MRD Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia - Full Text View -...
Busulfan ≥ 9mg/kg total dose (IV or PO). PK-based dosing is allowed, if intent is myeloablative dosing OR ... Having ,15% bone marrow blasts after 1st cycle and/or ,5% after 2nd cycle before achieving CR -and- ... MRD Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia. This study has been ... Three samples for MRD (measured by WT1 PCR and flow cytometry) will be collected from peripheral blood and bone marrow: 1) pre- ...https://clinicaltrials.gov/ct2/show/NCT01385787
Donor Stem Cell Transplant or Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia in Remission
Giving chemotherapy before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of... ... sibling bone marrow transplantation (BMT) (BuCy conditioning): Patients receive busulfan IV once daily on days -7 to -4 and ... The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will ... Anti-Thymocyte Globulin, Cyclosporine, and RAD in Islet Transplantation. This study was designed to test the safety and ...https://www.bioportfolio.com/resources/trial/70446/Donor-Stem-Cell-Transplant-or-Bone-Marrow-Transplant-in-Treating-Patients-With.html
Steven Goodman | Stanford Medicine Profiles
... trials will be necessary to establish how results of high-dose cyclophosphamide compare with either bone marrow transplantation ... All patients received conventional myeloablation with busulfan/cyclophosphamide (BuCy) and T cell-replete bone marrow followed ... The BCP test itself was examined in one study, and the signature was tested in a variety of formulations in several studies. ... EFFICACY OF IMMUNE GLOBULIN IN PREVENTING COMPLICATIONS OF BONE-MARROW TRANSPLANTATION - A METAANALYSIS BONE MARROW ...https://med.stanford.edu/profiles/steven-goodman
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies - Full Text View -...
Blood And Marrow Transplantation Leukemia Lymphoma Transplantation Infection Transplantation, Bone Marrow Drug: Melphalan Drug ... Busulfan pharmacokinetics performed with test dose and the first dose on Day -7 per standard of care. Doses of Days -5 and -4 ... Drug: Busulfan Busulfan per standard of care, test dose either as an outpatient prior to admission or as an inpatient on Day -9 ... Blood And Marrow Transplantation. Leukemia. Lymphoma. Pediatrics. Cord blood transplant. Cord Blood Fucosylation. Hematologic ...https://clinicaltrials.gov/ct2/show/NCT01471067?recr=Open&cond=%22Blood%22&rank=17
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study | Blood...
Bone marrow transplantation from matched related donors for patients with Fanconi anemia using low-dose busulfan and ... A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16(3):1141-1154. ... only 4 children in the lower-dose cohort had a dose reduction (P = .02). In the lower-dose busulfan group, mean busulfan dose ... low-dose busulfan and antithymocyte globulin as conditioning for Fanconi anemia patients receiving bone marrow transplantation ...http://www.bloodjournal.org/content/129/16/2308?sso-checked=true
Busulfan and Fludarabine in Patients With AML and MDS - Full Text View - ClinicalTrials.gov
... in combination with Fludarabine at a dose of 40 mg/m2 as preparation for bone marrow or peripheral stern cell transplantation ... 1 will initially receive a therapeutic test dose of busulfan to test the blood levels over time; this information will be used ... Bone Marrow Diseases. Hematologic Diseases. Fludarabine. Fludarabine phosphate. Busulfan. Vidarabine. Antineoplastic Agents. ... A Phase II Study of High-Dose Intravenous Busulfan and Fludarabine With Allogeneic Marrow and Peripheral Blood Progenitor Cell ...https://clinicaltrials.gov/ct2/show/NCT00502905
Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and...
... outcome of paediatric bone marrow recipients using a test dose and Bayesian pharmacokinetic individualization of busulfan ... a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients. Bone Marrow Transplant ... Pharmacokinetics of a test dose of intravenous busulfan guide dose modifications to achieve an optimal area under the curve of ... Initial dosing prediction. The initial busulfan dose for Q6h dosing frequency is provided by both the U.S. Food and Drug ...http://clincancerres.aacrjournals.org/content/20/3/754.long
A Randomized Trial to Compare Busulfan + Melphalan 140 mg/m2 With Melphalan 200 mg/m2 as Preparative Regimen for Autologous...
