells express only one graspase, ... The acidic granules of natural killer (NK) cells, T cells, mast cells, and neutrophils store large amounts of serine proteases ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:169381
*  Midostaurin Granted EU Approval for AML, Advanced Systemic Mastocytosis
Among the 16 patients with mast-cell leukemia, the median OS was 9.4 months (95% CI, 7.5-not estimated).. In advanced SM, the ... and 16 had mast-cell leukemia. The primary outcome was the best overall response.. The study used an adapted Fleming two-stage ... and mast cell leukemia.. Midostaurin is currently approved for AML in combination with standard cytarabine and daunorubicin ...
  http://www.targetedonc.com/news/midostaurin-granted-eu-approval-for-aml-advanced-systemic-mastocytosis
*  Cell lineage analysis of KIT D816V and NRAS G12D activating mutations in aggressive systemic mastocytosis (36.25) | The Journal...
Bone marrow and peripheral blood cells were collected from the patient. CD34+ progenitors, mast cells, neutrophils, monocytes, ... Mast cells harbored both mutations. The KIT D816V mutation was not detected in CD34+ progenitors, whereas presence of the NRAS ... Unlike other mature lineages, mast cell survival is dependent on KIT and the presence of these two mutations may have a greater ... Systemic mastocytosis is a clonal disorder characterized by the abnormal proliferation and accumulation of mast cells within ...
  http://www.jimmunol.org/content/184/1_Supplement/36.25
*  Two Different Face of Mastocytoma: Case Report | MedCrave
Mast cells and eosinophilles were observed in Tzanck smear. Multiple mast cells were observed in superficial dermis through ... Mast Cell leukemia, Mast Cell Sarcoma and Extracutaneous mastocytona. Cutaneous mastocytosis was classified as urticaria ... Clinical findings in all disease types depend on the changes caused by release of active editors in granules of the mast cells ... Mastocytosis is a disease group which develops as a result of proliferation of mast cells in different tissues and/or organs or ...
  http://googlescholar.medcraveonline.com/scholars/article_fulltext/1680
*  What is Mastocytosis? Symptoms and Treatments - Facty Health
Mast cells are a type of white blood cell which is part of the immune function in the body. These cells are responsible for ... Mastocytosis is a rare condition in which too many mast cells swell in the body's tissues. ...
  http://health.facty.com/ailments/body/what-is-mastocytosis-symptoms-and-treatments/
*  α2-Macroglobulin Capture Allows Detection of Mast Cell Chymase in Serum and Creates a Reservoir of Angiotensin II-Generating...
... in that in vitro assays of mast cells suggest that chymase "leaks" from mast cell granules in the absence of specific ... In the absence of specific mast cell stimulation, baseline leak of chymase from resident mast cells, combined with α2M capture ... The observed serum chymase activity in this study is likely to originate from mast cells in extravascular sites, since mast and ... Mono-Mac-6 cells, and human skin-derived mast cells. J. Immunol. 170: 5667-5673. ...
  http://www.jimmunol.org/content/182/9/5770.long
*  Neuropsychiatric features of mast cell disease: Part 1 of 2 - Mast Attack
... again indolent systemic mastocytosis MastAttack 107 mast cell activation syndrome mast cell biology mast cell disease mast cell ... A significant population of mast cells is found in the brain in close association with both blood vessels and nerve cells. Mast ... a common neuropsychiatric symptom for mast cell patients and has been seen in populations with both mastocytosis and mast cell ... mast cell patients because the somatic symptoms correlated with depression are often the same as physical symptoms of mast cell ...
  http://www.mastattack.org/2016/04/neuropsychiatric-features-of-mast-cell-disease-part-1-of-2/
*  The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human...
Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine proteases, graspases. ... Rat and mouse mast cells express numerous different graspases, whereas human and dog mast cells express only one graspase, ... These differences hamper functional comparisons of graspases and of immune cells in the two species. Studies of the mast cell ... To better understand mast cell functions in these species, one member of the mouse Mcpt8-family, mMCP-8, and human and dog ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:169384
*  Phase II Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia - Full Text View - ClinicalTrials.gov
Systemic Mastocytosis, Aggressive (ASM) Leukemia, Mast Cell Hematological Non-mast Cell Lineage Disease (AHNMD) Drug: ... and mast cell leukemia (MCL) are characterized by excessive bone marrow production of mast cells which can can infiltrate ... or mast cell leukemia (MCL) with or without associated clonal hematological non-mast cell lineage disease (AHNMD). ... Biopsy indicates diffuse infiltration by atypical, immature mast cells. *Bone marrow aspirate smears show at least 20% mast ...
  https://clinicaltrials.gov/ct2/show/NCT00233454?cond=MAST+CELL+DISEASE&rank=19
*  Basophils and Mast Cells | SpringerLink
... experts in this challenging field explore techniques to research these cells from the most practical point of view. Given the ... In Basophils and Mast Cells: Methods and Protocols, ... Generation of Mast Cells from Murine Stem Cell Progenitors ... Basophils and Mast Cells: Methods and Protocols will provide the necessary tools for future research into mast cells and ... Generation of a Human Allergic Mast Cell Phenotype from CD133+ Stem Cells ...
  https://link.springer.com/book/10.1007/978-1-4939-1173-8
*  Mast Cell Tumors - Posts
Treatments and Tools for Mast Cell Tumors. Find Mast Cell Tumors information, treatments for Mast Cell Tumors and Mast Cell ... MedHelp's Mast Cell Tumors Center for Information, Symptoms, Resources, ... Posts on Mast Cell Tumors. Mass Cell Tumor in Boston Terrier - Cancer in Pets Community ... My 15 yr old cockerpoo was dx w/mast cell ca multiple tumors to many and large to remove wi... ...
  http://www.medhelp.org/tags/show/148725/Mast-Cell-Tumors?section=subjects
*  Grading Mast Cell Tumors | Petfinder
Learn more about grading mast cell tumors here. ... There are three grades of mast cell tumors: Grade I (well- ... Grading Mast Cell Tumors. There are three grades of mast cell tumors: Grade I (well-differentiated), Grade II (moderately ... What are Mast Cell Tumors? Learn about Mast Cell Tumors in dogs and the best course of treatment. ... "Mast Cell Tumors in Dogs." Feb. 12, 2011. (April 30, 2011). http://www.petcancercenter.org/Cancer_Types_mast_cell_dog.html ...
  https://www.petfinder.com/dogs/dog-health/mast-cell-tumors-dogs-grade/
*  A selective stain for mast cells | SpringerLink
A selective stain for mast cells in tissue sections is presented. The procedure is based on the resistance to destaining with ... Mast Cell Tissue Section Complex Acid These keywords were added by machine and not by the authors. This process is experimental ... Butler, W. F. (1971). Variations in the staining of cutaneous mast cells.Histochem. J. 3, 365-70.Google Scholar ... A selective stain for mast cells in tissue sections is presented. The procedure is based on the resistance to destaining with ...
  https://link.springer.com/article/10.1007%2FBF01003596
*  mast cell heparin isolation
... Steven Pirie-Shepherd srps at galactose.mc.duke.edu Thu Oct 19 06:48:45 EST 1995 *Previous message ... Tilo Brunnee (tilo at brunnee.IN-Berlin.DE) wrote: : Hallo! : I attempt to isolate human mast cell heparin proteoglycan from ... mast cells? : - If so, is the heprain sidechain cleaved from the protein core during or : before degranulation? : - Is there ... Is there another source of heparin than mast cells in humans? : - I wonder how commercially available heparin is isolated. That ...
  http://www.bio.net/bionet/mm/glycosci/1995-October/000396.html
*  Mast Cell Tumor Dog Diagnosis
Symptoms of Mast Cell Tumors in Dogs. Mast cell tumors in dogs generally develop on the skin. They occur when mast cells, a ... Mast cell tumors make up about 20% of all dog skin tumors. Mast cell tumors can occur in dogs of any age, breed or gender, but ... Treating Mast Cell Tumors in Dogs. If your dog's mast cell tumors have not yet spread to other parts of his body, then surgical ... In some dogs with mast cell tumors, mast cells can be found circulating in the blood. ...
