Endothelin-1-Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca2+]i...
MAPK) by MAPK kinase has been suggested to play a role in smooth muscle sensitization to [Ca2+]i.21-28⇓⇓⇓⇓⇓⇓⇓ ... Endothelin-1-Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca2+]i ... Endothelin-1-Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca2+]i ... Endothelin-1-Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca2+]i ...http://hyper.ahajournals.org/content/39/2/543
Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle...
Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle- ... Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle- ... SDF-1Î± upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines. Pan, Feng; Ma, Shijie; Cao, ... While some differences of gene expression and function in papillary (Ta), superficial (T1) and muscle-invasive (â‰¥T2) bladder ...http://connection.ebscohost.com/c/articles/87623744/expression-microarray-meta-analysis-identifies-genes-associated-ras-mapk-related-pathways-progression-muscle-invasive-bladder-transition-cell-carcinoma
p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation. | Sigma-Aldrich
p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation.. [Eun-Sun Yun, ... which is a p38 MAPK specific inhibitor, or expression of the dominant negative p38 MAPK (DN p38 MAPK) gene blocked esculetin- ... The present results suggest an unexpected role of the p38 MAPK signaling pathway in esculetin-induced inhibition of VSMC growth ... The phenolic compound esculetin is known to inhibit the proliferation of vascular smooth muscle cells (VSMC). However, the ...https://www.sigmaaldrich.com/catalog/papers/21600278
Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway ...
... and 5-hydroxytryptamine 5-HT1B receptors in smooth muscle cells not only in the ischemic MCA but also in smooth muscle cells of ... expressed in the smooth muscle cells. The same antibodies were used as above but in addition mouse anti rat smooth muscle actin ... and 5-hydroxytryptamine 5-HT1B receptors versus smooth muscle actin, expressed in the smooth muscle cells, revealed clear co- ...https://rd.springer.com/article/10.1186/1471-2202-9-85
Embryonic anti-aging niche
In human muscle it is the age-specific loss of MAPK/pERK signaling strength that precludes the up-regulation of Delta and ... Keywords: stem cell aging, regeneration, niche, senescent, cell cycle, Notch, TGF-β, MAPK, muscle, hESC ... The interactions between MAPK and Delta/Notch signaling are also conserved between mammals and Drosophila, where the MAPK ... For example, it was found that satellite cells (muscle stem cells), residing in old muscle do not irreversibly lose their ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3156606/?lang=en-ca
KAKEN - Research Projects | αBクリスタリンの神経組織蓄積機構の解明 (KAKENHI-PROJECT-13877126)
Publications] Hirade, K.: 'Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle ... Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells'J ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13877126/
Muscling toward a longer life: Genetic aging pathway identified in flies
A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function and lifespan in Drosophila. Dev Cell 21, 783-795 ... Genetic clues »MAP »MEF2 »Medicine »MnSOD »Muscling »Sanyal »Vrailas-Mortimer »caloric restriction »cell death »nerve cell » ... Further reports about: , Genetic clues , MAP , MEF2 , Medicine , MnSOD , Muscling , Sanyal , Vrailas-Mortimer , caloric ... Researchers at Emory University School of Medicine have identified a set of genes that act in muscles to modulate aging and ...http://www.innovations-report.com/html/reports/life-sciences/muscling-a-longer-life-genetic-aging-pathway-184000.html
Understanding Atrophy | Science Signaling
Denervation caused less activation of NF-κB, JNK, AMPK, and p38 MAPK in TRAF6-depleted muscles. Finally, the activation of NF- ... Although muscle-specific knockout of TRAF6 did not cause any overt muscle phenotypes, muscle atrophy due to denervation was ... Skeletal muscle atrophy is a major health concern and can be caused by denervation, immobility, or chronic disease states, such ... Previous work had found that the denervated muscles were more responsive to the cytokine TWEAK, and the same group now reports ...http://stke.sciencemag.org/content/4/154/ec3
apoptosis | Articles related to apoptosis | Open Access Journal | Annex Publishers
MAPK Pathway in Skeletal Muscle Diseases. Articles related to apoptosis are open access to read here. ... MAPK Pathway in Skeletal Muscle Diseases. Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that ...http://www.annexpublishers.com/tag/apoptosis/
Tribbles: 'puzzling' regulators of cell signalling | Biochemical Society Transactions
2007) Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J. Biol. Chem. ... trb-1 has been shown to associate with MKK4 (MAPK kinase 4) and regulate smooth muscle cell proliferation . The ... 2005) Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells ( ... 2009) Antifungal innate immunity in C. elegans: PKCδ links G protein signaling and a conserved p38 MAPK cascade. Cell Host ...http://www.biochemsoctrans.org/content/39/2/684
Stephen Roth | UMD School of Public Health
Exercise alters mRNA expression of telomere-repeat binding factor 1 in skeletal muscle via p38 MAPK. Journal of Applied ... Roth, S.M. Genetic aspects of skeletal muscle strength and mass with relevance to sarcopenia. BoneKEy Reports, 1, Article ... Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. Journal of Gerontology: Biological Sciences ... skeletal muscle traits, and other health-related phenotypes, as well as understanding the role of physical activity in ...https://sph.umd.edu/people/stephen-roth
1992) MAPK activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J 11:2123-2129. ... using MEK and phospho-MAPK antibodies.Lanes 1 and 2 (preincubated in ATP) were reacted with phospho-MAPK antibody. Note that no ... Microcystin LR and antibody to phospho-independent MAPK were obtained from Calbiochem (La Jolla, CA). The antibody to the MAPK ... also may depend on MAPK phosphorylation. An immunocytochemical study at the light and EM levels has demonstrated that MAPK is ...http://www.jneurosci.org/content/18/11/4008
Similar articles for PubMed (Select 23994518) - PubMed - NCBI
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. ... Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle. ... Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive. ... Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=23994518
Anti-MEF2A antibody (ab51153) | Abcam
Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or ... Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform ... Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific ... Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. ...http://www.abcam.com/mef2a-antibody-ab51153.html
Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle CellsNovelty and Significance | Circulation...
Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent. Exp Cell Res. 2003;290 ... hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and ... Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle CellsNovelty and Significance. Amy Leung, ... Knockdown of Lnc-Ang362 decreases expression of miR-221 and miR-222 and reduces cell proliferation. Vascular smooth muscle ...http://circres.ahajournals.org/content/113/3/266.long
IJMS | Free Full-Text | The Role of Sialyl-Tn in Cancer
Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex- ...http://www.mdpi.com/1422-0067/17/3/275
Cell proliferation, tumorogenicity, and apoptosis sub-cluster 48
Oxidized LDL affects smooth muscle cell growth through MAPK-mediated actions on nuclear ... ... We studied trogocytosis in the interaction of T cells with human skeletal muscle cells modeling muscle-immune cell interactions ... In vitro skeletal muscle engineering involves the culture of isolated primary myogenic cells in an environment conducive to the ... A cardiac muscle cell culture serves as an excellent experimental system to investigate this phenomenon because timings of ...http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-48-p6.html
PI3-Kinase-Induced Hyperreactivity in DOCA-Salt Hypertension Is Independent of GSK-3 Activity | Hypertension
Extracellular magnesium deficiency induces contraction of arterial muscle: role of PI3-kinases and MAPK signaling pathways. ... PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways. J Appl Physiol. 2001; 91: 1819-1827. ... Src kinase and PI3-kinase as transduction pathway in ceramide-induced contraction of colonic smooth muscle. Am J Physiol. 1998; ... Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol ...http://hyper.ahajournals.org/content/41/4/898
Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo | JCB
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J. 24:974-984. ... MAPKs function as the terminal components of three-tiered cascades of kinases comprised of a MAPK kinase kinase (MAP3K), MAPK ... specificity between distinct MAPK subfamilies by assembling individual MAPK modules and (2) precise spatial and temporal ... The myriad roles of MAPK cascades indicate that the specificity of MAPK activation and function must be regulated. One ...http://jcb.rupress.org/content/175/3/383
TRIB1 - Wikipedia
2007). "Human Tribbles-1 Controls Proliferation and Chemotaxis of Smooth Muscle Cells via MAPK Signalling Pathways". J. Biol. ... It exerts its biological functions through binding to signalling proteins of the MAPKK level of the MAPK pathway, therefore ... which not only produces its function on the MAPK pathway, but also works to protect it from degradation whilst binding. This, ...https://en.wikipedia.org/wiki/TRIB1
The effect of QTL-rich region polymorphisms identified by targeted DNA-seq on pig production traits | SpringerLink
MAPK3 participates in the MAPK/ERK pathway, which is essential for muscle cell proliferation and regeneration . ENO3 is a ... The influence of the FN1 gene on the toughness of cooked semimembranosus muscle was observed with a significance of P , 0.05 ( ... This result suggests that FN1 expression is switched off when massive muscle growth occurs. Moreover, Ponsuksili et al. , ... Cassar-Malek I, Passelaigue F, Bernard C, Léger J, Hocquette J-F (2007) Target genes of myostatin loss-of-function in muscles ...https://link.springer.com/article/10.1007/s11033-018-4170-3
Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts | Heart and Circulatory...
24) reported that activation of p42/44 MAPK increased Rb phosphorylation in vascular smooth muscle cells. Tafazzin knockdown ... Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. J Biol Chem 286: 899-908, 2011. ... Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene 21: ... MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation. Life Sci 80: 2259-2262, 2007. ...http://ajpheart.physiology.org/content/305/9/H1332.long
P38 mitogen-activated protein kinases - Wikipedia
Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle ... Segalés J, Perdiguero E, Muñoz-Cánoves P (2016). "Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling ... Segalés, J (August 2016). "Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway". Front Cell Dev ... p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast ...https://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases
Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis | JEM
TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J. 19:362- ... Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) ... Muscle-specific E3 ubiquitin ligases, muscle atrophy F-box (MAFbx or atrogin-1), and muscle ring finger protein 1 (MuRF1; ... Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc. Natl. Acad. Sci. USA. 98:14440-14445. ...http://jem.rupress.org/content/early/2011/11/10/jem.20111020
Professor Endre Kiss-Toth - Publications - Publications - Staff and Student List - Infection, Immunity & Cardiovascular Disease...
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.. J Biol Chem. , 282( ... Guan H, Sung HY, Eder K, Dower S & Kiss-Toth E (2007) TRB proteins are competitive inhibitors of MAPK activation via ... Shuaib A, Hartwell A, Kiss-Toth E & Holcombe M (2016) Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to ... Sung HY, Francis S, Crossman DC & Kiss-Toth E (2005) Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates ...https://www.sheffield.ac.uk/iicd/profiles/publications/kiss-toth