autologous bone marrow transplantation. *Peripheral Blood Progenitor Cells. *PBPCs. Experimental: Melphalan High-dose Melphalan ... Drug: Busulfan Test dose (32 mg/m^2) on day -9 then 130 mg/m^2 by vein or adjusted dose on Days -7, -6, -5, and -4. ... Experimental: Busulfan + Melphalan Busulfan test dose (32 mg/m^2) on day -9 then 130 mg/m^2 intravenous (IV) Days -7, -6, -5, ... Drug: Busulfan Drug: Melphalan Other: Questionnaire Drug: G-CSF Drug: High Dose Melphalan Procedure: Stem cell transplant Phase ...https://clinicaltrials.gov/ct2/show/NCT01413178
1,4-Butanediol dimethanesulfonate | definition of 1,4-Butanediol dimethanesulfonate by Medical dictionary
... also used in lieu of whole body irradiation in bone marrow transplantation.. busulfan. (byo͞o-sŭl′fən). n.. An alkylating agent ... Because of its effects on bone marrow, it is used at high doses in lieu of whole body irradiation in bone marrow ... Drug-diagnostic tests.Alkaline phosphatase, aspartate aminotransferase, bilirubin, nitrogenous compounds (urea): increased ... busulfan. [bu-sul´fan] an alkylating agent that acts selectively on the bone marrow, depressing granulocyte formation, and is ...https://medical-dictionary.thefreedictionary.com/1%2C4-Butanediol+dimethanesulfonate
GVAX vs. Placebo for MDS/AML After Allo HSCT - Full Text View - ClinicalTrials.gov
... bone marrow aspirate and biopsy, blood tests, tuberculosis skin test, HLA antibody test, pregnancy test, urine test, ECHO, MUGA ... your transplant doctor will decide whether you receive a higher or lower dose of busulfan. Between 1-2 days after you finish ... Allogeneic stem cell transplantation is a standard treatment for MDS/CMML/AML. It can be effective because the cells from your ... a blood draw for future immune tests and a bone marrow biopsy and aspirate to assess your MDS/CMML/AML. ...https://clinicaltrials.gov/ct2/show/study/NCT01773395?show_desc=Y
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor | PNAS
Bone Marrow Transplantation.. Ten congenic B6 CD45.1 or AhR−/− (CD45.2) recipient mice were preconditioned with three ... To address this, we made chimeras by transplanting bone marrow (BM) cells into busulfan-conditioned recipients: In one set of ... Laquinimod was dosed orally at 25 mg⋅kg⋅d beginning on the day of immunization until the end of the experiment (days 0-30). ... Test Compounds and Formulation.. Laquinimod was synthesized at Teva Pharmaceutical Industries, Ltd. The compound was dissolved ...http://www.pnas.org/content/113/41/E6145
Impact of hepatitis C virus seropositivity on survival after allogeneic hematopoietic stem cell transplantation for hematologic...
1994) Liver function tests of recipients with hepatitis C virus infection after bone marrow transplantation. Bone Marrow ... Myeloablative strategies included regimens both with and without busulfan or total body irradiation. Busulfan doses were ... 1995) Hepatitis C virus infection and liver failure in patients undergoing allogeneic bone marrow transplantation. Bone Marrow ... a survey from the European Bone Marrow Transplantation (EBMT) Group--Infectious Diseases Working Party. Bone Marrow Transplant ...http://www.haematologica.org/content/94/2/249
Myleran Side Effects in Detail - Drugs.com
... busulfan). Includes common and rare side effects information for consumers and healthcare professionals. ... Bone Marrow Transplantation fluconazole, Diflucan, cisplatin, Neupogen, filgrastim, Zarxio, busulfan, Octagam, Leukine, ... De La Camara R, Tomas JF, Figuera A, Berberana M, Fernandez-Ranada JM "High dose busulfan and seizures." Bone Marrow Transplant ... However, pituitary function testing with metyrapone revealed a blunted 17-hydroxycorticosteroid excretion in two patients. ...https://www.drugs.com/sfx/myleran-side-effects.html
Nelson Jen An Chao, MD | medicine.duke.edu
... clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease ... "Mini test dose of intravenous busulfan (busulfex(®)) in allogeneic non-myeloablative stem cell transplantation, followed by ... "Preemptive dosing of plerixafor given to poor stem cell mobilizers on day 5 of G-CSF administration." Bone Marrow Transplant 47 ... "Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche." Cell Rep ...https://medicine.duke.edu/faculty/nelson-jen-chao-md?page=6
IV Busulfan With Allo-BMT: Study for Patients With Acute Myelogenous Leukemia and Myelodysplastic Syndrome
The goal of this clinical research study is to learn if giving busulfan in a dose based on blood levels, along with a fixed ( ... the year after transplantation to try to keep the leukemia from coming back.. You will undergo blood tests and bone marrow ... in the fixed-dose group will receive a fixed dose of busulfan without the test dose. If. you are assigned to the fixed-dose ... following the test dose and the first high-dose busulfan treatment; each sample is about 1. teaspoon of blood. A heparin lock ...http://www.knowcancer.com/cancer-trials/NCT00469144/
A Pilot Trial Examining Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic Stem Cell...