  https://www.vetinfo.com/mast-cell-tumor-dog-diagnosis.html
*  Mast Cell Blockers and Atopic Eczema | SpringerLink
Mast Cell Atopic Eczema Food Allergy Sodium Cromoglycate Systemic Mastocytosis These keywords were added by machine and not by ... Bienenstock J (1988) An update on mast cell heterogeneity. J Allergy Clin Immunol 81: 763PubMedCrossRefGoogle Scholar ... In: Pepys J, Edwards AM (eds) The mast cell: its role in health and disease. Pitman Medical, Bath, p 617Google Scholar ... Enerbäck L (1966) Mast cells in rat gastrointestinal mucosa. II. Dye binding and metachromatic properties. Acta Pathol ...
  https://link.springer.com/chapter/10.1007/978-3-662-02671-7_43
*  Lipid Rafts in Mast Cell Biology
... a cell line with homology to mucosal mast cells [80-84]. The D1 cell line is deficient in GM1 gangliosides and in mast cell ... Mast cells, like blood cells, are derived from pluripotent bone marrow hematopoietic stem cells but, unlike blood cells, they ... It is the microenvironment surrounding the mast cells that determines their mature phenotype [1-6]. Mast cells are effector ... S. J. Galli, "New insights into 'The riddle of the mast cells': microenvironmental regulation of mast cell development and ...
  https://www.hindawi.com/journals/jl/2011/752906/
*  Mast cells and atherosclerosis | Abcam
Including a table of selected mediators produced by or released from mast cells. ... Discover a review of recent developments in mast cells and atherosclerosis. ... mast cell reconstitution protocol in mast cell-deficient mice.. Apparently, mast cell reconstitution in mast cell-deficient ... and here mast cell-deficient mice directly proved that mast cells play a role atherosclerosis (Sun et al., 2007). Mast cell- ...
  https://www.abcam.com/research-areas/mast-cells-and-atherosclerosis
*  Feline mast cell tumor - Cats - MedHelp
He did great however the report not so great The tumor (neck) came back mast cell tumor. My cat is otherwise heal... ... Feline mast cell tumor. I have a male 11 yr old cat that had a rather large tumor removed surgically 2 wks ago. He did great ... He did great however the report not so great The tumor (neck) came back mast cell tumor. My cat is otherwise healthy he is ... came back mast cell tumor. My cat is otherwise healthy he is playing eating sleeping and bathroom normal. Vet has not really ...
  http://www.medhelp.org/posts/Cats/Feline-mast-cell-tumor/show/1673854
*  mast-cell-tumors-dogs-stomach-ulcers Archives | Petfinder
It is possible that a mast cell tumor will result in ulcers. Find out how this happens and what the sympoms are here. ...
  https://www.petfinder.com/tags/mast-cell-tumors-dogs-stomach-ulcers/
*  Mast Cell Tumors: Dogs Most Affected
... twenty-five percent of their cancer cases are due to mast cell tumors. For boxers, some of these mast cells are part of their ... A mast cell tumor dogs have a nodular skin growth consisting of cells that have high levels of histamine. The growths need to ... Mast cell tumors appear in a wide variety of shapes, sizes and textures and can from on any area of a dog's skin. Some of the ... Mast cell tumors(MCT) are tricky to diagnose in any breed. There is no sure-fire way to identify them without a biopsy. Some ...
  https://www.vetinfo.com/mast-cell-tumors.html
*  Biological implications of preformed mast cell mediators | SpringerLink
When mast cells degranulate, these are released and have a profound impact on any condition in... ... Mast cells store an impressive array of preformed compounds (mediators) in their secretory granules. ... The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are ... When mast cells degranulate, these are released and have a profound impact on any condition in which mast cell degranulation ...
  https://link.springer.com/article/10.1007%2Fs00018-010-0587-0
*  mast cell tumor - Animal Health - General - MedHelp
When my 4 year old cat was diagnosed with a mast cell tumor inside his ear I was devastated. He had this swelling inside his ... Cutaneous mast cell tumor in cats can be curative with surgery, if there is no metastasis. The prognosis is good in this case. ... When my 4 year old cat was diagnosed with a mast cell tumor inside his ear I was devastated. He had this swelling inside his ...
  https://www.medhelp.org/posts/Animal-Health---General/mast-cell-tumor/show/933533