... blood and bone marrow following transplantation (Objective #2). The site will correlate these laboratory results with clinical ... Phase II trials: A phase II trial continues to test the safety of the drug, and begins to evaluate how well the new drug works ... The site will use a myeloablative regimen of fludarabine with busulfan, adopted from CALGB 100801, to define clinical endpoints ... and what dose is safe. A phase I trial usually enrolls only a small number of patients, sometimes as few as a dozen. ...https://cancer.dartmouth.edu/patients/clinical_trial/D16127/
Gene Therapy for Metachromatic Leukodystrophy - Full Text View - ClinicalTrials.gov
Busulfan will be administered to the patients to enable engraftment of the transduced stem/progenitor cells in the bone marrow ... Hematopoietic cell transplantation (HCT) is ineffective in ameliorating patients' phenotype or delaying disease evolution. No ... Dose: ≥ 2x10^6 transduced CD34+ cells/Kg (maximum 20x10^6) at bedside for infusion. ... We have developed and tested a clinically applicable LV containing the ARSA cDNA controlled by a constitutive eukaryotic ...https://clinicaltrials.gov/ct2/show/NCT01560182?term=Metachromatic+Leukodystrophy&rank=3
Autologous hematopoietic cell transplantation - Renal and Urology News
In autologous transplantation, the reinfused stem cells are derived from the patient's own bone marrow and collected from the ... These tests are also used to assess any evidence of lingering or complicating infections (lung, liver) prior to high dose ... Busulfan. Seizures, nausea, vomiting, veno-occlusive disease. Alopecia, pulmonary fibrosis. Cisplatin. Renal impairment, ... lists the acute and long-term toxicities of the major agents used in bone marrow transplantation preparative regimens. ...https://www.renalandurologynews.com/hematology/autologous-hematopoietic-cell-transplantation/article/597176/
Leukemia, Chronic | definition of Leukemia, Chronic by Medical dictionary
Allogeneic (belonging to same species) bone marrow transplantations before blast crisis offer the best treatment option. ... Test. Normal Result. Abnormality With Condition. Explanation. Complete blood count and differential. Red blood cells (RBCs) 4- ... CML: Busulfan (Myleran) and hydroxyurea; when a blast crisis occurs, other drugs are used: cytosine arabinoside, omacetaxine, ... Environmental factors such as exposure to high-dose radiation may increase the risk of CML. In most patients with CML, there is ...http://medical-dictionary.thefreedictionary.com/Leukemia%2C+Chronic
Differential damage and recovery of human mesenchymal stem cells after exposure to chemotherapeutic agents - Li - 2004 -...
Autologous bone marrow repopulation following high-dose cyclophosphamide and allogeneic marrow transplantation in aplastic ... A variety of dose-response curves were produced with the chemotherapeutic agents tested. Increasing concentrations of etoposide ... Fried, W., Kedo, A. & Barone, J. (1977) Effects of cyclophosphamide and of busulfan on spleen colony-forming units and on ... High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow ...http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2004.05200.x/full
Reproductive issues in patients undergoing Hematopoietic Stem Cell Transplantation: an update | Springer for Research &...
In 1963 George Mathé announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. ... Long-term follow-up of secondary malignancies in adults after allogeneic bone marrow transplantation. Bone Marrow Transplant. ... HPV-test should be repeated every six-month. Bone mineral density evaluation by MOC-DEXA of the vertebral district and of the ... This counselling analyses type and dose of the chemotherapy regimen proposed, method of administration (oral versus intravenous ...https://rd.springer.com/article/10.1186/s13048-016-0279-y
Bone marrow is then transplanted after killing off the cancer cells. Transplantations have better outcomes if the donor has the ... Before transplantation can take place, the person receiving the transplant will be given aggressive high-dose chemotherapy and ... It may be detected on a routine blood test. Apart from Stem cell transplant there is no curative treatment currently available ... The most widely used chemotherapeutic agents for the control of chronic phase CML are busulfan and hydroxyurea. Interferon alfa ...https://www.news-medical.net/health/Leukemia-Treatments.aspx
Global Dialysis - Every donor kidney a perfect match: no more transplant drugs!
... and her colleagues have found a way to introduce foreign bone marrow stem cells from the donor into the recipient's bone marrow ... The technique involves using a small dose of Busulfan (a chemotherapy drug usually given before a stem cell transplant for ... There are many tests and trials to complete before it becomes a standard clinical treatment for transplants. But the fact that ... The details were published in the 10 July 2014 edition of the American Journal of Transplantation. ...http://www.globaldialysis.com/blogs/kamaldshah/item/519-every-donor-kidney-a-perfect-match-no-more-transplant-drugs.html
Gabriel Mannis, MD | UCSF Helen Diller Family Comprehensive Cancer Center
A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for ... Assistant Professor, Hematology/Blood and Marrow Transplantation, UCSF Cancer Center Program Memberships. Hematopoietic ... Risk-reducing salpingo-oophorectomy and ovarian cancer screening in 1077 women after BRCA testing. JAMA Intern Med. 2013 Jan 28 ... Bone Marrow Transplant. 2015 Jan; 50(1):40-4.. View on PubMed ... autologous stem cell transplantation in acute myeloid leukemia ...http://cancer.ucsf.edu/people/profiles/mannis_gabriel.7332
PNU 200577 - Aurora Kinases as Druggable Targets in Cancer Therapy
Graft Collection Preliminary canine HCT research involved the usage of bone tissue marrow PNU 200577 as the foundation of ... These findings weren't observed in a smaller sized variety of dogs conditioned with either busulfan or Cy. 129 Acute unwanted ... sufferers with aplastic anemia or other non-malignant diseases who had been candidates for marrow transplantation.125-127 ... incidences of infection.128 Fitness regimen-induced unwanted effects The primary long-term unwanted effects after high-dose TBI ...http://www.exposed-skin-care.net/tag/pnu-200577/